MOUSE:PAX6

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Species (Taxon ID)	Mus musculus (Mouse). (taxon:10090)
Gene Name(s)	Pax6 ( synonyms: Pax-6, Sey )
Protein Name(s)	Paired box protein Pax-6 Oculorhombin
External Links
UniProt Identifier	PAX6_MOUSE
UniProt Accessions	P63015, P32117, P70601, Q62222, Q64037, Q8CEI5, Q8VDB5, Q921Q8,
EMBL	X63963, X63963, Y19196, Y19199, AK028059, BC011272, BC036957, M77842,
PIR	S42234,
RefSeq	NP_038655.1,
IntAct	P63015,
Ensembl	ENSMUST00000090391, ENSMUST00000090397, ENSMUST00000111082, ENSMUST00000111083, ENSMUST00000111084, ENSMUST00000111085, ENSMUST00000111086, ENSMUST00000111087,
Pfam	PF00046, PF00292,

Annotations

Qualifier	GO ID	GO term name	Reference	Evidence Code	with/from	Aspect	Notes	Status
	GO:0005667	transcription factor complex		TAS: Traceable Author Statement		C	Source: MGI
	GO:0010843	promoter binding		IDA: Inferred from Direct Assay		F	Source: MGI
	GO:0005515	protein binding		IPI: Inferred from Physical Interaction		F	Source: MGI
	GO:0003700	transcription factor activity		IDA: Inferred from Direct Assay		F	Source: MGI
	GO:0048708	astrocyte differentiation		IMP: Inferred from Mutant Phenotype		P	Source: MGI
	GO:0007411	axon guidance		IMP: Inferred from Mutant Phenotype		P	Source: MGI
	GO:0001709	cell fate determination		IMP: Inferred from Mutant Phenotype		P	Source: MGI
	GO:0021902	commitment of a neuronal cell to a specific...		IMP: Inferred from Mutant Phenotype		P	Source: MGI
	GO:0009950	dorsal/ventral axis specification		IMP: Inferred from Mutant Phenotype		P	Source: MGI
	GO:0042462	eye photoreceptor cell development		IMP: Inferred from Mutant Phenotype		P	Source: MGI
	GO:0021797	forebrain anterior/posterior pattern formation		IMP: Inferred from Mutant Phenotype		P	Source: MGI
	GO:0021798	forebrain dorsal/ventral pattern formation		IMP: Inferred from Mutant Phenotype		P	Source: MGI
	GO:0021905	forebrain-midbrain boundary formation		IMP: Inferred from Mutant Phenotype		P	Source: MGI
	GO:0030216	keratinocyte differentiation		IMP: Inferred from Mutant Phenotype		P	Source: MGI
	GO:0032808	lacrimal gland development		IMP: Inferred from Mutant Phenotype		P	Source: MGI
	GO:0002088	lens development in camera-type eye		IMP: Inferred from Mutant Phenotype		P	Source: MGI
	GO:0050680	negative regulation of epithelial cell prol...		IMP: Inferred from Mutant Phenotype		P	Source: MGI
	GO:0045665	negative regulation of neuron differentiation		IGI: Inferred from Genetic Interaction		P	Source: MGI
	GO:0001764	neuron migration		IMP: Inferred from Mutant Phenotype		P	Source: MGI
	GO:0021778	oligodendrocyte cell fate specification		IMP: Inferred from Mutant Phenotype		P	Source: MGI
	GO:0021543	pallium development		IMP: Inferred from Mutant Phenotype		P	Source: MGI
	GO:0021983	pituitary gland development		IMP: Inferred from Mutant Phenotype		P	Source: MGI
	GO:0030858	positive regulation of epithelial cell diff...		IMP: Inferred from Mutant Phenotype		P	Source: MGI
	GO:0002052	positive regulation of neuroblast prolifera...		IMP: Inferred from Mutant Phenotype		P	Source: MGI
	GO:0045944	positive regulation of transcription from R...		IDA: Inferred from Direct Assay		P	Source: MGI
	GO:0033365	protein localization in organelle		IMP: Inferred from Mutant Phenotype		P	Source: MGI
	GO:0030334	regulation of cell migration		IMP: Inferred from Mutant Phenotype		P	Source: MGI
	GO:0048505	regulation of timing of cell differentiation		IMP: Inferred from Mutant Phenotype		P	Source: MGI
	GO:0021912	regulation of transcription from RNA polyme...		IMP: Inferred from Mutant Phenotype		P	Source: MGI
	GO:0021913	regulation of transcription from RNA polyme...		IMP: Inferred from Mutant Phenotype		P	Source: MGI
	GO:0021918	regulation of transcription from RNA polyme...		IMP: Inferred from Mutant Phenotype		P	Source: MGI
	GO:0007435	salivary gland morphogenesis		IMP: Inferred from Mutant Phenotype		P	Source: MGI
	GO:0007224	smoothened signaling pathway		IDA: Inferred from Direct Assay		P	Source: MGI
	GO:0006350	transcription		IEA: Inferred from Electronic Annotation		P	Source: UniProtKB-KW
	GO:0010628	positive regulation of gene expression	PMID:17064680^[1]	IMP: Inferred from Mutant Phenotype		P	Fig 6c+e	complete
	GO:0000790	nuclear chromatin	PMID:20592023^[2]	IDA: Inferred from Direct Assay		C
	GO:0000979	RNA polymerase II core promoter sequence-specific DNA binding	PMID:20592023^[2]	IDA: Inferred from Direct Assay		F
	GO:0000981	sequence-specific DNA binding RNA polymerase II transcription factor activity	PMID:20592023^[2]	IDA: Inferred from Direct Assay		F
	GO:0001709	cell fate determination	PMID:12756174^[3]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1934347	P
	GO:0001764	neuron migration	PMID:15758185^[4]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1856155	P
	GO:0002052	positive regulation of neuroblast proliferation	PMID:18287938^[5]	IMP: Inferred from Mutant Phenotype		P
	GO:0002088	lens development in camera-type eye	PMID:6877261^[6]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2156742	P
	GO:0003322	pancreatic A cell development	PMID:20592023^[2]	IMP: Inferred from Mutant Phenotype		P
	GO:0003677	DNA binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR001523	F
	GO:0003677	DNA binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR012287	F
	GO:0003677	DNA binding	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0238	F
	GO:0003677	DNA binding	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0371	F
	GO:0003677	DNA binding	PMID:12756174^[3]	IDA: Inferred from Direct Assay		F
	GO:0003700	sequence-specific DNA binding transcription factor activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR001356	F
	GO:0003700	sequence-specific DNA binding transcription factor activity	PMID:10197584^[7]	TAS: Traceable Author Statement		F
	GO:0003700	sequence-specific DNA binding transcription factor activity	PMID:18287938^[5]	IDA: Inferred from Direct Assay		F
