MOUSE:INSR

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Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Insr
Protein Name(s)	Insulin receptor IR Insulin receptor subunit alpha Insulin receptor subunit beta
External Links
UniProt	P15208
EMBL	J05149 M28869
IPI	IPI00128358
PIR	A34157
RefSeq	NP_034698.2
UniGene	Mm.268003
PDB	1LK2
PDBsum	1LK2
ProteinModelPortal	P15208
SMR	P15208
DIP	DIP-41452N
MINT	MINT-1516207
STRING	P15208
PhosphoSite	P15208
PRIDE	P15208
GeneID	16337
KEGG	mmu:16337
UCSC	uc009krc.2
CTD	3643
MGI	MGI:96575
HOGENOM	HBG316019
HOVERGEN	HBG006134
InParanoid	P15208
OrthoDB	EOG48WC15
BRENDA	2.7.10.1
NextBio	289438
ArrayExpress	P15208
Bgee	P15208
CleanEx	MM_INSR
Genevestigator	P15208
GermOnline	ENSMUSG00000005534
GO	GO:0005901 GO:0016021 GO:0005524 GO:0043559 GO:0043560 GO:0005009 GO:0046872 GO:0043548 GO:0051425 GO:0042169 GO:0071363 GO:0031017 GO:0030238 GO:0009887 GO:0045725 GO:0046777 GO:0051290
InterPro	IPR000494 IPR003961 IPR006211 IPR006212 IPR009030 IPR013783 IPR011009 IPR000719 IPR017441 IPR001245 IPR008266 IPR020635 IPR016246 IPR002011
Gene3D	G3DSA:2.60.40.10
KO	K04527
Pfam	PF00041 PF00757 PF07714 PF01030
PIRSF	PIRSF000620
PRINTS	PR00109
SMART	SM00060 SM00261 SM00219
SUPFAM	SSF49265 SSF57184 SSF56112
PROSITE	PS50853 PS00107 PS50011 PS00109 PS00239

