MOUSE:LRRK2

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Species (Taxon ID)	Mus musculus (Mouse). (taxon:10090)
Gene Name(s)	Lrrk2
Protein Name(s)	Leucine-rich repeat serine/threonine-protein kinase 2
External Links
UniProt Identifier	LRRK2_MOUSE
UniProt Accessions	Q5S006, E9QNJ2, Q8BWG7, Q8BZJ6, Q8CI84, Q8K062,
EMBL	AY792512, AC099704, AC158752, AK052591, AK034413, BC034074, BC035949,
RefSeq	NP_080006.3,
Ensembl	ENSMUST00000060642,
Pfam	PF00560, PF08477, PF00069,

Annotations

Qualifier	GO ID	GO term name	Reference	Evidence Code	with/from	Aspect	Notes	Status
	GO:0045121	membrane raft		IDA: Inferred from Direct Assay		C	Source: MGI
	GO:0005886	plasma membrane		IDA: Inferred from Direct Assay		C	Source: MGI
	GO:0008021	synaptic vesicle		IDA: Inferred from Direct Assay		C	Source: MGI
	GO:0005802	trans-Golgi network		IDA: Inferred from Direct Assay		C	Source: MGI
	GO:0005524	ATP binding		IEA: Inferred from Electronic Annotation		F	Source: UniProtKB-KW
	GO:0005525	GTP binding		IEA: Inferred from Electronic Annotation		F	Source: UniProtKB-KW
	GO:0005096	GTPase activator activity		IEA: Inferred from Electronic Annotation		F	Source: UniProtKB-KW
	GO:0007264	small GTPase mediated signal transduction		IEA: Inferred from Electronic Annotation		P	Source: InterPro
	GO:0010628	positive regulation of gene expression	PubMed ID: 20728949	IDA: Inferred from Direct Assay		P	Figure 3A shows that using qRT-PCR the levels of LRRK2 are detected to be substantially higher in B2 cells than B1 cells for samples obtained from spleen, peripheral blood, peritoneal cavity, and bone marrow.	complete
	GO:0045577	regulation of B cell differentiation	PubMed ID: 20728949	IDA: Inferred from Direct Assay		P	Figure 3A shows that pre-B cells separated from bone marrow tissue had a low amount of LRRK2 mRNA. Suggests differentiation-related expression profile.	complete
	GO:0030217	T cell differentiation	PubMed ID: 20728949	IDA: Inferred from Direct Assay		P	Figure 3A shows the T cells isolated from bone marrow have zero or very little LRRK2 expression.	complete
NOT	GO:0051059	NF-kappaB binding	PubMed ID: 20728949	IMP: Inferred from Mutant Phenotype		F	mutations are present in the NF-kB inducing kinase gene in alymphoplasia mice, yet figure 3A still shows the B-2 cells expressed a higher level of LRRK2 mRNA than B-1 cells in both the peritoneal cavity and spleen therefore the exxpression of LRRK2 by B cells can not be regulated by the NF-κB pathway.	complete
	GO:0023019	regulation of gene expression as a consequence of signal transmission	PubMed ID: 20728949	IMP: Inferred from Mutant Phenotype		P	Figure 4B: qRT-PCR shows that in mutant mice: LRRK2 expression by B-2 cells was downregulated upon activation.	complete
	GO:0023019	regulation of gene expression as a consequence of signal transmission	PubMed ID: 20728949	IDA: Inferred from Direct Assay		P	Figure 4A: LRRK2 expression by B-2 cells was downregulated by activation.	complete
	GO:0000166	nucleotide binding	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0547	F
	GO:0004672	protein kinase activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR000719	F
	GO:0004672	protein kinase activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR017442	F
	GO:0004674	protein serine/threonine kinase activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR008271	F
	GO:0004674	protein serine/threonine kinase activity	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0723	F
	GO:0005096	GTPase activator activity	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0343	F
	GO:0005488	binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR011989	F
	GO:0005488	binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR016024	F
	GO:0005524	ATP binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR000719	F
	GO:0005524	ATP binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR017441	F
	GO:0005524	ATP binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR017442	F
	GO:0005524	ATP binding	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0067	F
	GO:0005525	GTP binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR001806	F
	GO:0005525	GTP binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR005225	F
	GO:0005525	GTP binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR013684	F
	GO:0005525	GTP binding	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0342	F
	GO:0005622	intracellular	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR013684	C
	GO:0005802	trans-Golgi network	PMID:17341485^[1]	IDA: Inferred from Direct Assay		C
	GO:0005886	plasma membrane	PMID:17341485^[1]	IDA: Inferred from Direct Assay		C
	GO:0006468	protein phosphorylation	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR000719	P
	GO:0006468	protein phosphorylation	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR008271	P
	GO:0006468	protein phosphorylation	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR017442	P
	GO:0007264	small GTPase mediated signal transduction	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR001806	P
	GO:0007264	small GTPase mediated signal transduction	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR013684	P
	GO:0008021	synaptic vesicle	PMID:17341485^[1]	IDA: Inferred from Direct Assay		C
	GO:0010508	positive regulation of autophagy	PMID:20457918^[2]	IMP: Inferred from Mutant Phenotype		P
	GO:0016301	kinase activity	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0418	F
	GO:0016310	phosphorylation	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0418	P
	GO:0016740	transferase activity	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0808	F
	GO:0016772	transferase activity, transferring phosphorus-containing groups	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR011009	F
	GO:0032436	positive regulation of proteasomal ubiquitin-dependent protein catabolic process	PMID:20457918^[2]	IMP: Inferred from Mutant Phenotype		P
	GO:0035564	regulation of kidney size	PMID:20457918^[2]	IMP: Inferred from Mutant Phenotype		P
	GO:0043547	positive regulation of GTPase activity	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0343	P
	GO:0045121	membrane raft	PMID:17341485^[1]	IDA: Inferred from Direct Assay		C
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 Hatano T et al. (2007) Leucine-rich repeat kinase 2 associates with lipid rafts. Hum Mol Genet 16: 678-90 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 Tong Y et al. (2010) Loss of leucine-rich repeat kinase 2 causes impairment of protein degradation pathways, accumulation of alpha-synuclein, and apoptotic cell death in aged mice. Proc Natl Acad Sci U S A 107: 9879-84 PubMed GONUTS page

[PMID:17341485-0] 1.0 ^1.1 ^1.2 ^1.3 Hatano T et al. (2007) Leucine-rich repeat kinase 2 associates with lipid rafts. Hum Mol Genet 16: 678-90 PubMed GONUTS page

[PMID:20457918-1] 2.0 ^2.1 ^2.2 Tong Y et al. (2010) Loss of leucine-rich repeat kinase 2 causes impairment of protein degradation pathways, accumulation of alpha-synuclein, and apoptotic cell death in aged mice. Proc Natl Acad Sci U S A 107: 9879-84 PubMed GONUTS page

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MOUSE:LRRK2

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