MOUSE:GPX1

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Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Gpx1
Protein Name(s)	Glutathione peroxidase 1 GPx-1 GSHPx-1 Cellular glutathione peroxidase
External Links
UniProt	P11352
EMBL	X03920 AK002245 AK010999 AK011019 AK028171 AK150548 AK154833 AK160388 X15667
IPI	IPI00319652
PIR	A25106 S05317
RefSeq	NP_032186.2
UniGene	Mm.1090
ProteinModelPortal	P11352
SMR	P11352
STRING	P11352
PeroxiBase	3709
PhosphoSite	P11352
SWISS-2DPAGE	P11352
REPRODUCTION-2DPAGE	IPI00319652 P11352
PRIDE	P11352
Ensembl	ENSMUST00000082429
GeneID	14775
KEGG	mmu:14775
CTD	2876
MGI	MGI:104887
eggNOG	maNOG14464
HOGENOM	HBG648990
HOVERGEN	HBG004333
InParanoid	P11352
OMA	CRNDISW
OrthoDB	EOG4SBF08
PhylomeDB	P11352
NextBio	286877
ArrayExpress	P11352
Bgee	P11352
CleanEx	MM_GPX1
Genevestigator	P11352
GermOnline	ENSMUSG00000063856
GO	GO:0005739 GO:0004602 GO:0060055 GO:0043534 GO:0001885 GO:0045444 GO:0060047 GO:0042744 GO:0008631 GO:0051450 GO:0014902 GO:0051897 GO:0018158 GO:0043523 GO:0033194 GO:0009636 GO:0009410 GO:0007605 GO:0048741 GO:0043403 GO:0006641 GO:0042311
InterPro	IPR000889 IPR012336
Gene3D	G3DSA:3.40.30.10
KO	K00432
PANTHER	PTHR11592
Pfam	PF00255
PIRSF	PIRSF000303
PRINTS	PR01011
SUPFAM	SSF52833
PROSITE	PS00460 PS00763 PS51355