	GO:0005515	protein binding	PMID:16098226^[8]	IPI: Inferred from Physical Interaction	UniProtKB:P63168	F
	GO:0005515	protein binding	PMID:16098226^[8]	IPI: Inferred from Physical Interaction	UniProtKB:Q99JP6	F
	GO:0005515	protein binding	PMID:16098226^[8]	IPI: Inferred from Physical Interaction	UniProtKB:Q99PQ2	F
	GO:0005622	intracellular	PMID:16892058^[9]	IDA: Inferred from Direct Assay		C
	GO:0005634	nucleus	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR017970	C
	GO:0005634	nucleus	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0539	C
	GO:0005634	nucleus	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0191	C
	GO:0005634	nucleus	PMID:11209945^[10]	IDA: Inferred from Direct Assay		C
	GO:0005634	nucleus	PMID:12050133^[11]	IDA: Inferred from Direct Assay		C
	GO:0005634	nucleus	PMID:14625556^[12]	IDA: Inferred from Direct Assay		C
	GO:0005634	nucleus	PMID:16464444^[13]	IDA: Inferred from Direct Assay		C
	GO:0005634	nucleus	PMID:9230312^[14]	IDA: Inferred from Direct Assay		C
	GO:0005667	transcription factor complex	PMID:10197584^[7]	TAS: Traceable Author Statement		C
	GO:0006351	transcription, DNA-dependent	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0804	P
	GO:0006351	transcription, DNA-dependent	PMID:10197584^[7]	TAS: Traceable Author Statement		P
	GO:0006351	transcription, DNA-dependent	PMID:18287938^[5]	IDA: Inferred from Direct Assay		P
	GO:0006355	regulation of transcription, DNA-dependent	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR001356	P
	GO:0006355	regulation of transcription, DNA-dependent	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR001523	P
	GO:0006355	regulation of transcription, DNA-dependent	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR012287	P
	GO:0006355	regulation of transcription, DNA-dependent	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR017970	P
	GO:0006355	regulation of transcription, DNA-dependent	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0805	P
	GO:0006355	regulation of transcription, DNA-dependent	PMID:10197584^[7]	TAS: Traceable Author Statement		P
	GO:0006357	regulation of transcription from RNA polymerase II promoter	PMID:19521500^[15]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1856155	P
	GO:0006366	transcription from RNA polymerase II promoter	PMID:20592023^[2]	IDA: Inferred from Direct Assay		P
	GO:0006366	transcription from RNA polymerase II promoter	PMID:20592023^[2]	IMP: Inferred from Mutant Phenotype		P
	GO:0007224	smoothened signaling pathway	PMID:18590716^[16]	IDA: Inferred from Direct Assay		P
	GO:0007275	multicellular organismal development	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0217	P
	GO:0007409	axonogenesis	PMID:15514979^[17]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1856158	P
	GO:0007411	axon guidance	PMID:11967891^[18]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1856158	P
	GO:0007411	axon guidance	PMID:14586016^[19]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1856158	P
	GO:0007420	brain development	PMID:10409504^[20]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1856155	P
	GO:0007420	brain development	PMID:12196586^[21]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1856155	P
	GO:0007435	salivary gland morphogenesis	PMID:11731698^[22]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1856158	P
	GO:0008285	negative regulation of cell proliferation	PMID:15548580^[23]	IMP: Inferred from Mutant Phenotype	MGI:MGI:3521718	P
	GO:0009950	dorsal/ventral axis specification	PMID:10588713^[24]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1856155	P
	GO:0009950	dorsal/ventral axis specification	PMID:10588713^[24]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1934347	P
	GO:0009952	anterior/posterior pattern formation	PMID:12196586^[21]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1856155	P
	GO:0009952	anterior/posterior pattern formation	PMID:15917450^[25]	IGI: Inferred from Genetic Interaction	MGI:MGI:95388	P
	GO:0009953	dorsal/ventral pattern formation	PMID:15548580^[23]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1856155	P
	GO:0009953	dorsal/ventral pattern formation	PMID:15548580^[23]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2156741	P
	GO:0009953	dorsal/ventral pattern formation	PMID:15548580^[23]	IMP: Inferred from Mutant Phenotype	MGI:MGI:3521718	P
	GO:0009953	dorsal/ventral pattern formation	PMID:15878992^[26]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1856155	P
	GO:0010468	regulation of gene expression	PMID:12764040^[27]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1856155	P
	GO:0010468	regulation of gene expression	PMID:16919471^[28]	IMP: Inferred from Mutant Phenotype		P
	GO:0010468	regulation of gene expression	PMID:18799682^[29]	IMP: Inferred from Mutant Phenotype		P
	GO:0010628	positive regulation of gene expression	PMID:20592023^[2]	IMP: Inferred from Mutant Phenotype		P
	GO:0021543	pallium development	PMID:11124115^[30]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1856158	P
	GO:0021778	oligodendrocyte cell fate specification	PMID:9828088^[31]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1856155	P
	GO:0021796	cerebral cortex regionalization	PMID:12764040^[27]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1856155	P
	GO:0021797	forebrain anterior/posterior pattern formation	PMID:9169845^[32]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1856155	P
	GO:0021797	forebrain anterior/posterior pattern formation	PMID:9169845^[32]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1856158	P
	GO:0021798	forebrain dorsal/ventral pattern formation	PMID:11050125^[33]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1856155	P
	GO:0021798	forebrain dorsal/ventral pattern formation	PMID:11124115^[30]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1856158	P
	GO:0021902	commitment of neuronal cell to specific neuron type in forebrain	PMID:11124115^[30]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1856158	P
