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MOUSE:IRPL1
Contents |
| Species (Taxon ID) | Mus musculus (Mouse). ([1]) | |
| Gene Name(s) | Il1rapl1 | |
| Protein Name(s) | Interleukin-1 receptor accessory protein-like 1
IL-1-RAPL-1 IL-1RAPL-1 IL1RAPL-1 X-linked interleukin-1 receptor accessory protein-like 1 | |
| External Links | ||
| EMBL | AL844900 AL672059 AK081272 | |
| IPI | IPI00463026 | |
| UniGene | Mm.121680 Mm.426143 | |
| ProteinModelPortal | P59823 | |
| SMR | P59823 | |
| STRING | P59823 | |
| PhosphoSite | P59823 | |
| PRIDE | P59823 | |
| MGI | MGI:2687319 | |
| eggNOG | roNOG08440 | |
| GeneTree | ENSGT00570000079082 | |
| HOVERGEN | HBG052148 | |
| InParanoid | P59823 | |
| OrthoDB | EOG4H72B3 | |
| ArrayExpress | P59823 | |
| Bgee | P59823 | |
| CleanEx | MM_IL1RAPL1 | |
| Genevestigator | P59823 | |
| GO | GO:0005737 GO:0016021 GO:0005886 GO:0004888 GO:0045087 GO:0051927 GO:0045920 GO:0010975 | |
| InterPro | IPR007110 IPR013783 IPR013098 IPR003599 IPR003598 IPR015621 IPR004075 IPR000157 | |
| Gene3D | G3DSA:2.60.40.10 | |
| PANTHER | PTHR11890 | |
| Pfam | PF07679 PF01582 | |
| PRINTS | PR01537 | |
| SMART | SM00409 SM00408 SM00255 | |
| SUPFAM | SSF52200 | |
| PROSITE | PS50835 PS50104 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0004872 |
receptor activity |
IEA: Inferred from Electronic Annotation |
F |
Seeded From UniProt |
||||
| GO:0004888 |
transmembrane signaling receptor activity |
IEA: Inferred from Electronic Annotation |
F |
Seeded From UniProt |
||||
| GO:0004888 |
transmembrane signaling receptor activity |
IEA: Inferred from Electronic Annotation |
F |
Seeded From UniProt |
||||
| GO:0005737 |
cytoplasm |
IEA: Inferred from Electronic Annotation |
C |
Seeded From UniProt |
||||
| GO:0005737 |
cytoplasm |
IEA: Inferred from Electronic Annotation |
SP_SL:SL-0086 |
C |
Seeded From UniProt |
|||
| GO:0005886 |
plasma membrane |
IEA: Inferred from Electronic Annotation |
C |
Seeded From UniProt |
||||
| GO:0005886 |
plasma membrane |
IEA: Inferred from Electronic Annotation |
SP_SL:SL-0039 |
C |
Seeded From UniProt |
|||
| GO:0005886 |
plasma membrane |
ISS: Inferred from Sequence or Structural Similarity |
C |
Seeded From UniProt |
||||
| GO:0007165 |
signal transduction |
IEA: Inferred from Electronic Annotation |
P |
Seeded From UniProt |
||||
| GO:0007165 |
signal transduction |
IEA: Inferred from Electronic Annotation |
P |
Seeded From UniProt |
||||
| GO:0010975 |
regulation of neuron projection development |
ISS: Inferred from Sequence or Structural Similarity |
P |
Seeded From UniProt |
||||
| GO:0016020 |
membrane |
IEA: Inferred from Electronic Annotation |
C |
Seeded From UniProt |
||||
| GO:0016021 |
integral to membrane |
IEA: Inferred from Electronic Annotation |
C |
Seeded From UniProt |
||||
| GO:0031224 |
intrinsic to membrane |
IEA: Inferred from Electronic Annotation |
C |
Seeded From UniProt |
||||
| GO:0031224 |
intrinsic to membrane |
IEA: Inferred from Electronic Annotation |
C |
Seeded From UniProt |
||||
| GO:0045087 |
innate immune response |
IEA: Inferred from Electronic Annotation |
P |
Seeded From UniProt |
||||
| GO:0045087 |
innate immune response |
IEA: Inferred from Electronic Annotation |
P |
Seeded From UniProt |
||||
| GO:0045920 |
negative regulation of exocytosis |
ISS: Inferred from Sequence or Structural Similarity |
P |
Seeded From UniProt |
||||
| GO:0051927 |
negative regulation of calcium ion transport via voltage-gated calcium channel activity |
ISS: Inferred from Sequence or Structural Similarity |
P |
Seeded From UniProt |
||||
| GO:0019966 |
interleukin-1 binding |
ISS: Inferred from Sequence or Structural Similarity |
F |
Seeded From UniProt |
||||
| GO:0030425 |
dendrite |
IDA: Inferred from Direct Assay |
C |
Figure 1A shows antibody of endogenous Il1rapl1 clustered at dendrites colocalized with Shank1 protein. |
complete | |||
| GO:0097105 |
presynaptic membrane assembly |
IMP: Inferred from Mutant Phenotype |
P |
Knock down of Il1rapl1 by siRNA: Figure 1C shows decrease in Bassoon protein (presynaptic marker at the presynaptic active zone which is part of the plasma membrane of the presynaptic neuron). Also seen in figure 1D and E When the mouse Il1rapl1 was rescued synapse formation was restorde by increasing Bassoon marker. (figure 1C-E) |
complete | |||
| GO:0050775 |
positive regulation of dendrite morphogenesis |
IMP: Inferred from Mutant Phenotype |
P |
Knockdown of Il1rapl1 by siRNA: Figure 1C shows decrease in dendritic protrusion, also seen in figure 1D and E. When the mouse Il1rapl1 was rescued synapse formation was restore by increasing dendrite density (figure 1C-E)
|
complete | |||
| GO:0009986 |
cell surface |
IDA: Inferred from Direct Assay |
C |
HEK293T cells transfected with mouse Il1rapl1 co cultured on cortical neurons, after 24 hours there was an increase in Bassoon expression and VGluT1 on the surface of HEK293T (figure 2A,B). Immunostaining of Il1rapl1 and Bassoon co-localized on the surface of HEK293T cells. |
complete | |||
| GO:0007157 |
heterophilic cell-cell adhesion |
IDA: Inferred from Direct Assay |
P |
Figure 4C, HEK293T cell transfected with mouse Il1rapl1 labeled with EGFP and Receptor-type tyrosine-protein phosphatase delta (R-PTP-delta)labeled with RFP. Cell aggregated into large clumps suggesting that both Il1rapl1 and R-PTP-delta function as heterophilic cell adhesion molecules. But cell expressing either Il1rapl1 or R-PTP-delta did not show homophilic aggregation. |
complete | |||
| edit table |
Notes
References
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