MOUSE:HIF1A

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Hif1a
Protein Name(s)	Hypoxia-inducible factor 1-alpha HIF-1-alpha HIF1-alpha ARNT-interacting protein
External Links
UniProt	Q61221
EMBL	U59496 AF003695 AF004155 AF004141 AF004142 AF004143 AF004144 AF004145 AF004146 AF004147 AF004148 AF004149 AF004150 AF004151 AF004152 AF004153 AF004154 Y09085 Y09085 Y13656 AK034087 AK076395 AK033471 AK017853 BC026139 X95580 X95002
CCDS	CCDS25977.1
PIR	JC4837
RefSeq	NP_034561.2
UniGene	Mm.3879 Mm.446610
ProteinModelPortal	Q61221
SMR	Q61221
BioGrid	200304
IntAct	Q61221
MINT	MINT-1179248
BindingDB	Q61221
ChEMBL	CHEMBL6046
PhosphoSite	Q61221
PRIDE	Q61221
Ensembl	ENSMUST00000021530 ENSMUST00000110461 ENSMUST00000110464
GeneID	15251
KEGG	mmu:15251
UCSC	uc007nwo.2 uc007nwq.2
CTD	3091
MGI	MGI:106918
eggNOG	NOG289264
GeneTree	ENSGT00760000118788
HOVERGEN	HBG060456
InParanoid	Q61221
KO	K08268
OMA	QNAQRKR
OrthoDB	EOG7JDQX8
PhylomeDB	Q61221
TreeFam	TF317772
Reactome	REACT_196464 REACT_199104 REACT_199107 REACT_199108 REACT_241925
ChiTaRS	Hif1a
NextBio	287865
PRO	PR:Q61221
Proteomes	UP000000589
Bgee	Q61221
CleanEx	MM_HIF1A
Genevestigator	Q61221
GO	GO:0005829 GO:0031514 GO:0005730 GO:0005634 GO:0005667 GO:0003677 GO:0035035 GO:0042826 GO:0046982 GO:0001077 GO:0003705 GO:0001076 GO:0043565 GO:0003700 GO:0004871 GO:0044212 GO:0001525 GO:0019896 GO:0001922 GO:0001568 GO:0048514 GO:0003208 GO:0051216 GO:0030154 GO:0006879 GO:0071456 GO:0071347 GO:0021987 GO:0032963 GO:0002248 GO:0048546 GO:0071542 GO:0051541 GO:0035162 GO:0001892 GO:0061030 GO:0001837 GO:0042593 GO:0001947 GO:0042541 GO:0097411 GO:0060574 GO:0006089 GO:0007595 GO:0046716 GO:0043066 GO:0030502 GO:0045926 GO:2001054 GO:0043524 GO:0070244 GO:0032007 GO:0001755 GO:0021502 GO:0003151 GO:0032364 GO:0010634 GO:0045648 GO:0046886 GO:0035774 GO:0002052 GO:0010870 GO:0045944 GO:0061419 GO:0045893 GO:0030949 GO:0010575 GO:0050790 GO:0042127 GO:0006110 GO:0070243 GO:0043619 GO:0006355 GO:0032909 GO:0001666 GO:0014850 GO:0061298 GO:0006366 GO:0010573 GO:0001944 GO:0008542
InterPro	IPR011598 IPR001321 IPR014887 IPR021537 IPR001610 IPR000014 IPR013767
Pfam	PF11413 PF08778 PF00989
PRINTS	PR01080
SMART	SM00353 SM00086 SM00091
SUPFAM	SSF47459 SSF55785
TIGRFAMs	TIGR00229
PROSITE	PS50888 PS50112

