MOUSE:LITAF

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Litaf (synonyms: N4wbp3, Tbx1)
Protein Name(s)	Lipopolysaccharide-induced tumor necrosis factor-alpha factor homolog LPS-induced TNF-alpha factor homolog Estrogen-enhanced transcript protein mEET LITAF-like protein NEDD4 WW domain-binding protein 3
External Links
UniProt	Q9JLJ0
EMBL	AF171100 AF230522 AK018578 AK076162 AK151053 AK159533 BC018559 AF220207
CCDS	CCDS27958.1
RefSeq	NP_064364.1 XP_006522490.1
UniGene	Mm.294753
BioGrid	208144
IntAct	Q9JLJ0
MINT	MINT-147796
PhosphoSite	Q9JLJ0
PRIDE	Q9JLJ0
Ensembl	ENSMUST00000023143 ENSMUST00000117360
GeneID	56722
KEGG	mmu:56722
UCSC	uc007yen.2
CTD	9516
MGI	MGI:1929512
eggNOG	NOG41852
GeneTree	ENSGT00540000071542
HOGENOM	HOG000039585
HOVERGEN	HBG006272
InParanoid	Q9JLJ0
OMA	PFCIDAL
OrthoDB	EOG7XH6RR
PhylomeDB	Q9JLJ0
TreeFam	TF313294
NextBio	313198
PRO	PR:Q9JLJ0
Proteomes	UP000000589
Bgee	Q9JLJ0
CleanEx	MM_LITAF MM_TBX1
ExpressionAtlas	Q9JLJ0
Genevestigator	Q9JLJ0
GO	GO:0005794 GO:0005765 GO:0005634 GO:0005886 GO:0004871 GO:0050699 GO:0007568 GO:0006915 GO:0071222 GO:0042347 GO:0043123 GO:0001817 GO:0006355 GO:0032496 GO:0006351
InterPro	IPR006629
Pfam	PF10601
SMART	SM00714

