MOUSE:P53

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Species (Taxon ID)	Mus musculus (Mouse). (taxon:10090)
Gene Name(s)	Tp53 ( synonyms: P53, Trp53 )
Protein Name(s)	Cellular tumor antigen p53 Tumor suppressor p53
External Links
UniProt Identifier	P53_MOUSE
UniProt Accessions	P02340, Q9QUP3,
EMBL	X00876, X00877, X00878, X00879, X00880, X00881, X00882, X00883, X00884, X00885, X01237, X00741, M13872, M13873, M13874, AB021961, AF151353, AB017815, AB017816, AB020317, BC005448, S77930,
PIR	A22739, S38824,
RefSeq	NP_001120705.1, NP_035770.2,
PDB	1HU8, 2GEQ, 2IOI, 2IOM, 2IOO, 2P52, 3EXJ, 3EXL,
IntAct	P02340,
Ensembl	ENSMUST00000005371,
Pfam	PF00870, PF08563, PF07710,

Annotations

Qualifier	GO ID	GO term name	Reference	Evidence Code	with/from	Aspect	Notes	Status
	GO:0005829	cytosol		IDA: Inferred from Direct Assay		C	Source: MGI
	GO:0005783	endoplasmic reticulum		IEA: Inferred from Electronic Annotation		C	Source: UniProtKB-SubCell
	GO:0005739	mitochondrion		ISS: Inferred from Sequence or Structural Similarity		C	Source: UniProtKB
	GO:0005730	nucleolus		ISS: Inferred from Sequence or Structural Similarity		C	Source: UniProtKB
	GO:0005657	replication fork		IDA: Inferred from Direct Assay		C	Source: MGI
	GO:0005524	ATP binding		ISS: Inferred from Sequence or Structural Similarity		F	Source: UniProtKB
	GO:0003682	chromatin binding		IDA: Inferred from Direct Assay		F	Source: MGI
	GO:0005507	copper ion binding		ISS: Inferred from Sequence or Structural Similarity		F	Source: UniProtKB
	GO:0000739	DNA strand annealing activity		ISS: Inferred from Sequence or Structural Similarity		F	Source: UniProtKB
	GO:0035033	histone deacetylase regulator activity		IDA: Inferred from Direct Assay		F	Source: MGI
	GO:0003700	sequence-specific DNA binding transcription factor activity		IDA: Inferred from Direct Assay		F	Source: MGI
	GO:0016566	specific transcriptional repressor activity		IMP: Inferred from Mutant Phenotype		F	Source: BHF-UCL
	GO:0008270	zinc ion binding		IEA: Inferred from Electronic Annotation		F	Source: InterPro
	GO:0008635	activation of caspase activity by cytochrome c		ISS: Inferred from Sequence or Structural Similarity		P	Source: UniProtKB
	GO:0002326	B cell lineage commitment		IMP: Inferred from Mutant Phenotype		P	Source: MGI
	GO:0007569	cell aging		ISS: Inferred from Sequence or Structural Similarity		P	Source: UniProtKB
	GO:0034644	cellular response to UV		IGI: Inferred from Genetic Interaction		P	Source: MGI
	GO:0007417	central nervous system development		IGI: Inferred from Genetic Interaction		P	Source: MGI
	GO:0051276	chromosome organization		IGI: Inferred from Genetic Interaction		P	Source: MGI
	GO:0006977	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest		IGI: Inferred from Genetic Interaction		P	Source: MGI
	GO:0042771	DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis		IMP: Inferred from Mutant Phenotype		P	Source: MGI
	GO:0006302	double-strand break repair		IMP: Inferred from Mutant Phenotype		P	Source: MGI
	GO:0007369	gastrulation		IGI: Inferred from Genetic Interaction		P	Source: MGI
	GO:0001701	in utero embryonic development		IGI: Inferred from Genetic Interaction		P	Source: MGI
	GO:0035264	multicellular organism growth		IGI: Inferred from Genetic Interaction		P	Source: MGI
	GO:0043066	negative regulation of apoptosis		IMP: Inferred from Mutant Phenotype		P	Source: MGI
	GO:0030308	negative regulation of cell growth		ISS: Inferred from Sequence or Structural Similarity		P	Source: UniProtKB
	GO:0008156	negative regulation of DNA replication		IDA: Inferred from Direct Assay		P	Source: MGI
	GO:0048147	negative regulation of fibroblast proliferation		IMP: Inferred from Mutant Phenotype		P	Source: MGI
	GO:0010553	negative regulation of gene-specific transcription from RNA polymerase II promoter		IMP: Inferred from Mutant Phenotype		P	Source: BHF-UCL
	GO:0007406	negative regulation of neuroblast proliferation		IGI: Inferred from Genetic Interaction		P	Source: MGI
	GO:0030512	negative regulation of transforming growth factor beta receptor signaling pathway		IMP: Inferred from Mutant Phenotype		P	Source: MGI
	GO:0006289	nucleotide-excision repair		ISS: Inferred from Sequence or Structural Similarity		P	Source: UniProtKB
	GO:0031065	positive regulation of histone deacetylation		IDA: Inferred from Direct Assay		P	Source: MGI
	GO:0043525	positive regulation of neuron apoptosis		IDA: Inferred from Direct Assay		P	Source: MGI
	GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation		IMP: Inferred from Mutant Phenotype		P	Source: BHF-UCL
	GO:0000060	protein import into nucleus, translocation		IDA: Inferred from Direct Assay		P	Source: MGI
	GO:0046902	regulation of mitochondrial membrane permeability		IGI: Inferred from Genetic Interaction		P	Source: MGI
	GO:0001836	release of cytochrome c from mitochondria		IDA: Inferred from Direct Assay		P	Source: MGI
	GO:0042493	response to drug		IDA: Inferred from Direct Assay		P	Source: MGI
	GO:0010332	response to gamma radiation		IDA: Inferred from Direct Assay		P	Source: MGI
	GO:0009651	response to salt stress		IGI: Inferred from Genetic Interaction		P	Source: MGI
	GO:0002347	response to tumor cell		IEA: Inferred from Electronic Annotation		P	Source: InterPro
	GO:0010165	response to X-ray		IDA: Inferred from Direct Assay		P	Source: MGI
	GO:0009303	rRNA transcription		IGI: Inferred from Genetic Interaction		P	Source: MGI
	GO:0001756	somitogenesis		IGI: Inferred from Genetic Interaction		P	Source: MGI
	GO:0033077	T cell differentiation in thymus		IGI: Inferred from Genetic Interaction		P	Source: MGI
	GO:0002360	T cell lineage commitment		IMP: Inferred from Mutant Phenotype		P	Source: MGI
	GO:0002309	T cell proliferation involved in immune response		IGI: Inferred from Genetic Interaction		P	Source: MGI
	GO:0007179	transforming growth factor beta receptor signaling pathway		IGI: Inferred from Genetic Interaction		P	Source: MGI
	GO:0010259	multicellular organismal aging	PMID:20818388^[1]	IMP: Inferred from Mutant Phenotype		P	When compared with p53+/+ mice, p53TSD/– mice had a significantly shorter lifespan and died by 6 weeks of age (Fig. 1c)	complete
	GO:0090343	positive regulation of cell aging	PMID:20818388^[1]	IMP: Inferred from Mutant Phenotype		P	Furthermore, p53TSD/– mice exhibited a number of ageing-related phenotypes, including acute spine curvature (Fig. 1d), hypoplasia in the bone marrow (Fig. 2a) and lymphopenia and anaemia (Fig. 2c, d).	complete
	GO:0071865	regulation of apoptosis in bone marrow	PMID:20818388^[1]	IMP: Inferred from Mutant Phenotype		P	Figure 2b Progressive degeneration of the haematopoietic system in p53TSD/– mice. LSK cells are progressively depleted in p53+/+ and p53TSD/– mice. Note: a new more specific term (Positive regulation of apoptosis in haematopoietic stem cells) is suggested.	complete
