GONUTS is under stress! The website is currently experiencing long-wait times and frequent time-outs due to the record number of students, groups, and annotations related to CACAO this semester. We are currently working on increasing performance -- please accept our apologies for the technical difficulties.
You can help reduce stress on the server by:
- not reloading pages frequently - this just adds
- opening links in new windows (so you can read the old page)
MOUSE:PINK1
Contents |
| Species (Taxon ID) | Mus musculus (Mouse). ([1]) | |
| Gene Name(s) | Pink1 | |
| Protein Name(s) | Serine/threonine-protein kinase PINK1, mitochondrial
BRPK PTEN-induced putative kinase protein 1 | |
| External Links | ||
| EMBL | AB053476 AF316872 AL807249 BC044743 BC054349 BC067066 | |
| IPI | IPI00387511 | |
| RefSeq | NP_081156.2 | |
| UniGene | Mm.18539 | |
| ProteinModelPortal | Q99MQ3 | |
| SMR | Q99MQ3 | |
| IntAct | Q99MQ3 | |
| STRING | Q99MQ3 | |
| PRIDE | Q99MQ3 | |
| Ensembl | ENSMUST00000030536 | |
| GeneID | 68943 | |
| KEGG | mmu:68943 | |
| UCSC | uc008vku.1 | |
| CTD | 65018 | |
| MGI | MGI:1916193 | |
| GeneTree | ENSGT00390000001206 | |
| HOVERGEN | HBG053601 | |
| InParanoid | Q99MQ3 | |
| OMA | WNISAGS | |
| OrthoDB | EOG480HW9 | |
| PhylomeDB | Q99MQ3 | |
| NextBio | 328241 | |
| ArrayExpress | Q99MQ3 | |
| Bgee | Q99MQ3 | |
| CleanEx | MM_PINK1 | |
| Genevestigator | Q99MQ3 | |
| GermOnline | ENSMUSG00000028756 | |
| GO | GO:0005829 GO:0016021 GO:0005741 GO:0005524 GO:0000287 GO:0004674 GO:0007243 GO:0033603 GO:0032226 GO:0006950 | |
| InterPro | IPR011009 IPR000719 IPR017441 IPR017442 IPR008271 | |
| Pfam | PF00069 | |
| SUPFAM | SSF56112 | |
| PROSITE | PS00107 PS50011 PS00108 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0000166 |
nucleotide binding |
IEA: Inferred from Electronic Annotation |
F |
Seeded From UniProt |
||||
| GO:0000287 |
magnesium ion binding |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSP00000364204 |
F |
Seeded From UniProt |
|||
| GO:0000287 |
magnesium ion binding |
IDA: Inferred from Direct Assay |
|
F |
Seeded From UniProt |
|||
| GO:0000422 |
mitochondrion degradation |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSP00000364204 |
P |
Seeded From UniProt |
|||
| GO:0004672 |
protein kinase activity |
IEA: Inferred from Electronic Annotation |
F |
Seeded From UniProt |
||||
| GO:0004672 |
protein kinase activity |
IEA: Inferred from Electronic Annotation |
F |
Seeded From UniProt |
||||
| GO:0004674 |
protein serine/threonine kinase activity |
IEA: Inferred from Electronic Annotation |
F |
Seeded From UniProt |
||||
| GO:0004674 |
protein serine/threonine kinase activity |
IEA: Inferred from Electronic Annotation |
F |
Seeded From UniProt |
||||
| GO:0004674 |
protein serine/threonine kinase activity |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSP00000364204 |
F |
Seeded From UniProt |
|||
| GO:0004674 |
protein serine/threonine kinase activity |
IDA: Inferred from Direct Assay |
|
F |
Seeded From UniProt |
|||
| GO:0005524 |
ATP binding |
IEA: Inferred from Electronic Annotation |
F |
Seeded From UniProt |
||||
| GO:0005524 |
ATP binding |
IEA: Inferred from Electronic Annotation |
F |
Seeded From UniProt |
||||
| GO:0005524 |
ATP binding |
IEA: Inferred from Electronic Annotation |
F |
Seeded From UniProt |
||||
| GO:0005524 |
ATP binding |
IEA: Inferred from Electronic Annotation |
F |
Seeded From UniProt |
||||
| GO:0005524 |
ATP binding |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSP00000364204 |
F |
Seeded From UniProt |
|||
| GO:0005524 |
ATP binding |
IDA: Inferred from Direct Assay |
|
F |
Seeded From UniProt |
|||
| GO:0005737 |
cytoplasm |
IEA: Inferred from Electronic Annotation |
C |
Seeded From UniProt |
||||
| GO:0005739 |
mitochondrion |
IEA: Inferred from Electronic Annotation |
C |
Seeded From UniProt |
||||
| GO:0005739 |
mitochondrion |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSP00000364204 |
C |
Seeded From UniProt |
|||
| GO:0005739 |
mitochondrion |
ISS: Inferred from Sequence or Structural Similarity |
C |
Seeded From UniProt |
||||
| GO:0005739 |
mitochondrion |
IDA: Inferred from Direct Assay |
|
C |
Seeded From UniProt |
|||
| GO:0005741 |
mitochondrial outer membrane |
IEA: Inferred from Electronic Annotation |
C |
Seeded From UniProt |
||||
| GO:0005741 |
mitochondrial outer membrane |
IEA: Inferred from Electronic Annotation |
SP_SL:SL-0172 |
C |
Seeded From UniProt |
|||
| GO:0005829 |
cytosol |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSP00000364204 |
C |
Seeded From UniProt |
|||
| GO:0005829 |
cytosol |
IEA: Inferred from Electronic Annotation |
