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MOUSE:MD2L1
Contents |
| Species (Taxon ID) | Mus musculus (Mouse). ([1]) | |
| Gene Name(s) | Mad2l1 (synonyms: Mad2a) | |
| Protein Name(s) | Mitotic spindle assembly checkpoint protein MAD2A
Mitotic arrest deficient 2-like protein 1 MAD2-like protein 1 | |
| External Links | ||
| EMBL | U83902 AF261919 AK082934 | |
| IPI | IPI00323422 | |
| RefSeq | NP_062372.2 | |
| UniGene | Mm.485053 | |
| ProteinModelPortal | Q9Z1B5 | |
| SMR | Q9Z1B5 | |
| IntAct | Q9Z1B5 | |
| MINT | MINT-123716 | |
| STRING | Q9Z1B5 | |
| PhosphoSite | Q9Z1B5 | |
| PRIDE | Q9Z1B5 | |
| Ensembl | ENSMUST00000101343 ENSMUST00000116605 | |
| GeneID | 56150 | |
| KEGG | mmu:56150 | |
| CTD | 4085 | |
| MGI | MGI:1860374 | |
| GeneTree | ENSGT00390000007908 | |
| HOGENOM | HBG314247 | |
| HOVERGEN | HBG105691 | |
| InParanoid | Q9Z1B5 | |
| OMA | FQRGIYP | |
| OrthoDB | EOG43XV4F | |
| PhylomeDB | Q9Z1B5 | |
| NextBio | 311932 | |
| ArrayExpress | Q9Z1B5 | |
| Bgee | Q9Z1B5 | |
| Genevestigator | Q9Z1B5 | |
| GermOnline | ENSMUSG00000029910 | |
| GO | GO:0000777 GO:0005829 GO:0048471 GO:0000922 GO:0051301 GO:0007094 GO:0000070 GO:0043066 GO:0090267 | |
| InterPro | IPR003511 | |
| Gene3D | G3DSA:3.30.900.10 | |
| Pfam | PF02301 | |
| SUPFAM | SSF56019 | |
| PROSITE | PS50815 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0000070 |
mitotic sister chromatid segregation |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2178781 |
P |
Seeded From UniProt |
|||
| GO:0000775 |
chromosome, centromeric region |
IEA: Inferred from Electronic Annotation |
C |
Seeded From UniProt |
||||
| GO:0000775 |
chromosome, centromeric region |
IDA: Inferred from Direct Assay |
|
C |
Seeded From UniProt |
|||
| GO:0000776 |
kinetochore |
IEA: Inferred from Electronic Annotation |
C |
Seeded From UniProt |
||||
| GO:0000776 |
kinetochore |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSP00000296509 |
C |
Seeded From UniProt |
|||
| GO:0000776 |
kinetochore |
IDA: Inferred from Direct Assay |
|
C |
Seeded From UniProt |
|||
| GO:0000776 |
kinetochore |
IDA: Inferred from Direct Assay |
|
C |
Seeded From UniProt |
|||
| GO:0000777 |
condensed chromosome kinetochore |
IEA: Inferred from Electronic Annotation |
SP_SL:SL-0149 |
C |
Seeded From UniProt |
|||
| GO:0000922 |
spindle pole |
IEA: Inferred from Electronic Annotation |
SP_SL:SL-0448 |
C |
Seeded From UniProt |
|||
| GO:0000922 |
spindle pole |
IDA: Inferred from Direct Assay |
|
C |
Seeded From UniProt |
|||
| GO:0005634 |
nucleus |
IEA: Inferred from Electronic Annotation |
C |
Seeded From UniProt |
||||
| GO:0005634 |
nucleus |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSP00000296509 |
C |
Seeded From UniProt |
|||
| GO:0005634 |
nucleus |
IEA: Inferred from Electronic Annotation |
SP_SL:SL-0191 |
C |
Seeded From UniProt |
|||
| GO:0005634 |
nucleus |
ISS: Inferred from Sequence or Structural Similarity |
C |
Seeded From UniProt |
||||
| GO:0005643 |
nuclear pore |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSP00000296509 |
C |
Seeded From UniProt |
|||
| GO:0005694 |
chromosome |
IEA: Inferred from Electronic Annotation |
C |
Seeded From UniProt |
||||
| GO:0005737 |
cytoplasm |
IEA: Inferred from Electronic Annotation |
C |
Seeded From UniProt |
||||
| GO:0005737 |
cytoplasm |
IEA: Inferred from Electronic Annotation |
SP_SL:SL-0086 |
C |
Seeded From UniProt |
|||
| GO:0005829 |
cytosol |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSP00000296509 |
C |
Seeded From UniProt |
|||
| GO:0005829 |
cytosol |
ISS: Inferred from Sequence or Structural Similarity |
C |
Seeded From UniProt |
||||
| GO:0005856 |
cytoskeleton |
IEA: Inferred from Electronic Annotation |
C |
Seeded From UniProt |
||||
| GO:0007049 |
cell cycle |
IEA: Inferred from Electronic Annotation |
P |