	GO:0071425	cell proliferation in bone marrow	PMID:20818388^[1]	IMP: Inferred from Mutant Phenotype		P	Figure 2 Progressive degeneration of the haematopoietic system in p53TSD/– mice. (b) LSK cells are progressively depleted in p53+/+ and p53TSD/– mice. Note: a new more specific term (Negative regulation of hemopoietic stem cell proliferation) is suggested	complete
	GO:0002902	regulation of B cell apoptosis	PMID:20818388^[1]	IMP: Inferred from Mutant Phenotype		P	Figure 2c. Lymphopenia in p53TSD/– mice. The number of T- and B-cells in the spleen of two-week-old p53TSD/– is decreased compared to wild type. Note: a new more specific term (Negative regulation of B cell apoptosis) is suggested	complete
	GO:0070232	regulation of T cell apoptosis	PMID:20818388^[1]	IMP: Inferred from Mutant Phenotype		P	Figure 2c. Lymphopenia in p53TSD/– mice. The number of T- and B-cells in the spleen of two-week-old p53TSD/– is decreased compared to wild type. Note: a new more specific term (Negative regulation of T cell apoptosis) is suggested	complete
	GO:0070245	positive regulation of thymocyte apoptosis	PMID:20818388^[1]	IMP: Inferred from Mutant Phenotype		P	The number of thymocytes was markedly reduced in p53TSD/– mice when compared with wild-type controls (Fig. 1f).	complete
	GO:2000178	negative regulation of neural precursor cell proliferation	PMID:20818388^[1]	IMP: Inferred from Mutant Phenotype		P	Using Sox2, a marker specific for adult neural stem cells, we confirmed that neural stem cells are depleted in the dentate gyrus of one-month-old p53TSD/– mice (Fig. 3b).	complete
	GO:2000019	negative regulation of male gonad development	PMID:20818388^[1]	IMP: Inferred from Mutant Phenotype		P	The size of the p53TSD/– mice testes became increasingly smaller (Testicular atrophy) (Fig. 4a, b).	complete
	GO:0048133	male germ-line stem cell division	PMID:20818388^[1]	IMP: Inferred from Mutant Phenotype		P	The impaired spermatogenesis was because of the decreased number of SSCs (spermatogonial stem cells) (Epcam+, α6-integrin+ and c-Kit–) in the testes of p53TSD/– mice (Fig. 4c). Note: a new more specific term (Negative regulation of male germ-line stem cell division) is suggested	complete
	GO:0008630	DNA damage response, signal transduction resulting in induction of apoptosis	PMID:20818388^[1]	IMP: Inferred from Mutant Phenotype		P	Figure S2 DNA damage responses in thymocytes of different genotypes. (a) p53-dependent apoptosis in p53-/-, p53+/+, p53+/- and p53TSD/- thymocytes 10hrs after treating with 5, 10 and 20Gy of IR.	complete
	GO:0050680	negative regulation of epithelial cell proliferation	PMID:20818388^[1]	IMP: Inferred from Mutant Phenotype		P	Figure S6 Apoptosis is significantly increased in the crypt of small intestine of p53TSD/- mice.	complete
	GO:0042769	DNA damage response, detection of DNA damage	PMID:20818388^[1]	IMP: Inferred from Mutant Phenotype		P	Figure S2 DNA damage responses in thymocytes of different genotypes. (a) p53-dependent apoptosis in p53-/-, p53+/+, p53+/- and p53TSD/- thymocytes 10hrs after treating with 5, 10 and 20Gy of IR.	complete
	GO:0008285	negative regulation of cell proliferation	PMID:20818388^[1]	IMP: Inferred from Mutant Phenotype		P	the p53TSD/– mice were similar to their wild-type littermates by 2 weeks of age, these mice became runted and weighed about 50% of the sex- and age-matched p53+/+- and p53+/–-mice by 4 weeks of age (Fig. 1a,b).	complete
	GO:0010552	positive regulation of gene-specific transcription from RNA polymerase II promoter	PMID:20818388^[1]	IMP: Inferred from Mutant Phenotype		P	the expression of p53-target genes p21 and Puma in different tissues of p53TSD/– and wild-type mice were compared, including in brain, kidney, small intestine, liver, lung, skin and spleen. The mRNA levels of Puma and p21 were increased in most tissues of p53TSD/– mice, indicating that p53 is constitutively active in p53TSD/– mice (Supplementary Information, Fig. S2).	complete
	GO:0030308	negative regulation of cell growth	PMID:20818388^[1]	IMP: Inferred from Mutant Phenotype		P	Figure 1B. Growth rate of p53+/+, p53+/– and p53TSD/– mice between 14 and 28 days postnatal show decreased growth.	complete
	GO:0043065	positive regulation of apoptosis	PMID:20818388^[1]	IMP: Inferred from Mutant Phenotype		P	Figure S4e. Increased apoptosis of spermatogonia.	complete
	GO:0070215	MDM2 binding	PMID:20818388^[1]	IPI: Inferred from Physical Interaction	UniProtKB:P23804	F	The TSD mutation partially disrupted the interaction between p53 and its negative regulator Mdm2, accounting for the increased p53 stability and activity in p53TSD/– cells (Fig. 1g, h and Supplementary Information, Fig. S1g).	complete
	GO:0000060	protein import into nucleus, translocation	PMID:11799106^[2]	IDA: Inferred from Direct Assay		P
	GO:0000122	negative regulation of transcription from RNA polymerase II promoter	PMID:15657445^[3]	IGI: Inferred from Genetic Interaction	MGI:MGI:106203	P
	GO:0000122	negative regulation of transcription from RNA polymerase II promoter	PMID:18212064^[4]	IGI: Inferred from Genetic Interaction	MGI:MGI:98725	P
	GO:0000122	negative regulation of transcription from RNA polymerase II promoter	PMID:19411634^[5]	IGI: Inferred from Genetic Interaction	MGI:MGI:95661	P
	GO:0000122	negative regulation of transcription from RNA polymerase II promoter	PMID:19749791^[6]	IMP: Inferred from Mutant Phenotype		P
	GO:0000122	negative regulation of transcription from RNA polymerase II promoter	PMID:8183579^[7]	IDA: Inferred from Direct Assay		P
	GO:0000733	DNA strand renaturation	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:P04637	P
	GO:0000739	DNA strand annealing activity	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:P04637	F
	GO:0000785	chromatin	GO_REF:0000033	ISS: Inferred from Sequence or Structural Similarity	PANTHER:PTHR11447	C
	GO:0001701	in utero embryonic development	PMID:17325035^[8]	IGI: Inferred from Genetic Interaction	MGI:MGI:1343101	P
	GO:0001701	in utero embryonic development	PMID:9288110^[9]	IGI: Inferred from Genetic Interaction	MGI:MGI:101816	P
	GO:0001756	somitogenesis	PMID:17320900^[10]	IGI: Inferred from Genetic Interaction	MGI:MGI:1343101	P
	GO:0001836	release of cytochrome c from mitochondria	PMID:14963330^[11]	IGI: Inferred from Genetic Interaction	MGI:MGI:99702	P
	GO:0001836	release of cytochrome c from mitochondria	PMID:15483136^[12]	IDA: Inferred from Direct Assay		P
	GO:0002039	p53 binding	GO_REF:0000033	ISS: Inferred from Sequence or Structural Similarity	PANTHER:PTHR11447	F
	GO:0002309	T cell proliferation involved in immune response	PMID:16357222^[13]	IGI: Inferred from Genetic Interaction	MGI:MGI:98159	P
