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MOUSE:GLI3

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Contents

Species (Taxon ID) Mus musculus (Mouse). ([1])
Gene Name(s) Gli3
Protein Name(s) Transcriptional activator GLI3

GLI3 form of 190 kDa GLI3-190 GLI3 full length protein GLI3FL Transcriptional repressor GLI3R GLI3 C-terminally truncated form GLI3 form of 83 kDa GLI3-83

External Links
EMBL X95255
AC163610
AC173115
AC173210
IPI IPI00123429
RefSeq NP_032156.2
UniGene Mm.5098
ProteinModelPortal Q61602
SMR Q61602
STRING Q61602
PhosphoSite Q61602
PRIDE Q61602
Ensembl ENSMUST00000110510
GeneID 14634
KEGG mmu:14634
CTD 2737
MGI MGI:95729
GeneTree ENSGT00600000084058
HOGENOM HBG447235
HOVERGEN HBG005844
InParanoid Q61602
OrthoDB EOG45HRWN
NextBio 286490
ArrayExpress Q61602
Bgee Q61602
CleanEx MM_GLI3
Genevestigator Q61602
GermOnline ENSMUSG00000021318
GO GO:0005929
GO:0017053
GO:0003682
GO:0043565
GO:0003700
GO:0008270
GO:0060873
GO:0009952
GO:0060840
GO:0007411
GO:0001658
GO:0048593
GO:0061005
GO:0021801
GO:0048589
GO:0048557
GO:0042733
GO:0048704
GO:0021798
GO:0021861
GO:0060364
GO:0007507
GO:0007442
GO:0001701
GO:0060366
GO:0022018
GO:0060875
GO:0030324
GO:0060594
GO:0030318
GO:0001656
GO:0046639
GO:0043066
GO:0008285
GO:0045665
GO:0045879
GO:0045060
GO:0042475
GO:0048709
GO:0021631
GO:0060021
GO:0046638
GO:0032332
GO:0002052
GO:0045669
GO:0042307
GO:0045944
GO:0016485
GO:0009954
GO:0060367
GO:0060831
GO:0021776
GO:0021775
GO:0070242
GO:0043586
InterPro IPR007087
IPR015880
IPR013087
Gene3D G3DSA:3.30.160.60
Pfam PF00096
SMART SM00355
PROSITE PS00028
PS50157

Annotations

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0000122

negative regulation of transcription from RNA polymerase II promoter

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSP00000379258

P

Seeded From UniProt

GO:0001656

metanephros development

PMID:16396903[1]

IGI: Inferred from Genetic Interaction

MGI:MGI:98297

P

Seeded From UniProt

GO:0001658

branching involved in ureteric bud morphogenesis

PMID:16396903[1]

IGI: Inferred from Genetic Interaction

MGI:MGI:98297

P

Seeded From UniProt

GO:0001701

in utero embryonic development

PMID:16254602[2]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1856276

P

Seeded From UniProt

GO:0001822

kidney development

PMID:11172440[3]

IGI: Inferred from Genetic Interaction

MGI:MGI:95728

P

Seeded From UniProt

GO:0002052

positive regulation of neuroblast proliferation

PMID:20943929[4]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1856282

P

Seeded From UniProt

GO:0003676

nucleic acid binding

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR013087

F

Seeded From UniProt

GO:0003677

DNA binding

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0238

F

Seeded From UniProt

GO:0003682

chromatin binding

PMID:16396903[1]

IGI: Inferred from Genetic Interaction

MGI:MGI:108075

F

Seeded From UniProt

GO:0003700

sequence-specific DNA binding transcription factor activity

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSP00000379258

F

Seeded From UniProt

GO:0003700

sequence-specific DNA binding transcription factor activity

PMID:11053430[5]

IDA: Inferred from Direct Assay

F

Seeded From UniProt

GO:0005515

protein binding

PMID:10920228[6]

IPI: Inferred from Physical Interaction

UniProtKB:Q9Z0P7

F

Seeded From UniProt

GO:0005515

protein binding

PMID:12435627[7]

IPI: Inferred from Physical Interaction

UniProtKB:Q60698

F

Seeded From UniProt

GO:0005515

protein binding

PMID:19389374[8]

IPI: Inferred from Physical Interaction

UniProtKB:Q925H1

F

Seeded From UniProt

GO:0005515

protein binding

PMID:19549984[9]

IPI: Inferred from Physical Interaction

UniProtKB:B7ZNG0

F

Seeded From UniProt

GO:0005515

protein binding

PMID:20360384[10]

