MOUSE:PO5F1

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Species (Taxon ID)	Mus musculus (Mouse). (taxon:10090)
Gene Name(s)	Pou5f1 ( synonyms: Oct-3, Oct-4, Otf-3, Otf3 )
Protein Name(s)	POU domain, class 5, transcription factor 1 NF-A3 Octamer-binding protein 3 Oct-3 Octamer-binding protein 4 Oct-4 Octamer-binding transcription factor 3 OTF-3
External Links
UniProt Identifier	PO5F1_MOUSE
UniProt Accessions	P20263, Q63843,
EMBL	M34381, X52437, S58426, S58422, S58423, S58424, S58425, BC068268,
PIR	A34672, S17313,
RefSeq	NP_038661.2,
PDB	1OCP, 3L1P,
IntAct	P20263,
Ensembl	ENSMUST00000025271,
Pfam	PF00046, PF00157,

Annotations

Qualifier	GO ID	GO term name	Reference	Evidence Code	with/from	Aspect	Notes	Status
	GO:0005737	cytoplasm		IDA: Inferred from Direct Assay		C	Source: MGI
	GO:0005667	transcription factor complex		IDA: Inferred from Direct Assay		C	Source: MGI
	GO:0017053	transcriptional repressor complex		IDA: Inferred from Direct Assay		C	Source: MGI
	GO:0003682	chromatin binding		IDA: Inferred from Direct Assay		F	Source: MGI
	GO:0010843	promoter binding		IDA: Inferred from Direct Assay		F	Source: UniProtKB
	GO:0003700	sequence-specific DNA binding transcription...		IDA: Inferred from Direct Assay		F	Source: MGI
	GO:0003714	transcription corepressor activity		IDA: Inferred from Direct Assay		F	Source: MGI
	GO:0001712	ectodermal cell fate commitment		IDA: Inferred from Direct Assay		P	Source: MGI
	GO:0001711	endodermal cell fate commitment		IDA: Inferred from Direct Assay		P	Source: MGI
	GO:0030718	germ-line stem cell maintenance		IMP: Inferred from Mutant Phenotype		P	Source: MGI
	GO:0001710	mesodermal cell fate commitment		IDA: Inferred from Direct Assay		P	Source: MGI
	GO:0045955	negative regulation of calcium ion-dependen...		IDA: Inferred from Direct Assay		P	Source: MGI
	GO:0000122	negative regulation of transcription from R...		IGI: Inferred from Genetic Interaction		P	Source: MGI
	GO:0045944	positive regulation of transcription from R...		IDA: Inferred from Direct Assay		P	Source: MGI
	GO:0032526	response to retinoic acid		IDA: Inferred from Direct Assay		P	Source: MGI
	GO:0006366	transcription from RNA polymerase II promoter		IDA: Inferred from Direct Assay		P	Source: MGI
	GO:0001829	trophectodermal cell differentiation		IGI: Inferred from Genetic Interaction		P	Source: MGI
	GO:0031625	ubiquitin protein ligase binding	PMID:15047715^[1]	IPI: Inferred from Physical Interaction	UniProtKB:Q9DBH0	F	Fig 3. Wwp2 binds oct4 both in vitro and in vivo	complete
	GO:0005634	nucleus	PMID:15047715^[1]	IDA: Inferred from Direct Assay		C	fig 2b	complete
	GO:0045941	positive regulation of transcription	PMID:15047715^[1]	EXP: Inferred from Experiment		P	fig 6	complete
	GO:0000981	sequence-specific DNA binding RNA polymerase II transcription factor activity	PMID:15047715^[1]	IDA: Inferred from Direct Assay		F
	GO:0001710	mesodermal cell fate commitment	PMID:10742100^[2]	IDA: Inferred from Direct Assay		P
	GO:0001711	endodermal cell fate commitment	PMID:10742100^[2]	IDA: Inferred from Direct Assay		P
	GO:0001712	ectodermal cell fate commitment	PMID:10742100^[2]	IDA: Inferred from Direct Assay		P
	GO:0001824	blastocyst development	PMID:21258368^[3]	IEP: Inferred from Expression Pattern		P