Annotations

Qualifier	GO ID	GO term name	Reference	Evidence Code	with/from	Aspect	Notes
	GO:0000166	nucleotide binding	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0547	F	Seeded From UniProt
	GO:0004672	protein kinase activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR000719	F	Seeded From UniProt
	GO:0004672	protein kinase activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR001245	F	Seeded From UniProt
	GO:0004713	protein tyrosine kinase activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR008266	F	Seeded From UniProt
	GO:0004713	protein tyrosine kinase activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR020635	F	Seeded From UniProt
	GO:0004713	protein tyrosine kinase activity	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0829	F	Seeded From UniProt
	GO:0004714	transmembrane receptor protein tyrosine kinase activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR002011	F	Seeded From UniProt
	GO:0004714	transmembrane receptor protein tyrosine kinase activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR006211	F	Seeded From UniProt
	GO:0004714	transmembrane receptor protein tyrosine kinase activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR016246	F	Seeded From UniProt
	GO:0004714	transmembrane receptor protein tyrosine kinase activity	GO_REF:0000003	IEA: Inferred from Electronic Annotation	EC:2.7.10.1	F	Seeded From UniProt
	GO:0004872	receptor activity	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0675	F	Seeded From UniProt
	GO:0005009	insulin-activated receptor activity	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:P06213	F	Seeded From UniProt
	GO:0005515	protein binding	PMID:10196204^[1]	IPI: Inferred from Physical Interaction	UniProtKB:Q9JID9	F	Seeded From UniProt
	GO:0005515	protein binding	PMID:12917015^[2]	IPI: Inferred from Physical Interaction	UniProtKB:Q91VH2	F	Seeded From UniProt
	GO:0005515	protein binding	PMID:15169905^[3]	IPI: Inferred from Physical Interaction	UniProtKB:O35716	F	Seeded From UniProt
	GO:0005515	protein binding	PMID:15169905^[3]	IPI: Inferred from Physical Interaction	UniProtKB:O35718	F	Seeded From UniProt
	GO:0005515	protein binding	PMID:15664450^[4]	IPI: Inferred from Physical Interaction	UniProtKB:Q60760	F	Seeded From UniProt
	GO:0005515	protein binding	PMID:9447983^[5]	IPI: Inferred from Physical Interaction	UniProtKB:Q62417	F	Seeded From UniProt
	GO:0005515	protein binding	PMID:9447983^[5]	IPI: Inferred from Physical Interaction	UniProtKB:Q62417	F	Seeded From UniProt
	GO:0005524	ATP binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR000719	F	Seeded From UniProt
	GO:0005524	ATP binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR002011	F	Seeded From UniProt
	GO:0005524	ATP binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR006211	F	Seeded From UniProt
	GO:0005524	ATP binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR016246	F	Seeded From UniProt
	GO:0005524	ATP binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR017441	F	Seeded From UniProt
	GO:0005524	ATP binding	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0067	F	Seeded From UniProt
	GO:0005886	plasma membrane	PMID:14562105^[6]	IDA: Inferred from Direct Assay		C	Seeded From UniProt
	GO:0005901	caveola	PMID:16513830^[7]	IDA: Inferred from Direct Assay		C	Seeded From UniProt
	GO:0006468	protein phosphorylation	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR000719	P	Seeded From UniProt
	GO:0006468	protein phosphorylation	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR001245	P	Seeded From UniProt
	GO:0006468	protein phosphorylation	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR002011	P	Seeded From UniProt
	GO:0006468	protein phosphorylation	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR006211	P	Seeded From UniProt
	GO:0006468	protein phosphorylation	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR008266	P	Seeded From UniProt
	GO:0006468	protein phosphorylation	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR016246	P	Seeded From UniProt
	GO:0006468	protein phosphorylation	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR020635	P	Seeded From UniProt
	GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR002011	P	Seeded From UniProt
	GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR006211	P	Seeded From UniProt
	GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR016246	P	Seeded From UniProt
	GO:0008286	insulin receptor signaling pathway	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:P06213	P	Seeded From UniProt
	GO:0008286	insulin receptor signaling pathway	PMID:12488434^[8]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1857204	P	Seeded From UniProt
	GO:0009887	organ morphogenesis	PMID:12101187^[9]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1857204	P	Seeded From UniProt
	GO:0016020	membrane	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR000494	C	Seeded From UniProt
	GO:0016020	membrane	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR002011	C	Seeded From UniProt
	GO:0016020	membrane	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR006211	C	Seeded From UniProt
	GO:0016020	membrane	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0472	C	Seeded From UniProt
	GO:0016020	membrane	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0162	C	Seeded From UniProt
	GO:0016020	membrane	PMID:9447983^[5]	IDA: Inferred from Direct Assay		C	Seeded From UniProt
	GO:0016021	integral to membrane	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR016246	C	Seeded From UniProt
	GO:0016021	integral to membrane	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0812	C	Seeded From UniProt
	GO:0016301	kinase activity	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0418	F	Seeded From UniProt
	GO:0016310	phosphorylation	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0418	P	Seeded From UniProt
	GO:0016740	transferase activity	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0808	F	Seeded From UniProt
	GO:0016772	transferase activity, transferring phosphorus-containing groups	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR011009	F	Seeded From UniProt
	GO:0030238	male sex determination	PMID:14628051^[10]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1857204	P	Seeded From UniProt
	GO:0031017	exocrine pancreas development	PMID:12101187^[9]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1857204	P	Seeded From UniProt
	GO:0042169	SH2 domain binding	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:P06213	F	Seeded From UniProt
	GO:0043548	phosphatidylinositol 3-kinase binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR016246	F	Seeded From UniProt
	GO:0043548	phosphatidylinositol 3-kinase binding	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:P06213	F	Seeded From UniProt
	GO:0043559	insulin binding	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:P06213	F	Seeded From UniProt
	GO:0043560	insulin receptor substrate binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR016246	F	Seeded From UniProt
	GO:0043560	insulin receptor substrate binding	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:P06213	F	Seeded From UniProt
	GO:0045725	positive regulation of glycogen biosynthetic process	PMID:20032056^[11]	IMP: Inferred from Mutant Phenotype		P	Seeded From UniProt
	GO:0046777	protein autophosphorylation	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR016246	P	Seeded From UniProt
	GO:0046777	protein autophosphorylation	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:P06213	P	Seeded From UniProt
	GO:0051290	protein heterotetramerization	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:P06213	P	Seeded From UniProt
	GO:0051425	PTB domain binding	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:P06213	F	Seeded From UniProt
	GO:0071363	cellular response to growth factor stimulus	PMID:19744960^[12]	IDA: Inferred from Direct Assay		P	Seeded From UniProt
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Moodie SA et al. (1999) Identification of the APS protein as a novel insulin receptor substrate. J Biol Chem 274: 11186-93 PubMed GONUTS page
↑ MaCaulay SL et al. (2003) Insulin stimulates movement of sorting nexin 9 between cellular compartments: a putative role mediating cell surface receptor expression and insulin action. Biochem J 376: 123-34 PubMed GONUTS page
↑ ^3.0 ^3.1 Ueki K et al. (2004) Suppressor of cytokine signaling 1 (SOCS-1) and SOCS-3 cause insulin resistance through inhibition of tyrosine phosphorylation of insulin receptor substrate proteins by discrete mechanisms. Mol Cell Biol 24: 5434-46 PubMed GONUTS page
↑ Mori K et al. (2005) Distinct Grb10 domain requirements for effects on glucose uptake and insulin signaling. Mol Cell Endocrinol 230: 39-50 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 Ribon V et al. (1998) A novel, multifuntional c-Cbl binding protein in insulin receptor signaling in 3T3-L1 adipocytes. Mol Cell Biol 18: 872-9 PubMed GONUTS page
↑ Bogan JS et al. (2003) Functional cloning of TUG as a regulator of GLUT4 glucose transporter trafficking. Nature 425: 727-33 PubMed GONUTS page
↑ Lu X et al. (2006) DHCR24-knockout embryonic fibroblasts are susceptible to serum withdrawal-induced apoptosis because of dysfunction of caveolae and insulin-Akt-Bad signaling. Endocrinology 147: 3123-32 PubMed GONUTS page
↑ Kitamura T et al. (2002) The forkhead transcription factor Foxo1 links insulin signaling to Pdx1 regulation of pancreatic beta cell growth. J Clin Invest 110: 1839-47 PubMed GONUTS page
↑ ^9.0 ^9.1 Kido Y et al. (2002) Effects of mutations in the insulin-like growth factor signaling system on embryonic pancreas development and beta-cell compensation to insulin resistance. J Biol Chem 277: 36740-7 PubMed GONUTS page
↑ Nef S et al. (2003) Testis determination requires insulin receptor family function in mice. Nature 426: 291-5 PubMed GONUTS page
↑ Liang L et al. (2010) Insulin-like growth factor 2 and the insulin receptor, but not insulin, regulate fetal hepatic glycogen synthesis. Endocrinology 151: 741-7 PubMed GONUTS page
↑ Giovannone B et al. (2009) GIGYF2 gene disruption in mice results in neurodegeneration and altered insulin-like growth factor signaling. Hum Mol Genet 18: 4629-39 PubMed GONUTS page