	GO:0021905	forebrain-midbrain boundary formation	PMID:9169845^[32]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1856155	P
	GO:0021905	forebrain-midbrain boundary formation	PMID:9169845^[32]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1856158	P
	GO:0021912	regulation of transcription from RNA polymerase II promoter involved in spinal cord motor neuron fate specification	PMID:9230312^[14]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1856155	P
	GO:0021913	regulation of transcription from RNA polymerase II promoter involved in ventral spinal cord interneuron specification	PMID:9230312^[14]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1856155	P
	GO:0021918	regulation of transcription from RNA polymerase II promoter involved in somatic motor neuron fate commitment	PMID:9230312^[14]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1856155	P
	GO:0021983	pituitary gland development	PMID:10588713^[24]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1856155	P
	GO:0021983	pituitary gland development	PMID:10588713^[24]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1934347	P
	GO:0023019	signal transduction involved in regulation of gene expression	PMID:18462699^[34]	IDA: Inferred from Direct Assay		P
	GO:0030154	cell differentiation	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0221	P
	GO:0030154	cell differentiation	PMID:15031110^[35]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1856155	P
	GO:0030216	keratinocyte differentiation	PMID:16080917^[36]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1856158	P
	GO:0030334	regulation of cell migration	PMID:10409504^[20]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1856155	P
	GO:0030858	positive regulation of epithelial cell differentiation	PMID:16080917^[36]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1856158	P
	GO:0030900	forebrain development	PMID:15514979^[17]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1856158	P
	GO:0030900	forebrain development	PMID:15548580^[23]	IMP: Inferred from Mutant Phenotype	MGI:MGI:3521718	P
	GO:0030900	forebrain development	PMID:15758185^[4]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1856155	P
	GO:0031625	ubiquitin protein ligase binding	PMID:18628401^[37]	IPI: Inferred from Physical Interaction	UniProtKB:Q99PQ2	F
	GO:0032808	lacrimal gland development	PMID:10821755^[38]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1856155	P
	GO:0033365	protein localization to organelle	PMID:16024294^[39]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1856155	P
	GO:0042462	eye photoreceptor cell development	PMID:12648492^[40]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1856158	P
	GO:0043010	camera-type eye development	PMID:11062307^[41]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1931308	P
	GO:0043010	camera-type eye development	PMID:11069887^[42]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1934348	P
	GO:0043010	camera-type eye development	PMID:12072567^[43]	IGI: Inferred from Genetic Interaction	MGI:MGI:102764	P
	GO:0043010	camera-type eye development	PMID:12183364^[44]	IGI: Inferred from Genetic Interaction	MGI:MGI:108564	P
	GO:0043010	camera-type eye development	PMID:12648492^[40]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1856158	P
	GO:0043010	camera-type eye development	PMID:12756174^[3]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1934347	P
	GO:0043010	camera-type eye development	PMID:16080917^[36]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1856158	P
	GO:0043565	sequence-specific DNA binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR001356	F
	GO:0043565	sequence-specific DNA binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR017970	F
	GO:0044212	transcription regulatory region DNA binding	PMID:19521500^[15]	IDA: Inferred from Direct Assay		F
	GO:0044424	intracellular part	PMID:10868931^[45]	IDA: Inferred from Direct Assay		C
	GO:0044424	intracellular part	PMID:15793245^[46]	IDA: Inferred from Direct Assay		C
	GO:0045165	cell fate commitment	PMID:15229646^[47]	IGI: Inferred from Genetic Interaction	MGI:MGI:1100526	P
	GO:0045165	cell fate commitment	PMID:15878992^[26]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1856155	P
	GO:0045665	negative regulation of neuron differentiation	PMID:16950124^[48]	IGI: Inferred from Genetic Interaction	MGI:MGI:95728	P
	GO:0045893	positive regulation of transcription, DNA-dependent	PMID:20592023^[2]	IDA: Inferred from Direct Assay		P
	GO:0045944	positive regulation of transcription from RNA polymerase II promoter	PMID:15905411^[49]	IDA: Inferred from Direct Assay		P
	GO:0045944	positive regulation of transcription from RNA polymerase II promoter	PMID:18287938^[5]	IDA: Inferred from Direct Assay		P
	GO:0045944	positive regulation of transcription from RNA polymerase II promoter	PMID:19749747^[50]	IDA: Inferred from Direct Assay		P
	GO:0048505	regulation of timing of cell differentiation	PMID:9828088^[31]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1856155	P
	GO:0048708	astrocyte differentiation	PMID:19258013^[51]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1856155	P
	GO:0050680	negative regulation of epithelial cell proliferation	PMID:16080917^[36]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1856158	P
	GO:0050767	regulation of neurogenesis	PMID:15548580^[23]	IMP: Inferred from Mutant Phenotype	MGI:MGI:3521718	P
	GO:0070410	co-SMAD binding	PMID:17251190^[52]	IDA: Inferred from Direct Assay		F
	GO:0070412	R-SMAD binding	PMID:17251190^[52]	IDA: Inferred from Direct Assay		F
	GO:0071837	HMG box domain binding	PMID:16582099^[53]	IPI: Inferred from Physical Interaction	UniProtKB:O55170	F
	GO:0042462	eye photoreceptor cell development	PMID:10662634^[54]	IMP: Inferred from Mutant Phenotype		P	fig. 1, fig .2, fig .3, fig .4, table 1, table 2	complete
edit table