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0030279	negative regulation of ossification	PMID:22081627^[1]	ECO:0000315			P		Fig. 1, Fig. 4, and Fig. 5	complete CACAO 3001
enables	GO:0043565	sequence-specific DNA binding	PMID:26245371^[2]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0046982	protein heterodimerization activity	PMID:26245371^[2]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0070888	E-box binding	PMID:24011070^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		F	has_direct_input:(ENSEMBL:ENSMUSG00000078190)	Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:24011070^[3]	ECO:0000314	direct assay evidence used in manual assertion		P	regulates_expression_of:(ENSEMBL:ENSMUSG00000078190)	Seeded From UniProt	complete
involved_in	GO:0030279	negative regulation of ossification	PMID:22081627^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1903715	regulation of aerobic respiration	PMID:18281291^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	part_of:(GO:0071456) has_regulation_target:(UniProtKB:Q99J83) has_regulation_target:(UniProtKB:O88597)	Seeded From UniProt	complete
involved_in	GO:2000378	negative regulation of reactive oxygen species metabolic process	PMID:18281291^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	part_of:(GO:0071456)	Seeded From UniProt	complete
involved_in	GO:0043066	negative regulation of apoptotic process	PMID:18281291^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	part_of:(GO:0071456)	Seeded From UniProt	complete
involved_in	GO:0010508	positive regulation of autophagy	PMID:18281291^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	part_of:(GO:0071456)\|part_of:(GO:0071456) has_regulation_target:(UniProtKB:Q99J83)\|part_of(GO:0071456) has_regulation_target:(UniProtKB:O88597)\|part_of(GO:0071456) has_regulation_target:(UniProtKB:O55003)	Seeded From UniProt	complete
involved_in	GO:0010468	regulation of gene expression	PMID:18281291^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_regulation_target:(UniProtKB:O55003) part_of:(GO:0071456)\|has_regulation_target(UniProtKB:O55003) occurs_in:(UBERON:0002048)	Seeded From UniProt	complete
part_of	GO:0016607	nuclear speck	PMID:21546903^[5]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:21546903^[5]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:1903599	positive regulation of autophagy of mitochondrion	PMID:18281291^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	part_of:(GO:0071456) has_regulation_target:(UniProtKB:Q99J83) has_regulation_target:(UniProtKB:O88597)	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:24553947^[6]	ECO:0000314	direct assay evidence used in manual assertion		C	exists_during:(GO:0071456)	Seeded From UniProt	complete
involved_in	GO:0051541	elastin metabolic process	PMID:18037992^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0042826	histone deacetylase binding	PMID:19071119^[8]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q9UQL6	F		Seeded From UniProt	complete
enables	GO:0042826	histone deacetylase binding	PMID:19071119^[8]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P56524	F		Seeded From UniProt	complete
involved_in	GO:0032963	collagen metabolic process	PMID:18037992^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010634	positive regulation of epithelial cell migration	PMID:18037992^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0002248	connective tissue replacement involved in inflammatory response wound healing	PMID:18037992^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0001837	epithelial to mesenchymal transition	PMID:18037992^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0071456	cellular response to hypoxia	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q16665	P		Seeded From UniProt	complete
involved_in	GO:0061419	positive regulation of transcription from RNA polymerase II promoter in response to hypoxia	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q16665	P		Seeded From UniProt	complete
enables	GO:0046982	protein heterodimerization activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q16665	F		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q16665	P		Seeded From UniProt	complete
enables	GO:0035035	histone acetyltransferase binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q16665	F		Seeded From UniProt	complete
involved_in	GO:0019896	axonal transport of mitochondrion	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q16665	P		Seeded From UniProt	complete
involved_in	GO:0010575	positive regulation of vascular endothelial growth factor production	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q16665	P		Seeded From UniProt	complete
involved_in	GO:0006355	regulation of transcription, DNA-templated	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q16665	P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q16665	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:18295594^[9]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000115) part_of:(UBERON:0000956)	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q16665	C		Seeded From UniProt	complete
involved_in	GO:0001666	response to hypoxia	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q16665	P		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0039411 FB:FBgn0262139 FB:FBgn0266411 MGI:MGI:106918 MGI:MGI:109169 MGI:MGI:2664186 PANTHER:PTN001127032 RGD:61928 RGD:68404 RGD:70332 UniProtKB:Q16665 UniProtKB:Q8IUM7 UniProtKB:Q99814 WB:WBGene00000521 WB:WBGene00001851	P		Seeded From UniProt	complete
involved_in	GO:0006357	regulation of transcription by RNA polymerase II	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0039411 PANTHER:PTN000548738 UniProtKB:Q9Y2N7	P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0004666 FB:FBgn0039411 FB:FBgn0262139 FB:FBgn0266411 MGI:MGI:106918 MGI:MGI:109169 MGI:MGI:109205 MGI:MGI:1351610 MGI:MGI:1859778 MGI:MGI:2664186 MGI:MGI:98306 MGI:MGI:98307 PANTHER:PTN000548738 RGD:61928 RGD:68404 RGD:70332 UniProtKB:Q16665 UniProtKB:Q9XTA5 WB:WBGene00001851	C		Seeded From UniProt	complete
enables	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:106918 MGI:MGI:2664186 PANTHER:PTN000548738 UniProtKB:Q8IUM7	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001922	B-1 B cell homeostasis	PMID:11854513^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001892	embryonic placenta development	PMID:16287860^[12]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:109169	P	results_in_development_of:(EMAPA:16042)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001892	embryonic placenta development	PMID:16287860^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2179429	P	results_in_development_of:(EMAPA:16042)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001755	neural crest cell migration	PMID:14659802^[13]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2179429	P	occurs_in:(EMAPA:16272)\|occurs_in:(EMAPA:16399)\|occurs_in:(EMAPA:16346)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001666	response to hypoxia	PMID:17437992^[14]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:96552	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001666	response to hypoxia	PMID:9606183^[15]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2385358	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001666	response to hypoxia	PMID:19273585^[16]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2386679	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001666	response to hypoxia	PMID:11792862^[17]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857719	P	occurs_in:(EMAPA:19211)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001666	response to hypoxia	PMID:10074486^[18]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857719	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001666	response to hypoxia	PMID:8702901^[19]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001666	response to hypoxia	PMID:11801735^[20]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001666	response to hypoxia	PMID:11782478^[21]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q16665	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001666	response to hypoxia	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q16665	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001666	response to hypoxia	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:61928	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001568	blood vessel development	PMID:9436976^[22]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857719	P	occurs_in:(EMAPA:16104)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001525	angiogenesis	PMID:15073147^[23]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2386679	P	has_participant:(EMAPA:18513)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001525	angiogenesis	PMID:14659802^[13]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2179429	P	has_participant:(EMAPA:16104)	Seeded From UniProt	complete
enables	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	PMID:21856340^[24]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q16665	F		Seeded From UniProt	complete
enables	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	PMID:24030251^[25]	ECO:0000314	direct assay evidence used in manual assertion		F	occurs_in:(CL:0000653)\|occurs_in:(CL:0000653)\|occurs_in:(CL:0000653)	Seeded From UniProt	complete
enables	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q16665	F		Seeded From UniProt	complete
