MOUSE:HIPK2

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Species (Taxon ID)	Mus musculus (Mouse). (taxon:10090)
Gene Name(s)	Hipk2 ( synonyms: Nbak1, Stank )
Protein Name(s)	Homeodomain-interacting protein kinase 2 Nuclear body-associated kinase 1 Sialophorin tail-associated nuclear serine/threonine-protein kinase
External Links
UniProt Identifier	HIPK2_MOUSE
UniProt Accessions	Q9QZR5, O88905, Q99P45, Q99P46, Q9D2E6, Q9D474, Q9EQL2, Q9QZR4,
EMBL	AF077659, AF273680, AF208292, AF333791, AF333792, AF170301, AF170302, AK016742, AK019821,
PIR	T17088,
RefSeq	NP_001129537.1, NP_034563.2,
IntAct	Q9QZR5,
Ensembl	ENSMUST00000101516, ENSMUST00000114856, ENSMUST00000160360, ENSMUST00000160962, ENSMUST00000161779, ENSMUST00000162359, ENSMUST00000164534,
Pfam	PF00069,

Annotations

Qualifier	GO ID	GO term name	Reference	Evidence Code	with/from	Aspect	Notes	Status
	GO:0005737	cytoplasm		IDA: Inferred from Direct Assay		C	Source: MGI
	GO:0016605	PML body		TAS: Traceable Author Statement		C	Source: MGI
	GO:0005524	ATP binding		IEA: Inferred from Electronic Annotation		F	Source: UniProtKB-KW
	GO:0004674	protein serine/threonine kinase activity		IEA: Inferred from Electronic Annotation		F	Source: UniProtKB-KW
	GO:0003714	transcription corepressor activity		IDA: Inferred from Direct Assay		F	Source: UniProtKB
	GO:0046790	virion binding		ISS: Inferred from Sequence or Structural Similarity		F	Source: UniProtKB
	GO:0007628	adult walking behavior		IMP: Inferred from Mutant Phenotype		P	Source: MGI
	GO:0009952	anterior/posterior pattern formation		IGI: Inferred from Genetic Interaction		P	Source: MGI
	GO:0006915	apoptosis		IEA: Inferred from Electronic Annotation		P	Source: UniProtKB-KW
	GO:0042771	DNA damage response, signal transduction by...		IGI: Inferred from Genetic Interaction		P	Source: MGI
	GO:0043524	negative regulation of neuron apoptosis		IMP: Inferred from Mutant Phenotype		P	Source: MGI
	GO:0000122	negative regulation of transcription from R...		IDA: Inferred from Direct Assay		P	Source: UniProtKB
	GO:0008284	positive regulation of cell proliferation		IGI: Inferred from Genetic Interaction		P	Source: MGI
	GO:0043388	positive regulation of DNA binding		IDA: Inferred from Direct Assay		P	Source: UniProtKB
	GO:0046330	positive regulation of JNK cascade		ISS: Inferred from Sequence or Structural Similarity		P	Source: UniProtKB
	GO:0045944	positive regulation of transcription from R...		IGI: Inferred from Genetic Interaction		P	Source: MGI
	GO:0030511	positive regulation of transforming growth ...		ISS: Inferred from Sequence or Structural Similarity		P	Source: UniProtKB
	GO:0006468	protein amino acid phosphorylation		IDA: Inferred from Direct Assay		P	Source: UniProtKB
	GO:0007224	smoothened signaling pathway		IGI: Inferred from Genetic Interaction		P	Source: MGI
	GO:0006350	transcription		IEA: Inferred from Electronic Annotation		P	Source: UniProtKB-KW
	GO:0007179	transforming growth factor beta receptor si...		IMP: Inferred from Mutant Phenotype		P	Source: MGI
	GO:0050882	voluntary musculoskeletal movement		IMP: Inferred from Mutant Phenotype		P	Source: MGI
	GO:0008283	cell proliferation	PMID:20307497^[1]	IMP: Inferred from Mutant Phenotype		P	figure 4C	complete
	GO:0010629	negative regulation of gene expression	PMID:20307497^[1]	IMP: Inferred from Mutant Phenotype		P	figure 4D	complete
	GO:0000122	negative regulation of transcription from RNA polymerase II promoter	PMID:9748262^[2]	IDA: Inferred from Direct Assay		P
	GO:0000166	nucleotide binding	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0547	F
	GO:0003714	transcription corepressor activity	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000385571	F
	GO:0003714	transcription corepressor activity	PMID:9748262^[2]	IDA: Inferred from Direct Assay		F
	GO:0004672	protein kinase activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR000719	F
	GO:0004672	protein kinase activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR017442	F
	GO:0004672	protein kinase activity	PMID:9748262^[2]	IDA: Inferred from Direct Assay		F
	GO:0004674	protein serine/threonine kinase activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR002290	F
	GO:0004674	protein serine/threonine kinase activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR008271	F
	GO:0004674	protein serine/threonine kinase activity	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0723	F
