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MOUSE:NRX1B
Contents |
| Species (Taxon ID) | Mus musculus (Mouse). ([1]) | |
| Gene Name(s) | Nrxn1 | |
| Protein Name(s) | Neurexin-1-beta
Neurexin I-beta | |
| External Links | ||
| EMBL | CH466537 | |
| IPI | IPI01027669 | |
| Ensembl | ENSMUST00000172466 | |
| MGI | MGI:1096391 | |
| GO | GO:0044295 GO:0009986 GO:0030139 GO:0060076 GO:0060077 GO:0016021 GO:0048306 GO:0050839 GO:0043499 GO:0097109 GO:0001525 GO:0016339 GO:0045184 GO:0097112 GO:0097116 GO:0097117 GO:0007157 GO:0097114 GO:0097118 GO:0007158 GO:0090004 GO:2000463 GO:0051968 GO:0097119 GO:0097104 GO:0097105 GO:0097120 GO:2000311 GO:2000310 GO:0097091 | |
| InterPro | IPR008985 IPR013320 IPR001791 IPR012680 IPR003585 | |
| Gene3D | G3DSA:2.60.120.200 | |
| Pfam | PF02210 | |
| SMART | SM00294 SM00282 | |
| SUPFAM | SSF49899 | |
| PROSITE | PS50025 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0001525 |
angiogenesis |
IEA: Inferred from Electronic Annotation |
P |
Seeded From UniProt |
||||
| GO:0005886 |
plasma membrane |
IEA: Inferred from Electronic Annotation |
C |
Seeded From UniProt |
||||
| GO:0005886 |
plasma membrane |
IEA: Inferred from Electronic Annotation |
SP_SL:SL-0039 |
C |
Seeded From UniProt |
|||
| GO:0007155 |
cell adhesion |
IEA: Inferred from Electronic Annotation |
P |
Seeded From UniProt |
||||
| GO:0007157 |
heterophilic cell-cell adhesion |
IDA: Inferred from Direct Assay |
|
P |
Seeded From UniProt |
|||
| GO:0007158 |
neuron cell-cell adhesion |
IDA: Inferred from Direct Assay |
|
P |
Seeded From UniProt |
|||
| GO:0009986 |
cell surface |
ISS: Inferred from Sequence or Structural Similarity |
C |
Seeded From UniProt |
||||
| GO:0016020 |
membrane |
IEA: Inferred from Electronic Annotation |
C |
Seeded From UniProt |
||||
| GO:0016021 |
integral to membrane |
IEA: Inferred from Electronic Annotation |
C |
Seeded From UniProt |
||||
| GO:0016339 |
calcium-dependent cell-cell adhesion |
IDA: Inferred from Direct Assay |
|
P |
Seeded From UniProt |
|||
| GO:0030054 |
cell junction |
IEA: Inferred from Electronic Annotation |
C |
Seeded From UniProt |
||||
| GO:0030139 |
endocytic vesicle |
ISS: Inferred from Sequence or Structural Similarity |
C |
Seeded From UniProt |
||||
| GO:0035418 |
protein localization to synapse |
IDA: Inferred from Direct Assay |
|
P |
Seeded From UniProt |
|||
| GO:0043499 |
eukaryotic cell surface binding |
IDA: Inferred from Direct Assay |
|
F |
Seeded From UniProt |
|||
| GO:0044295 |
axonal growth cone |
IDA: Inferred from Direct Assay |
|
C |
Seeded From UniProt |
|||
| GO:0045184 |
establishment of protein localization |
IDA: Inferred from Direct Assay |
|
P |
Seeded From UniProt |
|||
| GO:0045202 |
synapse |
IEA: Inferred from Electronic Annotation |
C |
Seeded From UniProt |
||||
| GO:0045202 |
synapse |
IEA: Inferred from Electronic Annotation |
SP_SL:SL-0258 |
C |
Seeded From UniProt |
|||
| GO:0046872 |
metal ion binding |
IEA: Inferred from Electronic Annotation |
F |
Seeded From UniProt |
||||
| GO:0048306 |
calcium-dependent protein binding |
IDA: Inferred from Direct Assay |
|
F |
Seeded From UniProt |
|||
| GO:0050839 |
cell adhesion molecule binding |
IPI: Inferred from Physical Interaction |
F |
Seeded From UniProt |
||||
| GO:0050839 |
cell adhesion molecule binding |
IPI: Inferred from Physical Interaction |
F |
Seeded From UniProt |
||||
| GO:0051968 |
positive regulation of synaptic transmission, glutamatergic |
IDA: Inferred from Direct Assay |
|
P |
Seeded From UniProt |
|||
| GO:0060076 |
excitatory synapse |
IC: Inferred by Curator |
GO:0007416 |
C |
Seeded From UniProt |
|||
| GO:0060077 |
inhibitory synapse |
IC: Inferred by Curator |
GO:0007416 |
C |
Seeded From UniProt |
|||
| GO:0090004 |
positive regulation of establishment of protein localization in plasma membrane |
IDA: Inferred from Direct Assay |
|
P |
Seeded From UniProt |
|||
| GO:0097091 |
synaptic vesicle clustering |
IDA: Inferred from Direct Assay |
|
P |
Seeded From UniProt |
|||
| GO:0097104 |
postsynaptic membrane assembly |
IDA: Inferred from Direct Assay |
|
P |
Seeded From UniProt |
|||
| GO:0097105 |
presynaptic membrane assembly |
IDA: Inferred from Direct Assay |
|
P |
Seeded From UniProt |
|||
| GO:0097109 |
neuroligin family protein binding |
IPI: Inferred from Physical Interaction |
F |
Seeded From UniProt |
||||
| GO:0097109 |
neuroligin family protein binding |