[PMID:10196204-0] Moodie SA et al. (1999) Identification of the APS protein as a novel insulin receptor substrate. J Biol Chem 274: 11186-93 PubMed GONUTS page

[PMID:12917015-1] MaCaulay SL et al. (2003) Insulin stimulates movement of sorting nexin 9 between cellular compartments: a putative role mediating cell surface receptor expression and insulin action. Biochem J 376: 123-34 PubMed GONUTS page

[PMID:15169905-2] 3.0 ^3.1 Ueki K et al. (2004) Suppressor of cytokine signaling 1 (SOCS-1) and SOCS-3 cause insulin resistance through inhibition of tyrosine phosphorylation of insulin receptor substrate proteins by discrete mechanisms. Mol Cell Biol 24: 5434-46 PubMed GONUTS page

[PMID:15664450-3] Mori K et al. (2005) Distinct Grb10 domain requirements for effects on glucose uptake and insulin signaling. Mol Cell Endocrinol 230: 39-50 PubMed GONUTS page

[PMID:9447983-4] 5.0 ^5.1 ^5.2 Ribon V et al. (1998) A novel, multifuntional c-Cbl binding protein in insulin receptor signaling in 3T3-L1 adipocytes. Mol Cell Biol 18: 872-9 PubMed GONUTS page

[PMID:14562105-5] Bogan JS et al. (2003) Functional cloning of TUG as a regulator of GLUT4 glucose transporter trafficking. Nature 425: 727-33 PubMed GONUTS page

[PMID:16513830-6] Lu X et al. (2006) DHCR24-knockout embryonic fibroblasts are susceptible to serum withdrawal-induced apoptosis because of dysfunction of caveolae and insulin-Akt-Bad signaling. Endocrinology 147: 3123-32 PubMed GONUTS page

[PMID:12488434-7] Kitamura T et al. (2002) The forkhead transcription factor Foxo1 links insulin signaling to Pdx1 regulation of pancreatic beta cell growth. J Clin Invest 110: 1839-47 PubMed GONUTS page

[PMID:12101187-8] 9.0 ^9.1 Kido Y et al. (2002) Effects of mutations in the insulin-like growth factor signaling system on embryonic pancreas development and beta-cell compensation to insulin resistance. J Biol Chem 277: 36740-7 PubMed GONUTS page

[PMID:14628051-9] Nef S et al. (2003) Testis determination requires insulin receptor family function in mice. Nature 426: 291-5 PubMed GONUTS page

[PMID:20032056-10] Liang L et al. (2010) Insulin-like growth factor 2 and the insulin receptor, but not insulin, regulate fetal hepatic glycogen synthesis. Endocrinology 151: 741-7 PubMed GONUTS page

[PMID:19744960-11] Giovannone B et al. (2009) GIGYF2 gene disruption in mice results in neurodegeneration and altered insulin-like growth factor signaling. Hum Mol Genet 18: 4629-39 PubMed GONUTS page

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MOUSE:INSR

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