IPI: Inferred from Physical Interaction

UniProtKB:Q9Z0P7

F

Seeded From UniProt

GO:0005622

intracellular

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR007087

C

Seeded From UniProt

GO:0005622

intracellular

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR015880

C

Seeded From UniProt

GO:0005634

nucleus

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0539

C

Seeded From UniProt

GO:0005634

nucleus

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSP00000379258

C

Seeded From UniProt

GO:0005634

nucleus

GO_REF:0000023

IEA: Inferred from Electronic Annotation

SP_SL:SL-0191

C

Seeded From UniProt

GO:0005634

nucleus

PMID:12435627[7]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

GO:0005634

nucleus

PMID:20360384[10]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

GO:0005730

nucleolus

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSP00000379258

C

Seeded From UniProt

GO:0005737

cytoplasm

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0963

C

Seeded From UniProt

GO:0005737

cytoplasm

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSP00000379258

C

Seeded From UniProt

GO:0005737

cytoplasm

GO_REF:0000023

IEA: Inferred from Electronic Annotation

SP_SL:SL-0086

C

Seeded From UniProt

GO:0005737

cytoplasm

PMID:12435627[7]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

GO:0005737

cytoplasm

PMID:20360384[10]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

GO:0005829

cytosol

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSP00000379258

C

Seeded From UniProt

GO:0005929

cilium

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0969

C

Seeded From UniProt

GO:0005929

cilium

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSP00000379258

C

Seeded From UniProt

GO:0005929

cilium

GO_REF:0000023

IEA: Inferred from Electronic Annotation

SP_SL:SL-0066

C

Seeded From UniProt

GO:0006351

transcription, DNA-dependent

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0804

P

Seeded From UniProt

GO:0006351

transcription, DNA-dependent

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSP00000379258

P

Seeded From UniProt

GO:0006355

regulation of transcription, DNA-dependent

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0805

P

Seeded From UniProt

GO:0006355

regulation of transcription, DNA-dependent

PMID:9152009[11]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1856275

P

Seeded From UniProt

GO:0007224

smoothened signaling pathway

PMID:12435628[12]

IGI: Inferred from Genetic Interaction

MGI:MGI:108075

P

Seeded From UniProt

GO:0007224

smoothened signaling pathway

PMID:16284117[13]

IGI: Inferred from Genetic Interaction

MGI:MGI:96533

P

Seeded From UniProt

GO:0007224

smoothened signaling pathway

PMID:16396903[1]

IGI: Inferred from Genetic Interaction

MGI:MGI:98297

P

Seeded From UniProt

GO:0007224

smoothened signaling pathway

PMID:16571630[14]

IGI: Inferred from Genetic Interaction

MGI:MGI:98297

P

Seeded From UniProt

GO:0007411

axon guidance

PMID:15065125[15]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1856276

P

Seeded From UniProt

GO:0007411

axon guidance

PMID:20943929[4]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1856282

P

Seeded From UniProt

GO:0007417

central nervous system development

PMID:12435628[12]

IGI: Inferred from Genetic Interaction

MGI:MGI:108075

P

Seeded From UniProt

GO:0007417

central nervous system development

PMID:12435629[16]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1856276

P

Seeded From UniProt

GO:0007420

brain development

PMID:12435361[17]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1856276

P

Seeded From UniProt

GO:0007420

brain development

PMID:17395647[18]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1856276

P

Seeded From UniProt

GO:0007420

brain development

PMID:8026071[19]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1856282

P

Seeded From UniProt

GO:0007442

hindgut morphogenesis

PMID:11485934[20]

IGI: Inferred from Genetic Interaction

MGI:MGI:95728

P

Seeded From UniProt

GO:0007507

heart development

PMID:11172440[3]

IGI: Inferred from Genetic Interaction

MGI:MGI:95728

P

Seeded From UniProt

GO:0008013

beta-catenin binding

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSP00000379258

F

Seeded From UniProt

GO:0008270

zinc ion binding

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR007087

F

Seeded From UniProt

GO:0008270

zinc ion binding

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR015880

F

Seeded From UniProt

GO:0008285

negative regulation of cell proliferation

PMID:16396903[1]

IGI: Inferred from Genetic Interaction

MGI:MGI:98297

P

Seeded From UniProt

GO:0008285

negative regulation of cell proliferation

PMID:16396903[1]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1856275

P

Seeded From UniProt

GO:0008285

negative regulation of cell proliferation

PMID:17328886[21]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1856276

P

Seeded From UniProt

GO:0008285

negative regulation of cell proliferation

PMID:20570969[22]

