MOUSE:PARK7

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Species (Taxon ID)	Mus musculus (Mouse). (taxon:10090)
Gene Name(s)	Park7
Protein Name(s)	Protein DJ-1 Parkinson disease protein 7 homolog
External Links
UniProt Identifier	PARK7_MOUSE
UniProt Accessions	Q99LX0, O88306, Q3THB9, Q3U509,
EMBL	AB015652, AK146368, AK153948, AK168341, AL607084, BC002187,
RefSeq	NP_065594.2,
Ensembl	ENSMUST00000030805, ENSMUST00000105673, ENSMUST00000105674, ENSMUST00000105675,
Pfam	PF01965,

Annotations

Qualifier	GO ID	GO term name	Reference	Evidence Code	with/from	Aspect	Notes	Status
	GO:0001963	synaptic transmission, dopaminergic	PMID:15799973^[1]	IMP: Inferred from Mutant Phenotype	MGI:MGI:3586448	P
	GO:0003723	RNA binding	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0694	F
	GO:0003723	RNA binding	PMID:11223268^[2]	TAS: Traceable Author Statement		F
	GO:0003729	mRNA binding	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:Q99497	F
	GO:0004601	peroxidase activity	PMID:17766438^[3]	IMP: Inferred from Mutant Phenotype		F
	GO:0005634	nucleus	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0539	C
	GO:0005634	nucleus	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000340278	C
	GO:0005634	nucleus	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0191	C
	GO:0005634	nucleus	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:Q99497	C
	GO:0005737	cytoplasm	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0963	C
	GO:0005737	cytoplasm	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000340278	C
	GO:0005737	cytoplasm	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0086	C
	GO:0005737	cytoplasm	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:Q99497	C
	GO:0005739	mitochondrion	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0173	C
	GO:0005739	mitochondrion	PMID:17766438^[3]	IDA: Inferred from Direct Assay		C
	GO:0005739	mitochondrion	PMID:18614015^[4]	IDA: Inferred from Direct Assay		C
	GO:0005829	cytosol	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000052374	C
	GO:0006914	autophagy	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0072	P
	GO:0006950	response to stress	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0346	P
	GO:0006950	response to stress	PMID:16624565^[5]	IMP: Inferred from Mutant Phenotype	MGI:MGI:3579140	P
	GO:0006954	inflammatory response	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0395	P
	GO:0006979	response to oxidative stress	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000052374	P
	GO:0007005	mitochondrion organization	PMID:20186336^[6]	IMP: Inferred from Mutant Phenotype		P
	GO:0007338	single fertilization	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0278	P
	GO:0008233	peptidase activity	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0645	F
	GO:0008233	peptidase activity	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:Q99497	F
	GO:0008283	cell proliferation	PMID:11223268^[2]	TAS: Traceable Author Statement		P
	GO:0008344	adult locomotory behavior	PMID:15721235^[7]	IMP: Inferred from Mutant Phenotype	MGI:MGI:3579140	P
	GO:0008344	adult locomotory behavior	PMID:15799973^[1]	IMP: Inferred from Mutant Phenotype	MGI:MGI:3586448	P
	GO:0016787	hydrolase activity	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0378	F
	GO:0030424	axon	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000052374	C
	GO:0032091	negative regulation of protein binding	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000340278	P
	GO:0032091	negative regulation of protein binding	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:Q99497	P
	GO:0034599	cellular response to oxidative stress	PMID:21068725^[8]	IMP: Inferred from Mutant Phenotype		P
	GO:0042493	response to drug	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000052374	P
	GO:0042542	response to hydrogen peroxide	PMID:15784737^[9]	IDA: Inferred from Direct Assay		P
	GO:0042542	response to hydrogen peroxide	PMID:15784737^[9]	IMP: Inferred from Mutant Phenotype	MGI:MGI:3576227	P
	GO:0042743	hydrogen peroxide metabolic process	PMID:17766438^[3]	IMP: Inferred from Mutant Phenotype	MGI:MGI:3514165	P
	GO:0042803	protein homodimerization activity	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:Q99497	F
	GO:0043526	neuroprotection	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:Q99497	P
	GO:0050727	regulation of inflammatory response	PMID:19276172^[10]	IMP: Inferred from Mutant Phenotype		P
	GO:0050821	protein stabilization	PMID:17015834^[11]	IMP: Inferred from Mutant Phenotype		P