Notes

References

See Help:References for how to manage references in GONUTS.

↑ Blixt A et al. (2007) Foxe3 is required for morphogenesis and differentiation of the anterior segment of the eye and is sensitive to Pax6 gene dosage. Dev Biol 302: 218-29 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 ^2.6 ^2.7 Gosmain Y et al. (2010) Pax6 controls the expression of critical genes involved in pancreatic {alpha} cell differentiation and function. J Biol Chem 285: 33381-93 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 Bäumer N et al. (2003) Retinal pigmented epithelium determination requires the redundant activities of Pax2 and Pax6. Development 130: 2903-15 PubMed GONUTS page
↑ ^4.0 ^4.1 Tole S et al. (2005) Selective requirement of Pax6, but not Emx2, in the specification and development of several nuclei of the amygdaloid complex. J Neurosci 25: 2753-60 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 ^5.3 Wen J et al. (2008) Pax6 directly modulate Sox2 expression in the neural progenitor cells. Neuroreport 19: 413-7 PubMed GONUTS page
↑ Favor J (1983) A comparison of the dominant cataract and recessive specific-locus mutation rates induced by treatment of male mice with ethylnitrosourea. Mutat Res 110: 367-82 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 ^7.3 Mansouri A et al. (1999) Pax genes and their role in organogenesis. Cancer Res 59: 1707s-1709s; discussion 1709s-1710s PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 Cooper ST & Hanson IM (2005) A screen for proteins that interact with PAX6: C-terminal mutations disrupt interaction with HOMER3, DNCL1 and TRIM11. BMC Genet 6: 43 PubMed GONUTS page
↑ Cappello S et al. (2006) The Rho-GTPase cdc42 regulates neural progenitor fate at the apical surface. Nat Neurosci 9: 1099-107 PubMed GONUTS page
↑ Wolf LV et al. (2001) Coordinated expression of Hoxa2, Hoxd1 and Pax6 in the developing diencephalon. Neuroreport 12: 329-33 PubMed GONUTS page
↑ Zhu CC et al. (2002) Six3-mediated auto repression and eye development requires its interaction with members of the Groucho-related family of co-repressors. Development 129: 2835-49 PubMed GONUTS page
↑ Nishida A et al. (2003) Otx2 homeobox gene controls retinal photoreceptor cell fate and pineal gland development. Nat Neurosci 6: 1255-63 PubMed GONUTS page
↑ Kim J & Lauderdale JD (2006) Analysis of Pax6 expression using a BAC transgene reveals the presence of a paired-less isoform of Pax6 in the eye and olfactory bulb. Dev Biol 292: 486-505 PubMed GONUTS page
↑ ^14.0 ^14.1 ^14.2 ^14.3 Ericson J et al. (1997) Pax6 controls progenitor cell identity and neuronal fate in response to graded Shh signaling. Cell 90: 169-80 PubMed GONUTS page
↑ ^15.0 ^15.1 Sansom SN et al. (2009) The level of the transcription factor Pax6 is essential for controlling the balance between neural stem cell self-renewal and neurogenesis. PLoS Genet 5: e1000511 PubMed GONUTS page
↑ Cho A et al. (2008) FKBP8 cell-autonomously controls neural tube patterning through a Gli2- and Kif3a-dependent mechanism. Dev Biol 321: 27-39 PubMed GONUTS page
↑ ^17.0 ^17.1 Nural HF & Mastick GS (2004) Pax6 guides a relay of pioneer longitudinal axons in the embryonic mouse forebrain. J Comp Neurol 479: 399-409 PubMed GONUTS page
↑ Hevner RF et al. (2002) Cortical and thalamic axon pathfinding defects in Tbr1, Gbx2, and Pax6 mutant mice: evidence that cortical and thalamic axons interact and guide each other. J Comp Neurol 447: 8-17 PubMed GONUTS page
↑ Andrews GL & Mastick GS (2003) R-cadherin is a Pax6-regulated, growth-promoting cue for pioneer axons. J Neurosci 23: 9873-80 PubMed GONUTS page
↑ ^20.0 ^20.1 Engelkamp D et al. (1999) Role of Pax6 in development of the cerebellar system. Development 126: 3585-96 PubMed GONUTS page
↑ ^21.0 ^21.1 Bishop KM et al. (2002) Distinct actions of Emx1, Emx2, and Pax6 in regulating the specification of areas in the developing neocortex. J Neurosci 22: 7627-38 PubMed GONUTS page
↑ Jaskoll T et al. (2002) Embryonic submandibular gland morphogenesis: stage-specific protein localization of FGFs, BMPs, Pax6 and Pax9 in normal mice and abnormal SMG phenotypes in FgfR2-IIIc(+/Delta), BMP7(-/-) and Pax6(-/-) mice. Cells Tissues Organs 170: 83-98 PubMed GONUTS page
↑ ^23.0 ^23.1 ^23.2 ^23.3 ^23.4 ^23.5 Haubst N et al. (2004) Molecular dissection of Pax6 function: the specific roles of the paired domain and homeodomain in brain development. Development 131: 6131-40 PubMed GONUTS page
↑ ^24.0 ^24.1 ^24.2 ^24.3 Kioussi C et al. (1999) Pax6 is essential for establishing ventral-dorsal cell boundaries in pituitary gland development. Proc Natl Acad Sci U S A 96: 14378-82 PubMed GONUTS page
↑ Kimura J et al. (2005) Emx2 and Pax6 function in cooperation with Otx2 and Otx1 to develop caudal forebrain primordium that includes future archipallium. J Neurosci 25: 5097-108 PubMed GONUTS page
↑ ^26.0 ^26.1 Kroll TT & O'Leary DD (2005) Ventralized dorsal telencephalic progenitors in Pax6 mutant mice generate GABA interneurons of a lateral ganglionic eminence fate. Proc Natl Acad Sci U S A 102: 7374-9 PubMed GONUTS page