Annotations

Qualifier	GO ID	GO term name	Reference	Evidence Code	with/from	Aspect	Notes
	GO:0000302	response to reactive oxygen species	PMID:10915565^[1]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2158814	P	Seeded From UniProt
	GO:0000302	response to reactive oxygen species	PMID:11562367^[2]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2158814	P	Seeded From UniProt
	GO:0000302	response to reactive oxygen species	PMID:16373599^[3]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2158814	P	Seeded From UniProt
	GO:0000302	response to reactive oxygen species	PMID:16962942^[4]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2158814	P	Seeded From UniProt
	GO:0000302	response to reactive oxygen species	PMID:17145560^[5]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2158814	P	Seeded From UniProt
	GO:0001885	endothelial cell development	PMID:16373599^[3]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2158814	P	Seeded From UniProt
	GO:0004601	peroxidase activity	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0575	F	Seeded From UniProt
	GO:0004602	glutathione peroxidase activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR000889	F	Seeded From UniProt
	GO:0004602	glutathione peroxidase activity	GO_REF:0000003	IEA: Inferred from Electronic Annotation	EC:1.11.1.9	F	Seeded From UniProt
	GO:0004602	glutathione peroxidase activity	PMID:10490281^[6]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2158814	F	Seeded From UniProt
	GO:0004602	glutathione peroxidase activity	PMID:10915565^[1]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2158814	F	Seeded From UniProt
	GO:0004602	glutathione peroxidase activity	PMID:10915653^[7]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2158814	F	Seeded From UniProt
	GO:0004602	glutathione peroxidase activity	PMID:11311045^[8]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2158814	F	Seeded From UniProt
	GO:0004602	glutathione peroxidase activity	PMID:11518697^[9]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2158814	F	Seeded From UniProt
	GO:0004602	glutathione peroxidase activity	PMID:11545230^[10]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2158814	F	Seeded From UniProt
	GO:0004602	glutathione peroxidase activity	PMID:11893559^[11]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2158814	F	Seeded From UniProt
	GO:0004602	glutathione peroxidase activity	PMID:12117267^[12]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2158814	F	Seeded From UniProt
	GO:0004602	glutathione peroxidase activity	PMID:12521604^[13]	IDA: Inferred from Direct Assay		F	Seeded From UniProt
	GO:0004602	glutathione peroxidase activity	PMID:12646716^[14]	IDA: Inferred from Direct Assay		F	Seeded From UniProt
	GO:0004602	glutathione peroxidase activity	PMID:12751789^[15]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2158814	F	Seeded From UniProt
	GO:0004602	glutathione peroxidase activity	PMID:15182862^[16]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2158814	F	Seeded From UniProt
	GO:0004602	glutathione peroxidase activity	PMID:15827346^[17]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2388705	F	Seeded From UniProt
	GO:0004602	glutathione peroxidase activity	PMID:9386101^[18]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2158814	F	Seeded From UniProt
	GO:0004602	glutathione peroxidase activity	PMID:9788901^[19]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2158814	F	Seeded From UniProt
	GO:0005737	cytoplasm	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0963	C	Seeded From UniProt
	GO:0005737	cytoplasm	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0086	C	Seeded From UniProt
	GO:0005737	cytoplasm	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:P07203	C	Seeded From UniProt
	GO:0005739	mitochondrion	PMID:10754271^[20]	IMP: Inferred from Mutant Phenotype	MGI:MGI:3589261	C	Seeded From UniProt
	GO:0005739	mitochondrion	PMID:14651853^[21]	IDA: Inferred from Direct Assay		C	Seeded From UniProt
	GO:0005739	mitochondrion	PMID:18614015^[22]	IDA: Inferred from Direct Assay		C	Seeded From UniProt
	GO:0005739	mitochondrion	PMID:9126277^[23]	IDA: Inferred from Direct Assay		C	Seeded From UniProt
	GO:0006629	lipid metabolic process	PMID:10754271^[20]	IMP: Inferred from Mutant Phenotype	MGI:MGI:3589261	P	Seeded From UniProt
	GO:0006641	triglyceride metabolic process	PMID:12117267^[12]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2158814	P	Seeded From UniProt
	GO:0006915	apoptosis	PMID:16962942^[4]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2158814	P	Seeded From UniProt
	GO:0006917	induction of apoptosis	PMID:16373599^[3]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2158814	P	Seeded From UniProt
	GO:0006979	response to oxidative stress	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR000889	P	Seeded From UniProt
	GO:0006979	response to oxidative stress	PMID:10428770^[24]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2158814	P	Seeded From UniProt
	GO:0006979	response to oxidative stress	PMID:10627575^[25]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2158814	P	Seeded From UniProt
	GO:0006979	response to oxidative stress	PMID:10915565^[1]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2158814	P	Seeded From UniProt
	GO:0006979	response to oxidative stress	PMID:11893559^[11]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2158814	P	Seeded From UniProt
