MOUSE:MYF5

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Species (Taxon ID)	Mus musculus (Mouse). (taxon:10090)
Gene Name(s)	Myf5 ( synonyms: Myf-5 )
Protein Name(s)	Myogenic factor 5 Myf-5
External Links
UniProt Identifier	MYF5_MOUSE
UniProt Accessions	P24699, Q543W7,
EMBL	X56182, AK044894, AK083402,
PIR	S22825,
RefSeq	NP_032682.1,
Ensembl	ENSMUST00000000445,
Pfam	PF01586, PF00010, PF12232,

Annotations

Qualifier	GO ID	GO term name	Reference	Evidence Code	with/from	Aspect	Notes
	GO:0005634	nucleus		TAS: Traceable Author Statement		C	Source: MGI
	GO:0003705	RNA polymerase II transcription factor acti...		TAS: Traceable Author Statement		F	Source: MGI
	GO:0001502	cartilage condensation		IMP: Inferred from Mutant Phenotype		P	Source: MGI
	GO:0030154	cell differentiation		IEA: Inferred from Electronic Annotation		P	Source: UniProtKB-KW
	GO:0048704	embryonic skeletal system morphogenesis		IMP: Inferred from Mutant Phenotype		P	Source: MGI
	GO:0030198	extracellular matrix organization		IMP: Inferred from Mutant Phenotype		P	Source: MGI
	GO:0001503	ossification		IMP: Inferred from Mutant Phenotype		P	Source: MGI
	GO:0045944	positive regulation of transcription from R...		IDA: Inferred from Direct Assay		P	Source: MGI
	GO:0001952	regulation of cell-matrix adhesion		IMP: Inferred from Mutant Phenotype		P	Source: MGI
	GO:0007519	skeletal muscle tissue development		IGI: Inferred from Genetic Interaction		P	Source: MGI
	GO:0001756	somitogenesis		IMP: Inferred from Mutant Phenotype		P	Source: MGI
	GO:0001502	cartilage condensation	PMID:8565825^[1]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1857219	P
	GO:0001503	ossification	PMID:8587605^[2]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1857219	P
	GO:0001756	somitogenesis	PMID:10929709^[3]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2449231	P
	GO:0001756	somitogenesis	PMID:19531352^[4]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1857973	P
	GO:0001756	somitogenesis	PMID:8565825^[1]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1857219	P
	GO:0001952	regulation of cell-matrix adhesion	PMID:16554364^[5]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1857973	P
	GO:0003677	DNA binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR002546	F
	GO:0003677	DNA binding	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0238	F
	GO:0003705	sequence-specific enhancer binding RNA polymerase II transcription factor activity	PMID:1846704^[6]	TAS: Traceable Author Statement		F
	GO:0005634	nucleus	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR002546	C
	GO:0005634	nucleus	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR011598	C
	GO:0005634	nucleus	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0539	C
	GO:0005634	nucleus	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0191	C
	GO:0005634	nucleus	PMID:1846704^[6]	TAS: Traceable Author Statement		C
	GO:0005654	nucleoplasm	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000228644	C
	GO:0006355	regulation of transcription, DNA-dependent	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR001092	P
	GO:0006355	regulation of transcription, DNA-dependent	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR002546	P
	GO:0006355	regulation of transcription, DNA-dependent	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR011598	P
	GO:0007275	multicellular organismal development	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0217	P
	GO:0007517	muscle organ development	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR002546	P
	GO:0007517	muscle organ development	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0517	P
	GO:0007517	muscle organ development	PMID:15634692^[7]	IGI: Inferred from Genetic Interaction	MGI:MGI:97275	P
	GO:0007517	muscle organ development	PMID:8587605^[2]	IGI: Inferred from Genetic Interaction		P
	GO:0007517	muscle organ development	PMID:8587605^[2]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1857219	P
	GO:0007519	skeletal muscle tissue development	PMID:19531352^[4]	IGI: Inferred from Genetic Interaction	MGI:MGI:97253	P
	GO:0007519	skeletal muscle tissue development	PMID:19531352^[4]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1857973	P
	GO:0007519	skeletal muscle tissue development	PMID:19531352^[4]	IMP: Inferred from Mutant Phenotype	MGI:MGI:3055340	P
	GO:0007519	skeletal muscle tissue development	PMID:8269513^[8]	IGI: Inferred from Genetic Interaction	MGI:MGI:97275	P
	GO:0030154	cell differentiation	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0221	P
	GO:0030198	extracellular matrix organization	PMID:16554364^[5]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1857973	P
	GO:0043010	camera-type eye development	PMID:19531352^[4]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1857973	P
	GO:0043010	camera-type eye development	PMID:19531352^[4]	IMP: Inferred from Mutant Phenotype	MGI:MGI:3055340	P
	GO:0045944	positive regulation of transcription from RNA polymerase II promoter	PMID:17855775^[9]	IDA: Inferred from Direct Assay		P
	GO:0048644	muscle organ morphogenesis	PMID:19531352^[4]	IGI: Inferred from Genetic Interaction	MGI:MGI:98493	P
	GO:0048704	embryonic skeletal system morphogenesis	PMID:10929709^[3]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1857219	P
	GO:0051149	positive regulation of muscle cell differentiation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000228644	P
	GO:0060415	muscle tissue morphogenesis	PMID:19531352^[4]	IGI: Inferred from Genetic Interaction	MGI:MGI:97491	P
	GO:0060415	muscle tissue morphogenesis	PMID:19531352^[4]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1857973	P
	GO:0060415	muscle tissue morphogenesis	PMID:19531352^[4]	IMP: Inferred from Mutant Phenotype	MGI:MGI:3055340	P
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Grass S et al. (1996) Alterations in somite patterning of Myf-5-deficient mice: a possible role for FGF-4 and FGF-6. Development 122: 141-50 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 Wang Y et al. (1996) Functional redundancy of the muscle-specific transcription factors Myf5 and myogenin. Nature 379: 823-5 PubMed GONUTS page
↑ ^3.0 ^3.1 Kaul A et al. (2000) Myf-5 revisited: loss of early myotome formation does not lead to a rib phenotype in homozygous Myf-5 mutant mice. Cell 102: 17-9 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 ^4.4 ^4.5 ^4.6 ^4.7 ^4.8 ^4.9 Sambasivan R et al. (2009) Distinct regulatory cascades govern extraocular and pharyngeal arch muscle progenitor cell fates. Dev Cell 16: 810-21 PubMed GONUTS page
↑ ^5.0 ^5.1 Bajanca F et al. (2006) Integrin alpha6beta1-laminin interactions regulate early myotome formation in the mouse embryo. Development 133: 1635-44 PubMed GONUTS page
↑ ^6.0 ^6.1 Weintraub H et al. (1991) The myoD gene family: nodal point during specification of the muscle cell lineage. Science 251: 761-6 PubMed GONUTS page
↑ Brent AE et al. (2005) Genetic analysis of interactions between the somitic muscle, cartilage and tendon cell lineages during mouse development. Development 132: 515-28 PubMed GONUTS page
↑ Rudnicki MA et al. (1993) MyoD or Myf-5 is required for the formation of skeletal muscle. Cell 75: 1351-9 PubMed GONUTS page
↑ Hawke TJ et al. (2007) Xin, an actin binding protein, is expressed within muscle satellite cells and newly regenerated skeletal muscle fibers. Am J Physiol Cell Physiol 293: C1636-44 PubMed GONUTS page