	GO:0002326	B cell lineage commitment	PMID:8788039^[14]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1857590	P
	GO:0002360	T cell lineage commitment	PMID:8788039^[14]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1857590	P
	GO:0003677	DNA binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR002117	F
	GO:0003677	DNA binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR012346	F
	GO:0003677	DNA binding	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0238	F
	GO:0003677	DNA binding	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:P04637	F
	GO:0003677	DNA binding	PMID:10205143^[15]	IDA: Inferred from Direct Assay		F
	GO:0003677	DNA binding	PMID:12135983^[16]	IDA: Inferred from Direct Assay		F
	GO:0003677	DNA binding	PMID:16107883^[17]	IDA: Inferred from Direct Assay		F
	GO:0003677	DNA binding	PMID:16363065^[18]	IDA: Inferred from Direct Assay		F
	GO:0003682	chromatin binding	PMID:15657445^[3]	IDA: Inferred from Direct Assay		F
	GO:0003682	chromatin binding	PMID:18212064^[4]	IDA: Inferred from Direct Assay		F
	GO:0003684	damaged DNA binding	GO_REF:0000033	ISS: Inferred from Sequence or Structural Similarity	PANTHER:PTHR11447	F
	GO:0003690	double-stranded DNA binding	GO_REF:0000033	ISS: Inferred from Sequence or Structural Similarity	PANTHER:PTHR11447	F
	GO:0003700	sequence-specific DNA binding transcription factor activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR002117	F
	GO:0003700	sequence-specific DNA binding transcription factor activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR008967	F
	GO:0003700	sequence-specific DNA binding transcription factor activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR012346	F
	GO:0003700	sequence-specific DNA binding transcription factor activity	PMID:12135983^[16]	IDA: Inferred from Direct Assay		F
	GO:0003700	sequence-specific DNA binding transcription factor activity	PMID:16044147^[19]	IDA: Inferred from Direct Assay		F
	GO:0003700	sequence-specific DNA binding transcription factor activity	PMID:16098148^[20]	IDA: Inferred from Direct Assay		F
	GO:0005507	copper ion binding	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:P04637	F
	GO:0005515	protein binding	PMID:10205143^[15]	IPI: Inferred from Physical Interaction	UniProtKB:P23804	F
	GO:0005515	protein binding	PMID:10329696^[21]	IPI: Inferred from Physical Interaction	UniProtKB:Q9Z2R2	F
	GO:0005515	protein binding	PMID:10951572^[22]	IPI: Inferred from Physical Interaction	UniProtKB:Q99986	F
	GO:0005515	protein binding	PMID:11274052^[23]	IPI: Inferred from Physical Interaction	UniProtKB:P03070	F
	GO:0005515	protein binding	PMID:11388671^[24]	IPI: Inferred from Physical Interaction	UniProtKB:Q8N2W9	F
	GO:0005515	protein binding	PMID:11672522^[25]	IPI: Inferred from Physical Interaction	UniProtKB:Q923E4	F
	GO:0005515	protein binding	PMID:11799106^[2]	IPI: Inferred from Physical Interaction	UniProtKB:Q9Z1E3	F
	GO:0005515	protein binding	PMID:11900485^[26]	IPI: Inferred from Physical Interaction	UniProtKB:P38647	F
	GO:0005515	protein binding	PMID:14963330^[11]	IPI: Inferred from Physical Interaction	UniProtKB:Q64373-1	F
	GO:0005515	protein binding	PMID:15364958^[27]	IPI: Inferred from Physical Interaction	UniProtKB:P70399	F
	GO:0005515	protein binding	PMID:15526030^[28]	IPI: Inferred from Physical Interaction	UniProtKB:O35625	F
	GO:0005515	protein binding	PMID:15526030^[28]	IPI: Inferred from Physical Interaction	UniProtKB:Q9QZR5	F
	GO:0005515	protein binding	PMID:15678128^[29]	IPI: Inferred from Physical Interaction	UniProtKB:P23804	F
	GO:0005515	protein binding	PMID:15735665^[30]	IPI: Inferred from Physical Interaction	UniProtKB:Q80Z37	F
	GO:0005515	protein binding	PMID:15782130^[31]	IPI: Inferred from Physical Interaction	UniProtKB:O70445	F
	GO:0005515	protein binding	PMID:15989966^[32]	IPI: Inferred from Physical Interaction	UniProtKB:P23804	F
	GO:0005515	protein binding	PMID:16151013^[33]	IPI: Inferred from Physical Interaction	UniProtKB:Q07817-1	F
	GO:0005515	protein binding	PMID:16151013^[33]	IPI: Inferred from Physical Interaction	UniProtKB:Q64373	F
	GO:0005515	protein binding	PMID:17157788^[34]	IPI: Inferred from Physical Interaction	UniProtKB:O96017	F
	GO:0005515	protein binding	PMID:17157788^[34]	IPI: Inferred from Physical Interaction	UniProtKB:Q13315	F
	GO:0005515	protein binding	PMID:17254968^[35]	IPI: Inferred from Physical Interaction	UniProtKB:O54992	F
	GO:0005515	protein binding	PMID:17274640^[36]	IPI: Inferred from Physical Interaction	UniProtKB:P63087-1	F
	GO:0005515	protein binding	PMID:17936560^[37]	IPI: Inferred from Physical Interaction	UniProtKB:P23804	F
	GO:0005515	protein binding	PMID:18303029^[38]	IPI: Inferred from Physical Interaction	UniProtKB:Q61466	F
	GO:0005515	protein binding	PMID:18332125^[39]	IPI: Inferred from Physical Interaction	UniProtKB:O08586	F
	GO:0005515	protein binding	PMID:18612383^[40]	IPI: Inferred from Physical Interaction	UniProtKB:Q09472	F
	GO:0005515	protein binding	PMID:19411634^[5]	IPI: Inferred from Physical Interaction	UniProtKB:P17679	F
	GO:0005515	protein binding	PMID:19556538^[41]	IPI: Inferred from Physical Interaction	UniProtKB:Q64127	F
	GO:0005515	protein binding	PMID:20697359^[42]	IPI: Inferred from Physical Interaction	UniProtKB:P23804-1	F
	GO:0005524	ATP binding	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:P04637	F
	GO:0005634	nucleus	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR002117	C
	GO:0005634	nucleus	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR012346	C
	GO:0005634	nucleus	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0539	C
	GO:0005634	nucleus	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0191	C
	GO:0005634	nucleus	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:P04637	C
	GO:0005634	nucleus	PMID:11799106^[2]	IDA: Inferred from Direct Assay		C
	GO:0005634	nucleus	PMID:11900485^[26]	IDA: Inferred from Direct Assay		C
	GO:0005634	nucleus	PMID:12524542^[43]	IDA: Inferred from Direct Assay		C
	GO:0005634	nucleus	PMID:14729462^[44]	IDA: Inferred from Direct Assay		C
	GO:0005634	nucleus	PMID:18332125^[39]	IDA: Inferred from Direct Assay		C
	GO:0005634	nucleus	PMID:18545656^[45]	IDA: Inferred from Direct Assay		C
	GO:0005657	replication fork	PMID:15364958^[27]	IDA: Inferred from Direct Assay		C
	GO:0005667	transcription factor complex	GO_REF:0000033	ISS: Inferred from Sequence or Structural Similarity	PANTHER:PTHR11447	C
	GO:0005730	nucleolus	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:P04637	C
	GO:0005737	cytoplasm	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0963	C
	GO:0005737	cytoplasm	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0086	C
