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MOUSE:FOXL2
Contents |
| Species (Taxon ID) | Mus musculus (Mouse). ([1]) | |
| Gene Name(s) | Foxl2 (synonyms: Pfrk) | |
| Protein Name(s) | Forkhead box protein L2
Pituitary forkhead factor P-Frk | |
| External Links | ||
| EMBL | AF522275 AF060873 | |
| IPI | IPI00230400 | |
| RefSeq | NP_036150.1 | |
| UniGene | Mm.151239 | |
| ProteinModelPortal | O88470 | |
| SMR | O88470 | |
| IntAct | O88470 | |
| STRING | O88470 | |
| PhosphoSite | O88470 | |
| PRIDE | O88470 | |
| Ensembl | ENSMUST00000051312 | |
| GeneID | 26927 | |
| KEGG | mmu:26927 | |
| CTD | 668 | |
| MGI | MGI:1349428 | |
| eggNOG | maNOG04069 | |
| HOGENOM | HBG281213 | |
| HOVERGEN | HBG051651 | |
| InParanoid | O88470 | |
| OMA | SMMHCSY | |
| OrthoDB | EOG4B5P7G | |
| NextBio | 304821 | |
| ArrayExpress | O88470 | |
| Bgee | O88470 | |
| CleanEx | MM_FOXL2 | |
| Genevestigator | O88470 | |
| GermOnline | ENSMUSG00000050397 | |
| GO | GO:0005667 GO:0043028 GO:0008301 GO:0003690 GO:0030331 GO:0003705 GO:0043565 GO:0008134 GO:0031624 GO:0060026 GO:0006309 GO:0048048 GO:0002074 GO:0019101 GO:0060014 GO:0006917 GO:0042703 GO:0000122 GO:0001541 GO:0007389 GO:0043280 GO:0045944 GO:0051090 | |
| InterPro | IPR001766 IPR018122 IPR011991 | |
| Gene3D | G3DSA:1.10.10.10 | |
| KO | K09405 | |
| Pfam | PF00250 | |
| PRINTS | PR00053 | |
| SMART | SM00339 | |
| PROSITE | PS00657 PS00658 PS50039 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0000122 |
negative regulation of transcription from RNA polymerase II promoter |
PANTHER:PTHR11829 |
P |
Seeded From UniProt |
||||
| GO:0001541 |
ovarian follicle development |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSP00000333188 |
P |
Seeded From UniProt |
|||
| GO:0001541 |
ovarian follicle development |
ISS: Inferred from Sequence or Structural Similarity |
P |
Seeded From UniProt |
||||
| GO:0001541 |
ovarian follicle development |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:3029503 |
P |
Seeded From UniProt |
|||
| GO:0001541 |
ovarian follicle development |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:3044226 |
P |
Seeded From UniProt |
|||
| GO:0002074 |
extraocular skeletal muscle development |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSP00000333188 |
P |
Seeded From UniProt |
|||
| GO:0002074 |
extraocular skeletal muscle development |
ISS: Inferred from Sequence or Structural Similarity |
P |
Seeded From UniProt |
||||
| GO:0002074 |
extraocular skeletal muscle development |
PANTHER:PTHR11829 |
P |
Seeded From UniProt |
||||
| GO:0003677 |
DNA binding |
IEA: Inferred from Electronic Annotation |
F |
Seeded From UniProt |
||||
| GO:0003677 |
DNA binding |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSP00000333188 |
F |
Seeded From UniProt |
|||
| GO:0003677 |
DNA binding |
ISS: Inferred from Sequence or Structural Similarity |
F |
Seeded From UniProt |
||||
| GO:0003677 |
DNA binding |
IDA: Inferred from Direct Assay |
|
F |
Seeded From UniProt |
|||
| GO:0003690 |
double-stranded DNA binding |
PANTHER:PTHR11829 |
F |
Seeded From UniProt |
||||
| GO:0003700 |
sequence-specific DNA binding transcription factor activity |
IEA: Inferred from Electronic Annotation |
F |
Seeded From UniProt |
||||
| GO:0003700 |
sequence-specific DNA binding transcription factor activity |
IEA: Inferred from Electronic Annotation |
F |
Seeded From UniProt |
||||
| GO:0003700 |
sequence-specific DNA binding transcription factor activity |
IDA: Inferred from Direct Assay |
|
F |
Seeded From UniProt |
|||
| GO:0003700 |
sequence-specific DNA binding transcription factor activity |
TAS: Traceable Author Statement |
|
F |
Seeded From UniProt |
|||
| GO:0003705 |
sequence-specific distal enhancer binding RNA polymerase II transcription factor activity |
PANTHER:PTHR11829 |
F |
