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MOUSE:GRIA1
Contents |
| Species (Taxon ID) | Mus musculus (Mouse). ([1]) | |
| Gene Name(s) | Gria1 (synonyms: Glur1) | |
| Protein Name(s) | Glutamate receptor 1
GluR-1 AMPA-selective glutamate receptor 1 GluR-A GluR-K1 Glutamate receptor ionotropic, AMPA 1 GluA1 | |
| External Links | ||
| EMBL | X57497 | |
| IPI | IPI00136965 | |
| PIR | S12874 | |
| RefSeq | NP_001106796.1 | |
| UniGene | Mm.4920 | |
| ProteinModelPortal | P23818 | |
| SMR | P23818 | |
| IntAct | P23818 | |
| MINT | MINT-1897734 | |
| STRING | P23818 | |
| PhosphoSite | P23818 | |
| PRIDE | P23818 | |
| Ensembl | ENSMUST00000036315 | |
| GeneID | 14799 | |
| KEGG | mmu:14799 | |
| UCSC | uc007izs.2 | |
| CTD | 2890 | |
| MGI | MGI:95808 | |
| eggNOG | maNOG06626 | |
| HOGENOM | HBG381523 | |
| HOVERGEN | HBG051839 | |
| InParanoid | P23818 | |
| NextBio | 286953 | |
| ArrayExpress | P23818 | |
| Bgee | P23818 | |
| CleanEx | MM_GRIA1 | |
| Genevestigator | P23818 | |
| GermOnline | ENSMUSG00000020524 | |
| GO | GO:0032281 GO:0030054 GO:0005789 GO:0005624 GO:0043025 GO:0014069 GO:0045211 GO:0004971 GO:0005234 GO:0005515 GO:0007616 GO:0031623 GO:0007268 | |
| InterPro | IPR001828 IPR019594 IPR001320 IPR001508 | |
| Pfam | PF01094 PF00060 PF10613 | |
| PRINTS | PR00177 | |
| SMART | SM00918 SM00079 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0004872 |
receptor activity |
IEA: Inferred from Electronic Annotation |
F |
Seeded From UniProt |
||||
| GO:0004872 |
receptor activity |
IEA: Inferred from Electronic Annotation |
F |
Seeded From UniProt |
||||
| GO:0004970 |
ionotropic glutamate receptor activity |
IEA: Inferred from Electronic Annotation |
F |
Seeded From UniProt |
||||
| GO:0004970 |
ionotropic glutamate receptor activity |
IEA: Inferred from Electronic Annotation |
F |
Seeded From UniProt |
||||
| GO:0004971 |
alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSP00000285900 |
F |
Seeded From UniProt |
|||
| GO:0004971 |
alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity |
ISS: Inferred from Sequence or Structural Similarity |
F |
Seeded From UniProt |
||||
| GO:0005216 |
ion channel activity |
IEA: Inferred from Electronic Annotation |
F |
Seeded From UniProt |
||||
| GO:0005216 |
ion channel activity |
IEA: Inferred from Electronic Annotation |
F |
Seeded From UniProt |
||||
| GO:0005234 |
extracellular-glutamate-gated ion channel activity |
IEA: Inferred from Electronic Annotation |
F |
Seeded From UniProt |
||||
| GO:0005234 |
extracellular-glutamate-gated ion channel activity |
IEA: Inferred from Electronic Annotation |
F |
Seeded From UniProt |
||||
| GO:0005234 |
extracellular-glutamate-gated ion channel activity |
IEA: Inferred from Electronic Annotation |
F |
Seeded From UniProt |
||||
| GO:0005515 |
protein binding |
IPI: Inferred from Physical Interaction |
F |
Seeded From UniProt |
||||
| GO:0005515 |
protein binding |
IPI: Inferred from Physical Interaction |
F |
Seeded From UniProt |
||||
| GO:0005515 |
protein binding |
IPI: Inferred from Physical Interaction |
F |
Seeded From UniProt |
||||
| GO:0005515 |
protein binding |
IPI: Inferred from Physical Interaction |
F |
Seeded From UniProt |
||||
| GO:0005624 |
membrane fraction |
IDA: Inferred from Direct Assay |
|
C |
Seeded From UniProt |