	GO:0001829	trophectodermal cell differentiation	PMID:16325584^[4]	IGI: Inferred from Genetic Interaction	MGI:MGI:1201683	P
	GO:0003677	DNA binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR010982	F
	GO:0003677	DNA binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR012287	F
	GO:0003677	DNA binding	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0238	F
	GO:0003677	DNA binding	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0371	F
	GO:0003677	DNA binding	PMID:12665572^[5]	IDA: Inferred from Direct Assay		F
	GO:0003677	DNA binding	PMID:1967980^[6]	IDA: Inferred from Direct Assay		F
	GO:0003682	chromatin binding	PMID:15988017^[7]	IDA: Inferred from Direct Assay		F
	GO:0003682	chromatin binding	PMID:18467660^[8]	IDA: Inferred from Direct Assay		F
	GO:0003700	sequence-specific DNA binding transcription factor activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR000327	F
	GO:0003700	sequence-specific DNA binding transcription factor activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR001356	F
	GO:0003700	sequence-specific DNA binding transcription factor activity	PMID:12665572^[5]	IDA: Inferred from Direct Assay		F
	GO:0003700	sequence-specific DNA binding transcription factor activity	PMID:1967980^[6]	IDA: Inferred from Direct Assay		F
	GO:0003700	sequence-specific DNA binding transcription factor activity	PMID:1972777^[9]	IDA: Inferred from Direct Assay		F
	GO:0003700	sequence-specific DNA binding transcription factor activity	PMID:2357966^[10]	IDA: Inferred from Direct Assay		F
	GO:0003714	transcription corepressor activity	PMID:16325584^[4]	IDA: Inferred from Direct Assay		F
	GO:0005515	protein binding	PMID:15917470^[11]	IPI: Inferred from Physical Interaction	UniProtKB:Q61545	F
	GO:0005515	protein binding	PMID:17093407^[12]	IPI: Inferred from Physical Interaction	UniProtKB:Q61066	F
	GO:0005515	protein binding	PMID:17093407^[12]	IPI: Inferred from Physical Interaction	UniProtKB:Q80Z64	F
	GO:0005515	protein binding	PMID:17541407^[13]	IPI: Inferred from Physical Interaction	UniProtKB:P87377	F
	GO:0005515	protein binding	PMID:18191611^[14]	IPI: Inferred from Physical Interaction	UniProtKB:P52480	F
	GO:0005515	protein binding	PMID:18662995^[15]	IPI: Inferred from Physical Interaction	UniProtKB:Q61539	F
	GO:0005515	protein binding	PMID:19740739^[16]	IPI: Inferred from Physical Interaction	UniProtKB:Q3URR7	F
	GO:0005515	protein binding	PMID:20362542^[17]	IPI: Inferred from Physical Interaction	UniProtKB:P11103	F
	GO:0005515	protein binding	PMID:21076177^[18]	IPI: Inferred from Physical Interaction	UniProtKB:P63028	F
	GO:0005515	protein binding	PMID:21076177^[18]	IPI: Inferred from Physical Interaction	UniProtKB:Q5BL09	F
	GO:0005634	nucleus	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR017970	C
	GO:0005634	nucleus	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0539	C
	GO:0005634	nucleus	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0191	C
	GO:0005634	nucleus	PMID:12641567^[19]	IDA: Inferred from Direct Assay		C
	GO:0005634	nucleus	PMID:12665572^[5]	IC: Inferred by Curator	GO:0003700	C
	GO:0005634	nucleus	PMID:14502573^[20]	IDA: Inferred from Direct Assay		C
	GO:0005634	nucleus	PMID:15183310^[21]	IDA: Inferred from Direct Assay		C
	GO:0005634	nucleus	PMID:15525667^[22]	IDA: Inferred from Direct Assay		C
	GO:0005634	nucleus	PMID:15977177^[23]	IDA: Inferred from Direct Assay		C