	GO:0006979	response to oxidative stress	PMID:12196344^[26]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2158814	P	Seeded From UniProt
	GO:0006979	response to oxidative stress	PMID:15182862^[16]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2158814	P	Seeded From UniProt
	GO:0006979	response to oxidative stress	PMID:16962942^[4]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2158814	P	Seeded From UniProt
	GO:0007605	sensory perception of sound	PMID:11545230^[10]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2158814	P	Seeded From UniProt
	GO:0008283	cell proliferation	PMID:14732290^[27]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2388705	P	Seeded From UniProt
	GO:0008631	induction of apoptosis by oxidative stress	PMID:11562367^[2]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2158814	P	Seeded From UniProt
	GO:0008631	induction of apoptosis by oxidative stress	PMID:15663476^[28]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2158814	P	Seeded From UniProt
	GO:0009410	response to xenobiotic stimulus	PMID:10915565^[1]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2158814	P	Seeded From UniProt
	GO:0009611	response to wounding	PMID:11579147^[29]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2388705	P	Seeded From UniProt
	GO:0009636	response to toxin	PMID:10627575^[25]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2158814	P	Seeded From UniProt
	GO:0014902	myotube differentiation	PMID:12368211^[30]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2158814	P	Seeded From UniProt
	GO:0014902	myotube differentiation	PMID:16962942^[4]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2158814	P	Seeded From UniProt
	GO:0016491	oxidoreductase activity	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0560	F	Seeded From UniProt
	GO:0018158	protein oxidation	PMID:10428770^[24]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2158814	P	Seeded From UniProt
	GO:0033194	response to hydroperoxide	PMID:16723478^[31]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2388705	P	Seeded From UniProt
	GO:0042311	vasodilation	PMID:11893559^[11]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2158814	P	Seeded From UniProt
	GO:0042311	vasodilation	PMID:12196344^[26]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2158814	P	Seeded From UniProt
	GO:0042542	response to hydrogen peroxide	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:P07203	P	Seeded From UniProt
	GO:0042542	response to hydrogen peroxide	PMID:14732290^[27]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2388705	P	Seeded From UniProt
	GO:0042542	response to hydrogen peroxide	PMID:16373599^[3]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2158814	P	Seeded From UniProt
	GO:0042744	hydrogen peroxide catabolic process	PMID:10754271^[20]	IMP: Inferred from Mutant Phenotype	MGI:MGI:3589261	P	Seeded From UniProt
	GO:0042744	hydrogen peroxide catabolic process	PMID:10915565^[1]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2158814	P	Seeded From UniProt
	GO:0042744	hydrogen peroxide catabolic process	PMID:11545230^[10]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2158814	P	Seeded From UniProt
	GO:0042744	hydrogen peroxide catabolic process	PMID:15182862^[16]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2158814	P	Seeded From UniProt
	GO:0042744	hydrogen peroxide catabolic process	PMID:15827346^[17]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2388705	P	Seeded From UniProt
	GO:0042744	hydrogen peroxide catabolic process	PMID:9788901^[19]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2158814	P	Seeded From UniProt
	GO:0043066	negative regulation of apoptosis	PMID:16934683^[32]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2158814	P	Seeded From UniProt
	GO:0043403	skeletal muscle tissue regeneration	PMID:16962942^[4]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2158814	P	Seeded From UniProt
	GO:0043523	regulation of neuron apoptosis	PMID:11579147^[29]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2388705	P	Seeded From UniProt
	GO:0043534	blood vessel endothelial cell migration	PMID:16373599^[3]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2158814	P	Seeded From UniProt
	GO:0045444	fat cell differentiation	PMID:16962942^[4]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2158814	P	Seeded From UniProt
	GO:0048741	skeletal muscle fiber development	PMID:16962942^[4]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2158814	P	Seeded From UniProt
	GO:0051450	myoblast proliferation	PMID:12368211^[30]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2158814	P	Seeded From UniProt
	GO:0051450	myoblast proliferation	PMID:16962942^[4]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2158814	P	Seeded From UniProt
	GO:0051897	positive regulation of protein kinase B signaling cascade	PMID:15663476^[28]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2158814	P	Seeded From UniProt
	GO:0055114	oxidation-reduction process	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR000889	P	Seeded From UniProt
	GO:0055114	oxidation-reduction process	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0560	P	Seeded From UniProt
	GO:0060047	heart contraction	PMID:12196344^[26]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2158814	P	Seeded From UniProt
	GO:0060055	angiogenesis involved in wound healing	PMID:16373599^[3]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2158814	P	Seeded From UniProt
edit table

Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 Jiang D et al. (2000) Chronic brain oxidation in a glutathione peroxidase knockout mouse model results in increased resistance to induced epileptic seizures. Exp Neurol 164: 257-68 PubMed GONUTS page
↑ ^2.0 ^2.1 Fu Y et al. (2001) Opposite roles of selenium-dependent glutathione peroxidase-1 in superoxide generator diquat- and peroxynitrite-induced apoptosis and signaling. J Biol Chem 276: 43004-9 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 ^3.4 ^3.5 Galasso G et al. (2006) Impaired angiogenesis in glutathione peroxidase-1-deficient mice is associated with endothelial progenitor cell dysfunction. Circ Res 98: 254-61 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 ^4.4 ^4.5 ^4.6 ^4.7 Lee S et al. (2006) Glutathione-peroxidase-1 null muscle progenitor cells are globally defective. Free Radic Biol Med 41: 1174-84 PubMed GONUTS page
↑ Vasilaki A et al. (2006) Genetic modification of the manganese superoxide dismutase/glutathione peroxidase 1 pathway influences intracellular ROS generation in quiescent, but not contracting, skeletal muscle cells. Free Radic Biol Med 41: 1719-25 PubMed GONUTS page
↑ Fu Y et al. (1999) Knockout of cellular glutathione peroxidase gene renders mice susceptible to diquat-induced oxidative stress. Free Radic Biol Med 27: 605-11 PubMed GONUTS page
↑ Esworthy RS et al. (2000) Low glutathione peroxidase activity in Gpx1 knockout mice protects jejunum crypts from gamma-irradiation damage. Am J Physiol Gastrointest Liver Physiol 279: G426-36 PubMed GONUTS page
↑ Spector A et al. (2001) The effect of aging on glutathione peroxidase-i knockout mice-resistance of the lens to oxidative stress. Exp Eye Res 72: 533-45 PubMed GONUTS page
↑ Esworthy RS et al. (2001) Mice with combined disruption of Gpx1 and Gpx2 genes have colitis. Am J Physiol Gastrointest Liver Physiol 281: G848-55 PubMed GONUTS page
↑ ^10.0 ^10.1 ^10.2 Ohlemiller KK et al. (2000) Targeted mutation of the gene for cellular glutathione peroxidase (Gpx1) increases noise-induced hearing loss in mice. J Assoc Res Otolaryngol 1: 243-54 PubMed GONUTS page
↑ ^11.0 ^11.1 ^11.2 Forgione MA et al. (2002) Cellular glutathione peroxidase deficiency and endothelial dysfunction. Am J Physiol Heart Circ Physiol 282: H1255-61 PubMed GONUTS page
↑ ^12.0 ^12.1 South PK et al. (2002) Effects of dietary iron overload on glutathione peroxidase knockout mice. Biol Trace Elem Res 88: 79-85 PubMed GONUTS page
↑ Felix K et al. (2003) Redox imbalance and mutagenesis in spleens of mice harboring a hypomorphic allele of Gpdx(a) encoding glucose 6-phosphate dehydrogenase. Free Radic Biol Med 34: 226-32 PubMed GONUTS page
↑ Khan JY & Black SM (2003) Developmental changes in murine brain antioxidant enzymes. Pediatr Res 54: 77-82 PubMed GONUTS page
↑ Esworthy RS et al. (2003) Microflora trigger colitis in mice deficient in selenium-dependent glutathione peroxidase and induce Gpx2 gene expression. Biol Chem 384: 597-607 PubMed GONUTS page
↑ ^16.0 ^16.1 ^16.2 Van Remmen H et al. (2004) Multiple deficiencies in antioxidant enzymes in mice result in a compound increase in sensitivity to oxidative stress. Free Radic Biol Med 36: 1625-34 PubMed GONUTS page
