MOUSE:FRDA

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Species (Taxon ID)	Mus musculus (Mouse). ([1])
Gene Name(s)	Fxn (synonyms: Frda)
Protein Name(s)	Frataxin, mitochondrial Fxn Frataxin intermediate form Frataxin mature form
External Links
EMBL	U95736
IPI	IPI00136201
RefSeq	NP_032070.1
UniGene	Mm.7319
ProteinModelPortal	O35943
SMR	O35943
STRING	O35943
PRIDE	O35943
Ensembl	ENSMUST00000081333
GeneID	14297
KEGG	mmu:14297
CTD	2395
MGI	MGI:1096879
eggNOG	roNOG14548
HOGENOM	HBG125781
HOVERGEN	HBG005745
InParanoid	O35943
OMA	AYSGKGT
OrthoDB	EOG4ZCT5S
PhylomeDB	O35943
NextBio	285709
ArrayExpress	O35943
Bgee	O35943
CleanEx	MM_FXN
Genevestigator	O35943
GermOnline	ENSMUSG00000059363
GO	GO:0005739 GO:0004322 GO:0007628 GO:0009060 GO:0006879 GO:0009792 GO:0006783 GO:0006811 GO:0007005 GO:0040015 GO:0046621 GO:0006119 GO:0019230
InterPro	IPR017789 IPR002908 IPR020895 IPR001794
Gene3D	G3DSA:3.30.920.10
PANTHER	PTHR16821
Pfam	PF01491
PRINTS	PR00904
SUPFAM	SSF55387
TIGRFAMs	TIGR03421 TIGR03422
PROSITE	PS01344 PS50810

