MOUSE:EDN3

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Species (Taxon ID)	Mus musculus (Mouse). (taxon:10090)
Gene Name(s)	Edn3
Protein Name(s)	Endothelin-3 ET-3 Preproendothelin-3 PPET3
External Links
UniProt Identifier	EDN3_MOUSE
UniProt Accessions	P48299, Q543L0,
EMBL	U32330, AK048006, AK049775, AK079150,
PIR	I49351,
RefSeq	NP_031929.1,
Ensembl	ENSMUST00000029030,
Pfam	PF00322,

Annotations

Qualifier	GO ID	GO term name	Reference	Evidence Code	with/from	Aspect	Notes	Status
	GO:0030318	melanocyte differentiation		IDA: Inferred from Direct Assay		P	Source: MGI
	GO:0001755	neural crest cell migration		IMP: Inferred from Mutant Phenotype		P	Source: MGI
	GO:0030182	neuron differentiation		IMP: Inferred from Mutant Phenotype		P	Source: MGI
	GO:0008284	positive regulation of cell proliferation		IDA: Inferred from Direct Assay		P	Source: MGI
	GO:0048070	regulation of developmental pigmentation		IMP: Inferred from Mutant Phenotype		P	Source: MGI
	GO:0019229	regulation of vasoconstriction		IEA: Inferred from Electronic Annotation		P	Source: InterPro
	GO:0048484	enteric nervous system development	PMID 10021336	IDA: Inferred from Direct Assay		P	Figure 2 shows inhibited neuronal cell development with Et3 in crest derived cells	complete
	GO:0014043	negative regulation of neuron maturation	PMID 10021336	IDA: Inferred from Direct Assay		P	Figure 2 shows decreased neuronal maturation, this is concentration dependent. Figure 3 shows similar finding, dose dependent inhibition of enteric neuronal cell maturation	complete
	GO:0048659	smooth muscle cell proliferation	PMID 10021336	IDA: Inferred from Direct Assay		P	Figure 5 shows ET3 promotion of smooth muscle cell proliferation.	complete
	GO:0010629	negative regulation of gene expression	PMID 10021336	IDA: Inferred from Direct Assay		P	Figure 6 shows decreased expression of lamin alpha 1 in the presence of Et3	complete
	GO:0001755	neural crest cell migration	PMID:9624616^[1]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1856392	P
	GO:0002690	positive regulation of leukocyte chemotaxis	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000337128	P
	GO:0003100	regulation of systemic arterial blood pressure by endothelin	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000337128	P
	GO:0005179	hormone activity	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000337128	F
	GO:0005576	extracellular region	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR001928	C
	GO:0005576	extracellular region	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR019764	C
	GO:0005576	extracellular region	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0964	C
	GO:0005576	extracellular region	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000337128	C
	GO:0005576	extracellular region	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0243	C
	GO:0005615	extracellular space	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000337128	C
	GO:0007166	cell surface receptor linked signaling pathway	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000337128	P
	GO:0008284	positive regulation of cell proliferation	PMID:11401406^[2]	IDA: Inferred from Direct Assay		P
	GO:0010460	positive regulation of heart rate	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000337128	P
	GO:0014826	vein smooth muscle contraction	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000337128	P
	GO:0019229	regulation of vasoconstriction	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR001928	P
	GO:0019229	regulation of vasoconstriction	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR019764	P
	GO:0030072	peptide hormone secretion	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000337128	P
	GO:0030182	neuron differentiation	PMID:9624616^[1]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1856392	P
	GO:0030318	melanocyte differentiation	PMID:9012511^[3]	IDA: Inferred from Direct Assay		P
	GO:0030334	regulation of cell migration	PMID:14138974^[4]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1856392	P
	GO:0030593	neutrophil chemotaxis	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000337128	P
	GO:0031708	endothelin B receptor binding	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000337128	F
	GO:0042310	vasoconstriction	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0839	P
	GO:0042310	vasoconstriction	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000337128	P
	GO:0043406	positive regulation of MAP kinase activity	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000337128	P
	GO:0045840	positive regulation of mitosis	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000337128	P
	GO:0046887	positive regulation of hormone secretion	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000337128	P
	GO:0046888	negative regulation of hormone secretion	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000009826	P
	GO:0046928	regulation of neurotransmitter secretion	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000009826	P
	GO:0048016	inositol phosphate-mediated signaling	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000337128	P
	GO:0048070	regulation of developmental pigmentation	PMID:14138974^[4]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1856392	P
	GO:0050880	regulation of blood vessel size	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0838	P
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Howard MJ & Gershon MD (1998) Development of LBP110 expression by neural crest-derived enteric precursors: migration and differentiation potential in ls/ls mutant mice. J Neurobiol 35: 341-54 PubMed GONUTS page
↑ Wehrle-Haller B et al. (2001) Analysis of melanocyte precursors in Nf1 mutants reveals that MGF/KIT signaling promotes directed cell migration independent of its function in cell survival. Dev Biol 232: 471-83 PubMed GONUTS page
↑ Reid K et al. (1996) Multiple roles for endothelin in melanocyte development: regulation of progenitor number and stimulation of differentiation. Development 122: 3911-9 PubMed GONUTS page
↑ ^4.0 ^4.1 MAYER TC & MALTBY EL (1964) AN EXPERIMENTAL INVESTIGATION OF PATTERN DEVELOPMENT IN LETHAL SPOTTING AND BELTED MOUSE EMBRYOS. Dev Biol 22: 269-86 PubMed GONUTS page

[PMID:9624616-0] 1.0 ^1.1 Howard MJ & Gershon MD (1998) Development of LBP110 expression by neural crest-derived enteric precursors: migration and differentiation potential in ls/ls mutant mice. J Neurobiol 35: 341-54 PubMed GONUTS page

[PMID:11401406-1] Wehrle-Haller B et al. (2001) Analysis of melanocyte precursors in Nf1 mutants reveals that MGF/KIT signaling promotes directed cell migration independent of its function in cell survival. Dev Biol 232: 471-83 PubMed GONUTS page

[PMID:9012511-2] Reid K et al. (1996) Multiple roles for endothelin in melanocyte development: regulation of progenitor number and stimulation of differentiation. Development 122: 3911-9 PubMed GONUTS page

[PMID:14138974-3] 4.0 ^4.1 MAYER TC & MALTBY EL (1964) AN EXPERIMENTAL INVESTIGATION OF PATTERN DEVELOPMENT IN LETHAL SPOTTING AND BELTED MOUSE EMBRYOS. Dev Biol 22: 269-86 PubMed GONUTS page

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MOUSE:EDN3

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