MOUSE:HAND2

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Species (Taxon ID)	Mus musculus (Mouse). (taxon:10090)
Gene Name(s)	Hand2 ( synonyms: Dhand, Hed, Thing2 )
Protein Name(s)	Heart- and neural crest derivatives-expressed protein 2 Deciduum, heart, autonomic nervous system and neural crest derivatives-expressed protein 2 dHAND Helix-loop-helix transcription factor expressed in embryo and deciduum Thing-2
External Links
UniProt Identifier	HAND2_MOUSE
UniProt Accessions	Q61039, Q61100,
EMBL	U40039, AK035160, U43715,
RefSeq	NP_034532.3,
IntAct	Q61039,
Ensembl	ENSMUST00000040104,
Pfam	PF00010,

Annotations

Qualifier	GO ID	GO term name	Reference	Evidence Code	with/from	Aspect	Notes	Status
	GO:0005667	transcription factor complex		IDA: Inferred from Direct Assay		C	Source: BHF-UCL
	GO:0003677	DNA binding		IEA: Inferred from Electronic Annotation		F	Source: UniProtKB-KW
	GO:0046982	protein heterodimerization activity		IPI: Inferred from Physical Interaction		F	Source: MGI
	GO:0042803	protein homodimerization activity		IPI: Inferred from Physical Interaction		F	Source: BHF-UCL
	GO:0033613	transcription activator binding		ISS: Inferred from Sequence or Structural Similarity		F	Source: BHF-UCL
	GO:0003713	transcription coactivator activity		ISS: Inferred from Sequence or Structural Similarity		F	Source: BHF-UCL
	GO:0007512	adult heart development		IMP: Inferred from Mutant Phenotype		P	Source: MGI
	GO:0001525	angiogenesis		IEA: Inferred from Electronic Annotation		P	Source: UniProtKB-KW
	GO:0006915	apoptosis		IMP: Inferred from Mutant Phenotype		P	Source: MGI
	GO:0001947	heart looping		IMP: Inferred from Mutant Phenotype		P	Source: MGI
	GO:0001701	in utero embryonic development		IMP: Inferred from Mutant Phenotype		P	Source: MGI
	GO:0014032	neural crest cell development		IMP: Inferred from Mutant Phenotype		P	Source: MGI
	GO:0045944	positive regulation of transcription from R...		IDA: Inferred from Direct Assay		P	Source: BHF-UCL
	GO:0006350	transcription		IEA: Inferred from Electronic Annotation		P	Source: UniProtKB-KW
	GO:0060021	palate development	PMID:19341725^[1]	IMP: Inferred from Mutant Phenotype		P	Figure 1,4	complete
	GO:0008219	cell death	PMID:19341725^[1]	IMP: Inferred from Mutant Phenotype		P	Fig. 6A,B Fig. 7G–I	complete
	GO:0045941	positive regulation of transcription	PMID:19341725^[1]	IMP: Inferred from Mutant Phenotype		P	Figure 5A, 5B	complete
	GO:0008283	cell proliferation	PMID:19341725^[1]	IMP: Inferred from Mutant Phenotype		P	Figure 6C–E	complete
	GO:0001525	angiogenesis	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0037	P
	GO:0001701	in utero embryonic development	PMID:9171826^[2]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1857639	P
	GO:0001947	heart looping	PMID:9171826^[2]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1857639	P
	GO:0003007	heart morphogenesis	PMID:11784028^[3]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1857639	P
	GO:0003219	cardiac right ventricle formation	PMID:11076755^[4]	IMP: Inferred from Mutant Phenotype		P
	GO:0003266	regulation of secondary heart field cardioblast proliferation	PMID:19008477^[5]	IMP: Inferred from Mutant Phenotype		P
	GO:0003677	DNA binding	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0238	F
	GO:0003700	sequence-specific DNA binding transcription factor activity	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000033513	F
	GO:0003713	transcription coactivator activity	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000033513	F
	GO:0003713	transcription coactivator activity	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:P61295	F
	GO:0005515	protein binding	PMID:10924525^[6]	IPI: Inferred from Physical Interaction	UniProtKB:P15806	F
	GO:0005515	protein binding	PMID:10924525^[6]	IPI: Inferred from Physical Interaction	UniProtKB:Q64279	F
	GO:0005515	protein binding	PMID:10924525^[6]	IPI: Inferred from Physical Interaction	UniProtKB:Q64279	F
	GO:0005515	protein binding	PMID:10924525^[6]	IPI: Inferred from Physical Interaction	UniProtKB:Q9DBX7	F
	GO:0005515	protein binding	PMID:10924525^[6]	IPI: Inferred from Physical Interaction	UniProtKB:Q9QUS4	F
	GO:0005515	protein binding	PMID:10924525^[6]	IPI: Inferred from Physical Interaction	UniProtKB:Q9WV93	F
	GO:0005515	protein binding	PMID:15102471^[7]	IPI: Inferred from Physical Interaction	UniProtKB:Q99N72	F
	GO:0005515	protein binding	PMID:15351717^[8]	IPI: Inferred from Physical Interaction	UniProtKB:P15806	F
	GO:0005515	protein binding	PMID:15351717^[8]	IPI: Inferred from Physical Interaction	UniProtKB:Q60722	F
	GO:0005515	protein binding	PMID:15351717^[8]	IPI: Inferred from Physical Interaction	UniProtKB:Q61286	F
	GO:0005634	nucleus	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR011598	C
	GO:0005634	nucleus	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0539	C
	GO:0005634	nucleus	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0191	C
	GO:0005667	transcription factor complex	PMID:11812799^[9]	IDA: Inferred from Direct Assay		C
	GO:0006351	transcription, DNA-dependent	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0804	P
	GO:0006351	transcription, DNA-dependent	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000033513	P
	GO:0006355	regulation of transcription, DNA-dependent	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR001092	P