Annotations

Qualifier	GO ID	GO term name	Reference	Evidence Code	with/from	Aspect	Notes
	GO:0004322	ferroxidase activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR001794	F	Seeded From UniProt
	GO:0004322	ferroxidase activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR017789	F	Seeded From UniProt
	GO:0004322	ferroxidase activity	GO_REF:0000003	IEA: Inferred from Electronic Annotation	EC:1.16.3.1	F	Seeded From UniProt
	GO:0004322	ferroxidase activity	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000366482	F	Seeded From UniProt
	GO:0005737	cytoplasm	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0963	C	Seeded From UniProt
	GO:0005737	cytoplasm	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0086	C	Seeded From UniProt
	GO:0005739	mitochondrion	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR001794	C	Seeded From UniProt
	GO:0005739	mitochondrion	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0496	C	Seeded From UniProt
	GO:0005739	mitochondrion	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000366482	C	Seeded From UniProt
	GO:0005739	mitochondrion	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000020412	C	Seeded From UniProt
	GO:0005739	mitochondrion	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0173	C	Seeded From UniProt
	GO:0005739	mitochondrion	PMID:14651853^[1]	IDA: Inferred from Direct Assay		C	Seeded From UniProt
	GO:0005739	mitochondrion	PMID:17597094^[2]	IDA: Inferred from Direct Assay		C	Seeded From UniProt
	GO:0005739	mitochondrion	PMID:18614015^[3]	IDA: Inferred from Direct Assay		C	Seeded From UniProt
	GO:0005829	cytosol	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000366482	C	Seeded From UniProt
	GO:0006119	oxidative phosphorylation	PMID:16278235^[4]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2176228	P	Seeded From UniProt
	GO:0006119	oxidative phosphorylation	PMID:16278235^[4]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2177176	P	Seeded From UniProt
	GO:0006119	oxidative phosphorylation	PMID:17404227^[5]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2177176	P	Seeded From UniProt
	GO:0006119	oxidative phosphorylation	PMID:17404227^[5]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2182103	P	Seeded From UniProt
	GO:0006783	heme biosynthetic process	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0350	P	Seeded From UniProt
	GO:0006810	transport	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0813	P	Seeded From UniProt
	GO:0006811	ion transport	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0406	P	Seeded From UniProt
	GO:0006879	cellular iron ion homeostasis	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR001794	P	Seeded From UniProt
	GO:0006879	cellular iron ion homeostasis	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0409	P	Seeded From UniProt
	GO:0006879	cellular iron ion homeostasis	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000366482	P	Seeded From UniProt
	GO:0006879	cellular iron ion homeostasis	PMID:9405681^[6]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2177175	P	Seeded From UniProt
	GO:0006879	cellular iron ion homeostasis	PMID:9405681^[6]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2177176	P	Seeded From UniProt
	GO:0007005	mitochondrion organization	PMID:14985441^[7]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2177177	P	Seeded From UniProt
	GO:0007005	mitochondrion organization	PMID:9405681^[6]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2177175	P	Seeded From UniProt
	GO:0007005	mitochondrion organization	PMID:9405681^[6]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2177176	P	Seeded From UniProt
	GO:0007628	adult walking behavior	PMID:14985441^[7]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2177177	P	Seeded From UniProt
	GO:0007628	adult walking behavior	PMID:9405681^[6]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2177175	P	Seeded From UniProt
	GO:0007628	adult walking behavior	PMID:9405681^[6]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2177176	P	Seeded From UniProt
	GO:0008198	ferrous iron binding	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000366482	F	Seeded From UniProt
	GO:0008199	ferric iron binding	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000366482	F	Seeded From UniProt
	GO:0008284	positive regulation of cell proliferation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000366482	P	Seeded From UniProt
	GO:0009060	aerobic respiration	PMID:16278235^[4]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2176228	P	Seeded From UniProt
	GO:0009060	aerobic respiration	PMID:16278235^[4]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2177176	P	Seeded From UniProt
	GO:0009060	aerobic respiration	PMID:9405681^[6]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2177175	P	Seeded From UniProt
	GO:0009060	aerobic respiration	PMID:9405681^[6]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2177176	P	Seeded From UniProt
	GO:0009792	embryo development ending in birth or egg hatching	PMID:10767347^[8]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2177162	P	Seeded From UniProt
	GO:0010039	response to iron ion	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000366482	P	Seeded From UniProt
	GO:0010722	regulation of ferrochelatase activity	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000366482	P	Seeded From UniProt
	GO:0014070	response to organic cyclic compound	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000020412	P	Seeded From UniProt
	GO:0016226	iron-sulfur cluster assembly	PMID:16278235^[4]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2176228	P	Seeded From UniProt
	GO:0016226	iron-sulfur cluster assembly	PMID:16278235^[4]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2177176	P	Seeded From UniProt
	GO:0016226	iron-sulfur cluster assembly	PMID:17597094^[2]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2176228	P	Seeded From UniProt
	GO:0016226	iron-sulfur cluster assembly	PMID:17597094^[2]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2177176	P	Seeded From UniProt
	GO:0016491	oxidoreductase activity	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0560	F	Seeded From UniProt
	GO:0016540	protein autoprocessing	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000366482	P	Seeded From UniProt
	GO:0018283	iron incorporation into metallo-sulfur cluster	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000366482	P	Seeded From UniProt
	GO:0019230	proprioception	PMID:11175786^[9]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2177175	P	Seeded From UniProt
	GO:0019230	proprioception	PMID:11175786^[9]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2177176	P	Seeded From UniProt
	GO:0019230	proprioception	PMID:14985441^[7]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2177177	P	Seeded From UniProt
	GO:0019899	enzyme binding	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000020412	F	Seeded From UniProt
	GO:0030307	positive regulation of cell growth	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000366482	P	Seeded From UniProt
	GO:0034986	iron chaperone activity	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000366482	F	Seeded From UniProt
	GO:0040015	negative regulation of multicellular organism growth	PMID:17404227^[5]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2177176	P	Seeded From UniProt
	GO:0040015	negative regulation of multicellular organism growth	PMID:17404227^[5]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2182103	P	Seeded From UniProt
	GO:0042493	response to drug	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000020412	P	Seeded From UniProt
	GO:0043066	negative regulation of apoptosis	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000366482	P	Seeded From UniProt
	GO:0045773	positive regulation of axon extension	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000020412	P	Seeded From UniProt
	GO:0046621	negative regulation of organ growth	PMID:9405681^[6]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2177175	P	Seeded From UniProt
	GO:0046621	negative regulation of organ growth	PMID:9405681^[6]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2177176	P	Seeded From UniProt
	GO:0046872	metal ion binding	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0479	F	Seeded From UniProt
	GO:0048554	positive regulation of metalloenzyme activity	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000366482	P	Seeded From UniProt
	GO:0051347	positive regulation of transferase activity	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000366482	P	Seeded From UniProt
	GO:0051349	positive regulation of lyase activity	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000366482	P	Seeded From UniProt
	GO:0051353	positive regulation of oxidoreductase activity	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000366482	P	Seeded From UniProt
	GO:0051536	iron-sulfur cluster binding	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000366482	F	Seeded From UniProt
	GO:0051537	2 iron, 2 sulfur cluster binding	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000366482	F	Seeded From UniProt
	GO:0055072	iron ion homeostasis	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0410	P	Seeded From UniProt
	GO:0055114	oxidation-reduction process	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR001794	P	Seeded From UniProt
	GO:0055114	oxidation-reduction process	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR017789	P	Seeded From UniProt
	GO:0055114	oxidation-reduction process	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0560	P	Seeded From UniProt
	GO:0070301	cellular response to hydrogen peroxide	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000366482	P	Seeded From UniProt
	GO:0090201	negative regulation of release of cytochrome c from mitochondria	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000366482	P	Seeded From UniProt
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Mootha VK et al. (2003) Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria. Cell 115: 629-40 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 Martelli A et al. (2007) Frataxin is essential for extramitochondrial Fe-S cluster proteins in mammalian tissues. Hum Mol Genet 16: 2651-8 PubMed GONUTS page
↑ Pagliarini DJ et al. (2008) A mitochondrial protein compendium elucidates complex I disease biology. Cell 134: 112-23 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 ^4.4 ^4.5 Thierbach R et al. (2005) Targeted disruption of hepatic frataxin expression causes impaired mitochondrial function, decreased life span and tumor growth in mice. Hum Mol Genet 14: 3857-64 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 ^5.3 Pomplun D et al. (2007) Reduced expression of mitochondrial frataxin in mice exacerbates diet-induced obesity. Proc Natl Acad Sci U S A 104: 6377-81 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 ^6.3 ^6.4 ^6.5 ^6.6 ^6.7 ^6.8 ^6.9 Oliver PM et al. (1997) Hypertension, cardiac hypertrophy, and sudden death in mice lacking natriuretic peptide receptor A. Proc Natl Acad Sci U S A 94: 14730-5 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 Simon D et al. (2004) Friedreich ataxia mouse models with progressive cerebellar and sensory ataxia reveal autophagic neurodegeneration in dorsal root ganglia. J Neurosci 24: 1987-95 PubMed GONUTS page
↑ Cossée M et al. (2000) Inactivation of the Friedreich ataxia mouse gene leads to early embryonic lethality without iron accumulation. Hum Mol Genet 9: 1219-26 PubMed GONUTS page
↑ ^9.0 ^9.1 Puccio H et al. (2001) Mouse models for Friedreich ataxia exhibit cardiomyopathy, sensory nerve defect and Fe-S enzyme deficiency followed by intramitochondrial iron deposits. Nat Genet 27: 181-6 PubMed GONUTS page

