MOUSE:NF2L2

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Species (Taxon ID)	Mus musculus (Mouse). (taxon:10090)
Gene Name(s)	Nfe2l2 ( synonyms: Nrf-2, Nrf2 )
Protein Name(s)	Nuclear factor erythroid 2-related factor 2 NF-E2-related factor 2 NFE2-related factor 2 Nuclear factor, erythroid derived 2, like 2
External Links
UniProt Identifier	NF2L2_MOUSE
UniProt Accessions	Q60795, Q3UQK0,
EMBL	U70475, U70474, AK142347, AL772404, BC026943, U20532,
PIR	I49261,
RefSeq	NP_035032.1,
PDB	1X2R, 2DYH,
IntAct	Q60795,
Ensembl	ENSMUST00000102672,
Pfam	PF00170,

Annotations

Qualifier	GO ID	GO term name	Reference	Evidence Code	with/from	Aspect	Notes	Status
	GO:0005829	cytosol		IEA: Inferred from Electronic Annotation		C	Source: UniProtKB-SubCell
	GO:0005634	nucleus		IDA: Inferred from Direct Assay		C	Source: MGI
	GO:0046983	protein dimerization activity		IEA: Inferred from Electronic Annotation		F	Source: InterPro
	GO:0043565	sequence-specific DNA binding		IEA: Inferred from Electronic Annotation		F	Source: InterPro
	GO:0003700	sequence-specific DNA binding transcription factor activity		IDA: Inferred from Direct Assay		F	Source: MGI
	GO:0016563	transcription activator activity		IDA: Inferred from Direct Assay		F	Source: MGI
	GO:0030968	endoplasmic reticulum unfolded protein response		IDA: Inferred from Direct Assay		P	Source: MGI
	GO:0045893	positive regulation of transcription, DNA-dependent		IDA: Inferred from Direct Assay		P	Source: MGI
	GO:0045995	regulation of embryonic development		IGI: Inferred from Genetic Interaction		P	Source: MGI
	GO:0005634	nucleus	PMID:20978343^[1]	IDA: Inferred from Direct Assay		C	Figure 6A. Inhibition of src kinases increases accumulation of nuclear Nrf2	complete
	GO:0005737	cytoplasm	PMID:20978343^[1]	IDA: Inferred from Direct Assay		C	cellular fractionation studies showed that cytosolic Nrf2 levels were slightly higher in cd36–/– VSMCs than in WT VSMCs (Figure 5D)	complete
	GO:0016563	transcription activator activity	PMID:20978343^[1]	IDA: Inferred from Direct Assay		F	immunoblots of lysates from VSMC cells demonstrated dramatic upregulation of Prdx2 expression compared with that of cells transfected with a control plasmid, empty pCDNA3 (Figure 4D).	complete
	GO:0030528	transcription regulator activity	PMID:20978343^[1]	IDA: Inferred from Direct Assay		F	immunoblots of lysates from VSMC cells demonstrated dramatic upregulation of Prdx2 expression compared with that of cells transfected with a control plasmid, empty pCDNA3 (Figure 4D).	complete
	GO:0010671	negative regulation of oxygen and reactive oxygen species metabolic process	PMID:20978343^[1]	IMP: Inferred from Mutant Phenotype		P	Figure 7B. shRNA-based gene knockdown of nrf2 in cd36–/– cells significantly increased FeCl3-induced superoxide formation when compared with cd36–/– cells	complete
	GO:0000785	chromatin	PMID:20978343^[1]	IDA: Inferred from Direct Assay		C
	GO:0005739	mitochondrion	PMID:22072718^[2]	IDA: Inferred from Direct Assay		C	Fig. 6A	complete
	GO:0003677	DNA binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR008917	F
	GO:0043066	negative regulation of apoptosis	PMID:22072718^[2]	IMP: Inferred from Mutant Phenotype		P	Fig. 9CD	complete
	GO:0003677	DNA binding	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0238	F
	GO:0003677	DNA binding	PMID:12220541^[3]	IDA: Inferred from Direct Assay		F
	GO:0003677	DNA binding	PMID:14517290^[4]	IDA: Inferred from Direct Assay		F
	GO:0003677	DNA binding	PMID:15870285^[5]	IDA: Inferred from Direct Assay		F
	GO:0003700	sequence-specific DNA binding transcription factor activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR004827	F
	GO:0003700	sequence-specific DNA binding transcription factor activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR011616	F
	GO:0003700	sequence-specific DNA binding transcription factor activity	PMID:12220541^[3]	IDA: Inferred from Direct Assay		F
	GO:0003700	sequence-specific DNA binding transcription factor activity	PMID:14517290^[4]	IDA: Inferred from Direct Assay		F
	GO:0005515	protein binding	PMID:11583586^[6]	IPI: Inferred from Physical Interaction	UniProtKB:Q9CPV5	F
	GO:0005515	protein binding	PMID:14517290^[4]	IPI: Inferred from Physical Interaction	UniProtKB:Q9Z2B5	F
	GO:0005515	protein binding	PMID:14517290^[4]	IPI: Inferred from Physical Interaction	UniProtKB:Q9Z2X8	F
	GO:0005515	protein binding	PMID:15870285^[5]	IPI: Inferred from Physical Interaction	UniProtKB:Q9WU42	F
	GO:0005634	nucleus	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0539	C
	GO:0005634	nucleus	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000380252	C
	GO:0005634	nucleus	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0191	C
	GO:0005634	nucleus	PMID:14517290^[4]	IDA: Inferred from Direct Assay		C
	GO:0005634	nucleus	PMID:15087497^[7]	IDA: Inferred from Direct Assay		C
