GONUTS is under stress! The website is currently experiencing long-wait times and frequent time-outs due to the record number of students, groups, and annotations related to CACAO this semester. We are currently working on increasing performance -- please accept our apologies for the technical difficulties.
You can help reduce stress on the server by:
- not reloading pages frequently - this just adds
- opening links in new windows (so you can read the old page)
MOUSE:IL3
Contents |
| Species (Taxon ID) | Mus musculus (Mouse). (10090) | |
| Gene Name(s) | Il3 (synonyms: Csfmu, Il-3) | |
| Protein Name(s) | Interleukin-3
IL-3 Hematopoietic growth factor Mast cell growth factor MCGF Multipotential colony-stimulating factor P-cell-stimulating factor | |
| External Links | ||
| UniProt | P01586 | |
| EMBL | K01850 K01668 K03233 X02732 M20128 M14394 | |
| IPI | IPI00323906 | |
| PIR | A25481 | |
| RefSeq | NP_034686.2 | |
| UniGene | Mm.983 | |
| PDB | 2L3O | |
| PDBsum | 2L3O | |
| ProteinModelPortal | P01586 | |
| SMR | P01586 | |
| STRING | P01586 | |
| PRIDE | P01586 | |
| Ensembl | ENSMUST00000019058 | |
| GeneID | 16187 | |
| KEGG | mmu:16187 | |
| CTD | 3562 | |
| MGI | MGI:96552 | |
| HOVERGEN | HBG006148 | |
| InParanoid | P01586 | |
| OMA | NDSALPG | |
| OrthoDB | EOG4QNMXW | |
| NextBio | 289085 | |
| ArrayExpress | P01586 | |
| Bgee | P01586 | |
| CleanEx | MM_IL3 | |
| Genevestigator | P01586 | |
| GermOnline | ENSMUSG00000018914 | |
| GO | GO:0005615 GO:0005125 GO:0008083 GO:0005135 GO:0019221 GO:0006955 GO:0033028 GO:0010507 GO:0033026 GO:0046330 GO:0070668 GO:0002763 GO:0050731 GO:0045885 GO:0006110 GO:0035304 GO:0001666 | |
| InterPro | IPR009079 IPR012351 IPR002183 | |
| Gene3D | G3DSA:1.20.1250.10 | |
| KO | K04736 | |
| Pfam | PF02059 | |
| PIRSF | PIRSF001939 | |
| PRINTS | PR00430 | |
| SUPFAM | SSF47266 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0001666 |
response to hypoxia |
IGI: Inferred from Genetic Interaction |
MGI:MGI:106918 |
P |
Seeded From UniProt |
|||
| GO:0001934 |
positive regulation of protein phosphorylation |
IDA: Inferred from Direct Assay |
|
P |
Seeded From UniProt |
|||
| GO:0002763 |
positive regulation of myeloid leukocyte differentiation |
IGI: Inferred from Genetic Interaction |
MGI:MGI:96974 |
P |
Seeded From UniProt |
|||
| GO:0002763 |
positive regulation of myeloid leukocyte differentiation |
IGI: Inferred from Genetic Interaction |
MGI:MGI:96974 |
P |
Seeded From UniProt |
|||
| GO:0005125 |
cytokine activity |
IEA: Inferred from Electronic Annotation |
F |
Seeded From UniProt |
||||
| GO:0005125 |
cytokine activity |
IDA: Inferred from Direct Assay |
|
F |
Seeded From UniProt |
|||
| GO:0005125 |
cytokine activity |
IDA: Inferred from Direct Assay |
|
F |
Seeded From UniProt |
|||
| GO:0005125 |
cytokine activity |
IDA: Inferred from Direct Assay |
|
F |
Seeded From UniProt |
|||
| GO:0005125 |
cytokine activity |
IDA: Inferred from Direct Assay |
|
F |
Seeded From UniProt |
|||
| GO:0005125 |
cytokine activity |
IDA: Inferred from Direct Assay |
|
F |
Seeded From UniProt |
|||
| GO:0005125 |
cytokine activity |
IDA: Inferred from Direct Assay |
|
F |
Seeded From UniProt |
|||
| GO:0005125 |
cytokine activity |
IDA: Inferred from Direct Assay |
|
F |
Seeded From UniProt |
|||
| GO:0005125 |
cytokine activity |
IDA: Inferred from Direct Assay |
|
F |
Seeded From UniProt |
|||
| GO:0005135 |
interleukin-3 receptor binding |
IEA: Inferred from Electronic Annotation |