contributes_to	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q16665	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0000122	negative regulation of transcription by RNA polymerase II	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:61928	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:2001054	negative regulation of mesenchymal cell apoptotic process	PMID:10328919^[26]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857719	P	regulates_o_occurs_in:(EMAPA:16039) regulates_o_occurs_in:(CL:0000134)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1903377	negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q16665	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1902895	positive regulation of pri-miRNA transcription by RNA polymerase II	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q16665	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0097411	hypoxia-inducible factor-1alpha signaling pathway	PMID:8470821^[27]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0090575	RNA polymerase II transcription factor complex	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q16665	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071542	dopaminergic neuron differentiation	PMID:17215402^[28]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:103178	P	results_in_acquisition_of_features_of:(CL:0000700)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071542	dopaminergic neuron differentiation	PMID:17215402^[28]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2386679	P	occurs_in:(EMAPA:16974) results_in_acquisition_of_features_of:(CL:0000700)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071456	cellular response to hypoxia	PMID:24011070^[3]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:101884 MGI:MGI:2676890 MGI:MGI:3618742	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071456	cellular response to hypoxia	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q16665	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071456	cellular response to hypoxia	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:61928	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0070244	negative regulation of thymocyte apoptotic process	PMID:15456877^[29]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2386679,MGI:MGI:2448686	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0070243	regulation of thymocyte apoptotic process	PMID:15456877^[29]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:103223	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0061419	positive regulation of transcription from RNA polymerase II promoter in response to hypoxia	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q16665	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0061298	retina vasculature development in camera-type eye	PMID:21212189^[30]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2386679	P	results_in_development_of:(EMAPA:36520)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0061072	iris morphogenesis	PMID:22627278^[31]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:103223	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0061030	epithelial cell differentiation involved in mammary gland alveolus development	PMID:12620994^[32]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2386679	P	occurs_in:(EMAPA:36566) results_in_acquisition_of_features_of:(CL:0002325)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060992	response to fungicide	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:61928	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060574	intestinal epithelial cell maturation	PMID:20808783^[33]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2384429	P	occurs_in:(EMAPA:18852) results_in_maturation_of:(CL:0000584)\|occurs_in(EMAPA:18852) results_in_maturation_of:(CL:0000510)\|occurs_in(EMAPA:18852) results_in_maturation_of:(CL:0000164)	Seeded From UniProt	complete
enables	GO:0051879	Hsp90 protein binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q16665	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051216	cartilage development	PMID:11691837^[34]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2386649,MGI:MGI:2386679	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050790	regulation of catalytic activity	PMID:15328538^[35]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2386679	P	regulates_o_occurs_in:(EMAPA:18276)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048661	positive regulation of smooth muscle cell proliferation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:61928	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048593	camera-type eye morphogenesis	PMID:22627278^[31]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:103223	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048546	digestive tract morphogenesis	PMID:20808783^[33]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2384429	P	has_participant:(EMAPA:32834)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048514	blood vessel morphogenesis	PMID:9606183^[15]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2385358	P	has_participant:(EMAPA:16370)\|has_participant:(EMAPA:16201)\|has_participant:(EMAPA:16240)	Seeded From UniProt	complete
enables	GO:0046982	protein heterodimerization activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q16665	F		Seeded From UniProt	complete
enables	GO:0046982	protein heterodimerization activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:61928	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0046886	positive regulation of hormone biosynthetic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q16665	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0046716	muscle cell cellular homeostasis	PMID:15328538^[35]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2386679	P	occurs_in:(EMAPA:35578)\|occurs_in:(EMAPA:35375)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:9113979^[36]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:88071	P	has_regulation_target:(MGI:MGI:95407)\|has_regulation_target:(MGI:MGI:103178)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:15766748^[37]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:88071 MGI:MGI:97856 MGI:MGI:97857 MGI:MGI:97858	P	has_regulation_target:(MGI:MGI:95407)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:21856340^[24]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:17284606^[38]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2386679	P	has_regulation_target:(MGI:MGI:95407)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:8702901^[19]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:24030251^[25]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(CL:0000653)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:61928	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000008	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q16665	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045926	negative regulation of growth	PMID:11691837^[34]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2386649,MGI:MGI:2386679	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045906	negative regulation of vasoconstriction	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:61928	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045893	positive regulation of transcription, DNA-templated	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q16665	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045766	positive regulation of angiogenesis	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q16665	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045722	positive regulation of gluconeogenesis	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:61928	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045648	positive regulation of erythrocyte differentiation	PMID:16787915^[39]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857719	P		Seeded From UniProt	complete
enables	GO:0044877	protein-containing complex binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:61928	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043619	regulation of transcription from RNA polymerase II promoter in response to oxidative stress	PMID:12832481^[40]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2385358	P	regulates_o_occurs_in:(CL:0000057) has_regulation_target:(MGI:MGI:103178)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043619	regulation of transcription from RNA polymerase II promoter in response to oxidative stress	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q16665	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043619	regulation of transcription from RNA polymerase II promoter in response to oxidative stress	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:61928	P		Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	PMID:9368100^[41]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	PMID:24030251^[25]	ECO:0000314	direct assay evidence used in manual assertion		F	occurs_in:(CL:0000653)	Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:61928	F		Seeded From UniProt	complete