	GO:0005634	nucleus	PMID:16325584^[4]	IDA: Inferred from Direct Assay		C
	GO:0005634	nucleus	PMID:16611995^[24]	IDA: Inferred from Direct Assay		C
	GO:0005634	nucleus	PMID:17138661^[25]	IDA: Inferred from Direct Assay		C
	GO:0005634	nucleus	PMID:17882221^[26]	IDA: Inferred from Direct Assay		C
	GO:0005634	nucleus	PMID:18096721^[27]	IDA: Inferred from Direct Assay		C
	GO:0005634	nucleus	PMID:18423437^[28]	IDA: Inferred from Direct Assay		C
	GO:0005634	nucleus	PMID:18425773^[29]	IDA: Inferred from Direct Assay		C
	GO:0005634	nucleus	PMID:18662995^[15]	IDA: Inferred from Direct Assay		C
	GO:0005634	nucleus	PMID:20123909^[30]	IDA: Inferred from Direct Assay		C
	GO:0005634	nucleus	PMID:21258368^[3]	IDA: Inferred from Direct Assay		C
	GO:0005634	nucleus	PMID:7958450^[31]	IDA: Inferred from Direct Assay		C
	GO:0005634	nucleus	PMID:7969117^[32]	IDA: Inferred from Direct Assay		C
	GO:0005634	nucleus	PMID:9507072^[33]	IDA: Inferred from Direct Assay		C
	GO:0005654	nucleoplasm	PMID:21076177^[18]	IDA: Inferred from Direct Assay		C
	GO:0005667	transcription factor complex	PMID:17507372^[34]	IDA: Inferred from Direct Assay		C
	GO:0005667	transcription factor complex	PMID:7969117^[32]	IDA: Inferred from Direct Assay		C
	GO:0005737	cytoplasm	PMID:7958450^[31]	IDA: Inferred from Direct Assay		C
	GO:0006351	transcription, DNA-dependent	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0804	P
	GO:0006355	regulation of transcription, DNA-dependent	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR000327	P
	GO:0006355	regulation of transcription, DNA-dependent	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR001356	P
	GO:0006355	regulation of transcription, DNA-dependent	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR012287	P
	GO:0006355	regulation of transcription, DNA-dependent	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR017970	P
	GO:0006355	regulation of transcription, DNA-dependent	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0805	P
	GO:0006355	regulation of transcription, DNA-dependent	PMID:12665572^[5]	IDA: Inferred from Direct Assay		P
	GO:0006366	transcription from RNA polymerase II promoter	PMID:15047715^[1]	IDA: Inferred from Direct Assay		P
	GO:0006366	transcription from RNA polymerase II promoter	PMID:1967980^[6]	IDA: Inferred from Direct Assay		P
	GO:0007275	multicellular organismal development	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0217	P
	GO:0008134	transcription factor binding	PMID:17541407^[13]	IPI: Inferred from Physical Interaction	UniProtKB:P70062	F
	GO:0008134	transcription factor binding	PMID:19816951^[35]	IPI: Inferred from Physical Interaction	UniProtKB:Q60793	F
	GO:0008134	transcription factor binding	PMID:21076177^[18]	IPI: Inferred from Physical Interaction	UniProtKB:P48432	F
	GO:0009786	regulation of asymmetric cell division	PMID:21258368^[3]	IEP: Inferred from Expression Pattern		P
	GO:0017053	transcriptional repressor complex	PMID:16325584^[4]	IDA: Inferred from Direct Assay		C
	GO:0019827	stem cell maintenance	PMID:14502573^[20]	IMP: Inferred from Mutant Phenotype		P
	GO:0019827	stem cell maintenance	PMID:16767105^[36]	IMP: Inferred from Mutant Phenotype		P
	GO:0019827	stem cell maintenance	PMID:9814708^[37]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1933381	P
