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MOUSE:KEAP1
Contents |
| Species (Taxon ID) | Mus musculus (Mouse). ([1]) | |
| Gene Name(s) | Keap1 (synonyms: Inrf2, Kiaa0132) | |
| Protein Name(s) | Kelch-like ECH-associated protein 1
Cytosolic inhibitor of Nrf2 INrf2 | |
| External Links | ||
| EMBL | AB020063 AF454353 AK129061 AK046178 AK076234 AK150437 AK150485 AK152142 AK154430 AK155507 AK159858 BC055732 | |
| IPI | IPI00131516 | |
| RefSeq | NP_001103775.1 NP_001103776.1 NP_001103777.1 NP_057888.1 | |
| UniGene | Mm.248266 | |
| PDB | 1X2J 1X2R 2DYH 2Z32 3ADE | |
| PDBsum | 1X2J 1X2R 2DYH 2Z32 3ADE | |
| ProteinModelPortal | Q9Z2X8 | |
| SMR | Q9Z2X8 | |
| IntAct | Q9Z2X8 | |
| STRING | Q9Z2X8 | |
| PhosphoSite | Q9Z2X8 | |
| PRIDE | Q9Z2X8 | |
| Ensembl | ENSMUST00000049567 ENSMUST00000164812 | |
| GeneID | 50868 | |
| KEGG | mmu:50868 | |
| UCSC | uc009oko.2 | |
| CTD | 9817 | |
| MGI | MGI:1858732 | |
| GeneTree | ENSGT00570000078759 | |
| HOGENOM | HBG713858 | |
| HOVERGEN | HBG014286 | |
| InParanoid | Q9Z2X8 | |
| OMA | TLQVKYE | |
| OrthoDB | EOG4WH8KC | |
| PhylomeDB | Q9Z2X8 | |
| NextBio | 307831 | |
| ArrayExpress | Q9Z2X8 | |
| Bgee | Q9Z2X8 | |
| CleanEx | MM_KEAP1 | |
| Genevestigator | Q9Z2X8 | |
| GermOnline | ENSMUSG00000003308 | |
| GO | GO:0005783 GO:0005634 GO:0005515 GO:0001701 GO:0045604 GO:0006355 GO:0006351 | |
| InterPro | IPR011705 IPR000210 IPR011333 IPR013069 IPR017096 IPR015915 IPR006652 | |
| Gene3D | G3DSA:3.30.710.10 G3DSA:2.120.10.80 | |
| Pfam | PF07707 PF00651 PF01344 | |
| PIRSF | PIRSF037037 | |
| SMART | SM00875 SM00225 SM00612 | |
| SUPFAM | SSF54695 | |
| PROSITE | PS50097 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0001701 |
in utero embryonic development |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2681416 |
P |
Seeded From UniProt |
|||
| GO:0005515 |
protein binding |
IPI: Inferred from Physical Interaction |
F |
Seeded From UniProt |
||||
| GO:0005515 |
protein binding |
IPI: Inferred from Physical Interaction |
F |
Seeded From UniProt |
||||
| GO:0005515 |
protein binding |
IPI: Inferred from Physical Interaction |
F |
Seeded From UniProt |
||||
| GO:0005634 |
nucleus |
IEA: Inferred from Electronic Annotation |
C |
Seeded From UniProt |
||||
| GO:0005634 |
nucleus |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSP00000171111 |
C |
Seeded From UniProt |
|||
| GO:0005634 |
nucleus |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSRNOP00000028360 |
C |
Seeded From UniProt |
|||
| GO:0005634 |
nucleus |
IEA: Inferred from Electronic Annotation |
SP_SL:SL-0191 |
C |
Seeded From UniProt |
|||
| GO:0005737 |
cytoplasm |
IEA: Inferred from Electronic Annotation |
C |
Seeded From UniProt |
||||
| GO:0005737 |
cytoplasm |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSP00000171111 |
C |
Seeded From UniProt |
|||
| GO:0005737 |
cytoplasm |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSRNOP00000028360 |
C |
Seeded From UniProt |
|||
| GO:0005737 |
cytoplasm |
IEA: Inferred from Electronic Annotation |
SP_SL:SL-0086 |
C |
Seeded From UniProt |
|||
| GO:0005737 |
cytoplasm |
IPI: Inferred from Physical Interaction |
C |
Seeded From UniProt |
||||
| GO:0005783 |
endoplasmic reticulum |
IDA: Inferred from Direct Assay |
|
C |
Seeded From UniProt |
|||
| GO:0005813 |
centrosome |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSP00000171111 |
C |
Seeded From UniProt |
|||
| GO:0005913 |