	GO:0051583	dopamine uptake	PMID:15721235^[7]	IMP: Inferred from Mutant Phenotype	MGI:MGI:3579140	P
	GO:0051899	membrane depolarization	PMID:16624565^[5]	IMP: Inferred from Mutant Phenotype	MGI:MGI:3579140	P
	GO:0051920	peroxiredoxin activity	PMID:17766438^[3]	IMP: Inferred from Mutant Phenotype	MGI:MGI:3514165	F
	GO:0060081	membrane hyperpolarization	PMID:16624565^[5]	IMP: Inferred from Mutant Phenotype	MGI:MGI:3579140	P
	GO:0060548	negative regulation of cell death	PMID:15784737^[9]	IMP: Inferred from Mutant Phenotype		P
	GO:0060765	regulation of androgen receptor signaling pathway	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000340278	P
	GO:0070301	cellular response to hydrogen peroxide	PMID:15784737^[9]	IMP: Inferred from Mutant Phenotype		P
	GO:2000277	positive regulation of oxidative phosphorylation uncoupler activity	PMID:21068725^[8]	IMP: Inferred from Mutant Phenotype		P
	GO:0051583	dopamine uptake	PMID:15799973^[1]	IMP: Inferred from Mutant Phenotype		P	Figure 4: the loss of DJ-1 function in mice can lead to motor deficits as well as alterations in nigrostriatal dopaminergic function	complete
	GO:0001963	synaptic transmission, dopaminergic	PMID:15799973^[1]	IMP: Inferred from Mutant Phenotype	MGI:MGI:3586448	P
	GO:0003723	RNA binding	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0694	F
	GO:0003723	RNA binding	PMID:11223268^[2]	TAS: Traceable Author Statement		F
	GO:0003729	mRNA binding	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000340278	F
	GO:0003729	mRNA binding	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:Q99497	F
	GO:0004601	peroxidase activity	PMID:17766438^[3]	IMP: Inferred from Mutant Phenotype		F
	GO:0005634	nucleus	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0539	C
	GO:0005634	nucleus	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000340278	C
	GO:0005634	nucleus	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0191	C
	GO:0005634	nucleus	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:Q99497	C
	GO:0005737	cytoplasm	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0963	C
	GO:0005737	cytoplasm	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000340278	C
	GO:0005737	cytoplasm	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0086	C
	GO:0005737	cytoplasm	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:Q99497	C
	GO:0005739	mitochondrion	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0496	C
	GO:0005739	mitochondrion	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000340278	C
	GO:0005739	mitochondrion	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0173	C
	GO:0005739	mitochondrion	PMID:17766438^[3]	IDA: Inferred from Direct Assay		C
	GO:0005739	mitochondrion	PMID:18614015^[4]	IDA: Inferred from Direct Assay		C
	GO:0005829	cytosol	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000052374	C
	GO:0006914	autophagy	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0072	P
	GO:0006950	response to stress	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0346	P
	GO:0006950	response to stress	PMID:16624565^[5]	IMP: Inferred from Mutant Phenotype	MGI:MGI:3579140	P
	GO:0006954	inflammatory response	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0395	P
	GO:0006979	response to oxidative stress	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000052374	P
	GO:0007005	mitochondrion organization	PMID:20186336^[6]	IMP: Inferred from Mutant Phenotype		P
	GO:0007338	single fertilization	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0278	P
	GO:0008233	peptidase activity	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0645	F
	GO:0008233	peptidase activity	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000340278	F
	GO:0008233	peptidase activity	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:Q99497	F
	GO:0008283	cell proliferation	PMID:11223268^[2]	TAS: Traceable Author Statement		P
	GO:0008344	adult locomotory behavior	PMID:15721235^[7]	IMP: Inferred from Mutant Phenotype	MGI:MGI:3579140	P
	GO:0008344	adult locomotory behavior	PMID:15799973^[1]	IMP: Inferred from Mutant Phenotype	MGI:MGI:3586448	P
	GO:0016787	hydrolase activity	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0378	F
	GO:0030424	axon	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000052374	C
	GO:0032091	negative regulation of protein binding	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000340278	P
	GO:0032091	negative regulation of protein binding	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:Q99497	P
	GO:0034599	cellular response to oxidative stress	PMID:21068725^[8]	IMP: Inferred from Mutant Phenotype		P
