MOUSE:KGP1

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Species (Taxon ID)	Mus musculus (Mouse). (taxon:10090)
Gene Name(s)	Prkg1 ( synonyms: Prkg1b, Prkgr1a, Prkgr1b )
Protein Name(s)	cGMP-dependent protein kinase 1 cGK 1 cGK1 cGMP-dependent protein kinase I cGKI
External Links
UniProt Identifier	KGP1_MOUSE
UniProt Accessions	P0C605, Q14DK6, Q9Z0Z0,
EMBL	AF084547, AC102751, AC103405, AC108399, AC116507, AC119158, AC122548, BC113162,
RefSeq	NP_001013855.1, NP_035290.1,
Ensembl	ENSMUST00000065067, ENSMUST00000073581,
Pfam	PF00027, PF00069,

Annotations

Qualifier	GO ID	GO term name	Reference	Evidence Code	with/from	Aspect	Notes	Status
	GO:0005794	Golgi apparatus		IDA: Inferred from Direct Assay		C	Source: UniProtKB
	GO:0005524	ATP binding		IEA: Inferred from Electronic Annotation		F	Source: UniProtKB-KW
	GO:0030553	cGMP binding		IDA: Inferred from Direct Assay		F	Source: UniProtKB
	GO:0004692	cGMP-dependent protein kinase activity		IDA: Inferred from Direct Assay		F	Source: UniProtKB
	GO:0005515	protein binding		IPI: Inferred from Physical Interaction		F	Source: UniProtKB
	GO:0016358	dendrite development		IMP: Inferred from Mutant Phenotype		P	Source: MGI
	GO:0030900	forebrain development		IMP: Inferred from Mutant Phenotype		P	Source: MGI
	GO:0001764	neuron migration		IMP: Inferred from Mutant Phenotype		P	Source: MGI
	GO:0006468	protein phosphorylation		IDA: Inferred from Direct Assay		P	Source: UniProtKB
	GO:0007165	signal transduction		IDA: Inferred from Direct Assay		P	Source: UniProtKB
	GO:0005829	cytosol	PMID:19127022^[1]	IDA: Inferred from Direct Assay		C	Figure 7B: Immunohistochemistry shows PKG1-alpha localises to cytosol (striated pattern).	complete
	GO:0009279	cell outer membrane	PMID:19127022^[1]	IDA: Inferred from Direct Assay		C	Figure 7B-D: Immunohistochemistry shows PKG1-alpha protein in outer membrane.	complete
	GO:0090004	positive regulation of establishment of protein localization in plasma membrane	PMID:19127022^[1]	IDA: Inferred from Direct Assay		P	Figure 7: PKG1-alpha outer membrane localization occurs with RGS2 membrane localization	complete
	GO:0000166	nucleotide binding	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0547	F
	GO:0001764	neuron migration	PMID:16154207^[2]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2181586	P
	GO:0004672	protein kinase activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR000719	F
	GO:0004672	protein kinase activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR017442	F
	GO:0004672	protein kinase activity	PMID:10671526^[3]	IDA: Inferred from Direct Assay		F
	GO:0004672	protein kinase activity	PMID:15465019^[4]	IDA: Inferred from Direct Assay		F
	GO:0004674	protein serine/threonine kinase activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR000961	F
	GO:0004674	protein serine/threonine kinase activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR002290	F
	GO:0004674	protein serine/threonine kinase activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR008271	F
	GO:0004674	protein serine/threonine kinase activity	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0723	F
	GO:0004674	protein serine/threonine kinase activity	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000363092	F
	GO:0004692	cGMP-dependent protein kinase activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR002374	F
	GO:0004692	cGMP-dependent protein kinase activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR016232	F
	GO:0004692	cGMP-dependent protein kinase activity	GO_REF:0000003	IEA: Inferred from Electronic Annotation	EC:2.7.11.12	F
	GO:0004692	cGMP-dependent protein kinase activity	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000363092	F
	GO:0004692	cGMP-dependent protein kinase activity	PMID:10671526^[3]	IDA: Inferred from Direct Assay		F
	GO:0005515	protein binding	PMID:10671526^[3]	IPI: Inferred from Physical Interaction	UniProtKB:Q9JMB0	F
	GO:0005524	ATP binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR000719	F
	GO:0005524	ATP binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR000961	F
