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MOUSE:NPC2
Contents |
| Species (Taxon ID) | Mus musculus (Mouse). (taxon:10090) | |
| Gene Name(s) | Npc2 | |
| Protein Name(s) |
| |
| External Links | ||
| UniProt Identifier | NPC2_MOUSE | |
| UniProt Accessions | Q9Z0J0, Q3UB23, | |
| EMBL | AB021289, AK008603, AK009127, AK151067, AK151133, AK153020, AK153203, AK158624, AK165263, AK167869, AK170327, BC003471, BC007190, | |
| RefSeq | NP_075898.1, | |
| Ensembl | ENSMUST00000021668, | |
| Pfam | PF02221, | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0005576 |
extracellular region |
IEA: Inferred from Electronic Annotation |
C |
Source: UniProtKB-SubCell |
||||
| GO:0005764 |
lysosome |
ISS: Inferred from Sequence or Structural Similarity |
C |
Source: HGNC |
||||
| GO:0015485 |
cholesterol binding |
ISS: Inferred from Sequence or Structural Similarity |
F |
Source: HGNC |
||||
| GO:0042632 |
cholesterol homeostasis |
ISS: Inferred from Sequence or Structural Similarity |
P |
Source: HGNC |
||||
| GO:0032367 |
intracellular cholesterol transport |
IMP: Inferred from Mutant Phenotype |
P |
Source: HGNC |
||||
| GO:0005515 |
protein binding |
IPI: Inferred from Physical Interaction |
|
F |
figure 1A |
complete | ||
| GO:0005576 |
extracellular region |
IEA: Inferred from Electronic Annotation |
C |
|||||
| GO:0005576 |
extracellular region |
IEA: Inferred from Electronic Annotation |
SP_SL:SL-0243 |
C |
||||
| GO:0005622 |
intracellular |
IMP: Inferred from Mutant Phenotype |
C |
|||||
| GO:0005764 |
lysosome |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSP00000238633 |
C |
||||
| GO:0005764 |
lysosome |
ISS: Inferred from Sequence or Structural Similarity |
C |
|||||
| GO:0009615 |
response to virus |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSP00000238633 |
P |
||||
| GO:0015485 |
cholesterol binding |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSP00000238633 |
F |
||||
| GO:0015485 |
cholesterol binding |
ISS: Inferred from Sequence or Structural Similarity |
F |
|||||
| GO:0019899 |
enzyme binding |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSP00000238633 |
F |
||||
| GO:0030301 |
cholesterol transport |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSP00000238633 |
P |
||||
| GO:0030301 |
cholesterol transport |
ISS: Inferred from Sequence or Structural Similarity |
P |
|||||
| GO:0032366 |
intracellular sterol transport |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSP00000238633 |
P |
||||
| GO:0032366 |
intracellular sterol transport |
ISS: Inferred from Sequence or Structural Similarity |
P |
|||||
| GO:0032367 |
intracellular cholesterol transport |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSP00000238633 |
P |
||||
| GO:0032367 |
intracellular cholesterol transport |
IMP: Inferred from Mutant Phenotype |
P |
|||||
| GO:0033344 |
cholesterol efflux |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSP00000238633 |
P |
||||
| GO:0042632 |
cholesterol homeostasis |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSP00000238633 |
P |
||||
| GO:0042632 |
cholesterol homeostasis |
ISS: Inferred from Sequence or Structural Similarity |
P |
| ||||
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ Harrison KD et al. (2009) Nogo-B receptor stabilizes Niemann-Pick type C2 protein and regulates intracellular cholesterol trafficking. Cell Metab 10: 208-18 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 2.3 2.4 Liou HL et al. (2006) NPC2, the protein deficient in Niemann-Pick C2 disease, consists of multiple glycoforms that bind a variety of sterols. J Biol Chem 281: 36710-23 PubMed GONUTS page
- ↑ Naureckiene S et al. (2000) Identification of HE1 as the second gene of Niemann-Pick C disease. Science 290: 2298-301 PubMed GONUTS page
- ↑ Frolov A et al. (2003) NPC1 and NPC2 regulate cellular cholesterol homeostasis through generation of low density lipoprotein cholesterol-derived oxysterols. J Biol Chem 278: 25517-25 PubMed GONUTS page