IPI: Inferred from Physical Interaction |
F |
Seeded From UniProt |
||||
| GO:0097112 |
gamma-aminobutyric acid receptor clustering |
IDA: Inferred from Direct Assay |
|
P |
Seeded From UniProt |
|||
| GO:0097114 |
N-methyl-D-aspartate receptor clustering |
IDA: Inferred from Direct Assay |
|
P |
Seeded From UniProt |
|||
| GO:0097116 |
gephyrin clustering |
IDA: Inferred from Direct Assay |
|
P |
Seeded From UniProt |
|||
| GO:0097117 |
guanylate kinase-associated protein clustering |
IDA: Inferred from Direct Assay |
|
P |
Seeded From UniProt |
|||
| GO:0097118 |
neuroligin clustering |
IDA: Inferred from Direct Assay |
|
P |
Seeded From UniProt |
|||
| GO:0097119 |
postsynaptic density protein 95 clustering |
IDA: Inferred from Direct Assay |
|
P |
Seeded From UniProt |
|||
| GO:0097120 |
receptor localization to synapse |
IDA: Inferred from Direct Assay |
|
P |
Seeded From UniProt |
|||
| GO:2000310 |
regulation of N-methyl-D-aspartate selective glutamate receptor activity |
IDA: Inferred from Direct Assay |
|
P |
Seeded From UniProt |
|||
| GO:2000311 |
regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity |
IDA: Inferred from Direct Assay |
|
P |
Seeded From UniProt |
|||
| GO:2000463 |
positive regulation of excitatory postsynaptic membrane potential |
IDA: Inferred from Direct Assay |
|
P |
Seeded From UniProt |
|||
| GO:0046847 |
filopodium assembly |
IMP: Inferred from Mutant Phenotype |
P |
Figure 2A and D, soluble Nrxn1B interfere with filopodial density be increase rate in elimination of pre existing filopodia. Similar results seen in figure 2B and C. Figure 2E shows reduction in new filopodia stabilization when soluble Nrx1B is used, therefore showing that Nrxn1B and Nlgn1 interaction is needed for stabilization of dendrite filopodia. Similar results seen in figure 2I and J |
complete | |||
| GO:0043498 |
cell surface binding |
IDA: Inferred from Direct Assay |
F |
Figure 3B, C fusion protein B-NRX1-human bounds to surface of non-transfected and GFP-Nlgn1 transfected neurons. |
complete | |||
| GO:2000311 |
regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity |
IMP: Inferred from Mutant Phenotype |
P |
Figure 2L-N, showed that using soluble Nrx1B-Fc treatment decrease frequency of AMPA receptor mediated mEPSC. |
complete | |||
| GO:0097119 |
postsynaptic density protein 95 clustering |
IDA: Inferred from Direct Assay |
P |
Further increase in PSD-95 clustering when B-NRX-Fc was applied to neurons, (75% increase), figure 4C. |
complete | |||
| GO:0097119 |
postsynaptic density protein 95 clustering |
IMP: Inferred from Mutant Phenotype |
P |
Figure 2K showed decrease in PSD-95 density when neurons treated with soluble Nrx1B-Fc. Therefore interaction between Nlgn1 and Nrxn1B is needed for location of PSD-95 at the postsynaptic membrane, figure 2P and Q. |
complete | |||
| GO:0051968 |
positive regulation of synaptic transmission, glutamatergic |
IMP: Inferred from Mutant Phenotype |
P |
Figure 2L-N, showed that using soluble Nrx1B-Fc treatment decrease frequency of AMPA receptor mediated mEPSC. |
complete | |||
| GO:2000463 |
positive regulation of excitatory postsynaptic membrane potential |
IMP: Inferred from Mutant Phenotype |
P |
Figure 2L-N, showed that using soluble Nrx1B-Fc treatment decrease frequency of AMPA receptor mediated mEPSC. |
complete | |||
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 1.3 1.4 1.5 1.6 1.7 1.8 1.9 Dean C et al. (2003) Neurexin mediates the assembly of presynaptic terminals. Nat Neurosci 6: 708-16 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 2.3 2.4 2.5 2.6 2.7 2.8 Heine M et al. (2008) Activity-independent and subunit-specific recruitment of functional AMPA receptors at neurexin/neuroligin contacts. Proc Natl Acad Sci U S A 105: 20947-52 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 3.3 3.4 3.5 3.6 3.7 3.8 3.9 Graf ER et al. (2004) Neurexins induce differentiation of GABA and glutamate postsynaptic specializations via neuroligins. Cell 119: 1013-26 PubMed GONUTS page
- ↑ 4.0 4.1 4.2 4.3 4.4 Chen SX et al. (2010) Neurexin-neuroligin cell adhesion complexes contribute to synaptotropic dendritogenesis via growth stabilization mechanisms in vivo. Neuron 67: 967-83 PubMed GONUTS page
- ↑ 5.0 5.1 Barrow SL et al. (2009) Neuroligin1: a cell adhesion molecule that recruits PSD-95 and NMDA receptors by distinct mechanisms during synaptogenesis. Neural Dev 4: 17 PubMed GONUTS page
