MOUSE:HFE

From GONUTS

Jump to: navigation, search

Species (Taxon ID)	Mus musculus (Mouse). (taxon:10090)
Gene Name(s)	Hfe ( synonyms: Mr2 )
Protein Name(s)	Hereditary hemochromatosis protein homolog
External Links
UniProt Identifier	HFE_MOUSE
UniProt Accessions	P70387, Q14AQ5, Q5SZ90, Q9D754,
EMBL	AF007558, U66849, AK009581, AK150697, AL590388, CH466561, BC116744, BC116746, Y12650, U80604,
PIR	JC5382,
Ensembl	ENSMUST00000091706,
Pfam	PF07654, PF00129,

Annotations

Qualifier	GO ID	GO term name	Reference	Evidence Code	with/from	Aspect	Notes	Status
	GO:0002474	antigen processing and presentation of peptide antigen via MHC class I	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0490	P
	GO:0005769	early endosome	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000417404	C
	GO:0006955	immune response	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR001039	P
	GO:0006955	immune response	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR011161	P
	GO:0007565	female pregnancy	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000022881	P
	GO:0010106	cellular response to iron ion starvation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000022881	P
	GO:0016020	membrane	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR001039	C
	GO:0016020	membrane	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR011161	C
	GO:0016020	membrane	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0472	C
	GO:0016020	membrane	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0162	C
	GO:0016021	integral to membrane	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0812	C
	GO:0019882	antigen processing and presentation	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR001039	P
	GO:0019882	antigen processing and presentation	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR011161	P
	GO:0031410	cytoplasmic vesicle	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000417404	C
	GO:0042446	hormone biosynthetic process	PMID:15914561^[1]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2385353	P
	GO:0042612	MHC class I protein complex	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR001039	C
	GO:0042612	MHC class I protein complex	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0490	C
	GO:0045177	apical part of cell	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000417404	C
	GO:0045177	apical part of cell	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000022881	C
	GO:0045178	basal part of cell	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000417404	C
	GO:0048471	perinuclear region of cytoplasm	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000417404	C
	GO:0055037	recycling endosome	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000417404	C
	GO:0055072	iron ion homeostasis	PMID:15914561^[1]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2385353	P
	GO:0006955	immune response	PMID:19809161^[2]	IDA: Inferred from Direct Assay		P	Figure 1. Peritoneal macrophages from WT and Hfe KO mice were stimulated with LPS. Supernatants were collected and analyzed by ELISA for TNF-α. Observations on TNF-α expression support the notion that the abnormal TLR4-activated cytokine response of the Hfe KO macrophages is caused by the low intracellular iron in these cells rather than being a cell-autonomous consequence of Hfe deficiency.	complete
	GO:0060586	multicellular organismal iron ion homeostasis	PMID:10077651^[3]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2181388	P
	GO:0002474	antigen processing and presentation of peptide antigen via MHC class I	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0490	P
	GO:0006955	immune response	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR001039	P
	GO:0006955	immune response	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR011161	P
	GO:0016020	membrane	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR001039	C
	GO:0016020	membrane	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR011161	C
	GO:0016020	membrane	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0472	C
	GO:0016020	membrane	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0162	C
	GO:0016021	integral to membrane	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0812	C
	GO:0019882	antigen processing and presentation	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR001039	P
	GO:0019882	antigen processing and presentation	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR011161	P
	GO:0042612	MHC class I protein complex	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR001039	C
	GO:0042612	MHC class I protein complex	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0490	C
edit table

Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Makui H et al. (2005) Contribution of Hfe expression in macrophages to the regulation of hepatic hepcidin levels and iron loading. Blood 106: 2189-95 PubMed GONUTS page
↑ Wang L et al. (2009) Selective modulation of TLR4-activated inflammatory responses by altered iron homeostasis in mice. J Clin Invest 119: 3322-8 PubMed GONUTS page
↑ Fleming RE et al. (1999) Mechanism of increased iron absorption in murine model of hereditary hemochromatosis: increased duodenal expression of the iron transporter DMT1. Proc Natl Acad Sci U S A 96: 3143-8 PubMed GONUTS page

[PMID:15914561-0] 1.0 ^1.1 Makui H et al. (2005) Contribution of Hfe expression in macrophages to the regulation of hepatic hepcidin levels and iron loading. Blood 106: 2189-95 PubMed GONUTS page

[PMID:19809161-1] Wang L et al. (2009) Selective modulation of TLR4-activated inflammatory responses by altered iron homeostasis in mice. J Clin Invest 119: 3322-8 PubMed GONUTS page

[PMID:10077651-2] Fleming RE et al. (1999) Mechanism of increased iron absorption in murine model of hereditary hemochromatosis: increased duodenal expression of the iron transporter DMT1. Proc Natl Acad Sci U S A 96: 3143-8 PubMed GONUTS page

[1]

[2]

[3]

MOUSE:HFE

Contents

Annotations

Notes

References

a

b

c

e

f

h

i

m

p

r

Personal tools

Namespaces

Variants

Views

Actions

Search

Navigation

Cacao

Journal Clubs

page contributors

Toolbox