SP_SL:SL-0091 |
C |
Seeded From UniProt |
|||
| GO:0006468 |
protein phosphorylation |
IEA: Inferred from Electronic Annotation |
P |
Seeded From UniProt |
||||
| GO:0006468 |
protein phosphorylation |
IEA: Inferred from Electronic Annotation |
P |
Seeded From UniProt |
||||
| GO:0006468 |
protein phosphorylation |
IEA: Inferred from Electronic Annotation |
P |
Seeded From UniProt |
||||
| GO:0006468 |
protein phosphorylation |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSP00000364204 |
P |
Seeded From UniProt |
|||
| GO:0006468 |
protein phosphorylation |
IDA: Inferred from Direct Assay |
|
P |
Seeded From UniProt |
|||
| GO:0006914 |
autophagy |
IEA: Inferred from Electronic Annotation |
P |
Seeded From UniProt |
||||
| GO:0006950 |
response to stress |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSP00000364204 |
P |
Seeded From UniProt |
|||
| GO:0006950 |
response to stress |
ISS: Inferred from Sequence or Structural Similarity |
P |
Seeded From UniProt |
||||
| GO:0007243 |
intracellular protein kinase cascade |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSP00000364204 |
P |
Seeded From UniProt |
|||
| GO:0007243 |
intracellular protein kinase cascade |
IDA: Inferred from Direct Assay |
|
P |
Seeded From UniProt |
|||
| GO:0010857 |
calcium-dependent protein kinase activity |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSP00000364204 |
F |
Seeded From UniProt |
|||
| GO:0016020 |
membrane |
IEA: Inferred from Electronic Annotation |
C |
Seeded From UniProt |
||||
| GO:0016021 |
integral to membrane |
IEA: Inferred from Electronic Annotation |
C |
Seeded From UniProt |
||||
| GO:0016301 |
kinase activity |
IEA: Inferred from Electronic Annotation |
F |
Seeded From UniProt |
||||
| GO:0016301 |
kinase activity |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSP00000364204 |
F |
Seeded From UniProt |
|||
| GO:0016301 |
kinase activity |
IDA: Inferred from Direct Assay |
|
F |
Seeded From UniProt |
|||
| GO:0016310 |
phosphorylation |
IEA: Inferred from Electronic Annotation |
P |
Seeded From UniProt |
||||
| GO:0016740 |
transferase activity |
IEA: Inferred from Electronic Annotation |
F |
Seeded From UniProt |
||||
| GO:0016772 |
transferase activity, transferring phosphorus-containing groups |
IEA: Inferred from Electronic Annotation |
F |
Seeded From UniProt |
||||
| GO:0018105 |
peptidyl-serine phosphorylation |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSP00000364204 |
P |
Seeded From UniProt |
|||
| GO:0031396 |
regulation of protein ubiquitination |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSP00000364204 |
P |
Seeded From UniProt |
|||
| GO:0031625 |
ubiquitin protein ligase binding |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSP00000364204 |
F |
Seeded From UniProt |
|||
| GO:0032226 |
positive regulation of synaptic transmission, dopaminergic |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:3716083 |
P |
Seeded From UniProt |
|||
| GO:0033603 |
positive regulation of dopamine secretion |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:3716083 |
P |
Seeded From UniProt |
|||
| GO:0033605 |
positive regulation of catecholamine secretion |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:3716083 |
P |
Seeded From UniProt |
|||
| GO:0043123 |
positive regulation of I-kappaB kinase/NF-kappaB cascade |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSP00000364204 |
P |
Seeded From UniProt |
|||
| GO:0043254 |
regulation of protein complex assembly |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSP00000364204 |
P |
Seeded From UniProt |
|||
| GO:0046872 |
metal ion binding |
IEA: Inferred from Electronic Annotation |
F |
Seeded From UniProt |
||||
| GO:0055131 |
C3HC4-type RING finger domain binding |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSP00000364204 |
F |
Seeded From UniProt |
|||
| GO:0090200 |
positive regulation of release of cytochrome c from mitochondria |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSP00000364204 |
P |
Seeded From UniProt |
| ||
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 1.3 1.4 1.5 Nakajima A et al. (2003) BRPK, a novel protein kinase showing increased expression in mouse cancer cell lines with higher metastatic potential. Cancer Lett 201: 195-201 PubMed GONUTS page
- ↑ Pagliarini DJ et al. (2008) A mitochondrial protein compendium elucidates complex I disease biology. Cell 134: 112-23 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 Kitada T et al. (2007) Impaired dopamine release and synaptic plasticity in the striatum of PINK1-deficient mice. Proc Natl Acad Sci U S A 104: 11441-6 PubMed GONUTS page