|||
| GO:0005783 |
endoplasmic reticulum |
IEA: Inferred from Electronic Annotation |
C |
Seeded From UniProt |
||||
| GO:0005789 |
endoplasmic reticulum membrane |
IEA: Inferred from Electronic Annotation |
SP_SL:SL-0097 |
C |
Seeded From UniProt |
|||
| GO:0005886 |
plasma membrane |
IEA: Inferred from Electronic Annotation |
C |
Seeded From UniProt |
||||
| GO:0005886 |
plasma membrane |
IEA: Inferred from Electronic Annotation |
SP_SL:SL-0039 |
C |
Seeded From UniProt |
|||
| GO:0005886 |
plasma membrane |
IDA: Inferred from Direct Assay |
|
C |
Seeded From UniProt |
|||
| GO:0006810 |
transport |
IEA: Inferred from Electronic Annotation |
P |
Seeded From UniProt |
||||
| GO:0006811 |
ion transport |
IEA: Inferred from Electronic Annotation |
P |
Seeded From UniProt |
||||
| GO:0006811 |
ion transport |
IEA: Inferred from Electronic Annotation |
P |
Seeded From UniProt |
||||
| GO:0007268 |
synaptic transmission |
IGI: Inferred from Genetic Interaction |
MGI:MGI:1201678 |
P |
Seeded From UniProt |
|||
| GO:0007616 |
long-term memory |
IMP: Inferred from Mutant Phenotype |
|
P |
Seeded From UniProt |
|||
| GO:0014069 |
postsynaptic density |
IEA: Inferred from Electronic Annotation |
SP_SL:SL-0297 |
C |
Seeded From UniProt |
|||
| GO:0014069 |
postsynaptic density |
IDA: Inferred from Direct Assay |
|
C |
Seeded From UniProt |
|||
| GO:0014069 |
postsynaptic density |
IDA: Inferred from Direct Assay |
|
C |
Seeded From UniProt |
|||
| GO:0016020 |
membrane |
IEA: Inferred from Electronic Annotation |
C |
Seeded From UniProt |
||||
| GO:0016020 |
membrane |
IEA: Inferred from Electronic Annotation |
C |
Seeded From UniProt |
||||
| GO:0016020 |
membrane |
IEA: Inferred from Electronic Annotation |
C |
Seeded From UniProt |
||||
| GO:0016020 |
membrane |
IEA: Inferred from Electronic Annotation |
C |
Seeded From UniProt |
||||
| GO:0016021 |
integral to membrane |
IEA: Inferred from Electronic Annotation |
C |
Seeded From UniProt |
||||
| GO:0030054 |
cell junction |
IEA: Inferred from Electronic Annotation |
C |
Seeded From UniProt |
||||
| GO:0030425 |
dendrite |
IEA: Inferred from Electronic Annotation |
SP_SL:SL-0283 |
C |
Seeded From UniProt |
|||
| GO:0030425 |
dendrite |
IDA: Inferred from Direct Assay |
|
C |
Seeded From UniProt |
|||
| GO:0031623 |
receptor internalization |
IMP: Inferred from Mutant Phenotype |
|
P |
Seeded From UniProt |
|||
| GO:0032281 |
alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex |
IDA: Inferred from Direct Assay |
|
C |
Seeded From UniProt |
|||
| GO:0042995 |
cell projection |
IEA: Inferred from Electronic Annotation |
C |
Seeded From UniProt |
||||
| GO:0043025 |
neuronal cell body |
IDA: Inferred from Direct Assay |
|
C |
Seeded From UniProt |
|||
| GO:0043197 |
dendritic spine |
IEA: Inferred from Electronic Annotation |
SP_SL:SL-0284 |
C |
Seeded From UniProt |
|||
| GO:0043197 |
dendritic spine |
IDA: Inferred from Direct Assay |
|
C |
Seeded From UniProt |
|||
| GO:0044309 |
neuron spine |
IDA: Inferred from Direct Assay |
|
C |
Seeded From UniProt |
|||
| GO:0045202 |
synapse |
IEA: Inferred from Electronic Annotation |
C |
Seeded From UniProt |
||||
| GO:0045211 |
postsynaptic membrane |
IEA: Inferred from Electronic Annotation |
C |
Seeded From UniProt |
||||
| GO:0045211 |
postsynaptic membrane |