	GO:0005634	nucleus	PMID:15870285^[5]	IDA: Inferred from Direct Assay		C
	GO:0005737	cytoplasm	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0963	C
	GO:0005737	cytoplasm	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000380252	C
	GO:0005737	cytoplasm	PMID:14517290^[4]	IPI: Inferred from Physical Interaction	UniProtKB:Q9Z2X8	C
	GO:0005737	cytoplasm	PMID:20978343^[1]	IDA: Inferred from Direct Assay		C
	GO:0005813	centrosome	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000380252	C
	GO:0005829	cytosol	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0091	C
	GO:0005886	plasma membrane	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000380252	C
	GO:0006351	transcription, DNA-dependent	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0804	P
	GO:0006351	transcription, DNA-dependent	PMID:12220541^[3]	IDA: Inferred from Direct Assay		P
	GO:0006351	transcription, DNA-dependent	PMID:14517290^[4]	IDA: Inferred from Direct Assay		P
	GO:0006355	regulation of transcription, DNA-dependent	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR004827	P
	GO:0006355	regulation of transcription, DNA-dependent	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR008917	P
	GO:0006355	regulation of transcription, DNA-dependent	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR011616	P
	GO:0006355	regulation of transcription, DNA-dependent	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0805	P
	GO:0006355	regulation of transcription, DNA-dependent	PMID:12220541^[3]	IDA: Inferred from Direct Assay		P
	GO:0019904	protein domain specific binding	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000380252	F
	GO:0030194	positive regulation of blood coagulation	PMID:20978343^[1]	IMP: Inferred from Mutant Phenotype		P
	GO:0030968	endoplasmic reticulum unfolded protein response	PMID:14517290^[4]	IDA: Inferred from Direct Assay		P
	GO:0034599	cellular response to oxidative stress	PMID:20978343^[1]	IDA: Inferred from Direct Assay		P
	GO:0043565	sequence-specific DNA binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR004827	F
	GO:0043565	sequence-specific DNA binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR011616	F
	GO:0045893	positive regulation of transcription, DNA-dependent	PMID:14517290^[4]	IDA: Inferred from Direct Assay		P
	GO:0045893	positive regulation of transcription, DNA-dependent	PMID:15087497^[7]	IGI: Inferred from Genetic Interaction	MGI:MGI:1858732	P
	GO:0045893	positive regulation of transcription, DNA-dependent	PMID:15870285^[5]	IDA: Inferred from Direct Assay		P
	GO:0045944	positive regulation of transcription from RNA polymerase II promoter	PMID:20978343^[1]	IDA: Inferred from Direct Assay		P
	GO:0045995	regulation of embryonic development	PMID:15087497^[7]	IGI: Inferred from Genetic Interaction	MGI:MGI:1858732	P
	GO:0046983	protein dimerization activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR011616	F
	GO:2000121	regulation of removal of superoxide radicals	PMID:20978343^[1]	IMP: Inferred from Mutant Phenotype		P
	GO:2000379	positive regulation of reactive oxygen species metabolic process	PMID:20978343^[1]	IMP: Inferred from Mutant Phenotype		P
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.00 ^1.01 ^1.02 ^1.03 ^1.04 ^1.05 ^1.06 ^1.07 ^1.08 ^1.09 ^1.10 ^1.11 Li W et al. (2010) CD36 participates in a signaling pathway that regulates ROS formation in murine VSMCs. J Clin Invest 120: 3996-4006 PubMed GONUTS page
↑ ^2.0 ^2.1 Niture SK & Jaiswal AK (2011) Inhibitor of Nrf2 (INrf2 or Keap1) protein degrades Bcl-xL via phosphoglycerate mutase 5 and controls cellular apoptosis. J Biol Chem 286: 44542-56 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 Gong P et al. (2002) Multiple basic-leucine zipper proteins regulate induction of the mouse heme oxygenase-1 gene by arsenite. Arch Biochem Biophys 405: 265-74 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 ^4.4 ^4.5 ^4.6 ^4.7 ^4.8 Cullinan SB et al. (2003) Nrf2 is a direct PERK substrate and effector of PERK-dependent cell survival. Mol Cell Biol 23: 7198-209 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 ^5.3 Ki SH et al. (2005) Glucocorticoid receptor (GR)-associated SMRT binding to C/EBPbeta TAD and Nrf2 Neh4/5: role of SMRT recruited to GR in GSTA2 gene repression. Mol Cell Biol 25: 4150-65 PubMed GONUTS page
↑ Wang Y et al. (2001) Cloning and characterization of the mouse polyamine-modulated factor-1 (mPMF-1) gene: an alternatively spliced homologue of the human transcription factor. Biochem J 359: 387-92 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 Motohashi H et al. (2004) Small Maf proteins serve as transcriptional cofactors for keratinocyte differentiation in the Keap1-Nrf2 regulatory pathway. Proc Natl Acad Sci U S A 101: 6379-84 PubMed GONUTS page