contributes_to	GO:0043565	sequence-specific DNA binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q16665	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043536	positive regulation of blood vessel endothelial cell migration	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q16665	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043524	negative regulation of neuron apoptotic process	PMID:12972594^[42]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2677899	P	occurs_in:(EMAPA:16896) regulates_o_occurs_in:(CL:0000117)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043066	negative regulation of apoptotic process	PMID:17181398^[43]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857719	P	regulates_o_occurs_in:(EMAPA:32782) regulates_o_occurs_in:(CL:0000062)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043066	negative regulation of apoptotic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:61928	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043065	positive regulation of apoptotic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:61928	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042593	glucose homeostasis	PMID:17437992^[14]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042593	glucose homeostasis	PMID:15328538^[35]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2386679	P	has_participant:(EMAPA:18276)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042541	hemoglobin biosynthetic process	PMID:16787915^[39]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857719	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042127	regulation of cell population proliferation	PMID:17437992^[14]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0035774	positive regulation of insulin secretion involved in cellular response to glucose stimulus	PMID:20440072^[44]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2677892	P	regulates_o_occurs_in:(EMAPA:32927) regulates_o_occurs_in:(CL:0000169)	Seeded From UniProt	complete
enables	GO:0035257	nuclear hormone receptor binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q16665	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0035162	embryonic hemopoiesis	PMID:16787915^[39]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857719	P	has_participant:(EMAPA:16042)	Seeded From UniProt	complete
enables	GO:0035035	histone acetyltransferase binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q16665	F		Seeded From UniProt	complete
part_of	GO:0032991	protein-containing complex	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q16665	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032909	regulation of transforming growth factor beta2 production	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q16665	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032364	oxygen homeostasis	PMID:9436976^[22]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857719	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032364	oxygen homeostasis	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q16665	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032007	negative regulation of TOR signaling	PMID:20808783^[33]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2384429	P	regulates_o_occurs_in:(EMAPA:35778) regulates_o_occurs_in:(CL:0002563)	Seeded From UniProt	complete
enables	GO:0031625	ubiquitin protein ligase binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q16665	F		Seeded From UniProt	complete
enables	GO:0031625	ubiquitin protein ligase binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:61928	F		Seeded From UniProt	complete
part_of	GO:0031514	motile cilium	PMID:11818497^[45]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030949	positive regulation of vascular endothelial growth factor receptor signaling pathway	PMID:11691837^[34]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2386649,MGI:MGI:2386679	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030502	negative regulation of bone mineralization	PMID:17181398^[43]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857719	P	regulates_o_occurs_in:(EMAPA:19143)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030154	cell differentiation	PMID:16287860^[12]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:109169	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030154	cell differentiation	PMID:15073147^[23]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2386679	P	results_in_acquisition_of_features_of:(CL:0000138)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0021987	cerebral cortex development	PMID:12972594^[42]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2677899	P	results_in_development_of:(EMAPA:17544)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0021502	neural fold elevation formation	PMID:10328919^[26]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857719	P	results_in_formation_of:(EMAPA:16073)	Seeded From UniProt	complete
enables	GO:0019904	protein domain specific binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q16665	F		Seeded From UniProt	complete
enables	GO:0019901	protein kinase binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q16665	F		Seeded From UniProt	complete
enables	GO:0019899	enzyme binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q16665	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0019896	axonal transport of mitochondrion	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q16665	P		Seeded From UniProt	complete
part_of	GO:0016604	nuclear body	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q16665	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0016239	positive regulation of macroautophagy	PMID:19273585^[16]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2386679	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0014850	response to muscle activity	PMID:15328538^[35]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2386679	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010870	positive regulation of receptor biosynthetic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q16665	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010629	negative regulation of gene expression	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q16665	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010628	positive regulation of gene expression	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q16665	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010628	positive regulation of gene expression	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:61928	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010575	positive regulation of vascular endothelial growth factor production	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q16665	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010573	vascular endothelial growth factor production	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q16665	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010468	regulation of gene expression	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q16665	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008542	visual learning	PMID:12972594^[42]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2677899	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008284	positive regulation of cell population proliferation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:61928	P		Seeded From UniProt	complete
enables	GO:0008134	transcription factor binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q16665	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007595	lactation	PMID:12620994^[32]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2386679	P	has_participant:(EMAPA:17759)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007165	signal transduction	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q16665	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006879	cellular iron ion homeostasis	PMID:16787915^[39]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857719	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006366	transcription by RNA polymerase II	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q16665	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006355	regulation of transcription, DNA-templated	PMID:15456877^[29]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006355	regulation of transcription, DNA-templated	PMID:11782478^[21]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q16665	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006355	regulation of transcription, DNA-templated	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q16665	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006110	regulation of glycolytic process	PMID:17437992^[14]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:96552	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006089	lactate metabolic process	PMID:15328538^[35]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2386679	P	occurs_in:(EMAPA:35770)	Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q16665	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q16665	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:61928	C		Seeded From UniProt	complete
part_of	GO:0005667	transcription factor complex	GO_REF:0000008	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q16665	C		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q16665	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:24030251^[25]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000653)	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:22009797^[46]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:20440072^[44]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:15456877^[29]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:15016652^[47]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:11691837^[34]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:18513) part_of:(CL:0000138)	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q16665	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:61928	C		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	PMID:15456877^[29]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	PMID:11782478^[21]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q16665	F		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q16665	F		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	PMID:9113979^[36]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:88071	F	has_participant:(MGI:MGI:95407)	Seeded From UniProt	complete