↑ ^27.0 ^27.1 Muzio L & Mallamaci A (2003) Emx1, emx2 and pax6 in specification, regionalization and arealization of the cerebral cortex. Cereb Cortex 13: 641-7 PubMed GONUTS page
↑ Li H et al. (2006) Potential target genes of EMX2 include Odz/Ten-M and other gene families with implications for cortical patterning. Mol Cell Neurosci 33: 136-49 PubMed GONUTS page
↑ Tucker ES et al. (2008) Molecular specification and patterning of progenitor cells in the lateral and medial ganglionic eminences. J Neurosci 28: 9504-18 PubMed GONUTS page
↑ ^30.0 ^30.1 ^30.2 Yun K et al. (2001) Gsh2 and Pax6 play complementary roles in dorsoventral patterning of the mammalian telencephalon. Development 128: 193-205 PubMed GONUTS page
↑ ^31.0 ^31.1 Sun T et al. (1998) Pax6 influences the time and site of origin of glial precursors in the ventral neural tube. Mol Cell Neurosci 12: 228-39 PubMed GONUTS page
↑ ^32.0 ^32.1 ^32.2 ^32.3 Mastick GS et al. (1997) Pax-6 functions in boundary formation and axon guidance in the embryonic mouse forebrain. Development 124: 1985-97 PubMed GONUTS page
↑ Stoykova A et al. (2000) Pax6 modulates the dorsoventral patterning of the mammalian telencephalon. J Neurosci 20: 8042-50 PubMed GONUTS page
↑ Lee D et al. (2008) ER71 acts downstream of BMP, Notch, and Wnt signaling in blood and vessel progenitor specification. Cell Stem Cell 2: 497-507 PubMed GONUTS page
↑ Heller RS et al. (2004) The role of Brn4/Pou3f4 and Pax6 in forming the pancreatic glucagon cell identity. Dev Biol 268: 123-34 PubMed GONUTS page
↑ ^36.0 ^36.1 ^36.2 ^36.3 Ramaesh T et al. (2005) Developmental and cellular factors underlying corneal epithelial dysgenesis in the Pax6+/- mouse model of aniridia. Exp Eye Res 81: 224-35 PubMed GONUTS page
↑ Tuoc TC & Stoykova A (2008) Trim11 modulates the function of neurogenic transcription factor Pax6 through ubiquitin-proteosome system. Genes Dev 22: 1972-86 PubMed GONUTS page
↑ Makarenkova HP et al. (2000) FGF10 is an inducer and Pax6 a competence factor for lacrimal gland development. Development 127: 2563-72 PubMed GONUTS page
↑ Purcell P et al. (2005) Pax6-dependence of Six3, Eya1 and Dach1 expression during lens and nasal placode induction. Gene Expr Patterns 6: 110-8 PubMed GONUTS page
↑ ^40.0 ^40.1 Collinson JM et al. (2003) The roles of Pax6 in the cornea, retina, and olfactory epithelium of the developing mouse embryo. Dev Biol 255: 303-12 PubMed GONUTS page
↑ Lyon MF et al. (2000) Further genetic analysis of two autosomal dominant mouse eye defects, Ccw and Pax6(coop). Mol Vis 6: 199-203 PubMed GONUTS page
↑ Ashery-Padan R et al. (2000) Pax6 activity in the lens primordium is required for lens formation and for correct placement of a single retina in the eye. Genes Dev 14: 2701-11 PubMed GONUTS page
↑ Goudreau G et al. (2002) Mutually regulated expression of Pax6 and Six3 and its implications for the Pax6 haploinsufficient lens phenotype. Proc Natl Acad Sci U S A 99: 8719-24 PubMed GONUTS page
↑ Zhang X et al. (2002) Meis homeoproteins directly regulate Pax6 during vertebrate lens morphogenesis. Genes Dev 16: 2097-107 PubMed GONUTS page
↑ Jensen J et al. (2000) Independent development of pancreatic alpha- and beta-cells from neurogenin3-expressing precursors: a role for the notch pathway in repression of premature differentiation. Diabetes 49: 163-76 PubMed GONUTS page
↑ Chu K & Tsai MJ (2005) Neuronatin, a downstream target of BETA2/NeuroD1 in the pancreas, is involved in glucose-mediated insulin secretion. Diabetes 54: 1064-73 PubMed GONUTS page
↑ Schuurmans C et al. (2004) Sequential phases of cortical specification involve Neurogenin-dependent and -independent pathways. EMBO J 23: 2892-902 PubMed GONUTS page
↑ Lei Q et al. (2006) Wnt signaling inhibitors regulate the transcriptional response to morphogenetic Shh-Gli signaling in the neural tube. Dev Cell 11: 325-37 PubMed GONUTS page
↑ Mui SH et al. (2005) Vax genes ventralize the embryonic eye. Genes Dev 19: 1249-59 PubMed GONUTS page
↑ Pinto L et al. (2009) AP2gamma regulates basal progenitor fate in a region- and layer-specific manner in the developing cortex. Nat Neurosci 12: 1229-37 PubMed GONUTS page
↑ Genethliou N et al. (2009) Spatially distinct functions of PAX6 and NKX2.2 during gliogenesis in the ventral spinal cord. Biochem Biophys Res Commun 382: 69-73 PubMed GONUTS page
↑ ^52.0 ^52.1 Grocott T et al. (2007) The MH1 domain of Smad3 interacts with Pax6 and represses autoregulation of the Pax6 P1 promoter. Nucleic Acids Res 35: 890-901 PubMed GONUTS page
↑ Wissmüller S et al. (2006) The high-mobility-group domain of Sox proteins interacts with DNA-binding domains of many transcription factors. Nucleic Acids Res 34: 1735-44 PubMed GONUTS page
↑ Collinson JM et al. (2000) Different roles for Pax6 in the optic vesicle and facial epithelium mediate early morphogenesis of the murine eye. Development 127: 945-56 PubMed GONUTS page