F |
Seeded From UniProt |
||||
| GO:0005576 |
extracellular region |
IEA: Inferred from Electronic Annotation |
C |
Seeded From UniProt |
||||
| GO:0005576 |
extracellular region |
IEA: Inferred from Electronic Annotation |
C |
Seeded From UniProt |
||||
| GO:0005576 |
extracellular region |
IEA: Inferred from Electronic Annotation |
SP_SL:SL-0243 |
C |
Seeded From UniProt |
|||
| GO:0005615 |
extracellular space |
IEA: Inferred from Electronic Annotation |
C |
Seeded From UniProt |
||||
| GO:0005615 |
extracellular space |
IDA: Inferred from Direct Assay |
|
C |
Seeded From UniProt |
|||
| GO:0006110 |
regulation of glycolysis |
IGI: Inferred from Genetic Interaction |
MGI:MGI:106918 |
P |
Seeded From UniProt |
|||
| GO:0006955 |
immune response |
IEA: Inferred from Electronic Annotation |
P |
Seeded From UniProt |
||||
| GO:0008083 |
growth factor activity |
IEA: Inferred from Electronic Annotation |
F |
Seeded From UniProt |
||||
| GO:0008083 |
growth factor activity |
IEA: Inferred from Electronic Annotation |
F |
Seeded From UniProt |
||||
| GO:0008083 |
growth factor activity |
IDA: Inferred from Direct Assay |
|
F |
Seeded From UniProt |
|||
| GO:0008083 |
growth factor activity |
IDA: Inferred from Direct Assay |
|
F |
Seeded From UniProt |
|||
| GO:0008284 |
positive regulation of cell proliferation |
IDA: Inferred from Direct Assay |
|
P |
Seeded From UniProt |
|||
| GO:0008284 |
positive regulation of cell proliferation |
IGI: Inferred from Genetic Interaction |
MGI:MGI:96974 |
P |
Seeded From UniProt |
|||
| GO:0008284 |
positive regulation of cell proliferation |
IDA: Inferred from Direct Assay |
|
P |
Seeded From UniProt |
|||
| GO:0008284 |
positive regulation of cell proliferation |
IDA: Inferred from Direct Assay |
|
P |
Seeded From UniProt |
|||
| GO:0010468 |
regulation of gene expression |
IDA: Inferred from Direct Assay |
|
P |
Seeded From UniProt |
|||
| GO:0010507 |
negative regulation of autophagy |
IDA: Inferred from Direct Assay |
|
P |
Seeded From UniProt |
|||
| GO:0019221 |
cytokine-mediated signaling pathway |
IDA: Inferred from Direct Assay |
|
P |
Seeded From UniProt |
|||
| GO:0033026 |
negative regulation of mast cell apoptosis |
IDA: Inferred from Direct Assay |
|
P |
Seeded From UniProt |
|||
| GO:0033028 |
myeloid cell apoptosis |
IDA: Inferred from Direct Assay |
|
P |
Seeded From UniProt |
|||
| GO:0035304 |
regulation of protein dephosphorylation |
IDA: Inferred from Direct Assay |
|
P |
Seeded From UniProt |
|||
| GO:0042981 |
regulation of apoptotic process |
IDA: Inferred from Direct Assay |
|
P |
Seeded From UniProt |
|||
| GO:0042981 |
regulation of apoptotic process |
IDA: Inferred from Direct Assay |
|
P |
Seeded From UniProt |
|||
| GO:0043066 |
negative regulation of apoptotic process |
IDA: Inferred from Direct Assay |
|
P |
Seeded From UniProt |
|||
| GO:0045885 |
positive regulation of survival gene product expression |
IDA: Inferred from Direct Assay |
|
P |
Seeded From UniProt |
|||
| GO:0045885 |
positive regulation of survival gene product expression |
IDA: Inferred from Direct Assay |
|
P |
Seeded From UniProt |
|||
| GO:0046330 |
positive regulation of JNK cascade |
IDA: Inferred from Direct Assay |
|
P |
Seeded From UniProt |
|||
| GO:0050731 |
positive regulation of peptidyl-tyrosine phosphorylation |
IDA: Inferred from Direct Assay |
|
P |
Seeded From UniProt |
|||
| GO:0050731 |
positive regulation of peptidyl-tyrosine phosphorylation |
IDA: Inferred from Direct Assay |