[PMID:20978343-0] 1.00 ^1.01 ^1.02 ^1.03 ^1.04 ^1.05 ^1.06 ^1.07 ^1.08 ^1.09 ^1.10 ^1.11 Li W et al. (2010) CD36 participates in a signaling pathway that regulates ROS formation in murine VSMCs. J Clin Invest 120: 3996-4006 PubMed GONUTS page

[PMID:22072718-1] 2.0 ^2.1 Niture SK & Jaiswal AK (2011) Inhibitor of Nrf2 (INrf2 or Keap1) protein degrades Bcl-xL via phosphoglycerate mutase 5 and controls cellular apoptosis. J Biol Chem 286: 44542-56 PubMed GONUTS page

[PMID:12220541-2] 3.0 ^3.1 ^3.2 ^3.3 Gong P et al. (2002) Multiple basic-leucine zipper proteins regulate induction of the mouse heme oxygenase-1 gene by arsenite. Arch Biochem Biophys 405: 265-74 PubMed GONUTS page

[PMID:14517290-3] 4.0 ^4.1 ^4.2 ^4.3 ^4.4 ^4.5 ^4.6 ^4.7 ^4.8 Cullinan SB et al. (2003) Nrf2 is a direct PERK substrate and effector of PERK-dependent cell survival. Mol Cell Biol 23: 7198-209 PubMed GONUTS page

[PMID:15870285-4] 5.0 ^5.1 ^5.2 ^5.3 Ki SH et al. (2005) Glucocorticoid receptor (GR)-associated SMRT binding to C/EBPbeta TAD and Nrf2 Neh4/5: role of SMRT recruited to GR in GSTA2 gene repression. Mol Cell Biol 25: 4150-65 PubMed GONUTS page

[PMID:11583586-5] Wang Y et al. (2001) Cloning and characterization of the mouse polyamine-modulated factor-1 (mPMF-1) gene: an alternatively spliced homologue of the human transcription factor. Biochem J 359: 387-92 PubMed GONUTS page

[PMID:15087497-6] 7.0 ^7.1 ^7.2 Motohashi H et al. (2004) Small Maf proteins serve as transcriptional cofactors for keratinocyte differentiation in the Keap1-Nrf2 regulatory pathway. Proc Natl Acad Sci U S A 101: 6379-84 PubMed GONUTS page

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MOUSE:NF2L2

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