	GO:0006355	regulation of transcription, DNA-dependent	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR011598	P
	GO:0006355	regulation of transcription, DNA-dependent	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0805	P
	GO:0006355	regulation of transcription, DNA-dependent	PMID:15351717^[8]	IDA: Inferred from Direct Assay		P
	GO:0006915	apoptosis	PMID:11784028^[3]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1857639	P
	GO:0007275	multicellular organismal development	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0217	P
	GO:0007507	heart development	PMID:15576406^[10]	IGI: Inferred from Genetic Interaction	MGI:MGI:103577	P
	GO:0007512	adult heart development	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000352565	P
	GO:0007512	adult heart development	PMID:9171826^[2]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1857639	P
	GO:0008134	transcription factor binding	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000033513	F
	GO:0008134	transcription factor binding	PMID:11812799^[9]	IPI: Inferred from Physical Interaction	UniProtKB:P15806-1	F
	GO:0010667	negative regulation of cardiac muscle cell apoptosis	PMID:19008477^[5]	IMP: Inferred from Mutant Phenotype		P
	GO:0014032	neural crest cell development	PMID:9671575^[11]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1857639	P
	GO:0019904	protein domain specific binding	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000033513	F
	GO:0030154	cell differentiation	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0221	P
	GO:0033613	activating transcription factor binding	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000033513	F
	GO:0033613	activating transcription factor binding	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:P61295	F
	GO:0042802	identical protein binding	PMID:10924525^[6]	IPI: Inferred from Physical Interaction	UniProtKB:Q61039	F
	GO:0042803	protein homodimerization activity	PMID:11812799^[9]	IPI: Inferred from Physical Interaction	UniProtKB:Q61039	F
	GO:0045893	positive regulation of transcription, DNA-dependent	PMID:11812799^[9]	IDA: Inferred from Direct Assay		P
	GO:0045944	positive regulation of transcription from RNA polymerase II promoter	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000033513	P
	GO:0045944	positive regulation of transcription from RNA polymerase II promoter	PMID:11812799^[9]	IDA: Inferred from Direct Assay		P
	GO:0046982	protein heterodimerization activity	PMID:12392994^[12]	IPI: Inferred from Physical Interaction	UniProtKB:P42582	F
	GO:0048538	thymus development	PMID:19008477^[5]	IMP: Inferred from Mutant Phenotype		P
	GO:0061309	cardiac neural crest cell development involved in outflow tract morphogenesis	PMID:19008477^[5]	IMP: Inferred from Mutant Phenotype		P
contributes_to	GO:0044212	transcription regulatory region DNA binding	PMID:11812799^[9]	IDA: Inferred from Direct Assay		F
contributes_to	GO:0070888	E-box binding	PMID:11812799^[9]	IDA: Inferred from Direct Assay		F
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 Xiong W et al. (2009) Hand2 is required in the epithelium for palatogenesis in mice. Dev Biol 330: 131-41 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 Srivastava D et al. (1997) Regulation of cardiac mesodermal and neural crest development by the bHLH transcription factor, dHAND. Nat Genet 16: 154-60 PubMed GONUTS page
↑ ^3.0 ^3.1 Yamagishi H et al. (2001) The combinatorial activities of Nkx2.5 and dHAND are essential for cardiac ventricle formation. Dev Biol 239: 190-203 PubMed GONUTS page
↑ McFadden DG et al. (2000) A GATA-dependent right ventricular enhancer controls dHAND transcription in the developing heart. Development 127: 5331-41 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 ^5.3 Morikawa Y & Cserjesi P (2008) Cardiac neural crest expression of Hand2 regulates outflow and second heart field development. Circ Res 103: 1422-9 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 ^6.3 ^6.4 ^6.5 ^6.6 Firulli BA et al. (2000) The basic helix-loop-helix transcription factors dHAND and eHAND exhibit dimerization characteristics that suggest complex regulation of function. J Biol Chem 275: 33567-73 PubMed GONUTS page
↑ Papin J & Subramaniam S (2004) Bioinformatics and cellular signaling. Curr Opin Biotechnol 15: 78-81 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 ^8.3 Murakami M et al. (2004) Differential cooperation between dHAND and three different E-proteins. Biochem Biophys Res Commun 323: 168-74 PubMed GONUTS page
↑ ^9.0 ^9.1 ^9.2 ^9.3 ^9.4 ^9.5 ^9.6 Dai YS & Cserjesi P (2002) The basic helix-loop-helix factor, HAND2, functions as a transcriptional activator by binding to E-boxes as a heterodimer. J Biol Chem 277: 12604-12 PubMed GONUTS page
↑ McFadden DG et al. (2005) The Hand1 and Hand2 transcription factors regulate expansion of the embryonic cardiac ventricles in a gene dosage-dependent manner. Development 132: 189-201 PubMed GONUTS page
↑ Thomas T et al. (1998) A signaling cascade involving endothelin-1, dHAND and msx1 regulates development of neural-crest-derived branchial arch mesenchyme. Development 125: 3005-14 PubMed GONUTS page
↑ Thattaliyath BD et al. (2002) The basic-helix-loop-helix transcription factor HAND2 directly regulates transcription of the atrial naturetic peptide gene. J Mol Cell Cardiol 34: 1335-44 PubMed GONUTS page