|
P |
Seeded From UniProt |
|||
| GO:0070668 |
positive regulation of mast cell proliferation |
IDA: Inferred from Direct Assay |
|
P |
Seeded From UniProt |
|||
| GO:0070668 |
positive regulation of mast cell proliferation |
IDA: Inferred from Direct Assay |
|
P |
Seeded From UniProt |
| ||
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 Lum JJ et al. (2007) The transcription factor HIF-1alpha plays a critical role in the growth factor-dependent regulation of both aerobic and anaerobic glycolysis. Genes Dev 21: 1037-49 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 2.3 Yu C et al. (2004) JNK suppresses apoptosis via phosphorylation of the proapoptotic Bcl-2 family protein BAD. Mol Cell 13: 329-40 PubMed GONUTS page
- ↑ Tsuji K et al. (1992) Enhancement of murine hematopoiesis by synergistic interactions between steel factor (ligand for c-kit), interleukin-11, and other early acting factors in culture. Blood 79: 2855-60 PubMed GONUTS page
- ↑ 4.0 4.1 4.2 Ploemacher RE et al. (1993) Interleukin-12 enhances interleukin-3 dependent multilineage hematopoietic colony formation stimulated by interleukin-11 or steel factor. Leukemia 7: 1374-80 PubMed GONUTS page
- ↑ 5.0 5.1 Kieslinger M et al. (2000) Antiapoptotic activity of Stat5 required during terminal stages of myeloid differentiation. Genes Dev 14: 232-44 PubMed GONUTS page
- ↑ 6.0 6.1 Iseki M et al. (2000) Molecular cloning of the mouse APS as a member of the Lnk family adaptor proteins. Biochem Biophys Res Commun 272: 45-54 PubMed GONUTS page
- ↑ 7.0 7.1 7.2 7.3 Shelburne CP et al. (2003) Stat5 expression is critical for mast cell development and survival. Blood 102: 1290-7 PubMed GONUTS page
- ↑ 8.0 8.1 Okada S et al. (1992) Synergistic effect of IL-3 and IL-6 on highly enriched murine hemopoietic progenitors. Exp Hematol 20: 546-51 PubMed GONUTS page
- ↑ 9.0 9.1 9.2 Ito T et al. (1994) Interleukin 3 stimulates protein synthesis by regulating double-stranded RNA-dependent protein kinase. Proc Natl Acad Sci U S A 91: 7455-9 PubMed GONUTS page
- ↑ 10.0 10.1 10.2 Miyazaki T et al. (1995) Three distinct IL-2 signaling pathways mediated by bcl-2, c-myc, and lck cooperate in hematopoietic cell proliferation. Cell 81: 223-31 PubMed GONUTS page
- ↑ 11.0 11.1 11.2 Hilton DJ et al. (1994) Cloning of a murine IL-11 receptor alpha-chain; requirement for gp130 for high affinity binding and signal transduction. EMBO J 13: 4765-75 PubMed GONUTS page
- ↑ Traver D et al. (1998) Mice defective in two apoptosis pathways in the myeloid lineage develop acute myeloblastic leukemia. Immunity 9: 47-57 PubMed GONUTS page
- ↑ Lum JJ et al. (2005) Growth factor regulation of autophagy and cell survival in the absence of apoptosis. Cell 120: 237-48 PubMed GONUTS page
- ↑ Barge RM et al. (1997) Differential involvement of caspases in apoptosis of myeloid leukemic cells induced by chemotherapy versus growth factor withdrawal. FEBS Lett 409: 207-10 PubMed GONUTS page
- ↑ 15.0 15.1 Chiang CW et al. (2003) Protein phosphatase 2A dephosphorylation of phosphoserine 112 plays the gatekeeper role for BAD-mediated apoptosis. Mol Cell Biol 23: 6350-62 PubMed GONUTS page
- ↑ Seo SY et al. (2004) BAD is a pro-survival factor prior to activation of its pro-apoptotic function. J Biol Chem 279: 42240-9 PubMed GONUTS page
- ↑ Ikeda K et al. (2005) Stat5a is essential for the proliferation and survival of murine mast cells. Int Arch Allergy Immunol 137 Suppl 1: 45-50 PubMed GONUTS page