IGI: Inferred from Genetic Interaction

MGI:MGI:95516

P

Seeded From UniProt

GO:0008285

negative regulation of cell proliferation

PMID:20570969[22]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1856276

P

Seeded From UniProt

GO:0009952

anterior/posterior pattern specification

PMID:15315762[23]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1856276

P

Seeded From UniProt

GO:0009953

dorsal/ventral pattern formation

PMID:12435629[16]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1856276

P

Seeded From UniProt

GO:0009953

dorsal/ventral pattern formation

PMID:14723851[24]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1856275

P

Seeded From UniProt

GO:0009953

dorsal/ventral pattern formation

PMID:16571630[14]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1856276

P

Seeded From UniProt

GO:0009954

proximal/distal pattern formation

PMID:16342201[25]

IGI: Inferred from Genetic Interaction

MGI:MGI:95728

P

Seeded From UniProt

GO:0009954

proximal/distal pattern formation

PMID:16342201[25]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1856276

P

Seeded From UniProt

GO:0010468

regulation of gene expression

PMID:18799682[26]

IGI: Inferred from Genetic Interaction

MGI:MGI:98297

P

Seeded From UniProt

GO:0016485

protein processing

PMID:19036983[27]

IDA: Inferred from Direct Assay

P

Seeded From UniProt

GO:0016592

mediator complex

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSP00000379258

C

Seeded From UniProt

GO:0017053

transcriptional repressor complex

PMID:12435627[7]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

GO:0021513

spinal cord dorsal/ventral patterning

PMID:15215207[28]

IGI: Inferred from Genetic Interaction

MGI:MGI:95728

P

Seeded From UniProt

GO:0021513

spinal cord dorsal/ventral patterning

PMID:16364285[29]

IGI: Inferred from Genetic Interaction

MGI:MGI:99833

P

Seeded From UniProt

GO:0021537

telencephalon development

PMID:10625551[30]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1856276

P

Seeded From UniProt

GO:0021537

telencephalon development

PMID:19036983[27]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1856276

P

Seeded From UniProt

GO:0021537

telencephalon development

PMID:19048639[31]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1856276

P

Seeded From UniProt

GO:0021543

pallium development

PMID:10409502[32]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1856276

P

Seeded From UniProt

GO:0021544

subpallium development

PMID:20943929[4]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1856282

P

Seeded From UniProt

GO:0021631

optic nerve morphogenesis

PMID:16342201[25]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1856276

P

Seeded From UniProt

GO:0021775

smoothened signaling pathway involved in ventral spinal cord interneuron specification

PMID:15215207[28]

IGI: Inferred from Genetic Interaction

MGI:MGI:95728

P

Seeded From UniProt

GO:0021776

smoothened signaling pathway involved in spinal cord motor neuron cell fate specification

PMID:15215207[28]

IGI: Inferred from Genetic Interaction

MGI:MGI:95728

P

Seeded From UniProt

GO:0021798

forebrain dorsal/ventral pattern formation

PMID:10625551[30]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1856276

P

Seeded From UniProt

GO:0021801

cerebral cortex radial glia guided migration

PMID:9232833[33]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1856282

P

Seeded From UniProt

GO:0021861

forebrain radial glial cell differentiation

PMID:9232833[33]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1856282

P

Seeded From UniProt

GO:0021915

neural tube development

PMID:8387379[34]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1856276

P

Seeded From UniProt

GO:0022018

lateral ganglionic eminence cell proliferation

PMID:20943929[4]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1856282

P

Seeded From UniProt

GO:0030318

melanocyte differentiation

PMID:18397875[35]

IMP: Inferred from Mutant Phenotype

MGI:MGI:3720956

P

Seeded From UniProt

GO:0030324

lung development

PMID:15136151[36]

IGI: Inferred from Genetic Interaction

MGI:MGI:98297

P

Seeded From UniProt

GO:0030324

lung development

PMID:9268579[37]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1856276

P

Seeded From UniProt

GO:0030326

embryonic limb morphogenesis

PMID:12142027[38]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1856276

P

Seeded From UniProt

GO:0030326

embryonic limb morphogenesis

PMID:12435361[17]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1856276

P

Seeded From UniProt

GO:0030326

embryonic limb morphogenesis

PMID:12435627[7]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1856276

P

Seeded From UniProt

GO:0030326

embryonic limb morphogenesis

PMID:16284117[13]

IGI: Inferred from Genetic Interaction

MGI:MGI:96533

P

Seeded From UniProt

GO:0030326

embryonic limb morphogenesis

PMID:19422820[39]

