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MOUSE:FAS
Contents |
| Species (Taxon ID) | Mus musculus (Mouse). ([1]) | |
| Gene Name(s) | Fasn | |
| Protein Name(s) | Fatty acid synthase
[Acyl-carrier-protein] S-acetyltransferase [Acyl-carrier-protein] S-malonyltransferase 3-oxoacyl-[acyl-carrier-protein] synthase 3-oxoacyl-[acyl-carrier-protein] reductase 3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase Enoyl-[acyl-carrier-protein] reductase Oleoyl-[acyl-carrier-protein] hydrolase | |
| External Links | ||
| EMBL | AF127033 AL663090 BC046513 BC059850 AK080374 X13135 | |
| IPI | IPI00113223 | |
| PIR | A32262 | |
| RefSeq | NP_032014.3 | |
| UniGene | Mm.236443 | |
| ProteinModelPortal | P19096 | |
| SMR | P19096 | |
| IntAct | P19096 | |
| STRING | P19096 | |
| PhosphoSite | P19096 | |
| PRIDE | P19096 | |
| Ensembl | ENSMUST00000055655 | |
| GeneID | 14104 | |
| KEGG | mmu:14104 | |
| NMPDR | fig|10090.3.peg.25828 | |
| UCSC | uc007mut.1 | |
| CTD | 2194 | |
| MGI | MGI:95485 | |
| HOGENOM | HBG316016 | |
| HOVERGEN | HBG005640 | |
| InParanoid | P19096 | |
| OMA | EMFRESC | |
| OrthoDB | EOG4KH2T3 | |
| PhylomeDB | P19096 | |
| NextBio | 285138 | |
| ArrayExpress | P19096 | |
| Bgee | P19096 | |
| CleanEx | MM_FASN | |
| Genevestigator | P19096 | |
| GermOnline | ENSMUSG00000025153 | |
| GO | GO:0042587 GO:0042470 GO:0005739 GO:0004317 GO:0004316 GO:0004315 GO:0004313 GO:0004314 GO:0000036 GO:0048037 GO:0004319 GO:0016295 GO:0004320 GO:0016296 GO:0031177 GO:0008270 GO:0006633 | |
| InterPro | IPR001227 IPR009081 IPR014043 IPR016035 IPR013149 IPR000794 IPR023102 IPR011032 IPR018201 IPR014031 IPR014030 IPR016036 IPR013217 IPR016040 IPR006163 IPR020842 IPR020843 IPR013968 IPR006162 IPR001031 IPR016039 IPR016038 | |
| Gene3D | G3DSA:3.40.366.10 G3DSA:1.10.1200.10 G3DSA:1.10.1470.20 G3DSA:3.40.50.720 G3DSA:3.40.47.10 | |
| PANTHER | PTHR11712 | |
| Pfam | PF00698 PF00107 PF00109 PF02801 PF08659 PF08242 PF00550 PF00975 | |
| SMART | SM00829 SM00822 | |
| SUPFAM | SSF47336 SSF52151 SSF50129 SSF55048 SSF53901 | |
| PROSITE | PS50075 PS00606 PS00012 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0000036 |
acyl carrier activity |
IEA: Inferred from Electronic Annotation |
F |
Seeded From UniProt |
||||
| GO:0000166 |
nucleotide binding |
IEA: Inferred from Electronic Annotation |
F |
Seeded From UniProt |
||||
| GO:0003824 |
catalytic activity |
IEA: Inferred from Electronic Annotation |
F |
Seeded From UniProt |
||||
| GO:0003824 |
catalytic activity |
IEA: Inferred from Electronic Annotation |
F |
Seeded From UniProt |
||||
| GO:0003824 |
catalytic activity |
IEA: Inferred from Electronic Annotation |
F |
Seeded From UniProt |
||||
| GO:0003824 |
catalytic activity |
IEA: Inferred from Electronic Annotation |
F |
Seeded From UniProt |
||||
| GO:0003824 |
catalytic activity |
IEA: Inferred from Electronic Annotation |
F |
Seeded From UniProt |
||||
| GO:0004312 |
fatty acid synthase activity |
IEA: Inferred from Electronic Annotation |
F |
Seeded From UniProt |
||||
| GO:0004312 |
fatty acid synthase activity |
IEA: Inferred from Electronic Annotation |
F |
Seeded From UniProt |
||||
| GO:0004313 |
(acyl-carrier-protein) S-acetyltransferase activity |
IEA: Inferred from Electronic Annotation |
F |
Seeded From UniProt |
||||
| GO:0004313 |
(acyl-carrier-protein) S-acetyltransferase activity |
IEA: Inferred from Electronic Annotation |
F |
Seeded From UniProt |
||||
| GO:0004314 |
(acyl-carrier-protein) S-malonyltransferase activity |
IEA: Inferred from Electronic Annotation |
F |
Seeded From UniProt |
||||
| GO:0004314 |
(acyl-carrier-protein) S-malonyltransferase activity |
IEA: Inferred from Electronic Annotation |
F |
Seeded From UniProt |
||||
| GO:0004315 |
