MOUSE:IGF1R

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Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Igf1r
Protein Name(s)	Insulin-like growth factor 1 receptor Insulin-like growth factor I receptor IGF-I receptor Insulin-like growth factor 1 receptor alpha chain Insulin-like growth factor 1 receptor beta chain
External Links
UniProt	Q60751
EMBL	AF056187 U00182 M33422
IPI	IPI00120225
PIR	A48805 JH0113
RefSeq	NP_034643.2
UniGene	Mm.275742
ProteinModelPortal	Q60751
SMR	Q60751
MINT	MINT-219894
STRING	Q60751
PhosphoSite	Q60751
PRIDE	Q60751
GeneID	16001
KEGG	mmu:16001
UCSC	uc009hja.1
CTD	3480
MGI	MGI:96433
eggNOG	roNOG06957
GeneTree	ENSGT00600000084075
HOGENOM	HBG316019
HOVERGEN	HBG006134
InParanoid	Q60751
OrthoDB	EOG4Z62MR
BRENDA	2.7.10.1
NextBio	288790
ArrayExpress	Q60751
Bgee	Q60751
CleanEx	MM_IGF1R
Genevestigator	Q60751
GermOnline	ENSMUSG00000005533
GO	GO:0016021 GO:0005524 GO:0043560 GO:0005010 GO:0046872 GO:0043548 GO:0007420 GO:0031017 GO:0030238 GO:0030879 GO:0043409 GO:0051898 GO:0043410 GO:0051897 GO:0060740 GO:0046777 GO:0051262
InterPro	IPR000494 IPR003961 IPR006211 IPR006212 IPR009030 IPR013783 IPR011009 IPR000719 IPR017441 IPR001245 IPR008266 IPR020635 IPR016246 IPR002011
Gene3D	G3DSA:2.60.40.10
KO	K05087
Pfam	PF00041 PF00757 PF07714 PF01030
PIRSF	PIRSF000620
PRINTS	PR00109
SMART	SM00060 SM00261 SM00219
SUPFAM	SSF49265 SSF57184 SSF56112
PROSITE	PS50853 PS00107 PS50011 PS00109 PS00239