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
part_of	GO:0098574	cytoplasmic side of lysosomal membrane	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q99732	C	Seeded From UniProt	complete
part_of	GO:0098560	cytoplasmic side of late endosome membrane	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q99732	C	Seeded From UniProt	complete
part_of	GO:0098559	cytoplasmic side of early endosome membrane	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q99732	C	Seeded From UniProt	complete
part_of	GO:0009898	cytoplasmic side of plasma membrane	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q99732	C	Seeded From UniProt	complete
enables	GO:0008270	zinc ion binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q99732	F	Seeded From UniProt	complete
enables	GO:0050699	WW domain binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q99732	F	Seeded From UniProt	complete
involved_in	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q99732	P	Seeded From UniProt	complete
part_of	GO:0005794	Golgi apparatus	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q99732	C	Seeded From UniProt	complete
part_of	GO:0005794	Golgi apparatus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q99732	C	Seeded From UniProt	complete
part_of	GO:0005765	lysosomal membrane	PMID:11274176^[1]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q99732	C	Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q99732	C	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001817	regulation of cytokine production	PMID:16954198^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3687962	P	Seeded From UniProt	complete
enables	GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q99732	F	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1901223	negative regulation of NIK/NF-kappaB signaling	PMID:12914755^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0098574	cytoplasmic side of lysosomal membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q99732	C	Seeded From UniProt	complete
part_of	GO:0098560	cytoplasmic side of late endosome membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q99732	C	Seeded From UniProt	complete
part_of	GO:0098559	cytoplasmic side of early endosome membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q99732	C	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071222	cellular response to lipopolysaccharide	PMID:16954198^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3687962	P	Seeded From UniProt	complete
enables	GO:0050699	WW domain binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q99732	F	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q99732	P	Seeded From UniProt	complete
part_of	GO:0043231	intracellular membrane-bounded organelle	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q99732	C	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032496	response to lipopolysaccharide	PMID:22160695^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2182767,MGI:MGI:3687962	P	Seeded From UniProt	complete
part_of	GO:0009898	cytoplasmic side of plasma membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q99732	C	Seeded From UniProt	complete
enables	GO:0008270	zinc ion binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q99732	F	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q99732	C	Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q99732	C	Seeded From UniProt	complete
involved_in	GO:0007568	aging	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P0C0T0 ensembl:ENSRNOP00000003412	P	Seeded From UniProt	complete
part_of	GO:0098574	cytoplasmic side of lysosomal membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99732 ensembl:ENSP00000459533	C	Seeded From UniProt	complete
part_of	GO:0098560	cytoplasmic side of late endosome membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99732 ensembl:ENSP00000459533	C	Seeded From UniProt	complete
part_of	GO:0098559	cytoplasmic side of early endosome membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99732 ensembl:ENSP00000459533	C	Seeded From UniProt	complete
enables	GO:0050699	WW domain binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99732 ensembl:ENSP00000459533	F	Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99732 ensembl:ENSP00000459533	P	Seeded From UniProt	complete
part_of	GO:0043231	intracellular membrane-bounded organelle	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99732 ensembl:ENSP00000459533	C	Seeded From UniProt	complete
part_of	GO:0009898	cytoplasmic side of plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99732 ensembl:ENSP00000459533	C	Seeded From UniProt	complete
enables	GO:0008270	zinc ion binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99732 ensembl:ENSP00000459533	F	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99732 ensembl:ENSP00000459533	C	Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99732 ensembl:ENSP00000459533	C	Seeded From UniProt	complete
part_of	GO:0005794	Golgi apparatus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99732 ensembl:ENSP00000459533	C	Seeded From UniProt	complete
part_of	GO:0005765	lysosomal membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99732 ensembl:ENSP00000459533	C	Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99732 ensembl:ENSP00000459533	C	Seeded From UniProt	complete
enables	GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99732 ensembl:ENSP00000459533	F	Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F	Seeded From UniProt	complete
part_of	GO:0005768	endosome	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0967	C	Seeded From UniProt	complete
part_of	GO:0005794	Golgi apparatus	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0333	C	Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0238	F	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C	Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003 UniProtKB-SubCell:SL-0039	C	Seeded From UniProt	complete
part_of	GO:0005764	lysosome	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0458	C	Seeded From UniProt	complete
part_of	GO:0000139	Golgi membrane	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0134	C	Seeded From UniProt	complete
part_of	GO:0010008	endosome membrane	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0100	C	Seeded From UniProt	complete
part_of	GO:0031901	early endosome membrane	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0093	C	Seeded From UniProt	complete
part_of	GO:0031902	late endosome membrane	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0151	C	Seeded From UniProt	complete
part_of	GO:0005765	lysosomal membrane	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0157	C	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Moriwaki, Y et al. (2001) Mycobacterium bovis Bacillus Calmette-Guerin and its cell wall complex induce a novel lysosomal membrane protein, SIMPLE, that bridges the missing link between lipopolysaccharide and p53-inducible gene, LITAF(PIG7), and estrogen-inducible gene, EET-1. J. Biol. Chem. 276 23065-76 PubMed GONUTS page
↑ ^2.0 ^2.1 Tang, X et al. (2006) LPS-induced TNF-alpha factor (LITAF)-deficient mice express reduced LPS-induced cytokine: Evidence for LITAF-dependent LPS signaling pathways. Proc. Natl. Acad. Sci. U.S.A. 103 13777-82 PubMed GONUTS page
↑ Jin, C et al. (2003) SDF-1alpha production is negatively regulated by mouse estrogen enhanced transcript in a mouse thymus epithelial cell line. Cell. Immunol. 223 26-34 PubMed GONUTS page
↑ Merrill, JC et al. (2011) Whole-body deletion of LPS-induced TNF-α factor (LITAF) markedly improves experimental endotoxic shock and inflammatory arthritis. Proc. Natl. Acad. Sci. U.S.A. 108 21247-52 PubMed GONUTS page

[PMID:11274176-1] Moriwaki, Y et al. (2001) Mycobacterium bovis Bacillus Calmette-Guerin and its cell wall complex induce a novel lysosomal membrane protein, SIMPLE, that bridges the missing link between lipopolysaccharide and p53-inducible gene, LITAF(PIG7), and estrogen-inducible gene, EET-1. J. Biol. Chem. 276 23065-76 PubMed GONUTS page

[PMID:16954198-2] 2.0 ^2.1 Tang, X et al. (2006) LPS-induced TNF-alpha factor (LITAF)-deficient mice express reduced LPS-induced cytokine: Evidence for LITAF-dependent LPS signaling pathways. Proc. Natl. Acad. Sci. U.S.A. 103 13777-82 PubMed GONUTS page

[PMID:12914755-3] Jin, C et al. (2003) SDF-1alpha production is negatively regulated by mouse estrogen enhanced transcript in a mouse thymus epithelial cell line. Cell. Immunol. 223 26-34 PubMed GONUTS page

[PMID:22160695-4] Merrill, JC et al. (2011) Whole-body deletion of LPS-induced TNF-α factor (LITAF) markedly improves experimental endotoxic shock and inflammatory arthritis. Proc. Natl. Acad. Sci. U.S.A. 108 21247-52 PubMed GONUTS page

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MOUSE:LITAF

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