MOUSE:JAG2

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Annotations

Qualifier	GO ID	GO term name	Reference	Evidence Code	with/from	Aspect	Notes	Status
	GO:0005887	integral to plasma membrane		IDA: Inferred from Direct Assay		C	Source: UniProtKB
	GO:0005624	membrane fraction		IDA: Inferred from Direct Assay		C	Source: MGI
	GO:0005509	calcium ion binding		IEA: Inferred from Electronic Annotation		F	Source: InterPro
	GO:0008083	growth factor activity		ISS: Inferred from Sequence or Structural Similarity		F	Source: UniProtKB
	GO:0009912	auditory receptor cell fate commitment		IMP: Inferred from Mutant Phenotype		P	Source: UniProtKB
	GO:0007154	cell communication		IEA: Inferred from Electronic Annotation		P	Source: InterPro
	GO:0001709	cell fate determination		NAS: Non-traceable Author Statement		P	Source: UniProtKB
	GO:0042492	gamma-delta T cell differentiation		IMP: Inferred from Mutant Phenotype		P	Source: UniProtKB
	GO:0001701	in utero embryonic development		IMP: Inferred from Mutant Phenotype		P	Source: MGI
	GO:0016331	morphogenesis of embryonic epithelium		IMP: Inferred from Mutant Phenotype		P	Source: MGI
	GO:0007219	Notch signaling pathway		IEA: Inferred from Electronic Annotation		P	Source: UniProtKB-KW
	GO:0042475	odontogenesis of dentine-containing tooth		IMP: Inferred from Mutant Phenotype		P	Source: MGI
	GO:0042981	regulation of apoptosis		IMP: Inferred from Mutant Phenotype		P	Source: MGI
	GO:0030155	regulation of cell adhesion		IMP: Inferred from Mutant Phenotype		P	Source: MGI
	GO:0042127	regulation of cell proliferation		ISS: Inferred from Sequence or Structural Similarity		P	Source: UniProtKB
	GO:0003016	respiratory system process		IMP: Inferred from Mutant Phenotype		P	Source: MGI
	GO:0007605	sensory perception of sound		NAS: Non-traceable Author Statement		P	Source: UniProtKB
	GO:0001501	skeletal system development		IMP: Inferred from Mutant Phenotype		P	Source: MGI
	GO:0007283	spermatogenesis		ISS: Inferred from Sequence or Structural Similarity		P	Source: UniProtKB
	GO:0045061	thymic T cell selection		ISS: Inferred from Sequence or Structural Similarity		P	Source: UniProtKB
incorrect (CACAO)	GO:0060021	palate development	PMID:19341725^[1]	TAS: Traceable Author Statement		P	page 7 Abnormal palate-mandible fusion has been reported in Jagged2−/− ...mice...	complete
	GO:0001709	cell fate determination	PMID:10910909^[2]	NAS: Non-traceable Author Statement		P
	GO:0005509	calcium ion binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR001881	F
	GO:0005509	calcium ion binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR018097	F
	GO:0005515	protein binding	PMID:12496659^[3]	IPI: Inferred from Physical Interaction	UniProtKB:O35516	F
	GO:0005887	integral to plasma membrane	PMID:10910909^[2]	IDA: Inferred from Direct Assay		C
	GO:0007154	cell communication	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR001774	P
	GO:0007219	Notch signaling pathway	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR011651	P
	GO:0007219	Notch signaling pathway	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0914	P
	GO:0007275	multicellular organismal development	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR011651	P
	GO:0007275	multicellular organismal development	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0217	P
	GO:0007283	spermatogenesis	PMID:11700865^[4]	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:P97607	P
	GO:0007605	sensory perception of sound	PMID:10080181^[5]	NAS: Non-traceable Author Statement		P
	GO:0008083	growth factor activity	PMID:10383933^[6]	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:Q9Y219	F
	GO:0009912	auditory receptor cell fate commitment	PMID:10080181^[5]	IMP: Inferred from Mutant Phenotype		P
	GO:0016020	membrane	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR001774	C
	GO:0016020	membrane	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0472	C
	GO:0016020	membrane	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0162	C
	GO:0016021	integral to membrane	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR011651	C
	GO:0016021	integral to membrane	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0812	C
	GO:0042127	regulation of cell proliferation	PMID:10383933^[6]	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:Q9Y219	P
	GO:0042492	gamma-delta T cell differentiation	PMID:10383933^[6]	IMP: Inferred from Mutant Phenotype		P
	GO:0045061	thymic T cell selection	PMID:10383933^[6]	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:Q9Y219	P
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Xiong W et al. (2009) Hand2 is required in the epithelium for palatogenesis in mice. Dev Biol 330: 131-41 PubMed GONUTS page
↑ ^2.0 ^2.1 Tsai S et al. (2000) Mouse Jagged2 is differentially expressed in hematopoietic progenitors and endothelial cells and promotes the survival and proliferation of hematopoietic progenitors by direct cell-to-cell contact. Blood 96: 950-7 PubMed GONUTS page
↑ McCright B (2003) Notch signaling in kidney development. Curr Opin Nephrol Hypertens 12: 5-10 PubMed GONUTS page
↑ Hayashi T et al. (2001) Requirement of Notch 1 and its ligand jagged 2 expressions for spermatogenesis in rat and human testes. J Androl 22: 999-1011 PubMed GONUTS page
↑ ^5.0 ^5.1 Lanford PJ et al. (1999) Notch signalling pathway mediates hair cell development in mammalian cochlea. Nat Genet 21: 289-92 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 ^6.3 Felli MP et al. (1999) Expression pattern of notch1, 2 and 3 and Jagged1 and 2 in lymphoid and stromal thymus components: distinct ligand-receptor interactions in intrathymic T cell development. Int Immunol 11: 1017-25 PubMed GONUTS page