[PMID:17064680-0] Blixt A et al. (2007) Foxe3 is required for morphogenesis and differentiation of the anterior segment of the eye and is sensitive to Pax6 gene dosage. Dev Biol 302: 218-29 PubMed GONUTS page

[PMID:20592023-1] 2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 ^2.6 ^2.7 Gosmain Y et al. (2010) Pax6 controls the expression of critical genes involved in pancreatic {alpha} cell differentiation and function. J Biol Chem 285: 33381-93 PubMed GONUTS page

[PMID:12756174-2] 3.0 ^3.1 ^3.2 Bäumer N et al. (2003) Retinal pigmented epithelium determination requires the redundant activities of Pax2 and Pax6. Development 130: 2903-15 PubMed GONUTS page

[PMID:15758185-3] 4.0 ^4.1 Tole S et al. (2005) Selective requirement of Pax6, but not Emx2, in the specification and development of several nuclei of the amygdaloid complex. J Neurosci 25: 2753-60 PubMed GONUTS page

[PMID:18287938-4] 5.0 ^5.1 ^5.2 ^5.3 Wen J et al. (2008) Pax6 directly modulate Sox2 expression in the neural progenitor cells. Neuroreport 19: 413-7 PubMed GONUTS page

[PMID:6877261-5] Favor J (1983) A comparison of the dominant cataract and recessive specific-locus mutation rates induced by treatment of male mice with ethylnitrosourea. Mutat Res 110: 367-82 PubMed GONUTS page

[PMID:10197584-6] 7.0 ^7.1 ^7.2 ^7.3 Mansouri A et al. (1999) Pax genes and their role in organogenesis. Cancer Res 59: 1707s-1709s; discussion 1709s-1710s PubMed GONUTS page

[PMID:16098226-7] 8.0 ^8.1 ^8.2 Cooper ST & Hanson IM (2005) A screen for proteins that interact with PAX6: C-terminal mutations disrupt interaction with HOMER3, DNCL1 and TRIM11. BMC Genet 6: 43 PubMed GONUTS page

[PMID:16892058-8] Cappello S et al. (2006) The Rho-GTPase cdc42 regulates neural progenitor fate at the apical surface. Nat Neurosci 9: 1099-107 PubMed GONUTS page

[PMID:11209945-9] Wolf LV et al. (2001) Coordinated expression of Hoxa2, Hoxd1 and Pax6 in the developing diencephalon. Neuroreport 12: 329-33 PubMed GONUTS page

