MOUSE:KIF3A

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Species (Taxon ID)	Mus musculus (Mouse). ([1])
Gene Name(s)	Kif3a (synonyms: Kif3)
Protein Name(s)	Kinesin-like protein KIF3A Microtubule plus end-directed kinesin motor 3A
External Links
EMBL	D12645 AL596095 BC052707
IPI	IPI00881566
PIR	B44259
RefSeq	NP_032469.2
UniGene	Mm.88694
HSSP	P17119
ProteinModelPortal	P28741
DIP	DIP-46318N
STRING	P28741
PhosphoSite	P28741
PRIDE	P28741
Ensembl	ENSMUST00000108958 ENSMUST00000120613
GeneID	16568
MGI	MGI:107689
eggNOG	roNOG04329
HOVERGEN	HBG052255
NextBio	290073
ArrayExpress	P28741
Bgee	P28741
CleanEx	MM_KIF3A
Genevestigator	P28741
GermOnline	ENSMUSG00000018395
GO	GO:0005829 GO:0005874 GO:0032391 GO:0005524 GO:0003777 GO:0005515 GO:0009952 GO:0042384 GO:0007368 GO:0021904 GO:0007507 GO:0001701 GO:0001822 GO:0007018 GO:0007224
InterPro	IPR019821 IPR001752
Gene3D	G3DSA:3.40.850.10
Pfam	PF00225
PRINTS	PR00380
SMART	SM00129
PROSITE	PS00411 PS50067

Annotations

Qualifier	GO ID	GO term name	Reference	Evidence Code	with/from	Aspect	Notes	Status
	GO:0000166	nucleotide binding	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0547	F	Seeded From UniProt
	GO:0001701	in utero embryonic development	PMID:19286674^[1]	IGI: Inferred from Genetic Interaction	MGI:MGI:1329045	P	Seeded From UniProt
	GO:0001822	kidney development	PMID:15067314^[2]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2386464	P	Seeded From UniProt
	GO:0003777	microtubule motor activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR001752	F	Seeded From UniProt
	GO:0003777	microtubule motor activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR019821	F	Seeded From UniProt
	GO:0005515	protein binding	PMID:19015237^[3]	IPI: Inferred from Physical Interaction	UniProtKB:P97343	F	Seeded From UniProt
	GO:0005524	ATP binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR001752	F	Seeded From UniProt
	GO:0005524	ATP binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR019821	F	Seeded From UniProt
	GO:0005524	ATP binding	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0067	F	Seeded From UniProt
	GO:0005737	cytoplasm	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0963	C	Seeded From UniProt
	GO:0005829	cytosol	Reactome:REACT_24981	TAS: Traceable Author Statement		C	Seeded From UniProt
	GO:0005856	cytoskeleton	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0206	C	Seeded From UniProt
	GO:0005856	cytoskeleton	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0090	C	Seeded From UniProt
	GO:0005874	microtubule	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0493	C	Seeded From UniProt
	GO:0005929	cilium	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0969	C	Seeded From UniProt
	GO:0005929	cilium	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0066	C	Seeded From UniProt
	GO:0007018	microtubule-based movement	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR001752	P	Seeded From UniProt
	GO:0007018	microtubule-based movement	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR019821	P	Seeded From UniProt
	GO:0007224	smoothened signaling pathway	PMID:19286674^[1]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1861960	P	Seeded From UniProt
	GO:0007368	determination of left/right symmetry	PMID:10220415^[4]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1861960	P	Seeded From UniProt
	GO:0007368	determination of left/right symmetry	PMID:15755804^[5]	IMP: Inferred from Mutant Phenotype	MGI:MGI:3580660	P	Seeded From UniProt
	GO:0007507	heart development	PMID:18729223^[6]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2386464	P	Seeded From UniProt
	GO:0009952	anterior/posterior pattern specification	PMID:10220415^[4]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1861960	P	Seeded From UniProt
	GO:0009953	dorsal/ventral pattern formation	PMID:15755804^[5]	IMP: Inferred from Mutant Phenotype	MGI:MGI:3580660	P	Seeded From UniProt
	GO:0021904	dorsal/ventral neural tube patterning	PMID:18590716^[7]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1861960	P	Seeded From UniProt
	GO:0021904	dorsal/ventral neural tube patterning	PMID:19286674^[1]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1861960	P	Seeded From UniProt
	GO:0030030	cell projection organization	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0970	P	Seeded From UniProt
	GO:0032391	photoreceptor connecting cilium	PMID:19208653^[8]	IDA: Inferred from Direct Assay		C	Seeded From UniProt
	GO:0042384	cilium assembly	PMID:10220415^[4]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1861960	P	Seeded From UniProt
	GO:0042384	cilium assembly	PMID:21670265^[9]	IMP: Inferred from Mutant Phenotype		P	Seeded From UniProt
	GO:0042995	cell projection	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0966	C	Seeded From UniProt
	GO:0060271	cilium morphogenesis	PMID:18729223^[6]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2386464	P	Seeded From UniProt
	GO:0072372	primary cilium	PMID:21670265^[9]	IDA: Inferred from Direct Assay		C	Seeded From UniProt
	GO:0051236	establishment of RNA localization	PMID:21209331^[10]	IMP: Inferred from Mutant Phenotype		P	Fig S7B shows the Kif3a knockout alters the RNA localisation of Pax6	complete
	GO:0021904	dorsal/ventral neural tube patterning	PMID:21209331^[10]	IMP: Inferred from Mutant Phenotype		P	Fig S7B shows the Kif3a knockout alters the RNA localisation of Pax6 within the neural tube (known to be a ventralising gene). Abnormal dorsal/ventral morphology of the mutant phenotype	complete
	GO:0035083	cilium axoneme assembly	PMID:21209331^[10]	IMP: Inferred from Mutant Phenotype		P	Fig S7C shows the Kif3a mouse knockout fibroblast cells do not develop cilia axenomes	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 Norman RX et al. (2009) Tubby-like protein 3 (TULP3) regulates patterning in the mouse embryo through inhibition of Hedgehog signaling. Hum Mol Genet 18: 1740-54 PubMed GONUTS page
↑ Hiesberger T et al. (2004) Mutation of hepatocyte nuclear factor-1beta inhibits Pkhd1 gene expression and produces renal cysts in mice. J Clin Invest 113: 814-25 PubMed GONUTS page
↑ Cambray S et al. (2009) Protein kinase KIS localizes to RNA granules and enhances local translation. Mol Cell Biol 29: 726-35 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 Marszalek JR et al. (1999) Situs inversus and embryonic ciliary morphogenesis defects in mouse mutants lacking the KIF3A subunit of kinesin-II. Proc Natl Acad Sci U S A 96: 5043-8 PubMed GONUTS page
↑ ^5.0 ^5.1 García-García MJ et al. (2005) Analysis of mouse embryonic patterning and morphogenesis by forward genetics. Proc Natl Acad Sci U S A 102: 5913-9 PubMed GONUTS page
↑ ^6.0 ^6.1 Slough J et al. (2008) Monocilia in the embryonic mouse heart suggest a direct role for cilia in cardiac morphogenesis. Dev Dyn 237: 2304-14 PubMed GONUTS page
↑ Cho A et al. (2008) FKBP8 cell-autonomously controls neural tube patterning through a Gli2- and Kif3a-dependent mechanism. Dev Biol 321: 27-39 PubMed GONUTS page
↑ Jiang ST et al. (2009) Essential role of nephrocystin in photoreceptor intraflagellar transport in mouse. Hum Mol Genet 18: 1566-77 PubMed GONUTS page
↑ ^9.0 ^9.1 Choi YH et al. (2011) Polycystin-2 and phosphodiesterase 4C are components of a ciliary A-kinase anchoring protein complex that is disrupted in cystic kidney diseases. Proc Natl Acad Sci U S A 108: 10679-84 PubMed GONUTS page
↑ ^10.0 ^10.1 ^10.2 Qin J et al. (2011) Intraflagellar transport protein 122 antagonizes Sonic Hedgehog signaling and controls ciliary localization of pathway components. Proc Natl Acad Sci U S A 108: 1456-61 PubMed GONUTS page