Annotations

Qualifier	GO ID	GO term name	Reference	Evidence Code	with/from	Aspect	Notes
	GO:0000166	nucleotide binding	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0547	F	Seeded From UniProt
	GO:0004672	protein kinase activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR000719	F	Seeded From UniProt
	GO:0004672	protein kinase activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR001245	F	Seeded From UniProt
	GO:0004713	protein tyrosine kinase activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR008266	F	Seeded From UniProt
	GO:0004713	protein tyrosine kinase activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR020635	F	Seeded From UniProt
	GO:0004713	protein tyrosine kinase activity	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0829	F	Seeded From UniProt
	GO:0004713	protein tyrosine kinase activity	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000268035	F	Seeded From UniProt
	GO:0004713	protein tyrosine kinase activity	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:P08069	F	Seeded From UniProt
	GO:0004714	transmembrane receptor protein tyrosine kinase activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR002011	F	Seeded From UniProt
	GO:0004714	transmembrane receptor protein tyrosine kinase activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR006211	F	Seeded From UniProt
	GO:0004714	transmembrane receptor protein tyrosine kinase activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR016246	F	Seeded From UniProt
	GO:0004714	transmembrane receptor protein tyrosine kinase activity	GO_REF:0000003	IEA: Inferred from Electronic Annotation	EC:2.7.10.1	F	Seeded From UniProt
	GO:0004872	receptor activity	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0675	F	Seeded From UniProt
	GO:0005010	insulin-like growth factor-activated receptor activity	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000268035	F	Seeded From UniProt
	GO:0005010	insulin-like growth factor-activated receptor activity	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:P08069	F	Seeded From UniProt
	GO:0005158	insulin receptor binding	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000268035	F	Seeded From UniProt
	GO:0005515	protein binding	PMID:12771153^[1]	IPI: Inferred from Physical Interaction	UniProtKB:Q60760	F	Seeded From UniProt
	GO:0005515	protein binding	PMID:12771153^[1]	IPI: Inferred from Physical Interaction	UniProtKB:Q99MR1	F	Seeded From UniProt
	GO:0005515	protein binding	PMID:12917015^[2]	IPI: Inferred from Physical Interaction	UniProtKB:Q91VH2	F	Seeded From UniProt
	GO:0005520	insulin-like growth factor binding	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000268035	F	Seeded From UniProt
	GO:0005520	insulin-like growth factor binding	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:P08069	F	Seeded From UniProt
	GO:0005524	ATP binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR000719	F	Seeded From UniProt
	GO:0005524	ATP binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR002011	F	Seeded From UniProt
	GO:0005524	ATP binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR006211	F	Seeded From UniProt
	GO:0005524	ATP binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR016246	F	Seeded From UniProt
	GO:0005524	ATP binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR017441	F	Seeded From UniProt
	GO:0005524	ATP binding	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0067	F	Seeded From UniProt
	GO:0005792	microsome	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000268035	C	Seeded From UniProt
	GO:0005886	plasma membrane	PMID:18451178^[3]	IDA: Inferred from Direct Assay		C	Seeded From UniProt
	GO:0005901	caveola	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000019267	C	Seeded From UniProt
	GO:0006468	protein phosphorylation	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR000719	P	Seeded From UniProt
	GO:0006468	protein phosphorylation	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR001245	P	Seeded From UniProt
	GO:0006468	protein phosphorylation	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR002011	P	Seeded From UniProt
	GO:0006468	protein phosphorylation	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR006211	P	Seeded From UniProt
	GO:0006468	protein phosphorylation	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR008266	P	Seeded From UniProt
	GO:0006468	protein phosphorylation	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR016246	P	Seeded From UniProt
	GO:0006468	protein phosphorylation	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR020635	P	Seeded From UniProt
	GO:0006468	protein phosphorylation	PMID:18216249^[4]	IDA: Inferred from Direct Assay		P	Seeded From UniProt
	GO:0006955	immune response	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000268035	P	Seeded From UniProt
	GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR002011	P	Seeded From UniProt
	GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR006211	P	Seeded From UniProt
	GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR016246	P	Seeded From UniProt
	GO:0007409	axonogenesis	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000019267	P	Seeded From UniProt
	GO:0007420	brain development	PMID:12904469^[5]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1926486	P	Seeded From UniProt
	GO:0009887	organ morphogenesis	PMID:12101187^[6]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1926486	P	Seeded From UniProt
	GO:0016020	membrane	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR000494	C	Seeded From UniProt
	GO:0016020	membrane	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR002011	C	Seeded From UniProt
	GO:0016020	membrane	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR006211	C	Seeded From UniProt
	GO:0016020	membrane	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0472	C	Seeded From UniProt
	GO:0016020	membrane	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000268035	C	Seeded From UniProt
	GO:0016020	membrane	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0162	C	Seeded From UniProt
	GO:0016021	integral to membrane	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR016246	C	Seeded From UniProt
	GO:0016021	integral to membrane	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0812	C	Seeded From UniProt
	GO:0016301	kinase activity	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0418	F	Seeded From UniProt
	GO:0016310	phosphorylation	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0418	P	Seeded From UniProt
	GO:0016740	transferase activity	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0808	F	Seeded From UniProt
	GO:0016772	transferase activity, transferring phosphorus-containing groups	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR011009	F	Seeded From UniProt
	GO:0030010	establishment of cell polarity	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000019267	P	Seeded From UniProt
	GO:0030238	male sex determination	PMID:14628051^[7]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1926486	P	Seeded From UniProt
	GO:0030335	positive regulation of cell migration	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000268035	P	Seeded From UniProt
	GO:0030879	mammary gland development	PMID:17662267^[8]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1926486	P	Seeded From UniProt
	GO:0031017	exocrine pancreas development	PMID:12101187^[6]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1926486	P	Seeded From UniProt
	GO:0031175	neuron projection development	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000019267	P	Seeded From UniProt
	GO:0031994	insulin-like growth factor I binding	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000268035	F	Seeded From UniProt
	GO:0032467	positive regulation of cytokinesis	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000019267	P	Seeded From UniProt
	GO:0033197	response to vitamin E	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000019267	P	Seeded From UniProt
	GO:0042802	identical protein binding	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000268035	F	Seeded From UniProt
	GO:0043005	neuron projection	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000019267	C	Seeded From UniProt
	GO:0043409	negative regulation of MAPKKK cascade	PMID:18451178^[3]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2386328	P	Seeded From UniProt
	GO:0043410	positive regulation of MAPKKK cascade	PMID:18451178^[3]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2386328	P	Seeded From UniProt
	GO:0043548	phosphatidylinositol 3-kinase binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR016246	F	Seeded From UniProt
	GO:0043548	phosphatidylinositol 3-kinase binding	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000268035	F	Seeded From UniProt
	GO:0043548	phosphatidylinositol 3-kinase binding	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:P08069	F	Seeded From UniProt
	GO:0043559	insulin binding	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000268035	F	Seeded From UniProt
	GO:0043560	insulin receptor substrate binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR016246	F	Seeded From UniProt
	GO:0043560	insulin receptor substrate binding	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000268035	F	Seeded From UniProt
	GO:0043560	insulin receptor substrate binding	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:P08069	F	Seeded From UniProt
	GO:0045740	positive regulation of DNA replication	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000268035	P	Seeded From UniProt
	GO:0045768	positive regulation of anti-apoptosis	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000019267	P	Seeded From UniProt
	GO:0046777	protein autophosphorylation	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR016246	P	Seeded From UniProt
	GO:0046777	protein autophosphorylation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000268035	P	Seeded From UniProt
	GO:0046777	protein autophosphorylation	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:P08069	P	Seeded From UniProt
	GO:0048009	insulin-like growth factor receptor signaling pathway	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000268035	P	Seeded From UniProt
	GO:0048009	insulin-like growth factor receptor signaling pathway	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:P08069	P	Seeded From UniProt
	GO:0048009	insulin-like growth factor receptor signaling pathway	PMID:12771153^[1]	IC: Inferred by Curator	GO:0005520	P	Seeded From UniProt
	GO:0048015	phosphatidylinositol-mediated signaling	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000268035	P	Seeded From UniProt
	GO:0051054	positive regulation of DNA metabolic process	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000019267	P	Seeded From UniProt
	GO:0051262	protein tetramerization	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000268035	P	Seeded From UniProt
	GO:0051262	protein tetramerization	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:P08069	P	Seeded From UniProt
	GO:0051291	protein heterooligomerization	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000019267	P	Seeded From UniProt
	GO:0051897	positive regulation of protein kinase B signaling cascade	PMID:18451178^[3]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2386328	P	Seeded From UniProt
	GO:0051898	negative regulation of protein kinase B signaling cascade	PMID:18451178^[3]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2386328	P	Seeded From UniProt
	GO:0060740	prostate gland epithelium morphogenesis	PMID:18451178^[3]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2386328	P	Seeded From UniProt
	GO:0090031	positive regulation of steroid hormone biosynthetic process	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000019267	P	Seeded From UniProt
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 Giovannone B et al. (2003) Two novel proteins that are linked to insulin-like growth factor (IGF-I) receptors by the Grb10 adapter and modulate IGF-I signaling. J Biol Chem 278: 31564-73 PubMed GONUTS page
↑ MaCaulay SL et al. (2003) Insulin stimulates movement of sorting nexin 9 between cellular compartments: a putative role mediating cell surface receptor expression and insulin action. Biochem J 376: 123-34 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 ^3.4 ^3.5 Sutherland BW et al. (2008) Conditional deletion of insulin-like growth factor-I receptor in prostate epithelium. Cancer Res 68: 3495-504 PubMed GONUTS page
↑ Gatchel JR et al. (2008) The insulin-like growth factor pathway is altered in spinocerebellar ataxia type 1 and type 7. Proc Natl Acad Sci U S A 105: 1291-6 PubMed GONUTS page
↑ Schubert M et al. (2003) Insulin receptor substrate-2 deficiency impairs brain growth and promotes tau phosphorylation. J Neurosci 23: 7084-92 PubMed GONUTS page
↑ ^6.0 ^6.1 Kido Y et al. (2002) Effects of mutations in the insulin-like growth factor signaling system on embryonic pancreas development and beta-cell compensation to insulin resistance. J Biol Chem 277: 36740-7 PubMed GONUTS page
↑ Nef S et al. (2003) Testis determination requires insulin receptor family function in mice. Nature 426: 291-5 PubMed GONUTS page
↑ Heckman BM et al. (2007) Crosstalk between the p190-B RhoGAP and IGF signaling pathways is required for embryonic mammary bud development. Dev Biol 309: 137-49 PubMed GONUTS page