	GO:0005737	cytoplasm	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:P04637	C
	GO:0005737	cytoplasm	PMID:11799106^[2]	IDA: Inferred from Direct Assay		C
	GO:0005737	cytoplasm	PMID:11900485^[26]	IDA: Inferred from Direct Assay		C
	GO:0005737	cytoplasm	PMID:12524542^[43]	IDA: Inferred from Direct Assay		C
	GO:0005739	mitochondrion	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:P04637	C
	GO:0005739	mitochondrion	GO_REF:0000033	ISS: Inferred from Sequence or Structural Similarity	PANTHER:PTHR11447	C
	GO:0005783	endoplasmic reticulum	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0256	C
	GO:0005783	endoplasmic reticulum	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0095	C
	GO:0005829	cytosol	PMID:11799106^[2]	IDA: Inferred from Direct Assay		C
	GO:0006289	nucleotide-excision repair	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:P04637	P
	GO:0006302	double-strand break repair	PMID:17912366^[46]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1857989	P
	GO:0006351	transcription, DNA-dependent	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0804	P
	GO:0006351	transcription, DNA-dependent	PMID:12135983^[16]	IDA: Inferred from Direct Assay		P
	GO:0006351	transcription, DNA-dependent	PMID:16044147^[19]	IDA: Inferred from Direct Assay		P
	GO:0006351	transcription, DNA-dependent	PMID:16098148^[20]	IDA: Inferred from Direct Assay		P
	GO:0006355	regulation of transcription, DNA-dependent	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR002117	P
	GO:0006355	regulation of transcription, DNA-dependent	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR008967	P
	GO:0006355	regulation of transcription, DNA-dependent	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR012346	P
	GO:0006355	regulation of transcription, DNA-dependent	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0805	P
	GO:0006355	regulation of transcription, DNA-dependent	PMID:12135983^[16]	IDA: Inferred from Direct Assay		P
	GO:0006915	apoptosis	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR002117	P
	GO:0006915	apoptosis	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0053	P
	GO:0006915	apoptosis	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:P04637	P
	GO:0006915	apoptosis	PMID:14963330^[11]	IGI: Inferred from Genetic Interaction	MGI:MGI:99702	P
	GO:0006915	apoptosis	PMID:15485914^[47]	IGI: Inferred from Genetic Interaction	MGI:MGI:97740	P
	GO:0006915	apoptosis	PMID:16183742^[48]	IDA: Inferred from Direct Assay		P
	GO:0006915	apoptosis	PMID:17325035^[8]	IGI: Inferred from Genetic Interaction	MGI:MGI:1343101	P
	GO:0006917	induction of apoptosis	PMID:16107883^[17]	IDA: Inferred from Direct Assay		P
	GO:0006917	induction of apoptosis	PMID:17210642^[49]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1857590	P
	GO:0006974	response to DNA damage stimulus	PMID:11092819^[50]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1857590	P
	GO:0006974	response to DNA damage stimulus	PMID:12952892^[51]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1926340	P
	GO:0006974	response to DNA damage stimulus	PMID:14744935^[52]	IDA: Inferred from Direct Assay		P
	GO:0006974	response to DNA damage stimulus	PMID:15383658^[53]	IDA: Inferred from Direct Assay		P
	GO:0006977	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest	PMID:16107883^[17]	IGI: Inferred from Genetic Interaction	MGI:MGI:108027	P
	GO:0006978	DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator	GO_REF:0000033	ISS: Inferred from Sequence or Structural Similarity	PANTHER:PTHR11447	P
	GO:0007049	cell cycle	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0131	P
	GO:0007275	multicellular organismal development	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:P04637	P
	GO:0007369	gastrulation	PMID:17000767^[54]	IGI: Inferred from Genetic Interaction	MGI:MGI:98159	P
	GO:0007406	negative regulation of neuroblast proliferation	PMID:9608530^[55]	IGI: Inferred from Genetic Interaction	MGI:MGI:97306	P
	GO:0007417	central nervous system development	PMID:16199867^[56]	IGI: Inferred from Genetic Interaction	MGI:MGI:1335098	P
	GO:0007569	cell aging	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:P04637	P
	GO:0007569	cell aging	PMID:17053789^[57]	IGI: Inferred from Genetic Interaction	MGI:MGI:1920086	P
	GO:0008156	negative regulation of DNA replication	PMID:11884608^[58]	IDA: Inferred from Direct Assay		P
	GO:0008156	negative regulation of DNA replication	PMID:11884608^[58]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1926340	P
	GO:0008285	negative regulation of cell proliferation	PMID:10591652^[59]	IGI: Inferred from Genetic Interaction	MGI:MGI:97306	P
	GO:0008285	negative regulation of cell proliferation	PMID:10591653^[60]	IGI: Inferred from Genetic Interaction	MGI:MGI:97306	P
	GO:0008285	negative regulation of cell proliferation	PMID:10973261^[61]	IGI: Inferred from Genetic Interaction	MGI:MGI:97306	P
	GO:0008285	negative regulation of cell proliferation	PMID:11246230^[62]	IGI: Inferred from Genetic Interaction	MGI:MGI:97306	P
	GO:0008285	negative regulation of cell proliferation	PMID:16107883^[17]	IGI: Inferred from Genetic Interaction	MGI:MGI:108027	P
	GO:0008285	negative regulation of cell proliferation	PMID:19749791^[6]	IMP: Inferred from Mutant Phenotype		P
	GO:0008340	determination of adult lifespan	PMID:20818388^[1]	IMP: Inferred from Mutant Phenotype		P
	GO:0008635	activation of caspase activity by cytochrome c	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:P04637	P
	GO:0009303	rRNA transcription	PMID:18809582^[63]	IGI: Inferred from Genetic Interaction	MGI:MGI:104738	P
	GO:0009411	response to UV	PMID:10815637^[64]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1857590	P
	GO:0009411	response to UV	PMID:11092819^[50]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1857590	P
	GO:0009411	response to UV	PMID:12952892^[51]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1926340	P
	GO:0009411	response to UV	PMID:14744935^[52]	IDA: Inferred from Direct Assay		P
	GO:0009792	embryo development ending in birth or egg hatching	PMID:16702401^[65]	IGI: Inferred from Genetic Interaction	MGI:MGI:2138319	P
	GO:0010165	response to X-ray	PMID:11884608^[58]	IDA: Inferred from Direct Assay		P
	GO:0010332	response to gamma radiation	PMID:14744935^[52]	IDA: Inferred from Direct Assay		P
	GO:0010332	response to gamma radiation	PMID:17068116^[66]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1857590	P
	GO:0016605	PML body	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0465	C
	GO:0030308	negative regulation of cell growth	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:P04637	P
	GO:0030330	DNA damage response, signal transduction by p53 class mediator	PMID:11790307^[67]	IDA: Inferred from Direct Assay		P