	GO:0030718	germ-line stem cell maintenance	PMID:15486564^[38]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2177588	P
	GO:0030718	germ-line stem cell maintenance	PMID:15486564^[38]	IMP: Inferred from Mutant Phenotype	MGI:MGI:3578312	P
	GO:0031625	ubiquitin protein ligase binding	PMID:15047715^[1]	IPI: Inferred from Physical Interaction	UniProtKB:Q9DBH0	F
	GO:0032526	response to retinoic acid	PMID:18400104^[39]	IDA: Inferred from Direct Assay		P
	GO:0042221	response to chemical stimulus	PMID:18400104^[39]	IDA: Inferred from Direct Assay		P
	GO:0042789	mRNA transcription from RNA polymerase II promoter	PMID:15047715^[1]	IDA: Inferred from Direct Assay		P
	GO:0043565	sequence-specific DNA binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR001356	F
	GO:0043565	sequence-specific DNA binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR017970	F
	GO:0043565	sequence-specific DNA binding	PMID:16518401^[40]	IDA: Inferred from Direct Assay		F
	GO:0043565	sequence-specific DNA binding	PMID:1690859^[41]	IDA: Inferred from Direct Assay		F
	GO:0043565	sequence-specific DNA binding	PMID:18400104^[39]	IDA: Inferred from Direct Assay		F
	GO:0043565	sequence-specific DNA binding	PMID:7945330^[42]	IDA: Inferred from Direct Assay		F
	GO:0043565	sequence-specific DNA binding	PMID:7969117^[32]	IDA: Inferred from Direct Assay		F
	GO:0043565	sequence-specific DNA binding	PMID:8960364^[43]	IDA: Inferred from Direct Assay		F
	GO:0043565	sequence-specific DNA binding	PMID:9649510^[44]	IDA: Inferred from Direct Assay		F
	GO:0044212	transcription regulatory region DNA binding	PMID:17541407^[13]	IDA: Inferred from Direct Assay		F
	GO:0045165	cell fate commitment	PMID:9814708^[37]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1933381	P
	GO:0045596	negative regulation of cell differentiation	PMID:16325584^[4]	IGI: Inferred from Genetic Interaction	MGI:MGI:1201683	P
	GO:0045892	negative regulation of transcription, DNA-dependent	PMID:1967980^[6]	IDA: Inferred from Direct Assay		P
	GO:0045893	positive regulation of transcription, DNA-dependent	PMID:1967980^[6]	IDA: Inferred from Direct Assay		P
	GO:0045944	positive regulation of transcription from RNA polymerase II promoter	PMID:15988017^[7]	IMP: Inferred from Mutant Phenotype		P
	GO:0045944	positive regulation of transcription from RNA polymerase II promoter	PMID:17097055^[45]	IGI: Inferred from Genetic Interaction	MGI:MGI:98364	P
	GO:0045944	positive regulation of transcription from RNA polymerase II promoter	PMID:17507372^[34]	IGI: Inferred from Genetic Interaction	MGI:MGI:98364	P
	GO:0045944	positive regulation of transcription from RNA polymerase II promoter	PMID:1972777^[9]	IDA: Inferred from Direct Assay		P
	GO:0045944	positive regulation of transcription from RNA polymerase II promoter	PMID:7590241^[46]	IGI: Inferred from Genetic Interaction	MGI:MGI:98364	P
	GO:0045944	positive regulation of transcription from RNA polymerase II promoter	PMID:9649510^[44]	IDA: Inferred from Direct Assay		P
	GO:0045944	positive regulation of transcription from RNA polymerase II promoter	PMID:9649510^[44]	IGI: Inferred from Genetic Interaction	MGI:MGI:98364	P
	GO:0045955	negative regulation of calcium ion-dependent exocytosis	PMID:2357966^[10]	IDA: Inferred from Direct Assay		P
