MOUSE:HTRA2

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Species (Taxon ID)	Mus musculus (Mouse). (taxon:10090)
Gene Name(s)	Htra2 ( synonyms: Omi, Prss25 )
Protein Name(s)	Serine protease HTRA2, mitochondrial High temperature requirement protein A2 HtrA2 Omi stress-regulated endoprotease Serine protease 25 Serine proteinase OMI
External Links
UniProt Identifier	HTRA2_MOUSE
UniProt Accessions	Q9JIY5, Q9R108,
EMBL	AF164513, AF175324,
RefSeq	NP_062726.3,
IntAct	Q9JIY5,
Ensembl	ENSMUST00000089645,
Pfam	PF00595, PF00089,

Annotations

Qualifier	GO ID	GO term name	Reference	Evidence Code	with/from	Aspect	Notes	Status
	GO:0016021	integral to membrane		IEA: Inferred from Electronic Annotation		C	Source: UniProtKB-KW
	GO:0005758	mitochondrial intermembrane space		IEA: Inferred from Electronic Annotation		C	Source: UniProtKB-SubCell
	GO:0031966	mitochondrial membrane		IEA: Inferred from Electronic Annotation		C	Source: UniProtKB-SubCell
	GO:0004252	serine-type endopeptidase activity		IEA: Inferred from Electronic Annotation		F	Source: InterPro
	GO:0007628	adult walking behavior		IMP: Inferred from Mutant Phenotype		P	Source: MGI
	GO:0006915	apoptosis		IEA: Inferred from Electronic Annotation		P	Source: UniProtKB-KW
	GO:0030900	forebrain development		IMP: Inferred from Mutant Phenotype		P	Source: MGI
	GO:0008629	induction of apoptosis by intracellular signals		IMP: Inferred from Mutant Phenotype		P	Source: MGI
	GO:0007005	mitochondrion organization		IMP: Inferred from Mutant Phenotype		P	Source: MGI
	GO:0048666	neuron development		IMP: Inferred from Mutant Phenotype		P	Source: MGI
	GO:0006508	proteolysis		IEA: Inferred from Electronic Annotation		P	Source: InterPro
	GO:0040014	regulation of multicellular organism growth		IMP: Inferred from Mutant Phenotype		P	Source: MGI
	GO:0005515	protein binding	PMID:20614026^[1]	IPI: Inferred from Physical Interaction	UniProtKB:P27512	F	Figures 1 & 2 show co-immunoprecipitation using Western blot verification of mass spectrometry results of hmCD40 and hmCD40D67 ARC ‘‘activated receptor capture’’ samples.	complete
	GO:0009898	internal side of plasma membrane	PMID:20614026^[1]	IDA: Inferred from Direct Assay		C	Figure 2. Western blot verification of mass spectrometry results. hmCD40 and hmCD40D67 ARC ‘‘activated receptor capture’’ samples.	complete
	GO:0003824	catalytic activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR009003	F
	GO:0004252	serine-type endopeptidase activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR001254	F
	GO:0004252	serine-type endopeptidase activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR001940	F
	GO:0005739	mitochondrion	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0496	C
	GO:0005739	mitochondrion	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000030076	C
	GO:0005739	mitochondrion	PMID:14651853^[2]	IDA: Inferred from Direct Assay		C
	GO:0005739	mitochondrion	PMID:18614015^[3]	IDA: Inferred from Direct Assay		C
	GO:0005758	mitochondrial intermembrane space	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000258080	C
	GO:0005758	mitochondrial intermembrane space	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0169	C
	GO:0005829	cytosol	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000030076	C
	GO:0006508	proteolysis	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR001254	P
	GO:0006508	proteolysis	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR001940	P
	GO:0006915	apoptosis	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0053	P
	GO:0007005	mitochondrion organization	PMID:15574596^[4]	IMP: Inferred from Mutant Phenotype	MGI:MGI:3512633	P
	GO:0007628	adult walking behavior	PMID:8325640^[5]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1856960	P
	GO:0008233	peptidase activity	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0645	F
	GO:0008236	serine-type peptidase activity	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0720	F
	GO:0008236	serine-type peptidase activity	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000030076	F
	GO:0008344	adult locomotory behavior	PMID:15509788^[6]	IMP: Inferred from Mutant Phenotype	MGI:MGI:3512633	P
	GO:0008629	induction of apoptosis by intracellular signals	PMID:15509788^[6]	IMP: Inferred from Mutant Phenotype	MGI:MGI:3512633	P
	GO:0009898	internal side of plasma membrane	PMID:20614026^[1]	IDA: Inferred from Direct Assay		C
	GO:0016020	membrane	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0472	C
	GO:0016021	integral to membrane	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0812	C
	GO:0016787	hydrolase activity	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0378	F
	GO:0030900	forebrain development	PMID:15509788^[6]	IMP: Inferred from Mutant Phenotype	MGI:MGI:3512633	P
	GO:0031966	mitochondrial membrane	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0171	C
	GO:0035631	CD40 receptor complex	PMID:20614026^[1]	IDA: Inferred from Direct Assay		C
	GO:0040014	regulation of multicellular organism growth	PMID:15509788^[6]	IMP: Inferred from Mutant Phenotype	MGI:MGI:3512633	P
	GO:0040014	regulation of multicellular organism growth	PMID:8325640^[5]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1856960	P
	GO:0043065	positive regulation of apoptosis	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000030076	P
	GO:0048666	neuron development	PMID:8325640^[5]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1856960	P
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 Hostager BS et al. (2010) HOIL-1L interacting protein (HOIP) as an NF-kappaB regulating component of the CD40 signaling complex. PLoS One 5: e11380 PubMed GONUTS page
↑ Mootha VK et al. (2003) Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria. Cell 115: 629-40 PubMed GONUTS page
↑ Pagliarini DJ et al. (2008) A mitochondrial protein compendium elucidates complex I disease biology. Cell 134: 112-23 PubMed GONUTS page
↑ Dannenberg JH et al. (2004) Tissue-specific tumor suppressor activity of retinoblastoma gene homologs p107 and p130. Genes Dev 18: 2952-62 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 Jones JM et al. (1993) mnd2: a new mouse model of inherited motor neuron disease. Genomics 16: 669-77 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 ^6.3 Martins LM et al. (2004) Neuroprotective role of the Reaper-related serine protease HtrA2/Omi revealed by targeted deletion in mice. Mol Cell Biol 24: 9848-62 PubMed GONUTS page

