MOUSE:OTX2

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Annotations

Qualifier	GO ID	GO term name	Reference	Evidence Code	with/from	Aspect	Notes	Status
	GO:0005737	cytoplasm		IDA: Inferred from Direct Assay		C	Source: MGI
	GO:0005634	nucleus		IDA: Inferred from Direct Assay		C	Source: MGI
	GO:0046982	protein heterodimerization activity		IPI: Inferred from Physical Interaction		F	Source: MGI
	GO:0043565	sequence-specific DNA binding		IEA: Inferred from Electronic Annotation		F	Source: InterPro
	GO:0003700	transcription factor activity		IEA: Inferred from Electronic Annotation		F	Source: InterPro
	GO:0009952	anterior/posterior pattern formation		IMP: Inferred from Mutant Phenotype		P	Source: MGI
	GO:0001708	cell fate specification		IMP: Inferred from Mutant Phenotype		P	Source: MGI
	GO:0009953	dorsal/ventral pattern formation		IMP: Inferred from Mutant Phenotype		P	Source: MGI
	GO:0007492	endoderm development		IGI: Inferred from Genetic Interaction		P	Source: MGI
	GO:0042706	eye photoreceptor cell fate commitment		IMP: Inferred from Mutant Phenotype		P	Source: MGI
	GO:0030900	forebrain development		IMP: Inferred from Mutant Phenotype		P	Source: MGI
	GO:0042472	inner ear morphogenesis		IGI: Inferred from Genetic Interaction		P	Source: MGI
	GO:0030901	midbrain development		IMP: Inferred from Mutant Phenotype		P	Source: MGI
	GO:0045944	positive regulation of transcription from R...		IDA: Inferred from Direct Assay		P	Source: MGI
	GO:0010468	regulation of gene expression	PMID:20463215^[1]	IMP: Inferred from Mutant Phenotype		P	p6517 blimp1 expression is reduced in otx2 knockouts	complete
	GO:0003677	DNA binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR003022	F
	GO:0003677	DNA binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR003025	F
	GO:0003677	DNA binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR012287	F
	GO:0003677	DNA binding	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0238	F
	GO:0003677	DNA binding	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0371	F
	GO:0003700	sequence-specific DNA binding transcription factor activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR001356	F
	GO:0003700	sequence-specific DNA binding transcription factor activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR003022	F
	GO:0003700	sequence-specific DNA binding transcription factor activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR003025	F
	GO:0003700	sequence-specific DNA binding transcription factor activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR013851	F
	GO:0005634	nucleus	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR003022	C
	GO:0005634	nucleus	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR003025	C
	GO:0005634	nucleus	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR013851	C
	GO:0005634	nucleus	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR017970	C
	GO:0005634	nucleus	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0539	C
	GO:0005634	nucleus	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0191	C
	GO:0006351	transcription, DNA-dependent	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR001356	P
	GO:0006351	transcription, DNA-dependent	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR003022	P
	GO:0006351	transcription, DNA-dependent	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR003025	P
	GO:0006351	transcription, DNA-dependent	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR013851	P
	GO:0006355	regulation of transcription, DNA-dependent	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR001356	P
	GO:0006355	regulation of transcription, DNA-dependent	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR012287	P
	GO:0006355	regulation of transcription, DNA-dependent	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR017970	P
	GO:0007275	multicellular organismal development	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR003022	P
	GO:0007275	multicellular organismal development	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR003025	P
	GO:0007275	multicellular organismal development	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR013851	P
	GO:0007275	multicellular organismal development	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0217	P
	GO:0040019	positive regulation of embryonic development	PMID:11291865^[2]	IMP: Inferred from Mutant Phenotype		P
	GO:0043565	sequence-specific DNA binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR001356	F
	GO:0043565	sequence-specific DNA binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR017970	F
	GO:0045893	positive regulation of transcription, DNA-dependent	PMID:11291865^[2]	IMP: Inferred from Mutant Phenotype		P
	GO:0090009	primitive streak formation	PMID:11291865^[2]	IMP: Inferred from Mutant Phenotype		P
	GO:2000543	positive regulation of gastrulation	PMID:11291865^[2]	IMP: Inferred from Mutant Phenotype		P
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Katoh K et al. (2010) Blimp1 suppresses Chx10 expression in differentiating retinal photoreceptor precursors to ensure proper photoreceptor development. J Neurosci 30: 6515-26 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 Kinder SJ et al. (2001) Defects of the body plan of mutant embryos lacking Lim1, Otx2 or Hnf3beta activity. Int J Dev Biol 45: 347-55 PubMed GONUTS page

[PMID:20463215-0] Katoh K et al. (2010) Blimp1 suppresses Chx10 expression in differentiating retinal photoreceptor precursors to ensure proper photoreceptor development. J Neurosci 30: 6515-26 PubMed GONUTS page

[PMID:11291865-1] 2.0 ^2.1 ^2.2 ^2.3 Kinder SJ et al. (2001) Defects of the body plan of mutant embryos lacking Lim1, Otx2 or Hnf3beta activity. Int J Dev Biol 45: 347-55 PubMed GONUTS page

[1]

[2]

Species (Taxon ID)	Mus musculus (Mouse). (taxon:10090)
Gene Name(s)	Otx2 ( synonyms: Otx-2 )
Protein Name(s)	Homeobox protein OTX2 Orthodenticle homolog 2
External Links
UniProt Identifier	OTX2_MOUSE
UniProt Accessions	P80206,
EMBL	X68884,
PIR	S35346,
PDB	2DMS,
Pfam	PF00046, PF03529,

MOUSE:OTX2

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Annotations

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References

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