enables	GO:0003677	DNA binding	PMID:15456877^[29]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0003208	cardiac ventricle morphogenesis	PMID:9436976^[22]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857719	P	has_participant:(EMAPA:16350)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0003151	outflow tract morphogenesis	PMID:9436976^[22]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857719	P	has_participant:(EMAPA:16346)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0002052	positive regulation of neuroblast proliferation	PMID:17215402^[28]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:103178	P		Seeded From UniProt	complete
enables	GO:0002039	p53 binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q16665	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001947	heart looping	PMID:14659802^[13]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2179429	P	has_participant:(EMAPA:16105)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001944	vasculature development	PMID:18653562^[48]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1306784	P	results_in_development_of:(EMAPA:16198)	Seeded From UniProt	complete
part_of	GO:1904115	axon cytoplasm	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0019896	C		Seeded From UniProt	complete
part_of	GO:1904115	axon cytoplasm	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0019896	C		Seeded From UniProt	complete
part_of	GO:1904115	axon cytoplasm	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0019896	C		Seeded From UniProt	complete
involved_in	GO:0010628	positive regulation of gene expression	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:D4A8P8 ensembl:ENSRNOP00000042230	P		Seeded From UniProt	complete
involved_in	GO:1903377	negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q16665 ensembl:ENSP00000437955	P		Seeded From UniProt	complete
involved_in	GO:1902895	positive regulation of pri-miRNA transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q16665 ensembl:ENSP00000437955	P		Seeded From UniProt	complete
part_of	GO:0090575	RNA polymerase II transcription factor complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q16665 ensembl:ENSP00000437955	C		Seeded From UniProt	complete
involved_in	GO:0071456	cellular response to hypoxia	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q16665 ensembl:ENSP00000437955	P		Seeded From UniProt	complete
involved_in	GO:0071347	cellular response to interleukin-1	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q16665 ensembl:ENSP00000437955	P		Seeded From UniProt	complete
involved_in	GO:0061419	positive regulation of transcription from RNA polymerase II promoter in response to hypoxia	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q16665 ensembl:ENSP00000437955	P		Seeded From UniProt	complete
enables	GO:0051879	Hsp90 protein binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q16665 ensembl:ENSP00000437955	F		Seeded From UniProt	complete
enables	GO:0046982	protein heterodimerization activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q16665 ensembl:ENSP00000437955	F		Seeded From UniProt	complete
involved_in	GO:0046886	positive regulation of hormone biosynthetic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q16665 ensembl:ENSP00000437955	P		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q16665 ensembl:ENSP00000437955	P		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q16665 ensembl:ENSP00000437955	P		Seeded From UniProt	complete
involved_in	GO:0045766	positive regulation of angiogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q16665 ensembl:ENSP00000437955	P		Seeded From UniProt	complete
involved_in	GO:0043619	regulation of transcription from RNA polymerase II promoter in response to oxidative stress	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q16665 ensembl:ENSP00000437955	P		Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q16665 ensembl:ENSP00000437955	F		Seeded From UniProt	complete
involved_in	GO:0043536	positive regulation of blood vessel endothelial cell migration	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q16665 ensembl:ENSP00000437955	P		Seeded From UniProt	complete
enables	GO:0035257	nuclear hormone receptor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q16665 ensembl:ENSP00000437955	F		Seeded From UniProt	complete
enables	GO:0035035	histone acetyltransferase binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q16665 ensembl:ENSP00000437955	F		Seeded From UniProt	complete
part_of	GO:0032991	protein-containing complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q16665 ensembl:ENSP00000437955	C		Seeded From UniProt	complete
involved_in	GO:0032909	regulation of transforming growth factor beta2 production	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q16665 ensembl:ENSP00000437955	P		Seeded From UniProt	complete
involved_in	GO:0032364	oxygen homeostasis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q16665 ensembl:ENSP00000437955	P		Seeded From UniProt	complete
enables	GO:0031625	ubiquitin protein ligase binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q16665 ensembl:ENSP00000437955	F		Seeded From UniProt	complete
enables	GO:0019904	protein domain specific binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q16665 ensembl:ENSP00000437955	F		Seeded From UniProt	complete
enables	GO:0019901	protein kinase binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q16665 ensembl:ENSP00000437955	F		Seeded From UniProt	complete
enables	GO:0019899	enzyme binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q16665 ensembl:ENSP00000437955	F		Seeded From UniProt	complete
involved_in	GO:0019896	axonal transport of mitochondrion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q16665 ensembl:ENSP00000437955	P		Seeded From UniProt	complete
part_of	GO:0016604	nuclear body	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q16665 ensembl:ENSP00000437955	C		Seeded From UniProt	complete
involved_in	GO:0010870	positive regulation of receptor biosynthetic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q16665 ensembl:ENSP00000437955	P		Seeded From UniProt	complete
involved_in	GO:0010629	negative regulation of gene expression	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q16665 ensembl:ENSP00000437955	P		Seeded From UniProt	complete
involved_in	GO:0010628	positive regulation of gene expression	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q16665 ensembl:ENSP00000437955	P		Seeded From UniProt	complete
involved_in	GO:0010575	positive regulation of vascular endothelial growth factor production	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q16665 ensembl:ENSP00000437955	P		Seeded From UniProt	complete
involved_in	GO:0010573	vascular endothelial growth factor production	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q16665 ensembl:ENSP00000437955	P		Seeded From UniProt	complete
involved_in	GO:0010468	regulation of gene expression	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q16665 ensembl:ENSP00000437955	P		Seeded From UniProt	complete
involved_in	GO:0010039	response to iron ion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q16665 ensembl:ENSP00000437955	P		Seeded From UniProt	complete
enables	GO:0008134	transcription factor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q16665 ensembl:ENSP00000437955	F		Seeded From UniProt	complete
involved_in	GO:0007165	signal transduction	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q16665 ensembl:ENSP00000437955	P		Seeded From UniProt	complete
involved_in	GO:0006366	transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q16665 ensembl:ENSP00000437955	P		Seeded From UniProt	complete
involved_in	GO:0006355	regulation of transcription, DNA-templated	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q16665 ensembl:ENSP00000437955	P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q16665 ensembl:ENSP00000437955	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q16665 ensembl:ENSP00000437955	C		Seeded From UniProt	complete
part_of	GO:0005667	transcription factor complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q16665 ensembl:ENSP00000437955	C		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q16665 ensembl:ENSP00000437955	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q16665 ensembl:ENSP00000437955	C		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q16665 ensembl:ENSP00000437955	F		Seeded From UniProt	complete
enables	GO:0002039	p53 binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q16665 ensembl:ENSP00000437955	F		Seeded From UniProt	complete
involved_in	GO:0001666	response to hypoxia	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q16665 ensembl:ENSP00000437955	P		Seeded From UniProt	complete
enables	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q16665 ensembl:ENSP00000437955	F		Seeded From UniProt	complete
enables	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q16665 ensembl:ENSP00000437955	F		Seeded From UniProt	complete
enables	GO:0000977	RNA polymerase II regulatory region sequence-specific DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q16665 ensembl:ENSP00000437955	F		Seeded From UniProt	complete
part_of	GO:0000790	nuclear chromatin	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q16665 ensembl:ENSP00000437955	C		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001321	F		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001321	C		Seeded From UniProt	complete
involved_in	GO:0006355	regulation of transcription, DNA-templated	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001321 InterPro:IPR013767	P		Seeded From UniProt	complete
enables	GO:0046983	protein dimerization activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR011598 InterPro:IPR036638	F		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0238	F		Seeded From UniProt	complete
part_of	GO:0016607	nuclear speck	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0186	C		Seeded From UniProt	complete
edit table

Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Riddle, RC et al. (2011) Hypoxia-inducible factor-1α protein negatively regulates load-induced bone formation. J. Biol. Chem. 286 44449-56 PubMed GONUTS page
↑ ^2.0 ^2.1 Wu, D et al. (2015) Structural integration in hypoxia-inducible factors. Nature 524 303-8 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 el Azzouzi, H et al. (2013) The hypoxia-inducible microRNA cluster miR-199a∼214 targets myocardial PPARδ and impairs mitochondrial fatty acid oxidation. Cell Metab. 18 341-54 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 ^4.4 ^4.5 Zhang, H et al. (2008) Mitochondrial autophagy is an HIF-1-dependent adaptive metabolic response to hypoxia. J. Biol. Chem. 283 10892-903 PubMed GONUTS page
↑ ^5.0 ^5.1 Torii, S et al. (2011) Pro-apoptotic activity of inhibitory PAS domain protein (IPAS), a negative regulator of HIF-1, through binding to pro-survival Bcl-2 family proteins. Cell Death Differ. 18 1711-25 PubMed GONUTS page
↑ Lin, W et al. (2014) Loss of PINK1 attenuates HIF-1α induction by preventing 4E-BP1-dependent switch in protein translation under hypoxia. J. Neurosci. 34 3079-89 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 ^7.3 ^7.4 Higgins, DF et al. (2007) Hypoxia promotes fibrogenesis in vivo via HIF-1 stimulation of epithelial-to-mesenchymal transition. J. Clin. Invest. 117 3810-20 PubMed GONUTS page
↑ ^8.0 ^8.1 Seo, HW et al. (2009) Transcriptional activation of hypoxia-inducible factor-1alpha by HDAC4 and HDAC5 involves differential recruitment of p300 and FIH-1. FEBS Lett. 583 55-60 PubMed GONUTS page
↑ Kim, HG et al. (2008) Metallothionein-III induces HIF-1alpha-mediated VEGF expression in brain endothelial cells. Biochem. Biophys. Res. Commun. 369 666-71 PubMed GONUTS page
↑ ^10.0 ^10.1 ^10.2 ^10.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ Kojima, H et al. (2002) Abnormal B lymphocyte development and autoimmunity in hypoxia-inducible factor 1alpha -deficient chimeric mice. Proc. Natl. Acad. Sci. U.S.A. 99 2170-4 PubMed GONUTS page
↑ ^12.0 ^12.1 ^12.2 Cowden Dahl, KD et al. (2005) Hypoxia-inducible factors 1alpha and 2alpha regulate trophoblast differentiation. Mol. Cell. Biol. 25 10479-91 PubMed GONUTS page
↑ ^13.0 ^13.1 ^13.2 Compernolle, V et al. (2003) Cardia bifida, defective heart development and abnormal neural crest migration in embryos lacking hypoxia-inducible factor-1alpha. Cardiovasc. Res. 60 569-79 PubMed GONUTS page
↑ ^14.0 ^14.1 ^14.2 ^14.3 Lum, JJ et al. (2007) The transcription factor HIF-1alpha plays a critical role in the growth factor-dependent regulation of both aerobic and anaerobic glycolysis. Genes Dev. 21 1037-49 PubMed GONUTS page
↑ ^15.0 ^15.1 Ryan, HE et al. (1998) HIF-1 alpha is required for solid tumor formation and embryonic vascularization. EMBO J. 17 3005-15 PubMed GONUTS page
↑ ^16.0 ^16.1 Bellot, G et al. (2009) Hypoxia-induced autophagy is mediated through hypoxia-inducible factor induction of BNIP3 and BNIP3L via their BH3 domains. Mol. Cell. Biol. 29 2570-81 PubMed GONUTS page
↑ Kline, DD et al. (2002) Defective carotid body function and impaired ventilatory responses to chronic hypoxia in mice partially deficient for hypoxia-inducible factor 1 alpha. Proc. Natl. Acad. Sci. U.S.A. 99 821-6 PubMed GONUTS page
↑ Yu, AY et al. (1999) Impaired physiological responses to chronic hypoxia in mice partially deficient for hypoxia-inducible factor 1alpha. J. Clin. Invest. 103 691-6 PubMed GONUTS page
↑ ^19.0 ^19.1 Li, H et al. (1996) Induction of phosphoglycerate kinase 1 gene expression by hypoxia. Roles of Arnt and HIF1alpha. J. Biol. Chem. 271 21262-7 PubMed GONUTS page
↑ Mochizuki, Y et al. (2002) Angiopoietin 2 stimulates migration and tube-like structure formation of murine brain capillary endothelial cells through c-Fes and c-Fyn. J. Cell. Sci. 115 175-83 PubMed GONUTS page
↑ ^21.0 ^21.1 ^21.2 Woods, SL & Whitelaw, ML (2002) Differential activities of murine single minded 1 (SIM1) and SIM2 on a hypoxic response element. Cross-talk between basic helix-loop-helix/per-Arnt-Sim homology transcription factors. J. Biol. Chem. 277 10236-43 PubMed GONUTS page
↑ ^22.0 ^22.1 ^22.2 ^22.3 Iyer, NV et al. (1998) Cellular and developmental control of O2 homeostasis by hypoxia-inducible factor 1 alpha. Genes Dev. 12 149-62 PubMed GONUTS page
↑ ^23.0 ^23.1 Zelzer, E et al. (2004) VEGFA is necessary for chondrocyte survival during bone development. Development 131 2161-71 PubMed GONUTS page
↑ ^24.0 ^24.1 An, HJ et al. (2011) The survival effect of mitochondrial Higd-1a is associated with suppression of cytochrome C release and prevention of caspase activation. Biochim. Biophys. Acta 1813 2088-98 PubMed GONUTS page
↑ ^25.0 ^25.1 ^25.2 ^25.3 Bondeva, T et al. (2013) Advanced glycated end-products affect HIF-transcriptional activity in renal cells. Mol. Endocrinol. 27 1918-33 PubMed GONUTS page
↑ ^26.0 ^26.1 Kotch, LE et al. (1999) Defective vascularization of HIF-1alpha-null embryos is not associated with VEGF deficiency but with mesenchymal cell death. Dev. Biol. 209 254-67 PubMed GONUTS page
↑ Obara, N & Takeda, M (1993) Expression of neural cell adhesion molecule (NCAM) during the first molar development in the mouse. Anat. Embryol. 187 209-19 PubMed GONUTS page
↑ ^28.0 ^28.1 ^28.2 Milosevic, J et al. (2007) Lack of hypoxia-inducible factor-1 alpha impairs midbrain neural precursor cells involving vascular endothelial growth factor signaling. J. Neurosci. 27 412-21 PubMed GONUTS page
↑ ^29.0 ^29.1 ^29.2 ^29.3 ^29.4 ^29.5 Biju, MP et al. (2004) Vhlh gene deletion induces Hif-1-mediated cell death in thymocytes. Mol. Cell. Biol. 24 9038-47 PubMed GONUTS page
↑ Caprara, C et al. (2011) HIF1A is essential for the development of the intermediate plexus of the retinal vasculature. Invest. Ophthalmol. Vis. Sci. 52 2109-17 PubMed GONUTS page
↑ ^31.0 ^31.1 Lange, CA et al. (2012) Von Hippel-Lindau protein in the RPE is essential for normal ocular growth and vascular development. Development 139 2340-50 PubMed GONUTS page
↑ ^32.0 ^32.1 Seagroves, TN et al. (2003) HIF1alpha is a critical regulator of secretory differentiation and activation, but not vascular expansion, in the mouse mammary gland. Development 130 1713-24 PubMed GONUTS page
↑ ^33.0 ^33.1 ^33.2 Lussier, CR et al. (2010) Loss of hepatocyte-nuclear-factor-1alpha impacts on adult mouse intestinal epithelial cell growth and cell lineages differentiation. PLoS ONE 5 e12378 PubMed GONUTS page
↑ ^34.0 ^34.1 ^34.2 ^34.3 Schipani, E et al. (2001) Hypoxia in cartilage: HIF-1alpha is essential for chondrocyte growth arrest and survival. Genes Dev. 15 2865-76 PubMed GONUTS page
↑ ^35.0 ^35.1 ^35.2 ^35.3 ^35.4 Mason, SD et al. (2004) Loss of skeletal muscle HIF-1alpha results in altered exercise endurance. PLoS Biol. 2 e288 PubMed GONUTS page
↑ ^36.0 ^36.1 Ema, M et al. (1997) A novel bHLH-PAS factor with close sequence similarity to hypoxia-inducible factor 1alpha regulates the VEGF expression and is potentially involved in lung and vascular development. Proc. Natl. Acad. Sci. U.S.A. 94 4273-8 PubMed GONUTS page
↑ Makita, T et al. (2005) Retinoic acid, hypoxia, and GATA factors cooperatively control the onset of fetal liver erythropoietin expression and erythropoietic differentiation. Dev. Biol. 280 59-72 PubMed GONUTS page
↑ Gruber, M et al. (2007) Acute postnatal ablation of Hif-2alpha results in anemia. Proc. Natl. Acad. Sci. U.S.A. 104 2301-6 PubMed GONUTS page
↑ ^39.0 ^39.1 ^39.2 ^39.3 Yoon, D et al. (2006) Hypoxia-inducible factor-1 deficiency results in dysregulated erythropoiesis signaling and iron homeostasis in mouse development. J. Biol. Chem. 281 25703-11 PubMed GONUTS page
↑ Park, SK et al. (2003) Hypoxia-induced gene expression occurs solely through the action of hypoxia-inducible factor 1alpha (HIF-1alpha): role of cytoplasmic trapping of HIF-2alpha. Mol. Cell. Biol. 23 4959-71 PubMed GONUTS page
↑ Luo, G et al. (1997) Molecular characterization of the murine Hif-1 alpha locus. Gene Expr. 6 287-99 PubMed GONUTS page
↑ ^42.0 ^42.1 ^42.2 Tomita, S et al. (2003) Defective brain development in mice lacking the Hif-1alpha gene in neural cells. Mol. Cell. Biol. 23 6739-49 PubMed GONUTS page
↑ ^43.0 ^43.1 Komatsu, DE et al. (2007) Enhanced bone regeneration associated with decreased apoptosis in mice with partial HIF-1alpha deficiency. J. Bone Miner. Res. 22 366-74 PubMed GONUTS page
↑ ^44.0 ^44.1 Cheng, K et al. (2010) Hypoxia-inducible factor-1alpha regulates beta cell function in mouse and human islets. J. Clin. Invest. 120 2171-83 PubMed GONUTS page
↑ Marti, HH et al. (2002) Isoform-specific expression of hypoxia-inducible factor-1alpha during the late stages of mouse spermiogenesis. Mol. Endocrinol. 16 234-43 PubMed GONUTS page
↑ Shan, B et al. (2012) RSUME is implicated in HIF-1-induced VEGF-A production in pituitary tumour cells. Endocr. Relat. Cancer 19 13-27 PubMed GONUTS page
↑ Suliman, HB et al. (2004) Superoxide dismutase-3 promotes full expression of the EPO response to hypoxia. Blood 104 43-50 PubMed GONUTS page
↑ Chen, Y et al. (2008) Cited2 is required for the proper formation of the hyaloid vasculature and for lens morphogenesis. Development 135 2939-48 PubMed GONUTS page