[PMID:19341725-0] Xiong W et al. (2009) Hand2 is required in the epithelium for palatogenesis in mice. Dev Biol 330: 131-41 PubMed GONUTS page

[PMID:10910909-1] 2.0 ^2.1 Tsai S et al. (2000) Mouse Jagged2 is differentially expressed in hematopoietic progenitors and endothelial cells and promotes the survival and proliferation of hematopoietic progenitors by direct cell-to-cell contact. Blood 96: 950-7 PubMed GONUTS page

[PMID:12496659-2] McCright B (2003) Notch signaling in kidney development. Curr Opin Nephrol Hypertens 12: 5-10 PubMed GONUTS page

[PMID:11700865-3] Hayashi T et al. (2001) Requirement of Notch 1 and its ligand jagged 2 expressions for spermatogenesis in rat and human testes. J Androl 22: 999-1011 PubMed GONUTS page

[PMID:10080181-4] 5.0 ^5.1 Lanford PJ et al. (1999) Notch signalling pathway mediates hair cell development in mammalian cochlea. Nat Genet 21: 289-92 PubMed GONUTS page

[PMID:10383933-5] 6.0 ^6.1 ^6.2 ^6.3 Felli MP et al. (1999) Expression pattern of notch1, 2 and 3 and Jagged1 and 2 in lymphoid and stromal thymus components: distinct ligand-receptor interactions in intrathymic T cell development. Int Immunol 11: 1017-25 PubMed GONUTS page

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Species (Taxon ID)	Mus musculus (Mouse). (taxon:10090)
Gene Name(s)	Jag2
Protein Name(s)	Protein jagged-2 Jagged2
External Links
UniProt Identifier	JAG2_MOUSE
UniProt Accessions	Q9QYE5, O55139, O70219,
EMBL	AF038572, AF010137, Y14495,
Pfam	PF01414, PF00008, PF07645, PF07657,

MOUSE:JAG2

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