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MOUSE:CSKP
Contents |
| Species (Taxon ID) | Mus musculus (Mouse). ([1]) | |
| Gene Name(s) | Cask | |
| Protein Name(s) | Peripheral plasma membrane protein CASK
Calcium/calmodulin-dependent serine protein kinase | |
| External Links | ||
| EMBL | Y17138 Y17137 AL671117 AL672204 BX005215 AL671117 AL672204 BX005215 AL671117 AL672204 AL672204 AL671117 BX005215 AL672204 BX005215 AL671117 AL672204 AL671117 BX005215 AL672204 AL671117 BX005215 AL672204 AL671117 AK136523 | |
| IPI | IPI00119517 IPI00227910 IPI00776307 IPI00776341 IPI00844763 | |
| RefSeq | NP_033936.2 | |
| UniGene | Mm.327591 Mm.474948 | |
| PDB | 1Y74 | |
| PDBsum | 1Y74 | |
| ProteinModelPortal | O70589 | |
| SMR | O70589 | |
| IntAct | O70589 | |
| STRING | O70589 | |
| PhosphoSite | O70589 | |
| PRIDE | O70589 | |
| Ensembl | ENSMUST00000033321 ENSMUST00000115436 ENSMUST00000115438 | |
| GeneID | 12361 | |
| KEGG | mmu:12361 | |
| UCSC | uc009srp.1 uc009srq.1 uc012hez.1 | |
| CTD | 8573 | |
| MGI | MGI:1309489 | |
| eggNOG | roNOG12976 | |
| GeneTree | ENSGT00560000077048 | |
| HOGENOM | HBG446173 | |
| HOVERGEN | HBG001858 | |
| InParanoid | O70589 | |
| OMA | AIELVCT | |
| OrthoDB | EOG4FBHS6 | |
| BRENDA | 2.7.11.1 | |
| NextBio | 281028 | |
| ArrayExpress | O70589 | |
| Bgee | O70589 | |
| Genevestigator | O70589 | |
| GermOnline | ENSMUSG00000031012 | |
| GO | GO:0016323 GO:0005829 GO:0005634 GO:0045202 GO:0019717 GO:0005524 GO:0005516 GO:0004674 GO:0045944 | |
| InterPro | IPR008144 IPR008145 IPR020590 IPR011009 IPR004172 IPR014775 IPR001478 IPR000719 IPR017442 IPR002290 IPR011511 IPR001452 | |
| Pfam | PF00625 PF02828 PF00595 PF00069 PF07653 | |
| SMART | SM00072 SM00569 SM00228 SM00220 SM00326 | |
| SUPFAM | SSF56112 SSF50156 SSF50044 | |
| PROSITE | PS00856 PS50052 PS51022 PS50106 PS00107 PS50011 PS00108 PS50002 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0000166 |
nucleotide binding |
IEA: Inferred from Electronic Annotation |
F |
Seeded From UniProt |
||||
| GO:0004672 |
protein kinase activity |
IEA: Inferred from Electronic Annotation |
F |
Seeded From UniProt |
||||
| GO:0004672 |
protein kinase activity |
IEA: Inferred from Electronic Annotation |
F |
Seeded From UniProt |
||||
| GO:0004674 |
protein serine/threonine kinase activity |
IEA: Inferred from Electronic Annotation |
F |
Seeded From UniProt |
||||
| GO:0004674 |
protein serine/threonine kinase activity |
IEA: Inferred from Electronic Annotation |
F |
Seeded From UniProt |
||||
| GO:0005515 |
protein binding |
IPI: Inferred from Physical Interaction |
F |
Seeded From UniProt |
||||
| GO:0005515 |
protein binding |
IPI: Inferred from Physical Interaction |
F |
Seeded From UniProt |
||||
| GO:0005515 |
protein binding |
IPI: Inferred from Physical Interaction |
F |
Seeded From UniProt |
||||
| GO:0005516 |
calmodulin binding |
IEA: Inferred from Electronic Annotation |
F |
Seeded From UniProt |
||||
| GO:0005524 |
ATP binding |
IEA: Inferred from Electronic Annotation |
F |
Seeded From UniProt |
||||
| GO:0005524 |
ATP binding |
IEA: Inferred from Electronic Annotation |
F |
Seeded From UniProt |
||||
| GO:0005524 |
ATP binding |
IEA: Inferred from Electronic Annotation |
F |
Seeded From UniProt |
||||
| GO:0005524 |
ATP binding |
IEA: Inferred from Electronic Annotation |
F |
Seeded From UniProt |
||||
| GO:0005634 |
nucleus |
IEA: Inferred from Electronic Annotation |
C |
Seeded From UniProt |
||||
| GO:0005634 |
nucleus |
IEA: Inferred from Electronic Annotation |
SP_SL:SL-0191 |
C |
Seeded From UniProt |
|||
| GO:0005737 |
cytoplasm |
IEA: Inferred from Electronic Annotation |
C |
Seeded From UniProt |
||||
| GO:0005737 |
cytoplasm |
IEA: Inferred from Electronic Annotation |
SP_SL:SL-0086 |
C |
Seeded From UniProt |
|||
| GO:0005829 |
cytosol |
IDA: Inferred from Direct Assay |
|
C |
Seeded From UniProt |
|||
| GO:0005886 |
plasma membrane |
IEA: Inferred from Electronic Annotation |
C |
Seeded From UniProt |
||||
| GO:0005886 |
plasma membrane |