↑ ^17.0 ^17.1 de Haan JB et al. (2005) Kidney expression of glutathione peroxidase-1 is not protective against streptozotocin-induced diabetic nephropathy. Am J Physiol Renal Physiol 289: F544-51 PubMed GONUTS page
↑ Yoshida T et al. (1997) Glutathione peroxidase knockout mice are susceptible to myocardial ischemia reperfusion injury. Circulation 96: II-216-20 PubMed GONUTS page
↑ ^19.0 ^19.1 Ho YS et al. (1998) The nature of antioxidant defense mechanisms: a lesson from transgenic studies. Environ Health Perspect 106 Suppl 5: 1219-28 PubMed GONUTS page
↑ ^20.0 ^20.1 ^20.2 Esposito LA et al. (2000) Mitochondrial oxidative stress in mice lacking the glutathione peroxidase-1 gene. Free Radic Biol Med 28: 754-66 PubMed GONUTS page
↑ Mootha VK et al. (2003) Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria. Cell 115: 629-40 PubMed GONUTS page
↑ Pagliarini DJ et al. (2008) A mitochondrial protein compendium elucidates complex I disease biology. Cell 134: 112-23 PubMed GONUTS page
↑ Esworthy RS et al. (1997) The Gpx1 gene encodes mitochondrial glutathione peroxidase in the mouse liver. Arch Biochem Biophys 340: 59-63 PubMed GONUTS page
↑ ^24.0 ^24.1 Cheng W et al. (1999) Selenium-dependent cellular glutathione peroxidase protects mice against a pro-oxidant-induced oxidation of NADPH, NADH, lipids, and protein. FASEB J 13: 1467-75 PubMed GONUTS page
↑ ^25.0 ^25.1 Klivenyi P et al. (2000) Mice deficient in cellular glutathione peroxidase show increased vulnerability to malonate, 3-nitropropionic acid, and 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine. J Neurosci 20: 1-7 PubMed GONUTS page
↑ ^26.0 ^26.1 ^26.2 Forgione MA et al. (2002) Heterozygous cellular glutathione peroxidase deficiency in the mouse: abnormalities in vascular and cardiac function and structure. Circulation 106: 1154-8 PubMed GONUTS page
↑ ^27.0 ^27.1 de Haan JB et al. (2004) Fibroblasts derived from Gpx1 knockout mice display senescent-like features and are susceptible to H2O2-mediated cell death. Free Radic Biol Med 36: 53-64 PubMed GONUTS page
↑ ^28.0 ^28.1 Taylor JM et al. (2005) Diminished Akt phosphorylation in neurons lacking glutathione peroxidase-1 (Gpx1) leads to increased susceptibility to oxidative stress-induced cell death. J Neurochem 92: 283-93 PubMed GONUTS page
↑ ^29.0 ^29.1 Crack PJ et al. (2001) Increased infarct size and exacerbated apoptosis in the glutathione peroxidase-1 (Gpx-1) knockout mouse brain in response to ischemia/reperfusion injury. J Neurochem 78: 1389-99 PubMed GONUTS page
↑ ^30.0 ^30.1 Staversky RJ et al. (2002) Normal remodeling of the oxygen-injured lung requires the cyclin-dependent kinase inhibitor p21(Cip1/WAF1/Sdi1). Am J Pathol 161: 1383-93 PubMed GONUTS page
↑ Gosbell AD et al. (2006) Retinal light damage: structural and functional effects of the antioxidant glutathione peroxidase-1. Invest Ophthalmol Vis Sci 47: 2613-22 PubMed GONUTS page
↑ Gueven N et al. (2006) Dramatic extension of tumor latency and correction of neurobehavioral phenotype in Atm-mutant mice with a nitroxide antioxidant. Free Radic Biol Med 41: 992-1000 PubMed GONUTS page