	GO:0042493	response to drug	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000052374	P
	GO:0042542	response to hydrogen peroxide	PMID:15784737^[9]	IDA: Inferred from Direct Assay		P
	GO:0042542	response to hydrogen peroxide	PMID:15784737^[9]	IMP: Inferred from Mutant Phenotype	MGI:MGI:3576227	P
	GO:0042743	hydrogen peroxide metabolic process	PMID:17766438^[3]	IMP: Inferred from Mutant Phenotype	MGI:MGI:3514165	P
	GO:0042803	protein homodimerization activity	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000340278	F
	GO:0042803	protein homodimerization activity	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:Q99497	F
	GO:0043526	neuroprotection	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000340278	P
	GO:0043526	neuroprotection	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:Q99497	P
	GO:0050727	regulation of inflammatory response	PMID:19276172^[10]	IMP: Inferred from Mutant Phenotype		P
	GO:0050821	protein stabilization	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000340278	P
	GO:0050821	protein stabilization	PMID:17015834^[11]	IMP: Inferred from Mutant Phenotype		P
	GO:0051583	dopamine uptake	PMID:15721235^[7]	IMP: Inferred from Mutant Phenotype	MGI:MGI:3579140	P
	GO:0051899	membrane depolarization	PMID:16624565^[5]	IMP: Inferred from Mutant Phenotype	MGI:MGI:3579140	P
	GO:0051920	peroxiredoxin activity	PMID:17766438^[3]	IMP: Inferred from Mutant Phenotype	MGI:MGI:3514165	F
	GO:0060081	membrane hyperpolarization	PMID:16624565^[5]	IMP: Inferred from Mutant Phenotype	MGI:MGI:3579140	P
	GO:0060548	negative regulation of cell death	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000340278	P
	GO:0060548	negative regulation of cell death	PMID:15784737^[9]	IMP: Inferred from Mutant Phenotype		P
	GO:0060765	regulation of androgen receptor signaling pathway	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000340278	P
	GO:0070301	cellular response to hydrogen peroxide	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000340278	P
	GO:0070301	cellular response to hydrogen peroxide	PMID:15784737^[9]	IMP: Inferred from Mutant Phenotype		P
	GO:2000277	positive regulation of oxidative phosphorylation uncoupler activity	PMID:21068725^[8]	IMP: Inferred from Mutant Phenotype		P
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 Chen L et al. (2005) Age-dependent motor deficits and dopaminergic dysfunction in DJ-1 null mice. J Biol Chem 280: 21418-26 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 Taira T et al. (2001) Molecular cloning of human and mouse DJ-1 genes and identification of Sp1-dependent activation of the human DJ-1 promoter. Gene 263: 285-92 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 ^3.4 ^3.5 ^3.6 ^3.7 Andres-Mateos E et al. (2007) DJ-1 gene deletion reveals that DJ-1 is an atypical peroxiredoxin-like peroxidase. Proc Natl Acad Sci U S A 104: 14807-12 PubMed GONUTS page
↑ ^4.0 ^4.1 Pagliarini DJ et al. (2008) A mitochondrial protein compendium elucidates complex I disease biology. Cell 134: 112-23 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 ^5.3 ^5.4 ^5.5 Pisani A et al. (2006) Enhanced sensitivity of DJ-1-deficient dopaminergic neurons to energy metabolism impairment: role of Na+/K+ ATPase. Neurobiol Dis 23: 54-60 PubMed GONUTS page
↑ ^6.0 ^6.1 Krebiehl G et al. (2010) Reduced basal autophagy and impaired mitochondrial dynamics due to loss of Parkinson's disease-associated protein DJ-1. PLoS One 5: e9367 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 ^7.3 Goldberg MS et al. (2005) Nigrostriatal dopaminergic deficits and hypokinesia caused by inactivation of the familial Parkinsonism-linked gene DJ-1. Neuron 45: 489-96 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 ^8.3 Guzman JN et al. (2010) Oxidant stress evoked by pacemaking in dopaminergic neurons is attenuated by DJ-1. Nature 468: 696-700 PubMed GONUTS page
↑ ^9.0 ^9.1 ^9.2 ^9.3 ^9.4 ^9.5 ^9.6 ^9.7 Kim RH et al. (2005) Hypersensitivity of DJ-1-deficient mice to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyrindine (MPTP) and oxidative stress. Proc Natl Acad Sci U S A 102: 5215-20 PubMed GONUTS page
↑ ^10.0 ^10.1 Waak J et al. (2009) Regulation of astrocyte inflammatory responses by the Parkinson's disease-associated gene DJ-1. FASEB J 23: 2478-89 PubMed GONUTS page
↑ ^11.0 ^11.1 Clements CM et al. (2006) DJ-1, a cancer- and Parkinson's disease-associated protein, stabilizes the antioxidant transcriptional master regulator Nrf2. Proc Natl Acad Sci U S A 103: 15091-6 PubMed GONUTS page