	GO:0030330	DNA damage response, signal transduction by p53 class mediator	PMID:11884608^[58]	IDA: Inferred from Direct Assay		P
	GO:0030330	DNA damage response, signal transduction by p53 class mediator	PMID:16199867^[56]	IGI: Inferred from Genetic Interaction	MGI:MGI:106184	P
	GO:0030330	DNA damage response, signal transduction by p53 class mediator	PMID:17476307^[68]	IGI: Inferred from Genetic Interaction	MGI:MGI:109337	P
	GO:0030512	negative regulation of transforming growth factor beta receptor signaling pathway	PMID:15657445^[3]	IMP: Inferred from Mutant Phenotype		P
	GO:0031065	positive regulation of histone deacetylation	PMID:15657445^[3]	IDA: Inferred from Direct Assay		P
	GO:0031571	mitotic cell cycle G1/S transition DNA damage checkpoint	PMID:16107883^[17]	IMP: Inferred from Mutant Phenotype		P
	GO:0033077	T cell differentiation in thymus	PMID:16357222^[13]	IGI: Inferred from Genetic Interaction	MGI:MGI:98159	P
	GO:0034644	cellular response to UV	PMID:14963330^[11]	IGI: Inferred from Genetic Interaction	MGI:MGI:99702	P
	GO:0035033	histone deacetylase regulator activity	PMID:15657445^[3]	IDA: Inferred from Direct Assay		F
	GO:0035264	multicellular organism growth	PMID:17325035^[8]	IGI: Inferred from Genetic Interaction	MGI:MGI:1343101	P
	GO:0042127	regulation of cell proliferation	PMID:10716720^[69]	IGI: Inferred from Genetic Interaction	MGI:MGI:88039	P
	GO:0042127	regulation of cell proliferation	PMID:12878730^[70]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1857263	P
	GO:0042493	response to drug	PMID:9098922^[71]	IDA: Inferred from Direct Assay		P
	GO:0042771	DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis	PMID:12952892^[51]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1926340	P
	GO:0042771	DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis	PMID:16777961^[72]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1857263	P
	GO:0042771	DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis	PMID:17476307^[68]	IGI: Inferred from Genetic Interaction	MGI:MGI:109337	P
	GO:0042771	DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis	PMID:20818388^[1]	IMP: Inferred from Mutant Phenotype		P
	GO:0043065	positive regulation of apoptosis	PMID:17068116^[66]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1857590	P
	GO:0043065	positive regulation of apoptosis	PMID:9024662^[73]	IGI: Inferred from Genetic Interaction	MGI:MGI:99702	P
	GO:0043066	negative regulation of apoptosis	PMID:12952892^[51]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1926340	P
	GO:0043066	negative regulation of apoptosis	PMID:17912366^[46]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1857989	P
	GO:0043066	negative regulation of apoptosis	PMID:8183579^[7]	IMP: Inferred from Mutant Phenotype		P
	GO:0043523	regulation of neuron apoptosis	PMID:15483136^[12]	IGI: Inferred from Genetic Interaction	MGI:MGI:1336991	P
	GO:0043525	positive regulation of neuron apoptosis	PMID:10894779^[74]	IDA: Inferred from Direct Assay		P
	GO:0043525	positive regulation of neuron apoptosis	PMID:10911993^[75]	IGI: Inferred from Genetic Interaction	MGI:MGI:1335098	P
	GO:0043525	positive regulation of neuron apoptosis	PMID:11092819^[50]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1857590	P
	GO:0043525	positive regulation of neuron apoptosis	PMID:11150333^[76]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1857590	P
	GO:0043525	positive regulation of neuron apoptosis	PMID:15483136^[12]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1857590	P
	GO:0043525	positive regulation of neuron apoptosis	PMID:16777961^[72]	IGI: Inferred from Genetic Interaction	MGI:MGI:1927345	P
	GO:0043525	positive regulation of neuron apoptosis	PMID:9608530^[55]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1857263	P
	GO:0043565	sequence-specific DNA binding	GO_REF:0000033	ISS: Inferred from Sequence or Structural Similarity	PANTHER:PTHR11447	F
	GO:0044212	transcription regulatory region DNA binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR011615	F
	GO:0045892	negative regulation of transcription, DNA-dependent	PMID:19749791^[6]	IMP: Inferred from Mutant Phenotype		P
	GO:0045893	positive regulation of transcription, DNA-dependent	PMID:15735665^[30]	IDA: Inferred from Direct Assay		P
	GO:0045893	positive regulation of transcription, DNA-dependent	PMID:15735665^[30]	IGI: Inferred from Genetic Interaction	MGI:MGI:2146189	P
	GO:0045893	positive regulation of transcription, DNA-dependent	PMID:16044147^[19]	IDA: Inferred from Direct Assay		P
	GO:0045944	positive regulation of transcription from RNA polymerase II promoter	GO_REF:0000033	ISS: Inferred from Sequence or Structural Similarity	PANTHER:PTHR11447	P
	GO:0045944	positive regulation of transcription from RNA polymerase II promoter	PMID:16098148^[20]	IDA: Inferred from Direct Assay		P
	GO:0045944	positive regulation of transcription from RNA polymerase II promoter	PMID:16107883^[17]	IDA: Inferred from Direct Assay		P
	GO:0045944	positive regulation of transcription from RNA polymerase II promoter	PMID:19411634^[5]	IDA: Inferred from Direct Assay		P
	GO:0045944	positive regulation of transcription from RNA polymerase II promoter	PMID:8183579^[7]	IDA: Inferred from Direct Assay		P
	GO:0046872	metal ion binding	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0479	F
	GO:0046902	regulation of mitochondrial membrane permeability	PMID:14963330^[11]	IGI: Inferred from Genetic Interaction	MGI:MGI:99702	P
	GO:0048147	negative regulation of fibroblast proliferation	PMID:12952892^[51]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1926340	P
	GO:0048147	negative regulation of fibroblast proliferation	PMID:17332504^[77]	IMP: Inferred from Mutant Phenotype		P
	GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	PMID:19749791^[6]	IMP: Inferred from Mutant Phenotype		P
	GO:0051262	protein tetramerization	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR010991	P
	GO:0051276	chromosome organization	PMID:17200209^[78]	IGI: Inferred from Genetic Interaction	MGI:MGI:88039	P
	GO:0051726	regulation of cell cycle	PMID:15898111^[79]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1857263	P
	GO:0051726	regulation of cell cycle	PMID:18332125^[39]	IGI: Inferred from Genetic Interaction	MGI:MGI:109583	P
	GO:0070215	MDM2 binding	PMID:20818388^[1]	IPI: Inferred from Physical Interaction	UniProtKB:P23804	F
	GO:0070245	positive regulation of thymocyte apoptosis	PMID:20818388^[1]	IMP: Inferred from Mutant Phenotype		P
	GO:0090343	positive regulation of cell aging	PMID:10562313^[80]	IMP: Inferred from Mutant Phenotype		P
NOT	GO:0001701	in utero embryonic development	PMID:9425892^[81]	IGI: Inferred from Genetic Interaction	MGI:MGI:101816	P
edit table

Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.00 ^1.01 ^1.02 ^1.03 ^1.04 ^1.05 ^1.06 ^1.07 ^1.08 ^1.09 ^1.10 ^1.11 ^1.12 ^1.13 ^1.14 ^1.15 ^1.16 ^1.17 ^1.18 ^1.19 ^1.20 ^1.21 Liu D et al. (2010) Puma is required for p53-induced depletion of adult stem cells. Nat Cell Biol 12: 993-8 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 Chang NS (2002) The non-ankyrin C terminus of Ikappa Balpha physically interacts with p53 in vivo and dissociates in response to apoptotic stress, hypoxia, DNA damage, and transforming growth factor-beta 1-mediated growth suppression. J Biol Chem 277: 10323-31 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 ^3.4 Wilkinson DS et al. (2005) A direct intersection between p53 and transforming growth factor beta pathways targets chromatin modification and transcription repression of the alpha-fetoprotein gene. Mol Cell Biol 25: 1200-12 PubMed GONUTS page
↑ ^4.0 ^4.1 Wilkinson DS et al. (2008) Chromatin-bound p53 anchors activated Smads and the mSin3A corepressor to confer transforming-growth-factor-beta-mediated transcription repression. Mol Cell Biol 28: 1988-98 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 Trainor CD et al. (2009) GATA-1 associates with and inhibits p53. Blood 114: 165-73 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 ^6.3 Montano X (2009) Repression of SHP-1 expression by p53 leads to trkA tyrosine phosphorylation and suppression of breast cancer cell proliferation. Oncogene 28: 3787-800 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 Miyashita T et al. (1994) Tumor suppressor p53 is a regulator of bcl-2 and bax gene expression in vitro and in vivo. Oncogene 9: 1799-805 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 Bu P et al. (2007) Loss of Gcn5 acetyltransferase activity leads to neural tube closure defects and exencephaly in mouse embryos. Mol Cell Biol 27: 3405-16 PubMed GONUTS page
↑ Cranston A et al. (1997) Female embryonic lethality in mice nullizygous for both Msh2 and p53. Nat Genet 17: 114-8 PubMed GONUTS page
↑ Nueda ML et al. (2007) The EGF-like protein dlk1 inhibits notch signaling and potentiates adipogenesis of mesenchymal cells. J Mol Biol 367: 1281-93 PubMed GONUTS page
↑ ^11.0 ^11.1 ^11.2 ^11.3 ^11.4 Chipuk JE et al. (2004) Direct activation of Bax by p53 mediates mitochondrial membrane permeabilization and apoptosis. Science 303: 1010-4 PubMed GONUTS page
↑ ^12.0 ^12.1 ^12.2 Lee AF et al. (2004) Evidence that DeltaNp73 promotes neuronal survival by p53-dependent and p53-independent mechanisms. J Neurosci 24: 9174-84 PubMed GONUTS page
↑ ^13.0 ^13.1 Sulic S et al. (2005) Inactivation of S6 ribosomal protein gene in T lymphocytes activates a p53-dependent checkpoint response. Genes Dev 19: 3070-82 PubMed GONUTS page
↑ ^14.0 ^14.1 Li T et al. (1996) Distinct patterns of Fas cell surface expression during development of T- or B-lymphocyte lineages in normal, scid, and mutant mice lacking or overexpressing p53, bcl-2, or rag-2 genes. Cell Growth Differ 7: 107-14 PubMed GONUTS page
↑ ^15.0 ^15.1 Leri A et al. (1999) Overexpression of insulin-like growth factor-1 attenuates the myocyte renin-angiotensin system in transgenic mice. Circ Res 84: 752-62 PubMed GONUTS page
↑ ^16.0 ^16.1 ^16.2 ^16.3 Bourdon JC et al. (2002) Scotin, a novel p53-inducible proapoptotic protein located in the ER and the nuclear membrane. J Cell Biol 158: 235-46 PubMed GONUTS page
↑ ^17.0 ^17.1 ^17.2 ^17.3 ^17.4 ^17.5 Doumont G et al. (2005) G1 checkpoint failure and increased tumor susceptibility in mice lacking the novel p53 target Ptprv. EMBO J 24: 3093-103 PubMed GONUTS page
↑ Kulesz-Martin M et al. (2005) Melanocyte and keratinocyte carcinogenesis: p53 family protein activities and intersecting mRNA expression profiles. J Investig Dermatol Symp Proc 10: 142-52 PubMed GONUTS page
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↑ ^20.0 ^20.1 ^20.2 Watanabe-Fukunaga R et al. (2005) SEI family of nuclear factors regulates p53-dependent transcriptional activation. Genes Cells 10: 851-60 PubMed GONUTS page
↑ Wadhwa R et al. (1999) Cloning and characterization of a novel gene, striamin, that interacts with the tumor suppressor protein p53. J Biol Chem 274: 14948-55 PubMed GONUTS page
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↑ Rousset R et al. (2001) Naked cuticle targets dishevelled to antagonize Wnt signal transduction. Genes Dev 15: 658-71 PubMed GONUTS page
↑ Nelson V et al. (2001) A putative protein inhibitor of activated STAT (PIASy) interacts with p53 and inhibits p53-mediated transactivation but not apoptosis. Apoptosis 6: 221-34 PubMed GONUTS page
↑ Luo J et al. (2001) Negative control of p53 by Sir2alpha promotes cell survival under stress. Cell 107: 137-48 PubMed GONUTS page
↑ ^26.0 ^26.1 ^26.2 Wadhwa R et al. (2002) Hsp70 family member, mot-2/mthsp70/GRP75, binds to the cytoplasmic sequestration domain of the p53 protein. Exp Cell Res 274: 246-53 PubMed GONUTS page
↑ ^27.0 ^27.1 Sengupta S et al. (2004) Functional interaction between BLM helicase and 53BP1 in a Chk1-mediated pathway during S-phase arrest. J Cell Biol 166: 801-13 PubMed GONUTS page
↑ ^28.0 ^28.1 Rui Y et al. (2004) Axin stimulates p53 functions by activation of HIPK2 kinase through multimeric complex formation. EMBO J 23: 4583-94 PubMed GONUTS page
↑ Saito A et al. (2005) Modulation of p53 degradation via MDM2-mediated ubiquitylation and the ubiquitin-proteasome system during reperfusion after stroke: role of oxidative stress. J Cereb Blood Flow Metab 25: 267-80 PubMed GONUTS page
↑ ^30.0 ^30.1 ^30.2 Lin L et al. (2005) topors, a p53 and topoisomerase I-binding RING finger protein, is a coactivator of p53 in growth suppression induced by DNA damage. Oncogene 24: 3385-96 PubMed GONUTS page
↑ Feki A et al. (2005) BARD1 induces apoptosis by catalysing phosphorylation of p53 by DNA-damage response kinase. Oncogene 24: 3726-36 PubMed GONUTS page
↑ Yuan X et al. (2005) Genetic inactivation of the transcription factor TIF-IA leads to nucleolar disruption, cell cycle arrest, and p53-mediated apoptosis. Mol Cell 19: 77-87 PubMed GONUTS page
↑ ^33.0 ^33.1 Chipuk JE et al. (2005) PUMA couples the nuclear and cytoplasmic proapoptotic function of p53. Science 309: 1732-5 PubMed GONUTS page
↑ ^34.0 ^34.1 Bruno T et al. (2006) Che-1 phosphorylation by ATM/ATR and Chk2 kinases activates p53 transcription and the G2/M checkpoint. Cancer Cell 10: 473-86 PubMed GONUTS page
↑ Sun P et al. (2007) PRAK is essential for ras-induced senescence and tumor suppression. Cell 128: 295-308 PubMed GONUTS page