[PMID:22081627-1] 1.0 ^1.1 Riddle, RC et al. (2011) Hypoxia-inducible factor-1α protein negatively regulates load-induced bone formation. J. Biol. Chem. 286 44449-56 PubMed GONUTS page

[PMID:26245371-2] 2.0 ^2.1 Wu, D et al. (2015) Structural integration in hypoxia-inducible factors. Nature 524 303-8 PubMed GONUTS page

[PMID:24011070-3] 3.0 ^3.1 ^3.2 el Azzouzi, H et al. (2013) The hypoxia-inducible microRNA cluster miR-199a∼214 targets myocardial PPARδ and impairs mitochondrial fatty acid oxidation. Cell Metab. 18 341-54 PubMed GONUTS page

[PMID:18281291-4] 4.0 ^4.1 ^4.2 ^4.3 ^4.4 ^4.5 Zhang, H et al. (2008) Mitochondrial autophagy is an HIF-1-dependent adaptive metabolic response to hypoxia. J. Biol. Chem. 283 10892-903 PubMed GONUTS page

[PMID:21546903-5] 5.0 ^5.1 Torii, S et al. (2011) Pro-apoptotic activity of inhibitory PAS domain protein (IPAS), a negative regulator of HIF-1, through binding to pro-survival Bcl-2 family proteins. Cell Death Differ. 18 1711-25 PubMed GONUTS page

[PMID:24553947-6] Lin, W et al. (2014) Loss of PINK1 attenuates HIF-1α induction by preventing 4E-BP1-dependent switch in protein translation under hypoxia. J. Neurosci. 34 3079-89 PubMed GONUTS page

[PMID:18037992-7] 7.0 ^7.1 ^7.2 ^7.3 ^7.4 Higgins, DF et al. (2007) Hypoxia promotes fibrogenesis in vivo via HIF-1 stimulation of epithelial-to-mesenchymal transition. J. Clin. Invest. 117 3810-20 PubMed GONUTS page

[PMID:19071119-8] 8.0 ^8.1 Seo, HW et al. (2009) Transcriptional activation of hypoxia-inducible factor-1alpha by HDAC4 and HDAC5 involves differential recruitment of p300 and FIH-1. FEBS Lett. 583 55-60 PubMed GONUTS page

[PMID:18295594-9] Kim, HG et al. (2008) Metallothionein-III induces HIF-1alpha-mediated VEGF expression in brain endothelial cells. Biochem. Biophys. Res. Commun. 369 666-71 PubMed GONUTS page

[PMID:21873635-10] 10.0 ^10.1 ^10.2 ^10.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:11854513-11] Kojima, H et al. (2002) Abnormal B lymphocyte development and autoimmunity in hypoxia-inducible factor 1alpha -deficient chimeric mice. Proc. Natl. Acad. Sci. U.S.A. 99 2170-4 PubMed GONUTS page

[PMID:16287860-12] 12.0 ^12.1 ^12.2 Cowden Dahl, KD et al. (2005) Hypoxia-inducible factors 1alpha and 2alpha regulate trophoblast differentiation. Mol. Cell. Biol. 25 10479-91 PubMed GONUTS page

[PMID:14659802-13] 13.0 ^13.1 ^13.2 Compernolle, V et al. (2003) Cardia bifida, defective heart development and abnormal neural crest migration in embryos lacking hypoxia-inducible factor-1alpha. Cardiovasc. Res. 60 569-79 PubMed GONUTS page

[PMID:17437992-14] 14.0 ^14.1 ^14.2 ^14.3 Lum, JJ et al. (2007) The transcription factor HIF-1alpha plays a critical role in the growth factor-dependent regulation of both aerobic and anaerobic glycolysis. Genes Dev. 21 1037-49 PubMed GONUTS page

[PMID:9606183-15] 15.0 ^15.1 Ryan, HE et al. (1998) HIF-1 alpha is required for solid tumor formation and embryonic vascularization. EMBO J. 17 3005-15 PubMed GONUTS page

[PMID:19273585-16] 16.0 ^16.1 Bellot, G et al. (2009) Hypoxia-induced autophagy is mediated through hypoxia-inducible factor induction of BNIP3 and BNIP3L via their BH3 domains. Mol. Cell. Biol. 29 2570-81 PubMed GONUTS page

[PMID:11792862-17] Kline, DD et al. (2002) Defective carotid body function and impaired ventilatory responses to chronic hypoxia in mice partially deficient for hypoxia-inducible factor 1 alpha. Proc. Natl. Acad. Sci. U.S.A. 99 821-6 PubMed GONUTS page

[PMID:10074486-18] Yu, AY et al. (1999) Impaired physiological responses to chronic hypoxia in mice partially deficient for hypoxia-inducible factor 1alpha. J. Clin. Invest. 103 691-6 PubMed GONUTS page

[PMID:8702901-19] 19.0 ^19.1 Li, H et al. (1996) Induction of phosphoglycerate kinase 1 gene expression by hypoxia. Roles of Arnt and HIF1alpha. J. Biol. Chem. 271 21262-7 PubMed GONUTS page

[PMID:11801735-20] Mochizuki, Y et al. (2002) Angiopoietin 2 stimulates migration and tube-like structure formation of murine brain capillary endothelial cells through c-Fes and c-Fyn. J. Cell. Sci. 115 175-83 PubMed GONUTS page

[PMID:11782478-21] 21.0 ^21.1 ^21.2 Woods, SL & Whitelaw, ML (2002) Differential activities of murine single minded 1 (SIM1) and SIM2 on a hypoxic response element. Cross-talk between basic helix-loop-helix/per-Arnt-Sim homology transcription factors. J. Biol. Chem. 277 10236-43 PubMed GONUTS page

[PMID:9436976-22] 22.0 ^22.1 ^22.2 ^22.3 Iyer, NV et al. (1998) Cellular and developmental control of O2 homeostasis by hypoxia-inducible factor 1 alpha. Genes Dev. 12 149-62 PubMed GONUTS page

[PMID:15073147-23] 23.0 ^23.1 Zelzer, E et al. (2004) VEGFA is necessary for chondrocyte survival during bone development. Development 131 2161-71 PubMed GONUTS page

[PMID:21856340-24] 24.0 ^24.1 An, HJ et al. (2011) The survival effect of mitochondrial Higd-1a is associated with suppression of cytochrome C release and prevention of caspase activation. Biochim. Biophys. Acta 1813 2088-98 PubMed GONUTS page

[PMID:24030251-25] 25.0 ^25.1 ^25.2 ^25.3 Bondeva, T et al. (2013) Advanced glycated end-products affect HIF-transcriptional activity in renal cells. Mol. Endocrinol. 27 1918-33 PubMed GONUTS page