	GO:0048863	stem cell differentiation	PMID:20123909^[30]	IDA: Inferred from Direct Assay		P
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 ^1.6 Xu HM et al. (2004) Wwp2, an E3 ubiquitin ligase that targets transcription factor Oct-4 for ubiquitination. J Biol Chem 279: 23495-503 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 Niwa H et al. (2000) Quantitative expression of Oct-3/4 defines differentiation, dedifferentiation or self-renewal of ES cells. Nat Genet 24: 372-6 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 Plachta N et al. (2011) Oct4 kinetics predict cell lineage patterning in the early mammalian embryo. Nat Cell Biol 13: 117-23 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 ^4.4 Niwa H et al. (2005) Interaction between Oct3/4 and Cdx2 determines trophectoderm differentiation. Cell 123: 917-29 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 ^5.3 Tokuzawa Y et al. (2003) Fbx15 is a novel target of Oct3/4 but is dispensable for embryonic stem cell self-renewal and mouse development. Mol Cell Biol 23: 2699-708 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 ^6.3 ^6.4 Okamoto K et al. (1990) A novel octamer binding transcription factor is differentially expressed in mouse embryonic cells. Cell 60: 461-72 PubMed GONUTS page
↑ ^7.0 ^7.1 Chew JL et al. (2005) Reciprocal transcriptional regulation of Pou5f1 and Sox2 via the Oct4/Sox2 complex in embryonic stem cells. Mol Cell Biol 25: 6031-46 PubMed GONUTS page
↑ Tam WL et al. (2008) T-cell factor 3 regulates embryonic stem cell pluripotency and self-renewal by the transcriptional control of multiple lineage pathways. Stem Cells 26: 2019-31 PubMed GONUTS page
↑ ^9.0 ^9.1 Rosner MH et al. (1990) A POU-domain transcription factor in early stem cells and germ cells of the mammalian embryo. Nature 345: 686-92 PubMed GONUTS page
↑ ^10.0 ^10.1 Schöler HR et al. (1990) Oct-4: a germline-specific transcription factor mapping to the mouse t-complex. EMBO J 9: 2185-95 PubMed GONUTS page
↑ Lee J et al. (2005) Stimulation of Oct-4 activity by Ewing's sarcoma protein. Stem Cells 23: 738-51 PubMed GONUTS page
↑ ^12.0 ^12.1 Wang J et al. (2006) A protein interaction network for pluripotency of embryonic stem cells. Nature 444: 364-8 PubMed GONUTS page
↑ ^13.0 ^13.1 ^13.2 Cao Y et al. (2007) POU-V factors antagonize maternal VegT activity and beta-Catenin signaling in Xenopus embryos. EMBO J 26: 2942-54 PubMed GONUTS page
↑ Lee J et al. (2008) Pyruvate kinase isozyme type M2 (PKM2) interacts and cooperates with Oct-4 in regulating transcription. Int J Biochem Cell Biol 40: 1043-54 PubMed GONUTS page
↑ ^15.0 ^15.1 van den Berg DL et al. (2008) Estrogen-related receptor beta interacts with Oct4 to positively regulate Nanog gene expression. Mol Cell Biol 28: 5986-95 PubMed GONUTS page
↑ Yu HB et al. (2009) Zfp206, Oct4, and Sox2 are integrated components of a transcriptional regulatory network in embryonic stem cells. J Biol Chem 284: 31327-35 PubMed GONUTS page
↑ Pardo M et al. (2010) An expanded Oct4 interaction network: implications for stem cell biology, development, and disease. Cell Stem Cell 6: 382-95 PubMed GONUTS page
↑ ^18.0 ^18.1 ^18.2 ^18.3 Johansson H & Simonsson S (2010) Core transcription factors, Oct4, Sox2 and Nanog, individually form complexes with nucleophosmin (Npm1) to control embryonic stem (ES) cell fate determination. Aging (Albany NY) 2: 815-22 PubMed GONUTS page