	GO:0005515	protein binding	PMID:15082531^[3]	IPI: Inferred from Physical Interaction	UniProtKB:O54949	F
	GO:0005515	protein binding	PMID:15082531^[3]	IPI: Inferred from Physical Interaction	UniProtKB:P06876	F
	GO:0005515	protein binding	PMID:15526030^[4]	IPI: Inferred from Physical Interaction	UniProtKB:O35625	F
	GO:0005515	protein binding	PMID:15526030^[4]	IPI: Inferred from Physical Interaction	UniProtKB:P02340	F
	GO:0005515	protein binding	PMID:18093972^[5]	IPI: Inferred from Physical Interaction	UniProtKB:O54927	F
	GO:0005515	protein binding	PMID:18093972^[5]	IPI: Inferred from Physical Interaction	UniProtKB:Q9Y6I7	F
	GO:0005515	protein binding	PMID:9748262^[2]	IPI: Inferred from Physical Interaction	UniProtKB:P42580	F
	GO:0005515	protein binding	PMID:9748262^[2]	IPI: Inferred from Physical Interaction	UniProtKB:P42582	F
	GO:0005524	ATP binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR000719	F
	GO:0005524	ATP binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR002290	F
	GO:0005524	ATP binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR017441	F
	GO:0005524	ATP binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR017442	F
	GO:0005524	ATP binding	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0067	F
	GO:0005634	nucleus	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0539	C
	GO:0005634	nucleus	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000385571	C
	GO:0005634	nucleus	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0191	C
	GO:0005634	nucleus	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:Q9H2X6	C
	GO:0005634	nucleus	PMID:20579985^[6]	IDA: Inferred from Direct Assay		C
	GO:0005634	nucleus	PMID:9748262^[2]	IDA: Inferred from Direct Assay		C
	GO:0005737	cytoplasm	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0963	C
	GO:0005737	cytoplasm	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0086	C
	GO:0005737	cytoplasm	PMID:11078605^[7]	IDA: Inferred from Direct Assay		C
	GO:0005813	centrosome	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000385571	C
	GO:0006351	transcription, DNA-dependent	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0804	P
	GO:0006355	regulation of transcription, DNA-dependent	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0805	P
	GO:0006468	protein phosphorylation	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR000719	P
	GO:0006468	protein phosphorylation	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR002290	P
	GO:0006468	protein phosphorylation	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR008271	P
	GO:0006468	protein phosphorylation	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR017442	P
	GO:0006468	protein phosphorylation	PMID:9748262^[2]	IDA: Inferred from Direct Assay		P
	GO:0006915	apoptosis	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0053	P
	GO:0006978	DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000385571	P
	GO:0007179	transforming growth factor beta receptor signaling pathway	PMID:17159989^[8]	IMP: Inferred from Mutant Phenotype	MGI:MGI:3487301	P
	GO:0007224	smoothened signaling pathway	PMID:16537918^[9]	IGI: Inferred from Genetic Interaction	MGI:MGI:1314872	P
	GO:0007628	adult walking behavior	PMID:17159989^[8]	IMP: Inferred from Mutant Phenotype	MGI:MGI:3487301	P
	GO:0008284	positive regulation of cell proliferation	PMID:16537918^[9]	IGI: Inferred from Genetic Interaction	MGI:MGI:1314872	P
	GO:0008344	adult locomotory behavior	PMID:17159989^[8]	IMP: Inferred from Mutant Phenotype	MGI:MGI:3487301	P
	GO:0009952	anterior/posterior pattern formation	PMID:16537918^[9]	IGI: Inferred from Genetic Interaction	MGI:MGI:1314872	P
	GO:0010842	retina layer formation	PMID:20579985^[6]	IMP: Inferred from Mutant Phenotype		P
	GO:0016301	kinase activity	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0418	F
	GO:0016310	phosphorylation	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0418	P
	GO:0016604	nuclear body	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000385571	C
	GO:0016605	PML body	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000385571	C
	GO:0016605	PML body	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0465	C
	GO:0016605	PML body	PMID:12529400^[10]	TAS: Traceable Author Statement		C
	GO:0016740	transferase activity	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0808	F
