MOUSE:CUL4A

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Annotations

Qualifier	GO ID	GO term name	Reference	Evidence Code	with/from	Aspect	Notes	Status
	GO:0031464	Cul4A-RING ubiquitin ligase complex		ISS: Inferred from Sequence or Structural Similarity		C	Source: UniProtKB
	GO:0031625	ubiquitin protein ligase binding		IEA: Inferred from Electronic Annotation		F	Source: InterPro
	GO:0071445	cellular response to protein stimulus		IDA: Inferred from Direct Assay		P	Source: MGI
	GO:0006281	DNA repair		IEA: Inferred from Electronic Annotation		P	Source: UniProtKB-KW
	GO:0044419	interspecies interaction between organisms		IEA: Inferred from Electronic Annotation		P	Source: UniProtKB-KW
	GO:0045750	positive regulation of S phase of mitotic c...		IMP: Inferred from Mutant Phenotype		P	Source: MGI
	GO:0051246	regulation of protein metabolic process		IMP: Inferred from Mutant Phenotype		P	Source: MGI
	GO:0006511	ubiquitin-dependent protein catabolic process		IEA: Inferred from Electronic Annotation		P	Source: InterPro
incorrect (CACAO)	GO:0045995	regulation of embryonic development	PMID:18339895^[1]	TAS: Traceable Author Statement		P	intro “...mutant embryos did not survive….”	complete
	GO:0002244	hemopoietic progenitor cell differentiation	PMID:18339895^[1]	IMP: Inferred from Mutant Phenotype		P	Figure 3, table 1	complete
	GO:0006916	anti-apoptosis	PMID:18339895^[1]	IMP: Inferred from Mutant Phenotype		P	Figure.4A,B ... the frequency of apoptotic cells was 4.5-fold greater in the mutant cells…	complete
	GO:0051726	regulation of cell cycle	PMID:18339895^[1]	IMP: Inferred from Mutant Phenotype		P	figure 4C	complete
	GO:0051246	regulation of protein metabolic process	PMID:18339895^[1]	IMP: Inferred from Mutant Phenotype		P	figure 5	complete
	GO:0006281	DNA repair	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0234	P
	GO:0006511	ubiquitin-dependent protein catabolic process	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR001373	P
	GO:0006511	ubiquitin-dependent protein catabolic process	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR016157	P
	GO:0006511	ubiquitin-dependent protein catabolic process	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR016158	P
	GO:0006511	ubiquitin-dependent protein catabolic process	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR019559	P
	GO:0006974	response to DNA damage stimulus	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0227	P
	GO:0007346	regulation of mitotic cell cycle	PMID:19056892^[2]	IMP: Inferred from Mutant Phenotype		P
	GO:0031461	cullin-RING ubiquitin ligase complex	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR001373	C
	GO:0031461	cullin-RING ubiquitin ligase complex	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR016157	C
	GO:0031461	cullin-RING ubiquitin ligase complex	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR016158	C
	GO:0031461	cullin-RING ubiquitin ligase complex	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR019559	C
	GO:0031464	Cul4A-RING ubiquitin ligase complex	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000364589	C
	GO:0031464	Cul4A-RING ubiquitin ligase complex	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:Q13619	C
	GO:0031625	ubiquitin protein ligase binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR001373	F
	GO:0031625	ubiquitin protein ligase binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR016157	F
	GO:0031625	ubiquitin protein ligase binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR016158	F
	GO:0031625	ubiquitin protein ligase binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR019559	F
	GO:0044419	interspecies interaction between organisms	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0945	P
	GO:0045750	positive regulation of S phase of mitotic cell cycle	PMID:19056892^[2]	IMP: Inferred from Mutant Phenotype		P
	GO:0051246	regulation of protein metabolic process	PMID:19056892^[2]	IMP: Inferred from Mutant Phenotype		P
	GO:0071445	cellular response to protein stimulus	PMID:19056892^[2]	IDA: Inferred from Direct Assay		P
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 Waning DL et al. (2008) Cul4A is required for hematopoietic cell viability and its deficiency leads to apoptosis. Blood 112: 320-9 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 Miranda-Carboni GA et al. (2008) A functional link between Wnt signaling and SKP2-independent p27 turnover in mammary tumors. Genes Dev 22: 3121-34 PubMed GONUTS page

[PMID:18339895-0] 1.0 ^1.1 ^1.2 ^1.3 ^1.4 Waning DL et al. (2008) Cul4A is required for hematopoietic cell viability and its deficiency leads to apoptosis. Blood 112: 320-9 PubMed GONUTS page

[PMID:19056892-1] 2.0 ^2.1 ^2.2 ^2.3 Miranda-Carboni GA et al. (2008) A functional link between Wnt signaling and SKP2-independent p27 turnover in mammary tumors. Genes Dev 22: 3121-34 PubMed GONUTS page

[1]

[2]

Species (Taxon ID)	Mus musculus (Mouse). (taxon:10090)
Gene Name(s)	Cul4a
Protein Name(s)	Cullin-4A CUL-4A
External Links
UniProt Identifier	CUL4A_MOUSE
UniProt Accessions	Q3TCH7, Q3THM3, Q91Z44,
EMBL	AK168215, AK170722, BC010211,
RefSeq	NP_666319.2,
Ensembl	ENSMUST00000016680,
Pfam	PF00888, PF10557,

MOUSE:CUL4A

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