MOUSE:GP124

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Species (Taxon ID)	Mus musculus (Mouse). (taxon:10090)
Gene Name(s)	Gpr124 ( synonyms: Tem5 )
Protein Name(s)	G-protein coupled receptor 124 Tumor endothelial marker 5
External Links
UniProt Identifier	GP124_MOUSE
UniProt Accessions	Q91ZV8, B2RRK0,
EMBL	AF378759, BC138451, BC138452,
RefSeq	NP_473385.2,
Ensembl	ENSMUST00000033876, ENSMUST00000165366,
Pfam	PF00002, PF01825, PF02793, PF00560,

Annotations

Qualifier	GO ID	GO term name	Reference	Evidence Code	with/from	Aspect	Notes	Status
	GO:0001525	angiogenesis	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0037	P
	GO:0002040	sprouting angiogenesis	PMID:21071672^[1]	IMP: Inferred from Mutant Phenotype		P
	GO:0004871	signal transducer activity	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0807	F
	GO:0004872	receptor activity	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0675	F
	GO:0004888	transmembrane receptor activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR017981	F
	GO:0004930	G-protein coupled receptor activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR000832	F
	GO:0004930	G-protein coupled receptor activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR001879	F
	GO:0004930	G-protein coupled receptor activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR017983	F
	GO:0004930	G-protein coupled receptor activity	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0297	F
	GO:0005886	plasma membrane	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-1003	C
	GO:0005886	plasma membrane	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0039	C
	GO:0007165	signal transduction	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0807	P
	GO:0007166	cell surface receptor linked signaling pathway	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR017981	P
	GO:0007186	G-protein coupled receptor protein signaling pathway	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR000832	P
	GO:0007186	G-protein coupled receptor protein signaling pathway	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR017983	P
	GO:0007186	G-protein coupled receptor protein signaling pathway	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0297	P
	GO:0007218	neuropeptide signaling pathway	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR000203	P
	GO:0007417	central nervous system development	PMID:21071672^[1]	IMP: Inferred from Mutant Phenotype		P
	GO:0016020	membrane	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR000203	C
	GO:0016020	membrane	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR000832	C
	GO:0016020	membrane	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR001879	C
	GO:0016020	membrane	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR017981	C
	GO:0016020	membrane	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR017983	C
	GO:0016020	membrane	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0472	C
	GO:0016021	integral to membrane	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0812	C
	GO:0043542	endothelial cell migration	PMID:21071672^[1]	IMP: Inferred from Mutant Phenotype		P
	GO:0045765	regulation of angiogenesis	PMID:21071672^[1]	IMP: Inferred from Mutant Phenotype		P
	GO:0050920	regulation of chemotaxis	PMID:21071672^[1]	IMP: Inferred from Mutant Phenotype		P
	GO:0002040	sprouting angiogenesis	PMID:21282641^[2]	IMP: Inferred from Mutant Phenotype		P	Fig. 3. Gpr124 is required for normal angiogenic sprouting and development of vasculature within the forebrain and spinal cord.	complete
	GO:0060462	lung lobe development	PMID:21282641^[2]	IMP: Inferred from Mutant Phenotype		P	Fig. 2. D. Hypoplasia of lungs in Gpr124-deficient embryos.	complete
	GO:0060022	hard palate development	PMID:21282641^[2]	IMP: Inferred from Mutant Phenotype		P	Fig. 2. B. Failure in secondary palate formation in Gpr124-deficient embryos.	complete
	GO:0001525	angiogenesis	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0037	P
	GO:0002040	sprouting angiogenesis	PMID:21071672^[1]	IMP: Inferred from Mutant Phenotype		P
	GO:0003674	molecular function	GO_REF:0000015	ND: No biological Data available		F
	GO:0004871	signal transducer activity	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0807	F
	GO:0004872	receptor activity	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0675	F
	GO:0004888	transmembrane signaling receptor activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR017981	F
	GO:0004930	G-protein coupled receptor activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR000832	F
	GO:0004930	G-protein coupled receptor activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR001879	F
	GO:0004930	G-protein coupled receptor activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR017983	F
	GO:0004930	G-protein coupled receptor activity	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0297	F
	GO:0005886	plasma membrane	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-1003	C
	GO:0005886	plasma membrane	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0039	C
	GO:0007165	signal transduction	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0807	P
	GO:0007166	cell surface receptor linked signaling pathway	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR017981	P
	GO:0007186	G-protein coupled receptor protein signaling pathway	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR000832	P
	GO:0007186	G-protein coupled receptor protein signaling pathway	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR017983	P
	GO:0007186	G-protein coupled receptor protein signaling pathway	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0297	P
	GO:0007218	neuropeptide signaling pathway	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR000203	P
	GO:0007417	central nervous system development	PMID:21071672^[1]	IMP: Inferred from Mutant Phenotype		P
	GO:0016020	membrane	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR000203	C
	GO:0016020	membrane	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR001879	C
	GO:0016020	membrane	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR017981	C
	GO:0016020	membrane	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR017983	C
	GO:0016020	membrane	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0472	C
	GO:0016021	integral to membrane	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR000832	C
	GO:0016021	integral to membrane	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0812	C
	GO:0043542	endothelial cell migration	PMID:21071672^[1]	IMP: Inferred from Mutant Phenotype		P
	GO:0045765	regulation of angiogenesis	PMID:21071672^[1]	IMP: Inferred from Mutant Phenotype		P
	GO:0050920	regulation of chemotaxis	PMID:21071672^[1]	IMP: Inferred from Mutant Phenotype		P
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 ^1.6 ^1.7 ^1.8 ^1.9 Kuhnert F et al. (2010) Essential regulation of CNS angiogenesis by the orphan G protein-coupled receptor GPR124. Science 330: 985-9 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 Anderson KD et al. (2011) Angiogenic sprouting into neural tissue requires Gpr124, an orphan G protein-coupled receptor. Proc Natl Acad Sci U S A 108: 2807-12 PubMed GONUTS page

[PMID:21071672-0] 1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 ^1.6 ^1.7 ^1.8 ^1.9 Kuhnert F et al. (2010) Essential regulation of CNS angiogenesis by the orphan G protein-coupled receptor GPR124. Science 330: 985-9 PubMed GONUTS page

[PMID:21282641-1] 2.0 ^2.1 ^2.2 Anderson KD et al. (2011) Angiogenic sprouting into neural tissue requires Gpr124, an orphan G protein-coupled receptor. Proc Natl Acad Sci U S A 108: 2807-12 PubMed GONUTS page

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MOUSE:GP124

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