Seeded From UniProt |
||||
| GO:0005515 |
protein binding |
IPI: Inferred from Physical Interaction |
F |
Seeded From UniProt |
||||
| GO:0005634 |
nucleus |
IEA: Inferred from Electronic Annotation |
C |
Seeded From UniProt |
||||
| GO:0005634 |
nucleus |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSP00000333188 |
C |
Seeded From UniProt |
|||
| GO:0005634 |
nucleus |
IEA: Inferred from Electronic Annotation |
SP_SL:SL-0191 |
C |
Seeded From UniProt |
|||
| GO:0005634 |
nucleus |
ISS: Inferred from Sequence or Structural Similarity |
C |
Seeded From UniProt |
||||
| GO:0005634 |
nucleus |
IDA: Inferred from Direct Assay |
|
C |
Seeded From UniProt |
|||
| GO:0005634 |
nucleus |
IDA: Inferred from Direct Assay |
|
C |
Seeded From UniProt |
|||
| GO:0005667 |
transcription factor complex |
PANTHER:PTHR11829 |
C |
Seeded From UniProt |
||||
| GO:0006309 |
DNA fragmentation involved in apoptotic nuclear change |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSP00000333188 |
P |
Seeded From UniProt |
|||
| GO:0006309 |
DNA fragmentation involved in apoptotic nuclear change |
ISS: Inferred from Sequence or Structural Similarity |
P |
Seeded From UniProt |
||||
| GO:0006309 |
DNA fragmentation involved in apoptotic nuclear change |
PANTHER:PTHR11829 |
P |
Seeded From UniProt |
||||
| GO:0006351 |
transcription, DNA-dependent |
IEA: Inferred from Electronic Annotation |
P |
Seeded From UniProt |
||||
| GO:0006355 |
regulation of transcription, DNA-dependent |
IEA: Inferred from Electronic Annotation |
P |
Seeded From UniProt |
||||
| GO:0006355 |
regulation of transcription, DNA-dependent |
IEA: Inferred from Electronic Annotation |
P |
Seeded From UniProt |
||||
| GO:0006355 |
regulation of transcription, DNA-dependent |
IEA: Inferred from Electronic Annotation |
P |
Seeded From UniProt |
||||
| GO:0006355 |
regulation of transcription, DNA-dependent |
TAS: Traceable Author Statement |
|
P |
Seeded From UniProt |
|||
| GO:0006917 |
induction of apoptosis |
IDA: Inferred from Direct Assay |
|
P |
Seeded From UniProt |
|||
| GO:0007389 |
pattern specification process |
PANTHER:PTHR11829 |
P |
Seeded From UniProt |
||||
| GO:0008134 |
transcription factor binding |
PANTHER:PTHR11829 |
F |
Seeded From UniProt |
||||
| GO:0008301 |
DNA bending activity |
PANTHER:PTHR11829 |
F |
Seeded From UniProt |
||||
| GO:0019101 |
female somatic sex determination |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2182312 |
P |
Seeded From UniProt |
|||
| GO:0030154 |
cell differentiation |
IEA: Inferred from Electronic Annotation |
P |
Seeded From UniProt |
||||
| GO:0030331 |
estrogen receptor binding |
IPI: Inferred from Physical Interaction |
F |
Seeded From UniProt |
||||
| GO:0030331 |
estrogen receptor binding |
IPI: Inferred from Physical Interaction |
F |
Seeded From UniProt |
||||
| GO:0031624 |
ubiquitin conjugating enzyme binding |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSP00000333188 |
F |
Seeded From UniProt |
|||
| GO:0031624 |
ubiquitin conjugating enzyme binding |
PANTHER:PTHR11829 |
F |
Seeded From UniProt |
||||
| GO:0042703 |
menstruation |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSP00000333188 |
P |
Seeded From UniProt |
|||
| GO:0042703 |
menstruation |
ISS: Inferred from Sequence or Structural Similarity |
P |
Seeded From UniProt |
||||
| GO:0042703 |
menstruation |
PANTHER:PTHR11829 |
P |
Seeded From UniProt |
||||
| GO:0043028 |
cysteine-type endopeptidase regulator activity involved in apoptotic process |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSP00000333188 |
F |
Seeded From UniProt |
|||
| GO:0043028 |
cysteine-type endopeptidase regulator activity involved in apoptotic process |
ISS: Inferred from Sequence or Structural Similarity |
F |
Seeded From UniProt |
||||
| GO:0043028 |