IGI: Inferred from Genetic Interaction

MGI:MGI:98297

P

Seeded From UniProt

GO:0030326

embryonic limb morphogenesis

PMID:19809516[40]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1856276

P

Seeded From UniProt

GO:0030326

embryonic limb morphogenesis

PMID:8387379[34]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1856276

P

Seeded From UniProt

GO:0030879

mammary gland development

PMID:16914490[41]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1856276

P

Seeded From UniProt

GO:0030900

forebrain development

PMID:16168404[42]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1856276

P

Seeded From UniProt

GO:0032332

positive regulation of chondrocyte differentiation

PMID:17328886[21]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1856276

P

Seeded From UniProt

GO:0033077

T cell differentiation in thymus

PMID:15855276[43]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

GO:0033077

T cell differentiation in thymus

PMID:15855276[43]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1856276

P

Seeded From UniProt

GO:0035035

histone acetyltransferase binding

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSP00000379258

F

Seeded From UniProt

GO:0035108

limb morphogenesis

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSP00000379258

P

Seeded From UniProt

GO:0035108

limb morphogenesis

PMID:9268572[44]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1856276

P

Seeded From UniProt

GO:0035295

tube development

PMID:9731531[45]

IGI: Inferred from Genetic Interaction

MGI:MGI:95728

P

Seeded From UniProt

GO:0042127

regulation of cell proliferation

PMID:17191253[46]

IGI: Inferred from Genetic Interaction

MGI:MGI:96533

P

Seeded From UniProt

GO:0042307

positive regulation of protein import into nucleus

PMID:17043310[47]

IGI: Inferred from Genetic Interaction

MGI:MGI:108075

P

Seeded From UniProt

GO:0042475

odontogenesis of dentine-containing tooth

PMID:9655803[48]

IGI: Inferred from Genetic Interaction

MGI:MGI:95728

P

Seeded From UniProt

GO:0042733

embryonic digit morphogenesis

PMID:16254602[2]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1856276

P

Seeded From UniProt

GO:0042733

embryonic digit morphogenesis

PMID:19036983[27]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1856276

P

Seeded From UniProt

GO:0042733

embryonic digit morphogenesis

PMID:9268572[44]

IGI: Inferred from Genetic Interaction

MGI:MGI:88180

P

Seeded From UniProt

GO:0042733

embryonic digit morphogenesis

PMID:9268572[44]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1856276

P

Seeded From UniProt

GO:0042826

histone deacetylase binding

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSP00000379258

F

Seeded From UniProt

GO:0042981

regulation of apoptosis

PMID:8026071[19]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1856282

P

Seeded From UniProt

GO:0042995

cell projection

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0966

C

Seeded From UniProt

GO:0043010

camera-type eye development

PMID:18582859[49]

IGI: Inferred from Genetic Interaction

MGI:MGI:98297

P

Seeded From UniProt

GO:0043066

negative regulation of apoptosis

PMID:19048639[31]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1856276

P

Seeded From UniProt

GO:0043231

intracellular membrane-bounded organelle

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSP00000379258

C

Seeded From UniProt

GO:0043565

sequence-specific DNA binding

PMID:16611981[50]

IDA: Inferred from Direct Assay

F

Seeded From UniProt

GO:0043586

tongue development

PMID:18816854[51]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1856276

P

Seeded From UniProt

GO:0045060

negative thymic T cell selection

PMID:19667090[52]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

GO:0045595

regulation of cell differentiation

PMID:16284117[13]

IGI: Inferred from Genetic Interaction

MGI:MGI:96533

P

Seeded From UniProt

GO:0045596

negative regulation of cell differentiation

PMID:16284117[13]

IGI: Inferred from Genetic Interaction

MGI:MGI:96533

P

Seeded From UniProt

GO:0045665

negative regulation of neuron differentiation

PMID:19048639[31]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1856276

P

Seeded From UniProt

GO:0045669

positive regulation of osteoblast differentiation

PMID:20570969[22]

IGI: Inferred from Genetic Interaction

MGI:MGI:95516

P

Seeded From UniProt

GO:0045669

positive regulation of osteoblast differentiation

PMID:20570969[22]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1856276

P

Seeded From UniProt

GO:0045879

negative regulation of smoothened signaling pathway

PMID:19667090[52]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

GO:0045892

negative regulation of transcription, DNA-dependent

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSP00000379258

P

Seeded From UniProt

GO:0045892

negative regulation of transcription, DNA-dependent

PMID:12435627[7]