	GO:0016772	transferase activity, transferring phosphorus-containing groups	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR011009	F
	GO:0030182	neuron differentiation	PMID:20579985^[6]	IMP: Inferred from Mutant Phenotype		P
	GO:0030511	positive regulation of transforming growth factor beta receptor signaling pathway	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000385571	P
	GO:0030511	positive regulation of transforming growth factor beta receptor signaling pathway	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:Q9H2X6	P
	GO:0030514	negative regulation of BMP signaling pathway	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000385571	P
	GO:0031965	nuclear membrane	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000385571	C
	GO:0043388	positive regulation of DNA binding	PMID:9748262^[2]	IDA: Inferred from Direct Assay		P
	GO:0043524	negative regulation of neuron apoptosis	PMID:17159989^[8]	IMP: Inferred from Mutant Phenotype	MGI:MGI:3487301	P
	GO:0045893	positive regulation of transcription, DNA-dependent	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000385571	P
	GO:0046330	positive regulation of JNK cascade	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000385571	P
	GO:0046330	positive regulation of JNK cascade	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:Q9H2X6	P
	GO:0046332	SMAD binding	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000385571	F
	GO:0046790	virion binding	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000385571	F
	GO:0046790	virion binding	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:Q9H2X6	F
	GO:0048596	embryonic camera-type eye morphogenesis	PMID:20579985^[6]	IMP: Inferred from Mutant Phenotype		P
	GO:0050882	voluntary musculoskeletal movement	PMID:17159989^[8]	IMP: Inferred from Mutant Phenotype	MGI:MGI:3487301	P
	GO:0060059	embryonic retina morphogenesis in camera-type eye	PMID:20579985^[6]	IMP: Inferred from Mutant Phenotype		P
	GO:0060235	lens induction in camera-type eye	PMID:20579985^[6]	IMP: Inferred from Mutant Phenotype		P
	GO:0060395	SMAD protein signal transduction	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000385571	P
	GO:0061072	iris morphogenesis	PMID:20579985^[6]	IMP: Inferred from Mutant Phenotype		P
NOT	GO:0003677	DNA binding	PMID:9748262^[2]	IDA: Inferred from Direct Assay		F
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Kim EA et al. (2010) Homeodomain-interacting protein kinase 2 (HIPK2) targets beta-catenin for phosphorylation and proteasomal degradation. Biochem Biophys Res Commun 394: 966-71 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 ^2.6 ^2.7 ^2.8 Kim YH et al. (1998) Homeodomain-interacting protein kinases, a novel family of co-repressors for homeodomain transcription factors. J Biol Chem 273: 25875-9 PubMed GONUTS page
↑ ^3.0 ^3.1 Kanei-Ishii C et al. (2004) Wnt-1 signal induces phosphorylation and degradation of c-Myb protein via TAK1, HIPK2, and NLK. Genes Dev 18: 816-29 PubMed GONUTS page
↑ ^4.0 ^4.1 Rui Y et al. (2004) Axin stimulates p53 functions by activation of HIPK2 kinase through multimeric complex formation. EMBO J 23: 4583-94 PubMed GONUTS page
↑ ^5.0 ^5.1 Choi DW et al. (2008) Ubiquitination and degradation of homeodomain-interacting protein kinase 2 by WD40 repeat/SOCS box protein WSB-1. J Biol Chem 283: 4682-9 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 ^6.3 ^6.4 ^6.5 ^6.6 Inoue T et al. (2010) Involvement of the Hipk family in regulation of eyeball size, lens formation and retinal morphogenesis. FEBS Lett 584: 3233-8 PubMed GONUTS page
↑ Wang W et al. (2000) Identification and cloning of a CD43-associated serine/threonine kinase. Cell Immunol 205: 34-9 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 ^8.3 ^8.4 Zhang J et al. (2007) Essential function of HIPK2 in TGFbeta-dependent survival of midbrain dopamine neurons. Nat Neurosci 10: 77-86 PubMed GONUTS page
↑ ^9.0 ^9.1 ^9.2 Isono K et al. (2006) Overlapping roles for homeodomain-interacting protein kinases hipk1 and hipk2 in the mediation of cell growth in response to morphogenetic and genotoxic signals. Mol Cell Biol 26: 2758-71 PubMed GONUTS page
↑ Ecsedy JA et al. (2003) Homeodomain-interacting protein kinase 1 modulates Daxx localization, phosphorylation, and transcriptional activity. Mol Cell Biol 23: 950-60 PubMed GONUTS page