↑ Flores-Delgado G et al. (2007) A limited screen for protein interactions reveals new roles for protein phosphatase 1 in cell cycle control and apoptosis. J Proteome Res 6: 1165-75 PubMed GONUTS page
↑ Itahana K et al. (2007) Targeted inactivation of Mdm2 RING finger E3 ubiquitin ligase activity in the mouse reveals mechanistic insights into p53 regulation. Cancer Cell 12: 355-66 PubMed GONUTS page
↑ Oh J et al. (2008) BAF60a interacts with p53 to recruit the SWI/SNF complex. J Biol Chem 283: 11924-34 PubMed GONUTS page
↑ ^39.0 ^39.1 ^39.2 Chang CJ et al. (2008) PTEN nuclear localization is regulated by oxidative stress and mediates p53-dependent tumor suppression. Mol Cell Biol 28: 3281-9 PubMed GONUTS page
↑ Valbuena A et al. (2008) The C/H3 domain of p300 is required to protect VRK1 and VRK2 from their downregulation induced by p53. PLoS One 3: e2649 PubMed GONUTS page
↑ Allton K et al. (2009) Trim24 targets endogenous p53 for degradation. Proc Natl Acad Sci U S A 106: 11612-6 PubMed GONUTS page
↑ Giglio S et al. (2010) Regulation of MDM4 (MDMX) function by p76(MDM2): a new facet in the control of p53 activity. Oncogene 29: 5935-45 PubMed GONUTS page
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↑ Zhang S et al. (2004) Nuclear DNA helicase II (RNA helicase A) binds to an F-actin containing shell that surrounds the nucleolus. Exp Cell Res 293: 248-58 PubMed GONUTS page
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↑ Sugo N et al. (2004) p53 Deficiency rescues neuronal apoptosis but not differentiation in DNA polymerase beta-deficient mice. Mol Cell Biol 24: 9470-7 PubMed GONUTS page
↑ Berube C et al. (2005) Apoptosis caused by p53-induced protein with death domain (PIDD) depends on the death adapter protein RAIDD. Proc Natl Acad Sci U S A 102: 14314-20 PubMed GONUTS page
↑ Babbe H et al. (2007) The Bloom's syndrome helicase is critical for development and function of the alphabeta T-cell lineage. Mol Cell Biol 27: 1947-59 PubMed GONUTS page
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↑ ^51.0 ^51.1 ^51.2 ^51.3 ^51.4 Shibue T et al. (2003) Integral role of Noxa in p53-mediated apoptotic response. Genes Dev 17: 2233-8 PubMed GONUTS page
↑ ^52.0 ^52.1 ^52.2 Qu L et al. (2004) Endoplasmic reticulum stress induces p53 cytoplasmic localization and prevents p53-dependent apoptosis by a pathway involving glycogen synthase kinase-3beta. Genes Dev 18: 261-77 PubMed GONUTS page
↑ You H et al. (2004) p53-dependent inhibition of FKHRL1 in response to DNA damage through protein kinase SGK1. Proc Natl Acad Sci U S A 101: 14057-62 PubMed GONUTS page
↑ Panić L et al. (2006) Ribosomal protein S6 gene haploinsufficiency is associated with activation of a p53-dependent checkpoint during gastrulation. Mol Cell Biol 26: 8880-91 PubMed GONUTS page
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↑ He H et al. (2006) POT1b protects telomeres from end-to-end chromosomal fusions and aberrant homologous recombination. EMBO J 25: 5180-90 PubMed GONUTS page
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↑ Cichowski K et al. (1999) Mouse models of tumor development in neurofibromatosis type 1. Science 286: 2172-6 PubMed GONUTS page
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↑ Reilly KM et al. (2000) Nf1;Trp53 mutant mice develop glioblastoma with evidence of strain-specific effects. Nat Genet 26: 109-13 PubMed GONUTS page
↑ Bajenaru ML et al. (2001) Neurofibromatosis 1 (NF1) heterozygosity results in a cell-autonomous growth advantage for astrocytes. Glia 33: 314-23 PubMed GONUTS page
↑ Maggi LB Jr et al. (2008) Nucleophosmin serves as a rate-limiting nuclear export chaperone for the Mammalian ribosome. Mol Cell Biol 28: 7050-65 PubMed GONUTS page
↑ Hendry JH et al. (2000) Effects of deficiency in p53 or bcl-2 on the sensitivity of clonogenic cells in the small intestine to low dose-rate irradiation. Int J Radiat Biol 76: 559-65 PubMed GONUTS page
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↑ Weiss RS et al. (2002) Hus1 acts upstream of chk1 in a mammalian DNA damage response pathway. Curr Biol 12: 73-7 PubMed GONUTS page
↑ ^68.0 ^68.1 Frappart PO et al. (2007) BRCA2 is required for neurogenesis and suppression of medulloblastoma. EMBO J 26: 2732-42 PubMed GONUTS page
↑ Halberg RB et al. (2000) Tumorigenesis in the multiple intestinal neoplasia mouse: redundancy of negative regulators and specificity of modifiers. Proc Natl Acad Sci U S A 97: 3461-6 PubMed GONUTS page
↑ Fingerle-Rowson G et al. (2003) The p53-dependent effects of macrophage migration inhibitory factor revealed by gene targeting. Proc Natl Acad Sci U S A 100: 9354-9 PubMed GONUTS page
↑ Wlodarczyk BC et al. (1996) Valproic acid-induced changes in gene expression during neurulation in a mouse model. Teratology 54: 284-97 PubMed GONUTS page
↑ ^72.0 ^72.1 Orii KE et al. (2006) Selective utilization of nonhomologous end-joining and homologous recombination DNA repair pathways during nervous system development. Proc Natl Acad Sci U S A 103: 10017-22 PubMed GONUTS page
↑ Yin C et al. (1997) Bax suppresses tumorigenesis and stimulates apoptosis in vivo. Nature 385: 637-40 PubMed GONUTS page
↑ Pozniak CD et al. (2000) An anti-apoptotic role for the p53 family member, p73, during developmental neuron death. Science 289: 304-6 PubMed GONUTS page
↑ Frank KM et al. (2000) DNA ligase IV deficiency in mice leads to defective neurogenesis and embryonic lethality via the p53 pathway. Mol Cell 5: 993-1002 PubMed GONUTS page
↑ Zaidi AU et al. (2001) Bcl-X(L)-caspase-9 interactions in the developing nervous system: evidence for multiple death pathways. J Neurosci 21: 169-75 PubMed GONUTS page
↑ Takahashi K et al. (2007) Dynamic regulation of p53 subnuclear localization and senescence by MORC3. Mol Biol Cell 18: 1701-9 PubMed GONUTS page
↑ Alberici P et al. (2007) Aneuploidy arises at early stages of Apc-driven intestinal tumorigenesis and pinpoints conserved chromosomal loci of allelic imbalance between mouse and human. Am J Pathol 170: 377-87 PubMed GONUTS page
↑ Kalitsis P et al. (2005) Increased chromosome instability but not cancer predisposition in haploinsufficient Bub3 mice. Genes Chromosomes Cancer 44: 29-36 PubMed GONUTS page
↑ Hudson JD et al. (1999) A proinflammatory cytokine inhibits p53 tumor suppressor activity. J Exp Med 190: 1375-82 PubMed GONUTS page
↑ Toft NJ et al. (1998) No female embryonic lethality in mice nullizygous for Msh2 and p53. Nat Genet 18: 17 PubMed GONUTS page