IDA: Inferred from Direct Assay

P

Seeded From UniProt

GO:0045892

negative regulation of transcription, DNA-dependent

PMID:17400206[53]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

GO:0045893

positive regulation of transcription, DNA-dependent

PMID:11053430[5]

IDA: Inferred from Direct Assay

P

Seeded From UniProt

GO:0045893

positive regulation of transcription, DNA-dependent

PMID:17328886[21]

IDA: Inferred from Direct Assay

P

Seeded From UniProt

GO:0045893

positive regulation of transcription, DNA-dependent

PMID:17400206[53]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

GO:0045944

positive regulation of transcription from RNA polymerase II promoter

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSP00000379258

P

Seeded From UniProt

GO:0045944

positive regulation of transcription from RNA polymerase II promoter

PMID:19667090[52]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

GO:0046638

positive regulation of alpha-beta T cell differentiation

PMID:15855276[43]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

GO:0046639

negative regulation of alpha-beta T cell differentiation

PMID:19667090[52]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

GO:0046872

metal ion binding

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0479

F

Seeded From UniProt

GO:0048557

embryonic digestive tract morphogenesis

PMID:16247775[54]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1856276

P

Seeded From UniProt

GO:0048566

embryonic digestive tract development

PMID:10693670[55]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1856276

P

Seeded From UniProt

GO:0048589

developmental growth

PMID:9268579[37]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1856276

P

Seeded From UniProt

GO:0048593

camera-type eye morphogenesis

PMID:8387379[34]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1856276

P

Seeded From UniProt

GO:0048598

embryonic morphogenesis

PMID:8387379[34]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1856276

P

Seeded From UniProt

GO:0048646

anatomical structure formation involved in morphogenesis

PMID:9731531[45]

IGI: Inferred from Genetic Interaction

MGI:MGI:95728

P

Seeded From UniProt

GO:0048663

neuron fate commitment

PMID:16168404[42]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1856276

P

Seeded From UniProt

GO:0048704

embryonic skeletal system morphogenesis

PMID:15728667[56]

IGI: Inferred from Genetic Interaction

MGI:MGI:1277234

P

Seeded From UniProt

GO:0048709

oligodendrocyte differentiation

PMID:15880651[57]

IGI: Inferred from Genetic Interaction

MGI:MGI:98297

P

Seeded From UniProt

GO:0048754

branching morphogenesis of a tube

PMID:16247775[54]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1856276

P

Seeded From UniProt

GO:0048839

inner ear development

PMID:17395647[18]

IGI: Inferred from Genetic Interaction

MGI:MGI:98297

P

Seeded From UniProt

GO:0048856

anatomical structure development

PMID:11485934[20]

IGI: Inferred from Genetic Interaction

MGI:MGI:95728

P

Seeded From UniProt

GO:0060021

palate development

PMID:18816854[51]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1856276

P

Seeded From UniProt

GO:0060173

limb development

PMID:17400206[53]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

GO:0060364

frontal suture morphogenesis

PMID:20570969[22]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1856276

P

Seeded From UniProt

GO:0060366

lambdoid suture morphogenesis

PMID:20570969[22]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1856276

P

Seeded From UniProt

GO:0060367

sagittal suture morphogenesis

PMID:20570969[22]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1856276

P

Seeded From UniProt

GO:0060594

mammary gland specification

PMID:16720875[58]

IGI: Inferred from Genetic Interaction

MGI:MGI:1099809

P

Seeded From UniProt

GO:0060831

smoothened signaling pathway involved in dorsal/ventral neural tube patterning

PMID:17395647[18]

IGI: Inferred from Genetic Interaction

MGI:MGI:95728

P

Seeded From UniProt

GO:0060840

artery development

PMID:16968815[59]

IGI: Inferred from Genetic Interaction

MGI:MGI:98297

P

Seeded From UniProt

GO:0060873

anterior semicircular canal development

PMID:17395647[18]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1856276

P

Seeded From UniProt

GO:0060875

lateral semicircular canal development

PMID:17395647[18]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1856276

P

Seeded From UniProt

GO:0061005

cell differentiation involved in kidney development

PMID:19809516[40]

IGI: Inferred from Genetic Interaction

MGI:MGI:105373

P

Seeded From UniProt

GO:0070242

thymocyte apoptosis

PMID:19667090[52]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

GO:0090090

negative regulation of canonical Wnt receptor signaling pathway

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSP00000379258

P

Seeded From UniProt

GO:0035085

cilium axoneme

PMID:21209331[60]