[PMID:20307497-0] 1.0 ^1.1 Kim EA et al. (2010) Homeodomain-interacting protein kinase 2 (HIPK2) targets beta-catenin for phosphorylation and proteasomal degradation. Biochem Biophys Res Commun 394: 966-71 PubMed GONUTS page

[PMID:9748262-1] 2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 ^2.6 ^2.7 ^2.8 Kim YH et al. (1998) Homeodomain-interacting protein kinases, a novel family of co-repressors for homeodomain transcription factors. J Biol Chem 273: 25875-9 PubMed GONUTS page

[PMID:15082531-2] 3.0 ^3.1 Kanei-Ishii C et al. (2004) Wnt-1 signal induces phosphorylation and degradation of c-Myb protein via TAK1, HIPK2, and NLK. Genes Dev 18: 816-29 PubMed GONUTS page

[PMID:15526030-3] 4.0 ^4.1 Rui Y et al. (2004) Axin stimulates p53 functions by activation of HIPK2 kinase through multimeric complex formation. EMBO J 23: 4583-94 PubMed GONUTS page

[PMID:18093972-4] 5.0 ^5.1 Choi DW et al. (2008) Ubiquitination and degradation of homeodomain-interacting protein kinase 2 by WD40 repeat/SOCS box protein WSB-1. J Biol Chem 283: 4682-9 PubMed GONUTS page

[PMID:20579985-5] 6.0 ^6.1 ^6.2 ^6.3 ^6.4 ^6.5 ^6.6 Inoue T et al. (2010) Involvement of the Hipk family in regulation of eyeball size, lens formation and retinal morphogenesis. FEBS Lett 584: 3233-8 PubMed GONUTS page

[PMID:11078605-6] Wang W et al. (2000) Identification and cloning of a CD43-associated serine/threonine kinase. Cell Immunol 205: 34-9 PubMed GONUTS page

[PMID:17159989-7] 8.0 ^8.1 ^8.2 ^8.3 ^8.4 Zhang J et al. (2007) Essential function of HIPK2 in TGFbeta-dependent survival of midbrain dopamine neurons. Nat Neurosci 10: 77-86 PubMed GONUTS page

[PMID:16537918-8] 9.0 ^9.1 ^9.2 Isono K et al. (2006) Overlapping roles for homeodomain-interacting protein kinases hipk1 and hipk2 in the mediation of cell growth in response to morphogenetic and genotoxic signals. Mol Cell Biol 26: 2758-71 PubMed GONUTS page

[PMID:12529400-9] Ecsedy JA et al. (2003) Homeodomain-interacting protein kinase 1 modulates Daxx localization, phosphorylation, and transcriptional activity. Mol Cell Biol 23: 950-60 PubMed GONUTS page

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MOUSE:HIPK2

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