↑ Durcova-Hills G et al. (2003) Developmental fate of embryonic germ cells (EGCs), in vivo and in vitro. Differentiation 71: 135-41 PubMed GONUTS page
↑ ^20.0 ^20.1 Velkey JM & O'Shea KS (2003) Oct4 RNA interference induces trophectoderm differentiation in mouse embryonic stem cells. Genesis 37: 18-24 PubMed GONUTS page
↑ Liu L et al. (2004) Effect of ploidy and parental genome composition on expression of Oct-4 protein in mouse embryos. Gene Expr Patterns 4: 433-41 PubMed GONUTS page
↑ Kemler R et al. (2004) Stabilization of beta-catenin in the mouse zygote leads to premature epithelial-mesenchymal transition in the epiblast. Development 131: 5817-24 PubMed GONUTS page
↑ Barrow KM et al. (2005) Embryonic expression of murine 5T4 oncofoetal antigen is associated with morphogenetic events at implantation and in developing epithelia. Dev Dyn 233: 1535-45 PubMed GONUTS page
↑ Cormier S et al. (2006) The murine ortholog of notchless, a direct regulator of the notch pathway in Drosophila melanogaster, is essential for survival of inner cell mass cells. Mol Cell Biol 26: 3541-9 PubMed GONUTS page
↑ Kan NG et al. (2007) Gene replacement reveals a specific role for E-cadherin in the formation of a functional trophectoderm. Development 134: 31-41 PubMed GONUTS page
↑ Seandel M et al. (2007) Generation of functional multipotent adult stem cells from GPR125+ germline progenitors. Nature 449: 346-50 PubMed GONUTS page
↑ Kuntz S et al. (2008) Tex19, a mammalian-specific protein with a restricted expression in pluripotent stem cells and germ line. Stem Cells 26: 734-44 PubMed GONUTS page
↑ Wang H et al. (2008) Zonula occludens-1 (ZO-1) is involved in morula to blastocyst transformation in the mouse. Dev Biol 318: 112-25 PubMed GONUTS page
↑ Strizzi L et al. (2008) Netrin-1 can affect morphogenesis and differentiation of the mouse mammary gland. J Cell Physiol 216: 824-34 PubMed GONUTS page
↑ ^30.0 ^30.1 Niakan KK et al. (2010) Sox17 promotes differentiation in mouse embryonic stem cells by directly regulating extraembryonic gene expression and indirectly antagonizing self-renewal. Genes Dev 24: 312-26 PubMed GONUTS page
↑ ^31.0 ^31.1 Palmieri SL et al. (1994) Oct-4 transcription factor is differentially expressed in the mouse embryo during establishment of the first two extraembryonic cell lineages involved in implantation. Dev Biol 166: 259-67 PubMed GONUTS page
↑ ^32.0 ^32.1 ^32.2 Dailey L et al. (1994) Interaction between a novel F9-specific factor and octamer-binding proteins is required for cell-type-restricted activity of the fibroblast growth factor 4 enhancer. Mol Cell Biol 14: 7758-69 PubMed GONUTS page
↑ Pesce M et al. (1998) Differential expression of the Oct-4 transcription factor during mouse germ cell differentiation. Mech Dev 71: 89-98 PubMed GONUTS page
↑ ^34.0 ^34.1 Li J et al. (2007) A dominant-negative form of mouse SOX2 induces trophectoderm differentiation and progressive polyploidy in mouse embryonic stem cells. J Biol Chem 282: 19481-92 PubMed GONUTS page
↑ Wei Z et al. (2009) Klf4 interacts directly with Oct4 and Sox2 to promote reprogramming. Stem Cells 27: 2969-78 PubMed GONUTS page
