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MOUSE:H2AX

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Contents

Species (Taxon ID) Mus musculus (Mouse). (10090)
Gene Name(s) H2afx (synonyms: H2a.x, H2ax, Hist5-2ax)
Protein Name(s) Histone H2A.x

H2a/x

External Links
UniProt P27661
EMBL X58069
Z35401
BC005468
BC010336
IPI IPI00230264
PIR I48406
RefSeq NP_034566.1
UniGene Mm.245931
ProteinModelPortal P27661
SMR P27661
IntAct P27661
MINT MINT-1864212
STRING P27661
PhosphoSite P27661
PRIDE P27661
Ensembl ENSMUST00000052686
GeneID 15270
KEGG mmu:15270
CTD 3014
MGI MGI:102688
eggNOG roNOG15710
GeneTree ENSGT00600000084277
HOGENOM HBG610736
HOVERGEN HBG009342
InParanoid P27661
OMA RRGHYAE
OrthoDB EOG4TXBTD
PhylomeDB P27661
Reactome REACT_27235
REACT_75800
NextBio 287897
ArrayExpress P27661
Bgee P27661
CleanEx MM_H2AFX
Genevestigator P27661
GermOnline ENSMUSG00000049932
GO GO:0000794
GO:0001673
GO:0000790
GO:0005654
GO:0000786
GO:0005657
GO:0001741
GO:0003684
GO:0000724
GO:0007126
GO:0006334
GO:0007283
InterPro IPR009072
IPR007125
IPR002119
Gene3D G3DSA:1.10.20.10
KO K11251
Pfam PF00125
PRINTS PR00620
SMART SM00414
SUPFAM SSF47113
PROSITE PS00046

Annotations

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0000077

DNA damage checkpoint

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSP00000434024

P

Seeded From UniProt

GO:0000724

double-strand break repair via homologous recombination

PMID:11934988[1]

IMP: Inferred from Mutant Phenotype

MGI:MGI:2156048

P

Seeded From UniProt

GO:0000781

chromosome, telomeric region

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSP00000434024

C

Seeded From UniProt

GO:0000785

chromatin

PMID:11934988[1]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

GO:0000785

chromatin

PMID:15657431[2]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

GO:0000785

chromatin

PMID:18283110[3]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

GO:0000785

chromatin

PMID:18694567[4]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

GO:0000786

nucleosome

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR002119

C

Seeded From UniProt

GO:0000786

nucleosome

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0544

C

Seeded From UniProt

GO:0000790

nuclear chromatin

PMID:17696610[5]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

GO:0000794

condensed nuclear chromosome

PMID:20551173[6]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

GO:0001673

male germ cell nucleus

PMID:17696610[5]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

GO:0001741

XY body

PMID:18316482[7]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

GO:0001741

XY body

PMID:19074312[8]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

GO:0003677

DNA binding

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR002119

F

Seeded From UniProt

GO:0003677

DNA binding

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR007125

F

Seeded From UniProt

GO:0003677

DNA binding

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR009072

F

Seeded From UniProt

GO:0003677

DNA binding

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0238

F

Seeded From UniProt

GO:0003684

damaged DNA binding

PMID:11934988[1]

IDA: Inferred from Direct Assay

F

Seeded From UniProt

GO:0005515

protein binding

PMID:19092802[9]

IPI: Inferred from Physical Interaction

UniProtKB:Q9Z277

F

Seeded From UniProt

GO:0005634

nucleus

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR002119

C

Seeded From UniProt

GO:0005634

nucleus

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0539

C

Seeded From UniProt

GO:0005634

nucleus

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSP00000434024

C

Seeded From UniProt

GO:0005634

nucleus

GO_REF:0000023

IEA: Inferred from Electronic Annotation

SP_SL:SL-0191

C

Seeded From UniProt

GO:0005634

nucleus

PMID:14611631[10]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

GO:0005634

nucleus

PMID:17475928[11]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

GO:0005634

nucleus

PMID:17912366[12]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

GO:0005634

nucleus

PMID:19176879[13]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

GO:0005634

nucleus

PMID:20360685[14]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

GO:0005654

nucleoplasm

Reactome:REACT_27137

TAS: Traceable Author Statement

C

Seeded From UniProt

GO:0005654

nucleoplasm

Reactome:REACT_27201

TAS: Traceable Author Statement

C

Seeded From UniProt

GO:0005654

nucleoplasm

Reactome:REACT_27250

TAS: Traceable Author Statement

C

Seeded From UniProt

GO:0005654

nucleoplasm

Reactome:REACT_27284

TAS: Traceable Author Statement

C

Seeded From UniProt

GO:0005654

nucleoplasm

Reactome:REACT_75752

TAS: Traceable Author Statement

C

Seeded From UniProt

GO:0005654

nucleoplasm

Reactome:REACT_75759

TAS: Traceable Author Statement

C

Seeded From UniProt

GO:0005654

nucleoplasm

Reactome:REACT_75837

TAS: Traceable Author Statement

C

Seeded From UniProt

GO:0005657

replication fork

PMID:15364958[15]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

GO:0005694

chromosome

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0158

C

Seeded From UniProt

GO:0005694

chromosome

GO_REF:0000023

IEA: Inferred from Electronic Annotation

SP_SL:SL-0468

C

Seeded From UniProt

GO:0006281

DNA repair

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0234

P

Seeded From UniProt

GO:0006281

DNA repair

PMID:11934988[1]

