MOUSE:HYAS3

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Has3
Protein Name(s)	Hyaluronan synthase 3 Hyaluronate synthase 3 Hyaluronic acid synthase 3 HA synthase 3
External Links
UniProt	O08650
EMBL	U86408 AK028582 BC138152
CCDS	CCDS22640.1
RefSeq	NP_032243.2 XP_006530762.1 XP_006530763.1 XP_006530764.1
UniGene	Mm.56986
ProteinModelPortal	O08650
STRING	10090.ENSMUSP00000034385
CAZy	GT2
PhosphoSite	O08650
PaxDb	O08650
PRIDE	O08650
Ensembl	ENSMUST00000034385 ENSMUST00000176144
GeneID	15118
KEGG	mmu:15118
UCSC	uc009ngn.2
CTD	3038
MGI	MGI:109599
eggNOG	KOG2571 COG1215
GeneTree	ENSGT00390000010337
HOGENOM	HOG000112847
HOVERGEN	HBG000189
InParanoid	O08650
KO	K00752
OMA	RGRLWNI
OrthoDB	EOG77WWBZ
TreeFam	TF332506
BRENDA	2.4.1.212
Reactome	[www.reactome.org/content/detail/R-MMU-2142850 R-MMU-2142850]
UniPathway	UPA00341
PRO	PR:O08650
Proteomes	UP000000589
Bgee	O08650
CleanEx	MM_HAS3
ExpressionAtlas	O08650
Genevisible	O08650
GO	GO:0005737 GO:0036117 GO:0016021 GO:0050501 GO:0085029 GO:0045226 GO:0030213 GO:1900106 GO:0045893
Gene3D	3.90.550.10
InterPro	IPR026108 IPR026107 IPR029044
PANTHER	PTHR22913 PTHR22913:SF6
SUPFAM	SSF53448

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
	GO:0005737	cytoplasm	PMID:24057227^[1]	ECO:0000314			C	Figures 1,2,3,4	complete CACAO 8630
	GO:0005634	nucleus	PMID:24057227^[1]	ECO:0000314			C	Figure 7	complete CACAO 9078
part_of	GO:0005737	cytoplasm	PMID:24057227^[1]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0085029	extracellular matrix assembly	PMID:10455188^[2]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0050501	hyaluronan synthase activity	PMID:10455188^[2]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0045226	extracellular polysaccharide biosynthetic process	PMID:10455188^[2]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0085029	extracellular matrix assembly	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:106590 MGI:MGI:107821 MGI:MGI:109599 PANTHER:PTN000530809	P	Seeded From UniProt	complete
enables	GO:0050501	hyaluronan synthase activity	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:106590 MGI:MGI:107821 MGI:MGI:109599 PANTHER:PTN000530809 RGD:2781 UniProtKB:O00219 UniProtKB:Q92819	F	Seeded From UniProt	complete
involved_in	GO:0045226	extracellular polysaccharide biosynthetic process	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:106590 MGI:MGI:107821 MGI:MGI:109599 PANTHER:PTN000530809	P	Seeded From UniProt	complete
involved_in	GO:0030213	hyaluronan biosynthetic process	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:106590 MGI:MGI:107821 MGI:MGI:109599 PANTHER:PTN000530809 RGD:2781 UniProtKB:O00219 UniProtKB:Q92819	P	Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000530809 UniProtKB:Q92819	C	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1900106	positive regulation of hyaluranon cable assembly	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O00219	P	Seeded From UniProt	complete
enables	GO:0050501	hyaluronan synthase activity	PMID:9060470^[4]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0050501	hyaluronan synthase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O00219	F	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045893	positive regulation of transcription, DNA-templated	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O00219	P	Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O00219	F	Seeded From UniProt	complete
part_of	GO:0036117	hyaluranon cable	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O00219	C	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030213	hyaluronan biosynthetic process	PMID:9060470^[4]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030213	hyaluronan biosynthetic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O00219	P	Seeded From UniProt	complete
involved_in	GO:1900106	positive regulation of hyaluranon cable assembly	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O00219 ensembl:ENSP00000304440	P	Seeded From UniProt	complete
enables	GO:0050501	hyaluronan synthase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O00219 ensembl:ENSP00000304440	F	Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O00219 ensembl:ENSP00000304440	P	Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O00219 ensembl:ENSP00000304440	F	Seeded From UniProt	complete
part_of	GO:0036117	hyaluranon cable	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O00219 ensembl:ENSP00000304440	C	Seeded From UniProt	complete
involved_in	GO:0030213	hyaluronan biosynthetic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O00219 ensembl:ENSP00000304440	P	Seeded From UniProt	complete
involved_in	GO:0030213	hyaluronan biosynthetic process	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR026108	P	Seeded From UniProt	complete
enables	GO:0050501	hyaluronan synthase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR026108	F	Seeded From UniProt	complete
enables	GO:0050501	hyaluronan synthase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:2.4.1.212	F	Seeded From UniProt	complete
enables	GO:0016757	transferase activity, transferring glycosyl groups	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0328	F	Seeded From UniProt	complete
enables	GO:0016740	transferase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0808	F	Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472 UniProtKB-SubCell:SL-0162	C	Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C	Seeded From UniProt	complete
involved_in	GO:0030213	hyaluronan biosynthetic process	GO_REF:0000041	ECO:0000322	imported manually asserted information used in automatic assertion	UniPathway:UPA00341	P	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 Törrönen, K et al. (2014) Tissue distribution and subcellular localization of hyaluronan synthase isoenzymes. Histochem. Cell Biol. 141 17-31 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 Itano, N et al. (1999) Three isoforms of mammalian hyaluronan synthases have distinct enzymatic properties. J. Biol. Chem. 274 25085-92 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 ^3.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ ^4.0 ^4.1 Hoock, TC et al. (1997) Isoforms of ankyrin-3 that lack the NH2-terminal repeats associate with mouse macrophage lysosomes. J. Cell Biol. 136 1059-70 PubMed GONUTS page

[PMID:24057227-1] 1.0 ^1.1 ^1.2 Törrönen, K et al. (2014) Tissue distribution and subcellular localization of hyaluronan synthase isoenzymes. Histochem. Cell Biol. 141 17-31 PubMed GONUTS page

[PMID:10455188-2] 2.0 ^2.1 ^2.2 Itano, N et al. (1999) Three isoforms of mammalian hyaluronan synthases have distinct enzymatic properties. J. Biol. Chem. 274 25085-92 PubMed GONUTS page

[PMID:21873635-3] 3.0 ^3.1 ^3.2 ^3.3 ^3.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:9060470-4] 4.0 ^4.1 Hoock, TC et al. (1997) Isoforms of ankyrin-3 that lack the NH2-terminal repeats associate with mouse macrophage lysosomes. J. Cell Biol. 136 1059-70 PubMed GONUTS page

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MOUSE:HYAS3

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