	GO:0005524	ATP binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR002290	F
	GO:0005524	ATP binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR002374	F
	GO:0005524	ATP binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR017441	F
	GO:0005524	ATP binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR017442	F
	GO:0005524	ATP binding	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0067	F
	GO:0005794	Golgi apparatus	PMID:10671526^[3]	IDA: Inferred from Direct Assay		C
	GO:0005829	cytosol	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000363092	C
	GO:0005886	plasma membrane	PMID:19127022^[1]	IMP: Inferred from Mutant Phenotype		C
	GO:0006468	protein phosphorylation	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR000719	P
	GO:0006468	protein phosphorylation	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR000961	P
	GO:0006468	protein phosphorylation	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR002290	P
	GO:0006468	protein phosphorylation	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR008271	P
	GO:0006468	protein phosphorylation	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR017442	P
	GO:0006468	protein phosphorylation	PMID:10671526^[3]	IDA: Inferred from Direct Assay		P
	GO:0007165	signal transduction	PMID:10671526^[3]	IDA: Inferred from Direct Assay		P
	GO:0016301	kinase activity	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0418	F
	GO:0016310	phosphorylation	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0418	P
	GO:0016358	dendrite development	PMID:16154207^[2]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2181586	P
	GO:0016740	transferase activity	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0808	F
	GO:0016772	transferase activity, transferring phosphorus-containing groups	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR011009	F
	GO:0030553	cGMP binding	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0142	F
	GO:0030553	cGMP binding	PMID:10671526^[3]	IDA: Inferred from Direct Assay		F
	GO:0030900	forebrain development	PMID:16154207^[2]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2181586	P
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 Takimoto E et al. (2009) Regulator of G protein signaling 2 mediates cardiac compensation to pressure overload and antihypertrophic effects of PDE5 inhibition in mice. J Clin Invest 119: 408-20 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 Demyanenko GP et al. (2005) Abnormal neocortical development in mice lacking cGMP-dependent protein kinase I. Brain Res Dev Brain Res 160: 1-8 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 ^3.4 ^3.5 ^3.6 Yuasa K et al. (2000) Binding and phosphorylation of a novel male germ cell-specific cGMP-dependent protein kinase-anchoring protein by cGMP-dependent protein kinase Ialpha. J Biol Chem 275: 4897-905 PubMed GONUTS page
↑ Keicher C et al. (2004) Phosphorylation of mouse LASP-1 on threonine 156 by cAMP- and cGMP-dependent protein kinase. Biochem Biophys Res Commun 324: 308-16 PubMed GONUTS page

[PMID:19127022-0] 1.0 ^1.1 ^1.2 ^1.3 Takimoto E et al. (2009) Regulator of G protein signaling 2 mediates cardiac compensation to pressure overload and antihypertrophic effects of PDE5 inhibition in mice. J Clin Invest 119: 408-20 PubMed GONUTS page

[PMID:16154207-1] 2.0 ^2.1 ^2.2 Demyanenko GP et al. (2005) Abnormal neocortical development in mice lacking cGMP-dependent protein kinase I. Brain Res Dev Brain Res 160: 1-8 PubMed GONUTS page

[PMID:10671526-2] 3.0 ^3.1 ^3.2 ^3.3 ^3.4 ^3.5 ^3.6 Yuasa K et al. (2000) Binding and phosphorylation of a novel male germ cell-specific cGMP-dependent protein kinase-anchoring protein by cGMP-dependent protein kinase Ialpha. J Biol Chem 275: 4897-905 PubMed GONUTS page

[PMID:15465019-3] Keicher C et al. (2004) Phosphorylation of mouse LASP-1 on threonine 156 by cAMP- and cGMP-dependent protein kinase. Biochem Biophys Res Commun 324: 308-16 PubMed GONUTS page

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MOUSE:KGP1

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