[PMID:14651853-0] Mootha VK et al. (2003) Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria. Cell 115: 629-40 PubMed GONUTS page

[PMID:17597094-1] 2.0 ^2.1 ^2.2 Martelli A et al. (2007) Frataxin is essential for extramitochondrial Fe-S cluster proteins in mammalian tissues. Hum Mol Genet 16: 2651-8 PubMed GONUTS page

[PMID:18614015-2] Pagliarini DJ et al. (2008) A mitochondrial protein compendium elucidates complex I disease biology. Cell 134: 112-23 PubMed GONUTS page

[PMID:16278235-3] 4.0 ^4.1 ^4.2 ^4.3 ^4.4 ^4.5 Thierbach R et al. (2005) Targeted disruption of hepatic frataxin expression causes impaired mitochondrial function, decreased life span and tumor growth in mice. Hum Mol Genet 14: 3857-64 PubMed GONUTS page

[PMID:17404227-4] 5.0 ^5.1 ^5.2 ^5.3 Pomplun D et al. (2007) Reduced expression of mitochondrial frataxin in mice exacerbates diet-induced obesity. Proc Natl Acad Sci U S A 104: 6377-81 PubMed GONUTS page

[PMID:9405681-5] 6.0 ^6.1 ^6.2 ^6.3 ^6.4 ^6.5 ^6.6 ^6.7 ^6.8 ^6.9 Oliver PM et al. (1997) Hypertension, cardiac hypertrophy, and sudden death in mice lacking natriuretic peptide receptor A. Proc Natl Acad Sci U S A 94: 14730-5 PubMed GONUTS page

[PMID:14985441-6] 7.0 ^7.1 ^7.2 Simon D et al. (2004) Friedreich ataxia mouse models with progressive cerebellar and sensory ataxia reveal autophagic neurodegeneration in dorsal root ganglia. J Neurosci 24: 1987-95 PubMed GONUTS page

[PMID:10767347-7] Cossée M et al. (2000) Inactivation of the Friedreich ataxia mouse gene leads to early embryonic lethality without iron accumulation. Hum Mol Genet 9: 1219-26 PubMed GONUTS page

[PMID:11175786-8] 9.0 ^9.1 Puccio H et al. (2001) Mouse models for Friedreich ataxia exhibit cardiomyopathy, sensory nerve defect and Fe-S enzyme deficiency followed by intramitochondrial iron deposits. Nat Genet 27: 181-6 PubMed GONUTS page

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MOUSE:FRDA

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