[PMID:8565825-0] 1.0 ^1.1 Grass S et al. (1996) Alterations in somite patterning of Myf-5-deficient mice: a possible role for FGF-4 and FGF-6. Development 122: 141-50 PubMed GONUTS page

[PMID:8587605-1] 2.0 ^2.1 ^2.2 Wang Y et al. (1996) Functional redundancy of the muscle-specific transcription factors Myf5 and myogenin. Nature 379: 823-5 PubMed GONUTS page

[PMID:10929709-2] 3.0 ^3.1 Kaul A et al. (2000) Myf-5 revisited: loss of early myotome formation does not lead to a rib phenotype in homozygous Myf-5 mutant mice. Cell 102: 17-9 PubMed GONUTS page

[PMID:19531352-3] 4.0 ^4.1 ^4.2 ^4.3 ^4.4 ^4.5 ^4.6 ^4.7 ^4.8 ^4.9 Sambasivan R et al. (2009) Distinct regulatory cascades govern extraocular and pharyngeal arch muscle progenitor cell fates. Dev Cell 16: 810-21 PubMed GONUTS page

[PMID:16554364-4] 5.0 ^5.1 Bajanca F et al. (2006) Integrin alpha6beta1-laminin interactions regulate early myotome formation in the mouse embryo. Development 133: 1635-44 PubMed GONUTS page

[PMID:1846704-5] 6.0 ^6.1 Weintraub H et al. (1991) The myoD gene family: nodal point during specification of the muscle cell lineage. Science 251: 761-6 PubMed GONUTS page

[PMID:15634692-6] Brent AE et al. (2005) Genetic analysis of interactions between the somitic muscle, cartilage and tendon cell lineages during mouse development. Development 132: 515-28 PubMed GONUTS page

[PMID:8269513-7] Rudnicki MA et al. (1993) MyoD or Myf-5 is required for the formation of skeletal muscle. Cell 75: 1351-9 PubMed GONUTS page

[PMID:17855775-8] Hawke TJ et al. (2007) Xin, an actin binding protein, is expressed within muscle satellite cells and newly regenerated skeletal muscle fibers. Am J Physiol Cell Physiol 293: C1636-44 PubMed GONUTS page

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MOUSE:MYF5

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