Seeded From UniProt |
||||
| GO:0007067 |
mitosis |
IEA: Inferred from Electronic Annotation |
P |
Seeded From UniProt |
||||
| GO:0007067 |
mitosis |
IEA: Inferred from Electronic Annotation |
P |
Seeded From UniProt |
||||
| GO:0007093 |
mitotic cell cycle checkpoint |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSP00000296509 |
P |
Seeded From UniProt |
|||
| GO:0007094 |
mitotic cell cycle spindle assembly checkpoint |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2178781 |
P |
Seeded From UniProt |
|||
| GO:0042177 |
negative regulation of protein catabolic process |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSP00000296509 |
P |
Seeded From UniProt |
|||
| GO:0042177 |
negative regulation of protein catabolic process |
ISS: Inferred from Sequence or Structural Similarity |
P |
Seeded From UniProt |
||||
| GO:0042803 |
protein homodimerization activity |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSP00000296509 |
F |
Seeded From UniProt |
|||
| GO:0043066 |
negative regulation of apoptosis |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSP00000296509 |
P |
Seeded From UniProt |
|||
| GO:0043066 |
negative regulation of apoptosis |
IMP: Inferred from Mutant Phenotype |
|
P |
Seeded From UniProt |
|||
| GO:0045841 |
negative regulation of mitotic metaphase/anaphase transition |
TAS: Traceable Author Statement |
|
P |
Seeded From UniProt |
|||
| GO:0048471 |
perinuclear region of cytoplasm |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSP00000296509 |
C |
Seeded From UniProt |
|||
| GO:0048471 |
perinuclear region of cytoplasm |
ISS: Inferred from Sequence or Structural Similarity |
C |
Seeded From UniProt |
||||
| GO:0051301 |
cell division |
IEA: Inferred from Electronic Annotation |
P |
Seeded From UniProt |
||||
| GO:0060564 |
negative regulation of mitotic anaphase-promoting complex activity |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSP00000296509 |
P |
Seeded From UniProt |
|||
| GO:0090267 |
positive regulation of mitotic cell cycle spindle assembly checkpoint |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSP00000296509 |
P |
Seeded From UniProt |
|||
| GO:0090267 |
positive regulation of mitotic cell cycle spindle assembly checkpoint |
IMP: Inferred from Mutant Phenotype |
|
P |
Seeded From UniProt |
|||
| GO:0051301 |
cell division |
IDA: Inferred from Direct Assay |
P |
Noted in Fig.1 B and C |
complete | |||
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ Dobles M et al. (2000) Chromosome missegregation and apoptosis in mice lacking the mitotic checkpoint protein Mad2. Cell 101: 635-45 PubMed GONUTS page
- ↑ Hodges CA & Hunt PA (2002) Simultaneous analysis of chromosomes and chromosome-associated proteins in mammalian oocytes and embryos. Chromosoma 111: 165-9 PubMed GONUTS page
- ↑ 3.0 3.1 Kallio M et al. (2000) Differences in spindle association of the mitotic checkpoint protein Mad2 in mammalian spermatogenesis and oogenesis. Dev Biol 225: 112-23 PubMed GONUTS page
- ↑ Zheng P & Dean J (2009) Role of Filia, a maternal effect gene, in maintaining euploidy during cleavage-stage mouse embryogenesis. Proc Natl Acad Sci U S A 106: 7473-8 PubMed GONUTS page
- ↑ Michel LS et al. (2001) MAD2 haplo-insufficiency causes premature anaphase and chromosome instability in mammalian cells. Nature 409: 355-9 PubMed GONUTS page
- ↑ 6.0 6.1 Nakaya T et al. (2010) Critical role of Pcid2 in B cell survival through the regulation of MAD2 expression. J Immunol 185: 5180-7 PubMed GONUTS page
- ↑ Bahar R et al. (2002) Growth retardation, polyploidy, and multinucleation induced by Clast3, a novel cell cycle-regulated protein. J Biol Chem 277: 40012-9 PubMed GONUTS page
- ↑ Sotillo R et al. (2010) Mad2-induced chromosome instability leads to lung tumour relapse after oncogene withdrawal. Nature 464: 436-40 PubMed GONUTS page