3-oxoacyl-(acyl-carrier-protein) synthase activity |
IEA: Inferred from Electronic Annotation |
F |
Seeded From UniProt |
||||
| GO:0004315 |
3-oxoacyl-(acyl-carrier-protein) synthase activity |
IEA: Inferred from Electronic Annotation |
F |
Seeded From UniProt |
||||
| GO:0004316 |
3-oxoacyl-(acyl-carrier-protein) reductase (NADPH) activity |
IEA: Inferred from Electronic Annotation |
F |
Seeded From UniProt |
||||
| GO:0004316 |
3-oxoacyl-(acyl-carrier-protein) reductase (NADPH) activity |
IEA: Inferred from Electronic Annotation |
F |
Seeded From UniProt |
||||
| GO:0004317 |
3-hydroxypalmitoyl-(acyl-carrier-protein) dehydratase activity |
IEA: Inferred from Electronic Annotation |
F |
Seeded From UniProt |
||||
| GO:0004317 |
3-hydroxypalmitoyl-(acyl-carrier-protein) dehydratase activity |
IEA: Inferred from Electronic Annotation |
F |
Seeded From UniProt |
||||
| GO:0004319 |
enoyl-(acyl-carrier-protein) reductase (NADPH, B-specific) activity |
IEA: Inferred from Electronic Annotation |
F |
Seeded From UniProt |
||||
| GO:0004319 |
enoyl-(acyl-carrier-protein) reductase (NADPH, B-specific) activity |
IEA: Inferred from Electronic Annotation |
F |
Seeded From UniProt |
||||
| GO:0004320 |
oleoyl-(acyl-carrier-protein) hydrolase activity |
IEA: Inferred from Electronic Annotation |
F |
Seeded From UniProt |
||||
| GO:0004320 |
oleoyl-(acyl-carrier-protein) hydrolase activity |
IEA: Inferred from Electronic Annotation |
F |
Seeded From UniProt |
||||
| GO:0005488 |
binding |
IEA: Inferred from Electronic Annotation |
F |
Seeded From UniProt |
||||
| GO:0005737 |
cytoplasm |
IEA: Inferred from Electronic Annotation |
C |
Seeded From UniProt |
||||
| GO:0005737 |
cytoplasm |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSP00000304592 |
C |
Seeded From UniProt |
|||
| GO:0005737 |
cytoplasm |
IEA: Inferred from Electronic Annotation |
SP_SL:SL-0086 |
C |
Seeded From UniProt |
|||
| GO:0005739 |
mitochondrion |
IDA: Inferred from Direct Assay |
|
C |
Seeded From UniProt |
|||
| GO:0005794 |
Golgi apparatus |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSP00000304592 |
C |
Seeded From UniProt |
|||
| GO:0005886 |
plasma membrane |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSP00000304592 |
C |
Seeded From UniProt |
|||
| GO:0006633 |
fatty acid biosynthetic process |
IEA: Inferred from Electronic Annotation |
P |
Seeded From UniProt |
||||
| GO:0008152 |
metabolic process |
IEA: Inferred from Electronic Annotation |
P |
Seeded From UniProt |
||||
| GO:0008152 |
metabolic process |
IEA: Inferred from Electronic Annotation |
P |
Seeded From UniProt |
||||
| GO:0008152 |
metabolic process |
IEA: Inferred from Electronic Annotation |
P |
Seeded From UniProt |
||||
| GO:0008152 |
metabolic process |
IEA: Inferred from Electronic Annotation |
P |
Seeded From UniProt |
||||
| GO:0008152 |
metabolic process |
IEA: Inferred from Electronic Annotation |
P |
Seeded From UniProt |
||||
| GO:0008152 |
metabolic process |
IEA: Inferred from Electronic Annotation |
P |
Seeded From UniProt |
||||
| GO:0008270 |
zinc ion binding |
IEA: Inferred from Electronic Annotation |
F |
Seeded From UniProt |
||||
| GO:0008610 |
lipid biosynthetic process |
IEA: Inferred from Electronic Annotation |
P |
Seeded From UniProt |
||||
| GO:0009058 |
biosynthetic process |
IEA: Inferred from Electronic Annotation |
P |
Seeded From UniProt |
||||
| GO:0009058 |
biosynthetic process |
IEA: Inferred from Electronic Annotation |
P |
Seeded From UniProt |
||||
| GO:0016295 |
myristoyl-(acyl-carrier-protein) hydrolase activity |
IEA: Inferred from Electronic Annotation |
F |
Seeded From UniProt |
||||
| GO:0016295 |
myristoyl-(acyl-carrier-protein) hydrolase activity |