[PMID:19341725-0] 1.0 ^1.1 ^1.2 ^1.3 Xiong W et al. (2009) Hand2 is required in the epithelium for palatogenesis in mice. Dev Biol 330: 131-41 PubMed GONUTS page

[PMID:9171826-1] 2.0 ^2.1 ^2.2 Srivastava D et al. (1997) Regulation of cardiac mesodermal and neural crest development by the bHLH transcription factor, dHAND. Nat Genet 16: 154-60 PubMed GONUTS page

[PMID:11784028-2] 3.0 ^3.1 Yamagishi H et al. (2001) The combinatorial activities of Nkx2.5 and dHAND are essential for cardiac ventricle formation. Dev Biol 239: 190-203 PubMed GONUTS page

[PMID:11076755-3] McFadden DG et al. (2000) A GATA-dependent right ventricular enhancer controls dHAND transcription in the developing heart. Development 127: 5331-41 PubMed GONUTS page

[PMID:19008477-4] 5.0 ^5.1 ^5.2 ^5.3 Morikawa Y & Cserjesi P (2008) Cardiac neural crest expression of Hand2 regulates outflow and second heart field development. Circ Res 103: 1422-9 PubMed GONUTS page

[PMID:10924525-5] 6.0 ^6.1 ^6.2 ^6.3 ^6.4 ^6.5 ^6.6 Firulli BA et al. (2000) The basic helix-loop-helix transcription factors dHAND and eHAND exhibit dimerization characteristics that suggest complex regulation of function. J Biol Chem 275: 33567-73 PubMed GONUTS page

[PMID:15102471-6] Papin J & Subramaniam S (2004) Bioinformatics and cellular signaling. Curr Opin Biotechnol 15: 78-81 PubMed GONUTS page

[PMID:15351717-7] 8.0 ^8.1 ^8.2 ^8.3 Murakami M et al. (2004) Differential cooperation between dHAND and three different E-proteins. Biochem Biophys Res Commun 323: 168-74 PubMed GONUTS page

[PMID:11812799-8] 9.0 ^9.1 ^9.2 ^9.3 ^9.4 ^9.5 ^9.6 Dai YS & Cserjesi P (2002) The basic helix-loop-helix factor, HAND2, functions as a transcriptional activator by binding to E-boxes as a heterodimer. J Biol Chem 277: 12604-12 PubMed GONUTS page

[PMID:15576406-9] McFadden DG et al. (2005) The Hand1 and Hand2 transcription factors regulate expansion of the embryonic cardiac ventricles in a gene dosage-dependent manner. Development 132: 189-201 PubMed GONUTS page

[PMID:9671575-10] Thomas T et al. (1998) A signaling cascade involving endothelin-1, dHAND and msx1 regulates development of neural-crest-derived branchial arch mesenchyme. Development 125: 3005-14 PubMed GONUTS page

[PMID:12392994-11] Thattaliyath BD et al. (2002) The basic-helix-loop-helix transcription factor HAND2 directly regulates transcription of the atrial naturetic peptide gene. J Mol Cell Cardiol 34: 1335-44 PubMed GONUTS page

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MOUSE:HAND2

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