[PMID:15799973-0] 1.0 ^1.1 ^1.2 ^1.3 ^1.4 Chen L et al. (2005) Age-dependent motor deficits and dopaminergic dysfunction in DJ-1 null mice. J Biol Chem 280: 21418-26 PubMed GONUTS page

[PMID:11223268-1] 2.0 ^2.1 ^2.2 ^2.3 Taira T et al. (2001) Molecular cloning of human and mouse DJ-1 genes and identification of Sp1-dependent activation of the human DJ-1 promoter. Gene 263: 285-92 PubMed GONUTS page

[PMID:17766438-2] 3.0 ^3.1 ^3.2 ^3.3 ^3.4 ^3.5 ^3.6 ^3.7 Andres-Mateos E et al. (2007) DJ-1 gene deletion reveals that DJ-1 is an atypical peroxiredoxin-like peroxidase. Proc Natl Acad Sci U S A 104: 14807-12 PubMed GONUTS page

[PMID:18614015-3] 4.0 ^4.1 Pagliarini DJ et al. (2008) A mitochondrial protein compendium elucidates complex I disease biology. Cell 134: 112-23 PubMed GONUTS page

[PMID:16624565-4] 5.0 ^5.1 ^5.2 ^5.3 ^5.4 ^5.5 Pisani A et al. (2006) Enhanced sensitivity of DJ-1-deficient dopaminergic neurons to energy metabolism impairment: role of Na+/K+ ATPase. Neurobiol Dis 23: 54-60 PubMed GONUTS page

[PMID:20186336-5] 6.0 ^6.1 Krebiehl G et al. (2010) Reduced basal autophagy and impaired mitochondrial dynamics due to loss of Parkinson's disease-associated protein DJ-1. PLoS One 5: e9367 PubMed GONUTS page

[PMID:15721235-6] 7.0 ^7.1 ^7.2 ^7.3 Goldberg MS et al. (2005) Nigrostriatal dopaminergic deficits and hypokinesia caused by inactivation of the familial Parkinsonism-linked gene DJ-1. Neuron 45: 489-96 PubMed GONUTS page

[PMID:21068725-7] 8.0 ^8.1 ^8.2 ^8.3 Guzman JN et al. (2010) Oxidant stress evoked by pacemaking in dopaminergic neurons is attenuated by DJ-1. Nature 468: 696-700 PubMed GONUTS page

[PMID:15784737-8] 9.0 ^9.1 ^9.2 ^9.3 ^9.4 ^9.5 ^9.6 ^9.7 Kim RH et al. (2005) Hypersensitivity of DJ-1-deficient mice to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyrindine (MPTP) and oxidative stress. Proc Natl Acad Sci U S A 102: 5215-20 PubMed GONUTS page

[PMID:19276172-9] 10.0 ^10.1 Waak J et al. (2009) Regulation of astrocyte inflammatory responses by the Parkinson's disease-associated gene DJ-1. FASEB J 23: 2478-89 PubMed GONUTS page

[PMID:17015834-10] 11.0 ^11.1 Clements CM et al. (2006) DJ-1, a cancer- and Parkinson's disease-associated protein, stabilizes the antioxidant transcriptional master regulator Nrf2. Proc Natl Acad Sci U S A 103: 15091-6 PubMed GONUTS page

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MOUSE:PARK7

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