cysteine-type endopeptidase regulator activity involved in apoptotic process |
PANTHER:PTHR11829 |
F |
Seeded From UniProt |
||||
| GO:0043065 |
positive regulation of apoptosis |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSP00000333188 |
P |
Seeded From UniProt |
|||
| GO:0043065 |
positive regulation of apoptosis |
ISS: Inferred from Sequence or Structural Similarity |
P |
Seeded From UniProt |
||||
| GO:0043280 |
positive regulation of cysteine-type endopeptidase activity involved in apoptotic process |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSP00000333188 |
P |
Seeded From UniProt |
|||
| GO:0043280 |
positive regulation of cysteine-type endopeptidase activity involved in apoptotic process |
ISS: Inferred from Sequence or Structural Similarity |
P |
Seeded From UniProt |
||||
| GO:0043280 |
positive regulation of cysteine-type endopeptidase activity involved in apoptotic process |
PANTHER:PTHR11829 |
P |
Seeded From UniProt |
||||
| GO:0043565 |
sequence-specific DNA binding |
IEA: Inferred from Electronic Annotation |
F |
Seeded From UniProt |
||||
| GO:0043565 |
sequence-specific DNA binding |
IEA: Inferred from Electronic Annotation |
F |
Seeded From UniProt |
||||
| GO:0045892 |
negative regulation of transcription, DNA-dependent |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSP00000333188 |
P |
Seeded From UniProt |
|||
| GO:0045944 |
positive regulation of transcription from RNA polymerase II promoter |
IDA: Inferred from Direct Assay |
|
P |
Seeded From UniProt |
|||
| GO:0048048 |
embryonic eye morphogenesis |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:3044226 |
P |
Seeded From UniProt |
|||
| GO:0051090 |
regulation of sequence-specific DNA binding transcription factor activity |
PANTHER:PTHR11829 |
P |
Seeded From UniProt |
||||
| GO:0060014 |
granulosa cell differentiation |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:3029503 |
P |
Seeded From UniProt |
|||
| GO:0060026 |
convergent extension |
PANTHER:PTHR11829 |
P |
Seeded From UniProt |
||||
| GO:0006309 |
DNA fragmentation involved in apoptotic nuclear change |
IMP: Inferred from Mutant Phenotype |
P |
Figure1: Fragmentation assay of FOXL2 Figure 2: Overexpression of FOXL2 decreased the cell viability of granulose cells in mice |
complete | |||
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 Schmidt D et al. (2004) The murine winged-helix transcription factor Foxl2 is required for granulosa cell differentiation and ovary maintenance. Development 131: 933-42 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 Uda M et al. (2004) Foxl2 disruption causes mouse ovarian failure by pervasive blockage of follicle development. Hum Mol Genet 13: 1171-81 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 Ellsworth BS et al. (2003) The gonadotropin releasing hormone (GnRH) receptor activating sequence (GRAS) is a composite regulatory element that interacts with multiple classes of transcription factors including Smads, AP-1 and a forkhead DNA binding protein. Mol Cell Endocrinol 206: 93-111 PubMed GONUTS page
- ↑ 4.0 4.1 Treier M et al. (1998) Multistep signaling requirements for pituitary organogenesis in vivo. Genes Dev 12: 1691-704 PubMed GONUTS page
- ↑ 5.0 5.1 5.2 Lee K et al. (2005) Transcriptional factor FOXL2 interacts with DP103 and induces apoptosis. Biochem Biophys Res Commun 336: 876-81 PubMed GONUTS page
- ↑ 6.0 6.1 Kim SY et al. (2009) Foxl2, a forkhead transcription factor, modulates nonclassical activity of the estrogen receptor-alpha. Endocrinology 150: 5085-93 PubMed GONUTS page
- ↑ Ottolenghi C et al. (2005) Foxl2 is required for commitment to ovary differentiation. Hum Mol Genet 14: 2053-62 PubMed GONUTS page
- ↑ Uhlenhaut NH et al. (2009) Somatic sex reprogramming of adult ovaries to testes by FOXL2 ablation. Cell 139: 1130-42 PubMed GONUTS page