↑ Ivanova N et al. (2006) Dissecting self-renewal in stem cells with RNA interference. Nature 442: 533-8 PubMed GONUTS page
↑ ^37.0 ^37.1 Nichols J et al. (1998) Formation of pluripotent stem cells in the mammalian embryo depends on the POU transcription factor Oct4. Cell 95: 379-91 PubMed GONUTS page
↑ ^38.0 ^38.1 Kehler J et al. (2004) Oct4 is required for primordial germ cell survival. EMBO Rep 5: 1078-83 PubMed GONUTS page
↑ ^39.0 ^39.1 ^39.2 Kunarso G et al. (2008) Detailed characterization of the mouse embryonic stem cell transcriptome reveals novel genes and intergenic splicing associated with pluripotency. BMC Genomics 9: 155 PubMed GONUTS page
↑ Loh YH et al. (2006) The Oct4 and Nanog transcription network regulates pluripotency in mouse embryonic stem cells. Nat Genet 38: 431-40 PubMed GONUTS page
↑ Schöler HR et al. (1990) New type of POU domain in germ line-specific protein Oct-4. Nature 344: 435-9 PubMed GONUTS page
↑ Rosfjord E & Rizzino A (1994) The octamer motif present in the Rex-1 promoter binds Oct-1 and Oct-3 expressed by EC cells and ES cells. Biochem Biophys Res Commun 203: 1795-802 PubMed GONUTS page
↑ Wang L & Schultz GA (1996) Expression of Oct-4 during differentiation of murine F9 cells. Biochem Cell Biol 74: 579-84 PubMed GONUTS page
↑ ^44.0 ^44.1 ^44.2 Botquin V et al. (1998) New POU dimer configuration mediates antagonistic control of an osteopontin preimplantation enhancer by Oct-4 and Sox-2. Genes Dev 12: 2073-90 PubMed GONUTS page
↑ Tsuruzoe S et al. (2006) Inhibition of DNA binding of Sox2 by the SUMO conjugation. Biochem Biophys Res Commun 351: 920-6 PubMed GONUTS page
↑ Yuan H et al. (1995) Developmental-specific activity of the FGF-4 enhancer requires the synergistic action of Sox2 and Oct-3. Genes Dev 9: 2635-45 PubMed GONUTS page

[PMID:15047715-0] 1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 ^1.6 Xu HM et al. (2004) Wwp2, an E3 ubiquitin ligase that targets transcription factor Oct-4 for ubiquitination. J Biol Chem 279: 23495-503 PubMed GONUTS page

[PMID:10742100-1] 2.0 ^2.1 ^2.2 Niwa H et al. (2000) Quantitative expression of Oct-3/4 defines differentiation, dedifferentiation or self-renewal of ES cells. Nat Genet 24: 372-6 PubMed GONUTS page

[PMID:21258368-2] 3.0 ^3.1 ^3.2 Plachta N et al. (2011) Oct4 kinetics predict cell lineage patterning in the early mammalian embryo. Nat Cell Biol 13: 117-23 PubMed GONUTS page

[PMID:16325584-3] 4.0 ^4.1 ^4.2 ^4.3 ^4.4 Niwa H et al. (2005) Interaction between Oct3/4 and Cdx2 determines trophectoderm differentiation. Cell 123: 917-29 PubMed GONUTS page

[PMID:12665572-4] 5.0 ^5.1 ^5.2 ^5.3 Tokuzawa Y et al. (2003) Fbx15 is a novel target of Oct3/4 but is dispensable for embryonic stem cell self-renewal and mouse development. Mol Cell Biol 23: 2699-708 PubMed GONUTS page

[PMID:1967980-5] 6.0 ^6.1 ^6.2 ^6.3 ^6.4 Okamoto K et al. (1990) A novel octamer binding transcription factor is differentially expressed in mouse embryonic cells. Cell 60: 461-72 PubMed GONUTS page

[PMID:15988017-6] 7.0 ^7.1 Chew JL et al. (2005) Reciprocal transcriptional regulation of Pou5f1 and Sox2 via the Oct4/Sox2 complex in embryonic stem cells. Mol Cell Biol 25: 6031-46 PubMed GONUTS page

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MOUSE:PO5F1

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