[PMID:20614026-0] 1.0 ^1.1 ^1.2 ^1.3 Hostager BS et al. (2010) HOIL-1L interacting protein (HOIP) as an NF-kappaB regulating component of the CD40 signaling complex. PLoS One 5: e11380 PubMed GONUTS page

[PMID:14651853-1] Mootha VK et al. (2003) Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria. Cell 115: 629-40 PubMed GONUTS page

[PMID:18614015-2] Pagliarini DJ et al. (2008) A mitochondrial protein compendium elucidates complex I disease biology. Cell 134: 112-23 PubMed GONUTS page

[PMID:15574596-3] Dannenberg JH et al. (2004) Tissue-specific tumor suppressor activity of retinoblastoma gene homologs p107 and p130. Genes Dev 18: 2952-62 PubMed GONUTS page

[PMID:8325640-4] 5.0 ^5.1 ^5.2 Jones JM et al. (1993) mnd2: a new mouse model of inherited motor neuron disease. Genomics 16: 669-77 PubMed GONUTS page

[PMID:15509788-5] 6.0 ^6.1 ^6.2 ^6.3 Martins LM et al. (2004) Neuroprotective role of the Reaper-related serine protease HtrA2/Omi revealed by targeted deletion in mice. Mol Cell Biol 24: 9848-62 PubMed GONUTS page

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MOUSE:HTRA2

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