IDA: Inferred from Direct Assay

C

Fig 4A shows ciliary localisation in WT

complete

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ 1.0 1.1 1.2 1.3 1.4 1.5 Hu MC et al. (2006) GLI3-dependent transcriptional repression of Gli1, Gli2 and kidney patterning genes disrupts renal morphogenesis. Development 133: 569-78 PubMed GONUTS page
  2. ↑ 2.0 2.1 Haycraft CJ et al. (2005) Gli2 and Gli3 localize to cilia and require the intraflagellar transport protein polaris for processing and function. PLoS Genet 1: e53 PubMed GONUTS page
  3. ↑ 3.0 3.1 Kim PC et al. (2001) Murine models of VACTERL syndrome: Role of sonic hedgehog signaling pathway. J Pediatr Surg 36: 381-4 PubMed GONUTS page
  4. ↑ 4.0 4.1 4.2 4.3 Magnani D et al. (2010) The Gli3 hypomorphic mutation Pdn causes selective impairment in the growth, patterning, and axon guidance capability of the lateral ganglionic eminence. J Neurosci 30: 13883-94 PubMed GONUTS page
  5. ↑ 5.0 5.1 Mizugishi K et al. (2001) Molecular properties of Zic proteins as transcriptional regulators and their relationship to GLI proteins. J Biol Chem 276: 2180-8 PubMed GONUTS page
  6. ↑ Simon-Chazottes D et al. (2000) Genomic organization, chromosomal assignment, and expression analysis of the mouse suppressor of fused gene (Sufu) coding a Gli protein partner. Mamm Genome 11: 614-21 PubMed GONUTS page
  7. ↑ 7.0 7.1 7.2 7.3 7.4 7.5 Dai P et al. (2002) Ski is involved in transcriptional regulation by the repressor and full-length forms of Gli3. Genes Dev 16: 2843-8 PubMed GONUTS page
  8. ↑ Wuelling M et al. (2009) Trps1, a regulator of chondrocyte proliferation and differentiation, interacts with the activator form of Gli3. Dev Biol 328: 40-53 PubMed GONUTS page
  9. ↑ Cheung HO et al. (2009) The kinesin protein Kif7 is a critical regulator of Gli transcription factors in mammalian hedgehog signaling. Sci Signal 2: ra29 PubMed GONUTS page
  10. ↑ 10.0 10.1 10.2 Humke EW et al. (2010) The output of Hedgehog signaling is controlled by the dynamic association between Suppressor of Fused and the Gli proteins. Genes Dev 24: 670-82 PubMed GONUTS page
  11. ↑ Büscher D et al. (1997) Evidence for genetic control of Sonic hedgehog by Gli3 in mouse limb development. Mech Dev 62: 175-82 PubMed GONUTS page
  12. ↑ 12.0 12.1 Wijgerde M et al. (2002) A direct requirement for Hedgehog signaling for normal specification of all ventral progenitor domains in the presumptive mammalian spinal cord. Genes Dev 16: 2849-64 PubMed GONUTS page
  13. ↑ 13.0 13.1 13.2 13.3 Koziel L et al. (2005) Gli3 acts as a repressor downstream of Ihh in regulating two distinct steps of chondrocyte differentiation. Development 132: 5249-60 PubMed GONUTS page
  14. ↑ 14.0 14.1 Blaess S et al. (2006) Sonic hedgehog regulates Gli activator and repressor functions with spatial and temporal precision in the mid/hindbrain region. Development 133: 1799-809 PubMed GONUTS page
  15. ↑ Balmer CW & LaMantia AS (2004) Loss of Gli3 and Shh function disrupts olfactory axon trajectories. J Comp Neurol 472: 292-307 PubMed GONUTS page
  16. ↑ 16.0 16.1 Persson M et al. (2002) Dorsal-ventral patterning of the spinal cord requires Gli3 transcriptional repressor activity. Genes Dev 16: 2865-78 PubMed GONUTS page
  17. ↑ 17.0 17.1 Aoto K et al. (2002) Mouse GLI3 regulates Fgf8 expression and apoptosis in the developing neural tube, face, and limb bud. Dev Biol 251: 320-32 PubMed GONUTS page
  18. ↑ 18.0 18.1 18.2 18.3 18.4 Bok J et al. (2007) Opposing gradients of Gli repressor and activators mediate Shh signaling along the dorsoventral axis of the inner ear. Development 134: 1713-22 PubMed GONUTS page
  19. ↑ 19.0 19.1 Keino H et al. (1994) Apoptotic degeneration in the arhinencephalic brain of the mouse mutant Pdn/Pdn. Brain Res Dev Brain Res 78: 161-8 PubMed GONUTS page