[PMID:10915565-0] 1.0 ^1.1 ^1.2 ^1.3 ^1.4 Jiang D et al. (2000) Chronic brain oxidation in a glutathione peroxidase knockout mouse model results in increased resistance to induced epileptic seizures. Exp Neurol 164: 257-68 PubMed GONUTS page

[PMID:11562367-1] 2.0 ^2.1 Fu Y et al. (2001) Opposite roles of selenium-dependent glutathione peroxidase-1 in superoxide generator diquat- and peroxynitrite-induced apoptosis and signaling. J Biol Chem 276: 43004-9 PubMed GONUTS page

[PMID:16373599-2] 3.0 ^3.1 ^3.2 ^3.3 ^3.4 ^3.5 Galasso G et al. (2006) Impaired angiogenesis in glutathione peroxidase-1-deficient mice is associated with endothelial progenitor cell dysfunction. Circ Res 98: 254-61 PubMed GONUTS page

[PMID:16962942-3] 4.0 ^4.1 ^4.2 ^4.3 ^4.4 ^4.5 ^4.6 ^4.7 Lee S et al. (2006) Glutathione-peroxidase-1 null muscle progenitor cells are globally defective. Free Radic Biol Med 41: 1174-84 PubMed GONUTS page

[PMID:17145560-4] Vasilaki A et al. (2006) Genetic modification of the manganese superoxide dismutase/glutathione peroxidase 1 pathway influences intracellular ROS generation in quiescent, but not contracting, skeletal muscle cells. Free Radic Biol Med 41: 1719-25 PubMed GONUTS page

[PMID:10490281-5] Fu Y et al. (1999) Knockout of cellular glutathione peroxidase gene renders mice susceptible to diquat-induced oxidative stress. Free Radic Biol Med 27: 605-11 PubMed GONUTS page

[PMID:10915653-6] Esworthy RS et al. (2000) Low glutathione peroxidase activity in Gpx1 knockout mice protects jejunum crypts from gamma-irradiation damage. Am J Physiol Gastrointest Liver Physiol 279: G426-36 PubMed GONUTS page

[PMID:11311045-7] Spector A et al. (2001) The effect of aging on glutathione peroxidase-i knockout mice-resistance of the lens to oxidative stress. Exp Eye Res 72: 533-45 PubMed GONUTS page

[PMID:11518697-8] Esworthy RS et al. (2001) Mice with combined disruption of Gpx1 and Gpx2 genes have colitis. Am J Physiol Gastrointest Liver Physiol 281: G848-55 PubMed GONUTS page

[PMID:11545230-9] 10.0 ^10.1 ^10.2 Ohlemiller KK et al. (2000) Targeted mutation of the gene for cellular glutathione peroxidase (Gpx1) increases noise-induced hearing loss in mice. J Assoc Res Otolaryngol 1: 243-54 PubMed GONUTS page

[PMID:11893559-10] 11.0 ^11.1 ^11.2 Forgione MA et al. (2002) Cellular glutathione peroxidase deficiency and endothelial dysfunction. Am J Physiol Heart Circ Physiol 282: H1255-61 PubMed GONUTS page

[PMID:12117267-11] 12.0 ^12.1 South PK et al. (2002) Effects of dietary iron overload on glutathione peroxidase knockout mice. Biol Trace Elem Res 88: 79-85 PubMed GONUTS page

[PMID:12521604-12] Felix K et al. (2003) Redox imbalance and mutagenesis in spleens of mice harboring a hypomorphic allele of Gpdx(a) encoding glucose 6-phosphate dehydrogenase. Free Radic Biol Med 34: 226-32 PubMed GONUTS page

[PMID:12646716-13] Khan JY & Black SM (2003) Developmental changes in murine brain antioxidant enzymes. Pediatr Res 54: 77-82 PubMed GONUTS page

[PMID:12751789-14] Esworthy RS et al. (2003) Microflora trigger colitis in mice deficient in selenium-dependent glutathione peroxidase and induce Gpx2 gene expression. Biol Chem 384: 597-607 PubMed GONUTS page

[PMID:15182862-15] 16.0 ^16.1 ^16.2 Van Remmen H et al. (2004) Multiple deficiencies in antioxidant enzymes in mice result in a compound increase in sensitivity to oxidative stress. Free Radic Biol Med 36: 1625-34 PubMed GONUTS page

[PMID:15827346-16] 17.0 ^17.1 de Haan JB et al. (2005) Kidney expression of glutathione peroxidase-1 is not protective against streptozotocin-induced diabetic nephropathy. Am J Physiol Renal Physiol 289: F544-51 PubMed GONUTS page