cell-cell adherens junction |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSRNOP00000028360 |
C |
Seeded From UniProt |
|||
| GO:0005925 |
focal adhesion |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSRNOP00000028360 |
C |
Seeded From UniProt |
|||
| GO:0006351 |
transcription, DNA-dependent |
IEA: Inferred from Electronic Annotation |
P |
Seeded From UniProt |
||||
| GO:0006355 |
regulation of transcription, DNA-dependent |
IEA: Inferred from Electronic Annotation |
P |
Seeded From UniProt |
||||
| GO:0006355 |
regulation of transcription, DNA-dependent |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2681416 |
P |
Seeded From UniProt |
|||
| GO:0010629 |
negative regulation of gene expression |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSRNOP00000028360 |
P |
Seeded From UniProt |
|||
| GO:0030496 |
midbody |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSP00000171111 |
C |
Seeded From UniProt |
|||
| GO:0042994 |
cytoplasmic sequestering of transcription factor |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSRNOP00000028360 |
P |
Seeded From UniProt |
|||
| GO:0045604 |
regulation of epidermal cell differentiation |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2681416 |
P |
Seeded From UniProt |
|||
| GO:0005884 |
actin filament |
IDA: Inferred from Direct Assay |
C |
Figure 1 |
complete | |||
| GO:0005739 |
mitochondrion |
IDA: Inferred from Direct Assay |
C |
Fig. 6A |
complete | |||
| GO:0006309 |
DNA fragmentation involved in apoptotic nuclear change |
IDA: Inferred from Direct Assay |
P |
Fig. 9A |
complete | |||
| GO:0030972 |
cleavage of cytosolic proteins involved in apoptosis |
IDA: Inferred from Direct Assay |
P |
Fig. 8D |
complete | |||
| GO:0043280 |
positive regulation of cysteine-type endopeptidase activity involved in apoptotic process |
IDA: Inferred from Direct Assay |
P |
Fig. 8C |
complete | |||
| GO:0001836 |
release of cytochrome c from mitochondria |
IDA: Inferred from Direct Assay |
P |
Fig. 8B |
complete | |||
| GO:0032270 |
positive regulation of cellular protein metabolic process |
IDA: Inferred from Direct Assay |
P |
Fig. 8A |
complete | |||
| GO:0016567 |
protein ubiquitination |
IDA: Inferred from Direct Assay |
P |
Fig. 3BC |
complete | |||
| GO:0045732 |
positive regulation of protein catabolic process |
IDA: Inferred from Direct Assay |
P |
Fig. 1 and Fig. 8A |
complete | |||
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 Motohashi H et al. (2004) Small Maf proteins serve as transcriptional cofactors for keratinocyte differentiation in the Keap1-Nrf2 regulatory pathway. Proc Natl Acad Sci U S A 101: 6379-84 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 Cullinan SB et al. (2003) Nrf2 is a direct PERK substrate and effector of PERK-dependent cell survival. Mol Cell Biol 23: 7198-209 PubMed GONUTS page
- ↑ 3.0 3.1 Komatsu M et al. (2010) The selective autophagy substrate p62 activates the stress responsive transcription factor Nrf2 through inactivation of Keap1. Nat Cell Biol 12: 213-23 PubMed GONUTS page
- ↑ Kang MI et al. (2004) Scaffolding of Keap1 to the actin cytoskeleton controls the function of Nrf2 as key regulator of cytoprotective phase 2 genes. Proc Natl Acad Sci U S A 101: 2046-51 PubMed GONUTS page
- ↑ 5.0 5.1 5.2 5.3 5.4 5.5 5.6 5.7 Niture SK & Jaiswal AK (2011) Inhibitor of Nrf2 (INrf2 or Keap1) protein degrades Bcl-xL via phosphoglycerate mutase 5 and controls cellular apoptosis. J Biol Chem 286: 44542-56 PubMed GONUTS page