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[PMID:10716720-68] Halberg RB et al. (2000) Tumorigenesis in the multiple intestinal neoplasia mouse: redundancy of negative regulators and specificity of modifiers. Proc Natl Acad Sci U S A 97: 3461-6 PubMed GONUTS page

[PMID:12878730-69] Fingerle-Rowson G et al. (2003) The p53-dependent effects of macrophage migration inhibitory factor revealed by gene targeting. Proc Natl Acad Sci U S A 100: 9354-9 PubMed GONUTS page

[PMID:9098922-70] Wlodarczyk BC et al. (1996) Valproic acid-induced changes in gene expression during neurulation in a mouse model. Teratology 54: 284-97 PubMed GONUTS page

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[PMID:9024662-72] Yin C et al. (1997) Bax suppresses tumorigenesis and stimulates apoptosis in vivo. Nature 385: 637-40 PubMed GONUTS page

[PMID:10894779-73] Pozniak CD et al. (2000) An anti-apoptotic role for the p53 family member, p73, during developmental neuron death. Science 289: 304-6 PubMed GONUTS page

[PMID:10911993-74] Frank KM et al. (2000) DNA ligase IV deficiency in mice leads to defective neurogenesis and embryonic lethality via the p53 pathway. Mol Cell 5: 993-1002 PubMed GONUTS page

[PMID:11150333-75] Zaidi AU et al. (2001) Bcl-X(L)-caspase-9 interactions in the developing nervous system: evidence for multiple death pathways. J Neurosci 21: 169-75 PubMed GONUTS page

[PMID:17332504-76] Takahashi K et al. (2007) Dynamic regulation of p53 subnuclear localization and senescence by MORC3. Mol Biol Cell 18: 1701-9 PubMed GONUTS page

[PMID:17200209-77] Alberici P et al. (2007) Aneuploidy arises at early stages of Apc-driven intestinal tumorigenesis and pinpoints conserved chromosomal loci of allelic imbalance between mouse and human. Am J Pathol 170: 377-87 PubMed GONUTS page

[PMID:15898111-78] Kalitsis P et al. (2005) Increased chromosome instability but not cancer predisposition in haploinsufficient Bub3 mice. Genes Chromosomes Cancer 44: 29-36 PubMed GONUTS page

[PMID:10562313-79] Hudson JD et al. (1999) A proinflammatory cytokine inhibits p53 tumor suppressor activity. J Exp Med 190: 1375-82 PubMed GONUTS page

[PMID:9425892-80] Toft NJ et al. (1998) No female embryonic lethality in mice nullizygous for Msh2 and p53. Nat Genet 18: 17 PubMed GONUTS page

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MOUSE:P53

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