IEA: Inferred from Electronic Annotation |
SP_SL:SL-0219 |
C |
Seeded From UniProt |
|||
| GO:0009986 |
cell surface |
IMP: Inferred from Mutant Phenotype |
C |
Cell surface protein biotinylation and Western blotting was used. Figure 3 A-C, cells treated with Reelin showed increase levels of surface GluR1 compared to control. |
complete | |||
| GO:0030425 |
dendrite |
IMP: Inferred from Mutant Phenotype |
C |
Wild type primary dendrites show labelling of Glur1 by using immunofluorescence techniques, figure 6A. figure 6B in reelin mutant mice showed decrease NR1 which was corrected by treating cells with reelin, figure 6C. |
complete | |||
| GO:0032590 |
dendrite membrane |
IMP: Inferred from Mutant Phenotype |
C |
Mutant Shank3 mice, Figure 6E and F, showed decrease in cluster at plasma membrane of dendrite. |
complete | |||
| GO:0019717 |
synaptosome |
IMP: Inferred from Mutant Phenotype |
C |
Figure 6B and D, A decrease of receptor subunit in synaptosome membrane fraction. There was a decrease in GluA1 subunit in mutant Shank3 mice compared to control. Similar results was seen in figure 6E, confirmed by quantitative analyses. |
complete | |||
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ Metzler M et al. (2003) Disruption of the endocytic protein HIP1 results in neurological deficits and decreased AMPA receptor trafficking. EMBO J 22: 3254-66 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 2.3 2.4 Uchino S et al. (2006) Direct interaction of post-synaptic density-95/Dlg/ZO-1 domain-containing synaptic molecule Shank3 with GluR1 alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptor. J Neurochem 97: 1203-14 PubMed GONUTS page
- ↑ Kalashnikova E et al. (2010) SynDIG1: an activity-regulated, AMPA- receptor-interacting transmembrane protein that regulates excitatory synapse development. Neuron 65: 80-93 PubMed GONUTS page
- ↑ Lai C et al. (2006) Amyotrophic lateral sclerosis 2-deficiency leads to neuronal degeneration in amyotrophic lateral sclerosis through altered AMPA receptor trafficking. J Neurosci 26: 11798-806 PubMed GONUTS page
- ↑ Hildebrand ME et al. (2009) Functional coupling between mGluR1 and Cav3.1 T-type calcium channels contributes to parallel fiber-induced fast calcium signaling within Purkinje cell dendritic spines. J Neurosci 29: 9668-82 PubMed GONUTS page
- ↑ 6.0 6.1 6.2 Lee HK et al. (2003) Phosphorylation of the AMPA receptor GluR1 subunit is required for synaptic plasticity and retention of spatial memory. Cell 112: 631-43 PubMed GONUTS page
- ↑ 7.0 7.1 7.2 Kato AS et al. (2010) Hippocampal AMPA receptor gating controlled by both TARP and cornichon proteins. Neuron 68: 1082-96 PubMed GONUTS page
- ↑ Fukata Y et al. (2005) Molecular constituents of neuronal AMPA receptors. J Cell Biol 169: 399-404 PubMed GONUTS page
- ↑ 9.0 9.1 Qiu S & Weeber EJ (2007) Reelin signaling facilitates maturation of CA1 glutamatergic synapses. J Neurophysiol 97: 2312-21 PubMed GONUTS page
- ↑ Verpelli C et al. (2011) Importance of Shank3 protein in regulating metabotropic glutamate receptor 5 (mGluR5) expression and signaling at synapses. J Biol Chem 286: 34839-50 PubMed GONUTS page
- ↑ Wang X et al. (2011) Synaptic dysfunction and abnormal behaviors in mice lacking major isoforms of Shank3. Hum Mol Genet 20: 3093-108 PubMed GONUTS page