IEA: Inferred from Electronic Annotation |
F |
Seeded From UniProt |
||||
| GO:0016296 |
palmitoyl-(acyl-carrier-protein) hydrolase activity |
IEA: Inferred from Electronic Annotation |
F |
Seeded From UniProt |
||||
| GO:0016296 |
palmitoyl-(acyl-carrier-protein) hydrolase activity |
IEA: Inferred from Electronic Annotation |
F |
Seeded From UniProt |
||||
| GO:0016297 |
acyl-(acyl-carrier-protein) hydrolase activity |
IEA: Inferred from Electronic Annotation |
F |
Seeded From UniProt |
||||
| GO:0016297 |
acyl-(acyl-carrier-protein) hydrolase activity |
IEA: Inferred from Electronic Annotation |
F |
Seeded From UniProt |
||||
| GO:0016491 |
oxidoreductase activity |
IEA: Inferred from Electronic Annotation |
F |
Seeded From UniProt |
||||
| GO:0016491 |
oxidoreductase activity |
IEA: Inferred from Electronic Annotation |
F |
Seeded From UniProt |
||||
| GO:0016491 |
oxidoreductase activity |
IEA: Inferred from Electronic Annotation |
F |
Seeded From UniProt |
||||
| GO:0016740 |
transferase activity |
IEA: Inferred from Electronic Annotation |
F |
Seeded From UniProt |
||||
| GO:0016740 |
transferase activity |
IEA: Inferred from Electronic Annotation |
F |
Seeded From UniProt |
||||
| GO:0016747 |
transferase activity, transferring acyl groups other than amino-acyl groups |
IEA: Inferred from Electronic Annotation |
F |
Seeded From UniProt |
||||
| GO:0016787 |
hydrolase activity |
IEA: Inferred from Electronic Annotation |
F |
Seeded From UniProt |
||||
| GO:0016788 |
hydrolase activity, acting on ester bonds |
IEA: Inferred from Electronic Annotation |
F |
Seeded From UniProt |
||||
| GO:0016829 |
lyase activity |
IEA: Inferred from Electronic Annotation |
F |
Seeded From UniProt |
||||
| GO:0031177 |
phosphopantetheine binding |
IEA: Inferred from Electronic Annotation |
F |
Seeded From UniProt |
||||
| GO:0042470 |
melanosome |
IEA: Inferred from Electronic Annotation |
SP_SL:SL-0161 |
C |
Seeded From UniProt |
|||
| GO:0042587 |
glycogen granule |
IDA: Inferred from Direct Assay |
|
C |
Seeded From UniProt |
|||
| GO:0048037 |
cofactor binding |
IEA: Inferred from Electronic Annotation |
F |
Seeded From UniProt |
||||
| GO:0055114 |
oxidation-reduction process |
IEA: Inferred from Electronic Annotation |
P |
Seeded From UniProt |
||||
| GO:0055114 |
oxidation-reduction process |
IEA: Inferred from Electronic Annotation |
P |
Seeded From UniProt |
||||
| GO:0055114 |
oxidation-reduction process |
IEA: Inferred from Electronic Annotation |
P |
Seeded From UniProt |
||||
| GO:0004312 |
fatty acid synthase activity |
IMP: Inferred from Mutant Phenotype |
F |
FAS serves to synthesize fatty acids but has a low activity to stored and secreted triglycerides and mice deficient in hepatic FAS have demonstrated FAS as a signaling protein.
|
complete | |||
| GO:0008286 |
insulin receptor signaling pathway |
IDA: Inferred from Direct Assay |
P |
"we also demonstrated that FAS is induced by insulin using freshly isolated human endothelial cells (Fig. 1B" |
complete | |||
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ Pagliarini DJ et al. (2008) A mitochondrial protein compendium elucidates complex I disease biology. Cell 134: 112-23 PubMed GONUTS page
- ↑ Ridsdale R & Post M (2004) Surfactant lipid synthesis and lamellar body formation in glycogen-laden type II cells. Am J Physiol Lung Cell Mol Physiol 287: L743-51 PubMed GONUTS page
- ↑ Jensen-Urstad AP & Semenkovich CF (2012) Fatty acid synthase and liver triglyceride metabolism: Housekeeper or messenger? Biochim Biophys Acta 1821: 747-53 PubMed GONUTS page
- ↑ Wei X et al. (2011) De novo lipogenesis maintains vascular homeostasis through endothelial nitric-oxide synthase (eNOS) palmitoylation. J Biol Chem 286: 2933-45 PubMed GONUTS page