  20. ↑ 20.0 20.1 Mo R et al. (2001) Anorectal malformations caused by defects in sonic hedgehog signaling. Am J Pathol 159: 765-74 PubMed GONUTS page
  21. ↑ 21.0 21.1 21.2 Mau E et al. (2007) PTHrP regulates growth plate chondrocyte differentiation and proliferation in a Gli3 dependent manner utilizing hedgehog ligand dependent and independent mechanisms. Dev Biol 305: 28-39 PubMed GONUTS page
  22. ↑ 22.0 22.1 22.2 22.3 22.4 22.5 22.6 Rice DP et al. (2010) Gli3Xt-J/Xt-J mice exhibit lambdoid suture craniosynostosis which results from altered osteoprogenitor proliferation and differentiation. Hum Mol Genet 19: 3457-67 PubMed GONUTS page
  23. ↑ Ahn S & Joyner AL (2004) Dynamic changes in the response of cells to positive hedgehog signaling during mouse limb patterning. Cell 118: 505-16 PubMed GONUTS page
  24. ↑ Bai CB et al. (2004) All mouse ventral spinal cord patterning by hedgehog is Gli dependent and involves an activator function of Gli3. Dev Cell 6: 103-15 PubMed GONUTS page
  25. ↑ 25.0 25.1 25.2 Furimsky M & Wallace VA (2006) Complementary Gli activity mediates early patterning of the mouse visual system. Dev Dyn 235: 594-605 PubMed GONUTS page
  26. ↑ Tucker ES et al. (2008) Molecular specification and patterning of progenitor cells in the lateral and medial ganglionic eminences. J Neurosci 28: 9504-18 PubMed GONUTS page
  27. ↑ 27.0 27.1 27.2 Willaredt MA et al. (2008) A crucial role for primary cilia in cortical morphogenesis. J Neurosci 28: 12887-900 PubMed GONUTS page
  28. ↑ 28.0 28.1 28.2 Lei Q et al. (2004) Transduction of graded Hedgehog signaling by a combination of Gli2 and Gli3 activator functions in the developing spinal cord. Development 131: 3593-604 PubMed GONUTS page
  29. ↑ Eggenschwiler JT et al. (2006) Mouse Rab23 regulates hedgehog signaling from smoothened to Gli proteins. Dev Biol 290: 1-12 PubMed GONUTS page
  30. ↑ 30.0 30.1 Tole S et al. (2000) Dorsoventral patterning of the telencephalon is disrupted in the mouse mutant extra-toes(J). Dev Biol 217: 254-65 PubMed GONUTS page
  31. ↑ 31.0 31.1 31.2 Yu T et al. (2009) Analysis of early ventral telencephalic defects in mice lacking functional Gli3 protein. J Comp Neurol 512: 613-27 PubMed GONUTS page
  32. ↑ Theil T et al. (1999) Gli3 is required for Emx gene expression during dorsal telencephalon development. Development 126: 3561-71 PubMed GONUTS page
  33. ↑ 33.0 33.1 Ueda S et al. (1997) Local disturbance of neuronal migration in the S-100beta-retarded mutant mouse. Cell Tissue Res 289: 547-51 PubMed GONUTS page
  34. ↑ 34.0 34.1 34.2 34.3 Hui CC & Joyner AL (1993) A mouse model of greig cephalopolysyndactyly syndrome: the extra-toesJ mutation contains an intragenic deletion of the Gli3 gene. Nat Genet 3: 241-6 PubMed GONUTS page
  35. ↑ Matera I et al. (2008) A sensitized mutagenesis screen identifies Gli3 as a modifier of Sox10 neurocristopathy. Hum Mol Genet 17: 2118-31 PubMed GONUTS page
  36. ↑ Li Y et al. (2004) Sonic hedgehog signaling regulates Gli3 processing, mesenchymal proliferation, and differentiation during mouse lung organogenesis. Dev Biol 270: 214-31 PubMed GONUTS page
  37. ↑ 37.0 37.1 Grindley JC et al. (1997) Evidence for the involvement of the Gli gene family in embryonic mouse lung development. Dev Biol 188: 337-48 PubMed GONUTS page
  38. ↑ O'Rourke MP et al. (2002) Twist plays an essential role in FGF and SHH signal transduction during mouse limb development. Dev Biol 248: 143-56 PubMed GONUTS page
  39. ↑ Lallemand Y et al. (2009) Msx genes are important apoptosis effectors downstream of the Shh/Gli3 pathway in the limb. Dev Biol 331: 189-98 PubMed GONUTS page