[PMID:12771153-0] 1.0 ^1.1 ^1.2 Giovannone B et al. (2003) Two novel proteins that are linked to insulin-like growth factor (IGF-I) receptors by the Grb10 adapter and modulate IGF-I signaling. J Biol Chem 278: 31564-73 PubMed GONUTS page

[PMID:12917015-1] MaCaulay SL et al. (2003) Insulin stimulates movement of sorting nexin 9 between cellular compartments: a putative role mediating cell surface receptor expression and insulin action. Biochem J 376: 123-34 PubMed GONUTS page

[PMID:18451178-2] 3.0 ^3.1 ^3.2 ^3.3 ^3.4 ^3.5 Sutherland BW et al. (2008) Conditional deletion of insulin-like growth factor-I receptor in prostate epithelium. Cancer Res 68: 3495-504 PubMed GONUTS page

[PMID:18216249-3] Gatchel JR et al. (2008) The insulin-like growth factor pathway is altered in spinocerebellar ataxia type 1 and type 7. Proc Natl Acad Sci U S A 105: 1291-6 PubMed GONUTS page

[PMID:12904469-4] Schubert M et al. (2003) Insulin receptor substrate-2 deficiency impairs brain growth and promotes tau phosphorylation. J Neurosci 23: 7084-92 PubMed GONUTS page

[PMID:12101187-5] 6.0 ^6.1 Kido Y et al. (2002) Effects of mutations in the insulin-like growth factor signaling system on embryonic pancreas development and beta-cell compensation to insulin resistance. J Biol Chem 277: 36740-7 PubMed GONUTS page

[PMID:14628051-6] Nef S et al. (2003) Testis determination requires insulin receptor family function in mice. Nature 426: 291-5 PubMed GONUTS page

[PMID:17662267-7] Heckman BM et al. (2007) Crosstalk between the p190-B RhoGAP and IGF signaling pathways is required for embryonic mammary bud development. Dev Biol 309: 137-49 PubMed GONUTS page

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MOUSE:IGF1R

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