[PMID:12050133-10] Zhu CC et al. (2002) Six3-mediated auto repression and eye development requires its interaction with members of the Groucho-related family of co-repressors. Development 129: 2835-49 PubMed GONUTS page

[PMID:14625556-11] Nishida A et al. (2003) Otx2 homeobox gene controls retinal photoreceptor cell fate and pineal gland development. Nat Neurosci 6: 1255-63 PubMed GONUTS page

[PMID:16464444-12] Kim J & Lauderdale JD (2006) Analysis of Pax6 expression using a BAC transgene reveals the presence of a paired-less isoform of Pax6 in the eye and olfactory bulb. Dev Biol 292: 486-505 PubMed GONUTS page

[PMID:9230312-13] 14.0 ^14.1 ^14.2 ^14.3 Ericson J et al. (1997) Pax6 controls progenitor cell identity and neuronal fate in response to graded Shh signaling. Cell 90: 169-80 PubMed GONUTS page

[PMID:19521500-14] 15.0 ^15.1 Sansom SN et al. (2009) The level of the transcription factor Pax6 is essential for controlling the balance between neural stem cell self-renewal and neurogenesis. PLoS Genet 5: e1000511 PubMed GONUTS page

[PMID:18590716-15] Cho A et al. (2008) FKBP8 cell-autonomously controls neural tube patterning through a Gli2- and Kif3a-dependent mechanism. Dev Biol 321: 27-39 PubMed GONUTS page

[PMID:15514979-16] 17.0 ^17.1 Nural HF & Mastick GS (2004) Pax6 guides a relay of pioneer longitudinal axons in the embryonic mouse forebrain. J Comp Neurol 479: 399-409 PubMed GONUTS page

[PMID:11967891-17] Hevner RF et al. (2002) Cortical and thalamic axon pathfinding defects in Tbr1, Gbx2, and Pax6 mutant mice: evidence that cortical and thalamic axons interact and guide each other. J Comp Neurol 447: 8-17 PubMed GONUTS page

[PMID:14586016-18] Andrews GL & Mastick GS (2003) R-cadherin is a Pax6-regulated, growth-promoting cue for pioneer axons. J Neurosci 23: 9873-80 PubMed GONUTS page

[PMID:10409504-19] 20.0 ^20.1 Engelkamp D et al. (1999) Role of Pax6 in development of the cerebellar system. Development 126: 3585-96 PubMed GONUTS page

[PMID:12196586-20] 21.0 ^21.1 Bishop KM et al. (2002) Distinct actions of Emx1, Emx2, and Pax6 in regulating the specification of areas in the developing neocortex. J Neurosci 22: 7627-38 PubMed GONUTS page

[PMID:11731698-21] Jaskoll T et al. (2002) Embryonic submandibular gland morphogenesis: stage-specific protein localization of FGFs, BMPs, Pax6 and Pax9 in normal mice and abnormal SMG phenotypes in FgfR2-IIIc(+/Delta), BMP7(-/-) and Pax6(-/-) mice. Cells Tissues Organs 170: 83-98 PubMed GONUTS page

[PMID:15548580-22] 23.0 ^23.1 ^23.2 ^23.3 ^23.4 ^23.5 Haubst N et al. (2004) Molecular dissection of Pax6 function: the specific roles of the paired domain and homeodomain in brain development. Development 131: 6131-40 PubMed GONUTS page

[PMID:10588713-23] 24.0 ^24.1 ^24.2 ^24.3 Kioussi C et al. (1999) Pax6 is essential for establishing ventral-dorsal cell boundaries in pituitary gland development. Proc Natl Acad Sci U S A 96: 14378-82 PubMed GONUTS page

[PMID:15917450-24] Kimura J et al. (2005) Emx2 and Pax6 function in cooperation with Otx2 and Otx1 to develop caudal forebrain primordium that includes future archipallium. J Neurosci 25: 5097-108 PubMed GONUTS page

[PMID:15878992-25] 26.0 ^26.1 Kroll TT & O'Leary DD (2005) Ventralized dorsal telencephalic progenitors in Pax6 mutant mice generate GABA interneurons of a lateral ganglionic eminence fate. Proc Natl Acad Sci U S A 102: 7374-9 PubMed GONUTS page

[PMID:12764040-26] 27.0 ^27.1 Muzio L & Mallamaci A (2003) Emx1, emx2 and pax6 in specification, regionalization and arealization of the cerebral cortex. Cereb Cortex 13: 641-7 PubMed GONUTS page

[PMID:16919471-27] Li H et al. (2006) Potential target genes of EMX2 include Odz/Ten-M and other gene families with implications for cortical patterning. Mol Cell Neurosci 33: 136-49 PubMed GONUTS page

[PMID:18799682-28] Tucker ES et al. (2008) Molecular specification and patterning of progenitor cells in the lateral and medial ganglionic eminences. J Neurosci 28: 9504-18 PubMed GONUTS page

[PMID:11124115-29] 30.0 ^30.1 ^30.2 Yun K et al. (2001) Gsh2 and Pax6 play complementary roles in dorsoventral patterning of the mammalian telencephalon. Development 128: 193-205 PubMed GONUTS page

[PMID:9828088-30] 31.0 ^31.1 Sun T et al. (1998) Pax6 influences the time and site of origin of glial precursors in the ventral neural tube. Mol Cell Neurosci 12: 228-39 PubMed GONUTS page