[PMID:10328919-26] 26.0 ^26.1 Kotch, LE et al. (1999) Defective vascularization of HIF-1alpha-null embryos is not associated with VEGF deficiency but with mesenchymal cell death. Dev. Biol. 209 254-67 PubMed GONUTS page

[PMID:8470821-27] Obara, N & Takeda, M (1993) Expression of neural cell adhesion molecule (NCAM) during the first molar development in the mouse. Anat. Embryol. 187 209-19 PubMed GONUTS page

[PMID:17215402-28] 28.0 ^28.1 ^28.2 Milosevic, J et al. (2007) Lack of hypoxia-inducible factor-1 alpha impairs midbrain neural precursor cells involving vascular endothelial growth factor signaling. J. Neurosci. 27 412-21 PubMed GONUTS page

[PMID:15456877-29] 29.0 ^29.1 ^29.2 ^29.3 ^29.4 ^29.5 Biju, MP et al. (2004) Vhlh gene deletion induces Hif-1-mediated cell death in thymocytes. Mol. Cell. Biol. 24 9038-47 PubMed GONUTS page

[PMID:21212189-30] Caprara, C et al. (2011) HIF1A is essential for the development of the intermediate plexus of the retinal vasculature. Invest. Ophthalmol. Vis. Sci. 52 2109-17 PubMed GONUTS page

[PMID:22627278-31] 31.0 ^31.1 Lange, CA et al. (2012) Von Hippel-Lindau protein in the RPE is essential for normal ocular growth and vascular development. Development 139 2340-50 PubMed GONUTS page

[PMID:12620994-32] 32.0 ^32.1 Seagroves, TN et al. (2003) HIF1alpha is a critical regulator of secretory differentiation and activation, but not vascular expansion, in the mouse mammary gland. Development 130 1713-24 PubMed GONUTS page

[PMID:20808783-33] 33.0 ^33.1 ^33.2 Lussier, CR et al. (2010) Loss of hepatocyte-nuclear-factor-1alpha impacts on adult mouse intestinal epithelial cell growth and cell lineages differentiation. PLoS ONE 5 e12378 PubMed GONUTS page

[PMID:11691837-34] 34.0 ^34.1 ^34.2 ^34.3 Schipani, E et al. (2001) Hypoxia in cartilage: HIF-1alpha is essential for chondrocyte growth arrest and survival. Genes Dev. 15 2865-76 PubMed GONUTS page

[PMID:15328538-35] 35.0 ^35.1 ^35.2 ^35.3 ^35.4 Mason, SD et al. (2004) Loss of skeletal muscle HIF-1alpha results in altered exercise endurance. PLoS Biol. 2 e288 PubMed GONUTS page

[PMID:9113979-36] 36.0 ^36.1 Ema, M et al. (1997) A novel bHLH-PAS factor with close sequence similarity to hypoxia-inducible factor 1alpha regulates the VEGF expression and is potentially involved in lung and vascular development. Proc. Natl. Acad. Sci. U.S.A. 94 4273-8 PubMed GONUTS page

[PMID:15766748-37] Makita, T et al. (2005) Retinoic acid, hypoxia, and GATA factors cooperatively control the onset of fetal liver erythropoietin expression and erythropoietic differentiation. Dev. Biol. 280 59-72 PubMed GONUTS page

[PMID:17284606-38] Gruber, M et al. (2007) Acute postnatal ablation of Hif-2alpha results in anemia. Proc. Natl. Acad. Sci. U.S.A. 104 2301-6 PubMed GONUTS page

[PMID:16787915-39] 39.0 ^39.1 ^39.2 ^39.3 Yoon, D et al. (2006) Hypoxia-inducible factor-1 deficiency results in dysregulated erythropoiesis signaling and iron homeostasis in mouse development. J. Biol. Chem. 281 25703-11 PubMed GONUTS page

[PMID:12832481-40] Park, SK et al. (2003) Hypoxia-induced gene expression occurs solely through the action of hypoxia-inducible factor 1alpha (HIF-1alpha): role of cytoplasmic trapping of HIF-2alpha. Mol. Cell. Biol. 23 4959-71 PubMed GONUTS page

[PMID:9368100-41] Luo, G et al. (1997) Molecular characterization of the murine Hif-1 alpha locus. Gene Expr. 6 287-99 PubMed GONUTS page

[PMID:12972594-42] 42.0 ^42.1 ^42.2 Tomita, S et al. (2003) Defective brain development in mice lacking the Hif-1alpha gene in neural cells. Mol. Cell. Biol. 23 6739-49 PubMed GONUTS page

[PMID:17181398-43] 43.0 ^43.1 Komatsu, DE et al. (2007) Enhanced bone regeneration associated with decreased apoptosis in mice with partial HIF-1alpha deficiency. J. Bone Miner. Res. 22 366-74 PubMed GONUTS page

[PMID:20440072-44] 44.0 ^44.1 Cheng, K et al. (2010) Hypoxia-inducible factor-1alpha regulates beta cell function in mouse and human islets. J. Clin. Invest. 120 2171-83 PubMed GONUTS page

[PMID:11818497-45] Marti, HH et al. (2002) Isoform-specific expression of hypoxia-inducible factor-1alpha during the late stages of mouse spermiogenesis. Mol. Endocrinol. 16 234-43 PubMed GONUTS page

[PMID:22009797-46] Shan, B et al. (2012) RSUME is implicated in HIF-1-induced VEGF-A production in pituitary tumour cells. Endocr. Relat. Cancer 19 13-27 PubMed GONUTS page

[PMID:15016652-47] Suliman, HB et al. (2004) Superoxide dismutase-3 promotes full expression of the EPO response to hypoxia. Blood 104 43-50 PubMed GONUTS page

[PMID:18653562-48] Chen, Y et al. (2008) Cited2 is required for the proper formation of the hyaloid vasculature and for lens morphogenesis. Development 135 2939-48 PubMed GONUTS page

[1]

[2]

[3]

[4]

[5]

[6]

[7]

[8]

[9]

[10]

[11]

[12]

[13]

[14]

[15]

[16]

[17]

[18]

[19]

[20]

[21]

[22]

[23]

[24]

[25]

[26]

[27]

[28]

[29]

[30]

[31]

[32]

[33]

[34]

[35]

[36]

[37]

[38]

[39]

[40]

[41]

[42]

[43]

[44]

[45]

[46]

[47]

[48]

MOUSE:HIF1A

Contents

Annotations

Notes

References

a

b

c

d

e

g

h

i

l

m

n

o

p

r

s

t

u

v

Navigation menu

Personal tools

Namespaces

Variants

Views

More

Search

Navigation

Cacao

Links

Tools