[PMID:19286674-0] 1.0 ^1.1 ^1.2 Norman RX et al. (2009) Tubby-like protein 3 (TULP3) regulates patterning in the mouse embryo through inhibition of Hedgehog signaling. Hum Mol Genet 18: 1740-54 PubMed GONUTS page

[PMID:15067314-1] Hiesberger T et al. (2004) Mutation of hepatocyte nuclear factor-1beta inhibits Pkhd1 gene expression and produces renal cysts in mice. J Clin Invest 113: 814-25 PubMed GONUTS page

[PMID:19015237-2] Cambray S et al. (2009) Protein kinase KIS localizes to RNA granules and enhances local translation. Mol Cell Biol 29: 726-35 PubMed GONUTS page

[PMID:10220415-3] 4.0 ^4.1 ^4.2 Marszalek JR et al. (1999) Situs inversus and embryonic ciliary morphogenesis defects in mouse mutants lacking the KIF3A subunit of kinesin-II. Proc Natl Acad Sci U S A 96: 5043-8 PubMed GONUTS page

[PMID:15755804-4] 5.0 ^5.1 García-García MJ et al. (2005) Analysis of mouse embryonic patterning and morphogenesis by forward genetics. Proc Natl Acad Sci U S A 102: 5913-9 PubMed GONUTS page

[PMID:18729223-5] 6.0 ^6.1 Slough J et al. (2008) Monocilia in the embryonic mouse heart suggest a direct role for cilia in cardiac morphogenesis. Dev Dyn 237: 2304-14 PubMed GONUTS page

[PMID:18590716-6] Cho A et al. (2008) FKBP8 cell-autonomously controls neural tube patterning through a Gli2- and Kif3a-dependent mechanism. Dev Biol 321: 27-39 PubMed GONUTS page

[PMID:19208653-7] Jiang ST et al. (2009) Essential role of nephrocystin in photoreceptor intraflagellar transport in mouse. Hum Mol Genet 18: 1566-77 PubMed GONUTS page

[PMID:21670265-8] 9.0 ^9.1 Choi YH et al. (2011) Polycystin-2 and phosphodiesterase 4C are components of a ciliary A-kinase anchoring protein complex that is disrupted in cystic kidney diseases. Proc Natl Acad Sci U S A 108: 10679-84 PubMed GONUTS page

[PMID:21209331-9] 10.0 ^10.1 ^10.2 Qin J et al. (2011) Intraflagellar transport protein 122 antagonizes Sonic Hedgehog signaling and controls ciliary localization of pathway components. Proc Natl Acad Sci U S A 108: 1456-61 PubMed GONUTS page

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MOUSE:KIF3A

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