[PMID:9169845-31] 32.0 ^32.1 ^32.2 ^32.3 Mastick GS et al. (1997) Pax-6 functions in boundary formation and axon guidance in the embryonic mouse forebrain. Development 124: 1985-97 PubMed GONUTS page

[PMID:11050125-32] Stoykova A et al. (2000) Pax6 modulates the dorsoventral patterning of the mammalian telencephalon. J Neurosci 20: 8042-50 PubMed GONUTS page

[PMID:18462699-33] Lee D et al. (2008) ER71 acts downstream of BMP, Notch, and Wnt signaling in blood and vessel progenitor specification. Cell Stem Cell 2: 497-507 PubMed GONUTS page

[PMID:15031110-34] Heller RS et al. (2004) The role of Brn4/Pou3f4 and Pax6 in forming the pancreatic glucagon cell identity. Dev Biol 268: 123-34 PubMed GONUTS page

[PMID:16080917-35] 36.0 ^36.1 ^36.2 ^36.3 Ramaesh T et al. (2005) Developmental and cellular factors underlying corneal epithelial dysgenesis in the Pax6+/- mouse model of aniridia. Exp Eye Res 81: 224-35 PubMed GONUTS page

[PMID:18628401-36] Tuoc TC & Stoykova A (2008) Trim11 modulates the function of neurogenic transcription factor Pax6 through ubiquitin-proteosome system. Genes Dev 22: 1972-86 PubMed GONUTS page

[PMID:10821755-37] Makarenkova HP et al. (2000) FGF10 is an inducer and Pax6 a competence factor for lacrimal gland development. Development 127: 2563-72 PubMed GONUTS page

[PMID:16024294-38] Purcell P et al. (2005) Pax6-dependence of Six3, Eya1 and Dach1 expression during lens and nasal placode induction. Gene Expr Patterns 6: 110-8 PubMed GONUTS page

[PMID:12648492-39] 40.0 ^40.1 Collinson JM et al. (2003) The roles of Pax6 in the cornea, retina, and olfactory epithelium of the developing mouse embryo. Dev Biol 255: 303-12 PubMed GONUTS page

[PMID:11062307-40] Lyon MF et al. (2000) Further genetic analysis of two autosomal dominant mouse eye defects, Ccw and Pax6(coop). Mol Vis 6: 199-203 PubMed GONUTS page

[PMID:11069887-41] Ashery-Padan R et al. (2000) Pax6 activity in the lens primordium is required for lens formation and for correct placement of a single retina in the eye. Genes Dev 14: 2701-11 PubMed GONUTS page

[PMID:12072567-42] Goudreau G et al. (2002) Mutually regulated expression of Pax6 and Six3 and its implications for the Pax6 haploinsufficient lens phenotype. Proc Natl Acad Sci U S A 99: 8719-24 PubMed GONUTS page

[PMID:12183364-43] Zhang X et al. (2002) Meis homeoproteins directly regulate Pax6 during vertebrate lens morphogenesis. Genes Dev 16: 2097-107 PubMed GONUTS page

[PMID:10868931-44] Jensen J et al. (2000) Independent development of pancreatic alpha- and beta-cells from neurogenin3-expressing precursors: a role for the notch pathway in repression of premature differentiation. Diabetes 49: 163-76 PubMed GONUTS page

[PMID:15793245-45] Chu K & Tsai MJ (2005) Neuronatin, a downstream target of BETA2/NeuroD1 in the pancreas, is involved in glucose-mediated insulin secretion. Diabetes 54: 1064-73 PubMed GONUTS page

[PMID:15229646-46] Schuurmans C et al. (2004) Sequential phases of cortical specification involve Neurogenin-dependent and -independent pathways. EMBO J 23: 2892-902 PubMed GONUTS page

[PMID:16950124-47] Lei Q et al. (2006) Wnt signaling inhibitors regulate the transcriptional response to morphogenetic Shh-Gli signaling in the neural tube. Dev Cell 11: 325-37 PubMed GONUTS page

[PMID:15905411-48] Mui SH et al. (2005) Vax genes ventralize the embryonic eye. Genes Dev 19: 1249-59 PubMed GONUTS page

[PMID:19749747-49] Pinto L et al. (2009) AP2gamma regulates basal progenitor fate in a region- and layer-specific manner in the developing cortex. Nat Neurosci 12: 1229-37 PubMed GONUTS page

[PMID:19258013-50] Genethliou N et al. (2009) Spatially distinct functions of PAX6 and NKX2.2 during gliogenesis in the ventral spinal cord. Biochem Biophys Res Commun 382: 69-73 PubMed GONUTS page

[PMID:17251190-51] 52.0 ^52.1 Grocott T et al. (2007) The MH1 domain of Smad3 interacts with Pax6 and represses autoregulation of the Pax6 P1 promoter. Nucleic Acids Res 35: 890-901 PubMed GONUTS page

[PMID:16582099-52] Wissmüller S et al. (2006) The high-mobility-group domain of Sox proteins interacts with DNA-binding domains of many transcription factors. Nucleic Acids Res 34: 1735-44 PubMed GONUTS page

[PMID:10662634-53] Collinson JM et al. (2000) Different roles for Pax6 in the optic vesicle and facial epithelium mediate early morphogenesis of the murine eye. Development 127: 945-56 PubMed GONUTS page

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MOUSE:PAX6

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