[PMID:9386101-17] Yoshida T et al. (1997) Glutathione peroxidase knockout mice are susceptible to myocardial ischemia reperfusion injury. Circulation 96: II-216-20 PubMed GONUTS page

[PMID:9788901-18] 19.0 ^19.1 Ho YS et al. (1998) The nature of antioxidant defense mechanisms: a lesson from transgenic studies. Environ Health Perspect 106 Suppl 5: 1219-28 PubMed GONUTS page

[PMID:10754271-19] 20.0 ^20.1 ^20.2 Esposito LA et al. (2000) Mitochondrial oxidative stress in mice lacking the glutathione peroxidase-1 gene. Free Radic Biol Med 28: 754-66 PubMed GONUTS page

[PMID:14651853-20] Mootha VK et al. (2003) Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria. Cell 115: 629-40 PubMed GONUTS page

[PMID:18614015-21] Pagliarini DJ et al. (2008) A mitochondrial protein compendium elucidates complex I disease biology. Cell 134: 112-23 PubMed GONUTS page

[PMID:9126277-22] Esworthy RS et al. (1997) The Gpx1 gene encodes mitochondrial glutathione peroxidase in the mouse liver. Arch Biochem Biophys 340: 59-63 PubMed GONUTS page

[PMID:10428770-23] 24.0 ^24.1 Cheng W et al. (1999) Selenium-dependent cellular glutathione peroxidase protects mice against a pro-oxidant-induced oxidation of NADPH, NADH, lipids, and protein. FASEB J 13: 1467-75 PubMed GONUTS page

[PMID:10627575-24] 25.0 ^25.1 Klivenyi P et al. (2000) Mice deficient in cellular glutathione peroxidase show increased vulnerability to malonate, 3-nitropropionic acid, and 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine. J Neurosci 20: 1-7 PubMed GONUTS page

[PMID:12196344-25] 26.0 ^26.1 ^26.2 Forgione MA et al. (2002) Heterozygous cellular glutathione peroxidase deficiency in the mouse: abnormalities in vascular and cardiac function and structure. Circulation 106: 1154-8 PubMed GONUTS page

[PMID:14732290-26] 27.0 ^27.1 de Haan JB et al. (2004) Fibroblasts derived from Gpx1 knockout mice display senescent-like features and are susceptible to H2O2-mediated cell death. Free Radic Biol Med 36: 53-64 PubMed GONUTS page

[PMID:15663476-27] 28.0 ^28.1 Taylor JM et al. (2005) Diminished Akt phosphorylation in neurons lacking glutathione peroxidase-1 (Gpx1) leads to increased susceptibility to oxidative stress-induced cell death. J Neurochem 92: 283-93 PubMed GONUTS page

[PMID:11579147-28] 29.0 ^29.1 Crack PJ et al. (2001) Increased infarct size and exacerbated apoptosis in the glutathione peroxidase-1 (Gpx-1) knockout mouse brain in response to ischemia/reperfusion injury. J Neurochem 78: 1389-99 PubMed GONUTS page

[PMID:12368211-29] 30.0 ^30.1 Staversky RJ et al. (2002) Normal remodeling of the oxygen-injured lung requires the cyclin-dependent kinase inhibitor p21(Cip1/WAF1/Sdi1). Am J Pathol 161: 1383-93 PubMed GONUTS page

[PMID:16723478-30] Gosbell AD et al. (2006) Retinal light damage: structural and functional effects of the antioxidant glutathione peroxidase-1. Invest Ophthalmol Vis Sci 47: 2613-22 PubMed GONUTS page

[PMID:16934683-31] Gueven N et al. (2006) Dramatic extension of tumor latency and correction of neurobehavioral phenotype in Atm-mutant mice with a nitroxide antioxidant. Free Radic Biol Med 41: 992-1000 PubMed GONUTS page

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