  40. ↑ 40.0 40.1 Cain JE et al. (2009) GLI3 repressor controls nephron number via regulation of Wnt11 and Ret in ureteric tip cells. PLoS One 4: e7313 PubMed GONUTS page
  41. ↑ Hatsell SJ & Cowin P (2006) Gli3-mediated repression of Hedgehog targets is required for normal mammary development. Development 133: 3661-70 PubMed GONUTS page
  42. ↑ 42.0 42.1 Theil T (2005) Gli3 is required for the specification and differentiation of preplate neurons. Dev Biol 286: 559-71 PubMed GONUTS page
  43. ↑ 43.0 43.1 43.2 Hager-Theodorides AL et al. (2005) The transcription factor Gli3 regulates differentiation of fetal CD4- CD8- double-negative thymocytes. Blood 106: 1296-304 PubMed GONUTS page
  44. ↑ 44.0 44.1 44.2 Dunn NR et al. (1997) Haploinsufficient phenotypes in Bmp4 heterozygous null mice and modification by mutations in Gli3 and Alx4. Dev Biol 188: 235-47 PubMed GONUTS page
  45. ↑ 45.0 45.1 Motoyama J et al. (1998) Essential function of Gli2 and Gli3 in the formation of lung, trachea and oesophagus. Nat Genet 20: 54-7 PubMed GONUTS page
  46. ↑ Shibukawa Y et al. (2007) Temporomandibular joint formation and condyle growth require Indian hedgehog signaling. Dev Dyn 236: 426-34 PubMed GONUTS page
  47. ↑ Kim JW & Lemke G (2006) Hedgehog-regulated localization of Vax2 controls eye development. Genes Dev 20: 2833-47 PubMed GONUTS page
  48. ↑ Hardcastle Z et al. (1998) The Shh signalling pathway in tooth development: defects in Gli2 and Gli3 mutants. Development 125: 2803-11 PubMed GONUTS page
  49. ↑ Dakubo GD et al. (2008) Indian hedgehog signaling from endothelial cells is required for sclera and retinal pigment epithelium development in the mouse eye. Dev Biol 320: 242-55 PubMed GONUTS page
  50. ↑ Pan Y et al. (2006) Sonic hedgehog signaling regulates Gli2 transcriptional activity by suppressing its processing and degradation. Mol Cell Biol 26: 3365-77 PubMed GONUTS page
  51. ↑ 51.0 51.1 Huang X et al. (2008) Gli3-deficient mice exhibit cleft palate associated with abnormal tongue development. Dev Dyn 237: 3079-87 PubMed GONUTS page
  52. ↑ 52.0 52.1 52.2 52.3 52.4 Hager-Theodorides AL et al. (2009) The Gli3 transcription factor expressed in the thymus stroma controls thymocyte negative selection via Hedgehog-dependent and -independent mechanisms. J Immunol 183: 3023-32 PubMed GONUTS page
  53. ↑ 53.0 53.1 53.2 Wang C et al. (2007) The Shh-independent activator function of the full-length Gli3 protein and its role in vertebrate limb digit patterning. Dev Biol 305: 460-9 PubMed GONUTS page
  54. ↑ 54.0 54.1 Kim JH et al. (2005) Gli3 null mice display glandular overgrowth of the developing stomach. Dev Dyn 234: 984-91 PubMed GONUTS page
  55. ↑ Kimmel SG et al. (2000) New mouse models of congenital anorectal malformations. J Pediatr Surg 35: 227-30; discussion 230-1 PubMed GONUTS page
  56. ↑ Kuijper S et al. (2005) Genetics of shoulder girdle formation: roles of Tbx15 and aristaless-like genes. Development 132: 1601-10 PubMed GONUTS page
  57. ↑ Oh S et al. (2005) Specific requirements of sonic hedgehog signaling during oligodendrocyte development. Dev Dyn 234: 489-96 PubMed GONUTS page
  58. ↑ Veltmaat JM et al. (2006) Gli3-mediated somitic Fgf10 expression gradients are required for the induction and patterning of mammary epithelium along the embryonic axes. Development 133: 2325-35 PubMed GONUTS page
  59. ↑ Alt B et al. (2006) Arteries define the position of the thyroid gland during its developmental relocalisation. Development 133: 3797-804 PubMed GONUTS page
  60. ↑ Qin J et al. (2011) Intraflagellar transport protein 122 antagonizes Sonic Hedgehog signaling and controls ciliary localization of pathway components. Proc Natl Acad Sci U S A 108: 1456-61 PubMed GONUTS page
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