IMP: Inferred from Mutant Phenotype

MGI:MGI:2156048

P

Seeded From UniProt

GO:0006281

DNA repair

PMID:15364958[15]

IDA: Inferred from Direct Assay

P

Seeded From UniProt

GO:0006310

DNA recombination

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0233

P

Seeded From UniProt

GO:0006334

nucleosome assembly

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR002119

P

Seeded From UniProt

GO:0006974

response to DNA damage stimulus

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0227

P

Seeded From UniProt

GO:0006974

response to DNA damage stimulus

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSP00000434024

P

Seeded From UniProt

GO:0007049

cell cycle

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0131

P

Seeded From UniProt

GO:0007126

meiosis

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0469

P

Seeded From UniProt

GO:0007283

spermatogenesis

PMID:11934988[1]

IMP: Inferred from Mutant Phenotype

MGI:MGI:2156048

P

Seeded From UniProt

GO:0019899

enzyme binding

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSP00000434024

F

Seeded From UniProt

GO:0042393

histone binding

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSP00000434024

F

Seeded From UniProt

GO:0000077

DNA damage checkpoint

PMID:11934988[1]

IMP: Inferred from Mutant Phenotype

MGI:MGI:2156048

P

Seeded From UniProt


edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ 1.0 1.1 1.2 1.3 1.4 1.5 Celeste A et al. (2002) Genomic instability in mice lacking histone H2AX. Science 296: 922-7 PubMed GONUTS page
  2. ↑ Baarends WM et al. (2005) Silencing of unpaired chromatin and histone H2A ubiquitination in mammalian meiosis. Mol Cell Biol 25: 1041-53 PubMed GONUTS page
  3. ↑ Yang F et al. (2008) Mouse TEX15 is essential for DNA double-strand break repair and chromosomal synapsis during male meiosis. J Cell Biol 180: 673-9 PubMed GONUTS page
  4. ↑ Soper SF et al. (2008) Mouse maelstrom, a component of nuage, is essential for spermatogenesis and transposon repression in meiosis. Dev Cell 15: 285-97 PubMed GONUTS page
  5. ↑ 5.0 5.1 Li XC & Schimenti JC (2007) Mouse pachytene checkpoint 2 (trip13) is required for completing meiotic recombination but not synapsis. PLoS Genet 3: e130 PubMed GONUTS page
  6. ↑ Kumar R et al. (2010) Functional conservation of Mei4 for meiotic DNA double-strand break formation from yeasts to mice. Genes Dev 24: 1266-80 PubMed GONUTS page
  7. ↑ Yang F et al. (2008) Meiotic failure in male mice lacking an X-linked factor. Genes Dev 22: 682-91 PubMed GONUTS page
  8. ↑ Mihola O et al. (2009) A mouse speciation gene encodes a meiotic histone H3 methyltransferase. Science 323: 373-5 PubMed GONUTS page
  9. ↑ Xiao A et al. (2009) WSTF regulates the H2A.X DNA damage response via a novel tyrosine kinase activity. Nature 457: 57-62 PubMed GONUTS page
  10. ↑ Saunders PT et al. (2003) Absence of mDazl produces a final block on germ cell development at meiosis. Reproduction 126: 589-97 PubMed GONUTS page
  11. ↑ Reynard LN et al. (2007) Expression analysis of the mouse multi-copy X-linked gene Xlr-related, meiosis-regulated (Xmr), reveals that Xmr encodes a spermatid-expressed cytoplasmic protein, SLX/XMR. Biol Reprod 77: 329-35 PubMed GONUTS page
  12. ↑ Paul C et al. (2007) Deletion of genes implicated in protecting the integrity of male germ cells has differential effects on the incidence of DNA breaks and germ cell loss. PLoS One 2: e989 PubMed GONUTS page
  13. ↑ Reynard LN et al. (2009) The multi-copy mouse gene Sycp3-like Y-linked (Sly) encodes an abundant spermatid protein that interacts with a histone acetyltransferase and an acrosomal protein. Biol Reprod 81: 250-7 PubMed GONUTS page
  14. ↑ Artus C et al. (2010) AIF promotes chromatinolysis and caspase-independent programmed necrosis by interacting with histone H2AX. EMBO J 29: 1585-99 PubMed GONUTS page
  15. ↑ 15.0 15.1 Sengupta S et al. (2004) Functional interaction between BLM helicase and 53BP1 in a Chk1-mediated pathway during S-phase arrest. J Cell Biol 166: 801-13 PubMed GONUTS page
Retrieved from "http://gowiki.tamu.edu/wiki/index.php/MOUSE:H2AX"
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