IEA: Inferred from Electronic Annotation |
SP_SL:SL-0039 |
C |
Seeded From UniProt |
|||
| GO:0006468 |
protein phosphorylation |
IEA: Inferred from Electronic Annotation |
P |
Seeded From UniProt |
||||
| GO:0006468 |
protein phosphorylation |
IEA: Inferred from Electronic Annotation |
P |
Seeded From UniProt |
||||
| GO:0006468 |
protein phosphorylation |
IEA: Inferred from Electronic Annotation |
P |
Seeded From UniProt |
||||
| GO:0016020 |
membrane |
IEA: Inferred from Electronic Annotation |
C |
Seeded From UniProt |
||||
| GO:0016301 |
kinase activity |
IEA: Inferred from Electronic Annotation |
F |
Seeded From UniProt |
||||
| GO:0016310 |
phosphorylation |
IEA: Inferred from Electronic Annotation |
P |
Seeded From UniProt |
||||
| GO:0016323 |
basolateral plasma membrane |
IDA: Inferred from Direct Assay |
|
C |
Seeded From UniProt |
|||
| GO:0016323 |
basolateral plasma membrane |
IDA: Inferred from Direct Assay |
|
C |
Seeded From UniProt |
|||
| GO:0016740 |
transferase activity |
IEA: Inferred from Electronic Annotation |
F |
Seeded From UniProt |
||||
| GO:0016772 |
transferase activity, transferring phosphorus-containing groups |
IEA: Inferred from Electronic Annotation |
F |
Seeded From UniProt |
||||
| GO:0019717 |
synaptosome |
IDA: Inferred from Direct Assay |
|
C |
Seeded From UniProt |
|||
| GO:0045202 |
synapse |
IDA: Inferred from Direct Assay |
|
C |
Seeded From UniProt |
|||
| GO:0045202 |
synapse |
IDA: Inferred from Direct Assay |
|
C |
Seeded From UniProt |
|||
| GO:0045944 |
positive regulation of transcription from RNA polymerase II promoter |
IGI: Inferred from Genetic Interaction |
MGI:MGI:107404 |
P |
Seeded From UniProt |
|||
| GO:0005634 |
nucleus |
IDA: Inferred from Direct Assay |
C |
Figure 1A,B, E immunofluorescence used in new born mice, CASK is located in nucleus and colocalized with nucleoskeletal protein lamin A in nuclei of cells of the basal layer of the epidermis. |
complete | |||
| GO:0005604 |
basement membrane |
IDA: Inferred from Direct Assay |
C |
Figure 1C immunofluorescence used in adult mice, Cask localizes to cell borders of cells of the basal layer of the epidermis. Dashed line indicate basement membrane zone. |
complete | |||
| GO:0005737 |
cytoplasm |
IDA: Inferred from Direct Assay |
C |
Figure 1E found CASK in new born mice primary keratinocytes in cytoplasm, which was confirmed in western blot in cytosolic protein fraction, figure 1F. |
complete | |||
| GO:0005911 |
cell-cell junction |
IDA: Inferred from Direct Assay |
C |
Figure 1E found CASK in new born primary mouse keratinocytes at intercellular junction of cells. |
complete | |||
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 Naim E et al. (2005) Mutagenesis of the epithelial polarity gene, discs large 1, perturbs nephrogenesis in the developing mouse kidney. Kidney Int 68: 955-65 PubMed GONUTS page
- ↑ 2.0 2.1 Olsen O et al. (2005) Neurotransmitter release regulated by a MALS-liprin-alpha presynaptic complex. J Cell Biol 170: 1127-34 PubMed GONUTS page
- ↑ Gerke P et al. (2006) Neuronal expression and interaction with the synaptic protein CASK suggest a role for Neph1 and Neph2 in synaptogenesis. J Comp Neurol 498: 466-75 PubMed GONUTS page
- ↑ 4.0 4.1 Biederer T et al. (2002) SynCAM, a synaptic adhesion molecule that drives synapse assembly. Science 297: 1525-31 PubMed GONUTS page
- ↑ Karnak D et al. (2002) Identification of multiple binding partners for the amino-terminal domain of synapse-associated protein 97. J Biol Chem 277: 46730-5 PubMed GONUTS page
- ↑ Bamji SX et al. (2003) Role of beta-catenin in synaptic vesicle localization and presynaptic assembly. Neuron 40: 719-31 PubMed GONUTS page
- ↑ Wang TF et al. (2004) Identification of Tbr-1/CASK complex target genes in neurons. J Neurochem 91: 1483-92 PubMed GONUTS page
- ↑ 8.0 8.1 8.2 8.3 Ojeh N et al. (2008) The MAGUK-family protein CASK is targeted to nuclei of the basal epidermis and controls keratinocyte proliferation. J Cell Sci 121: 2705-17 PubMed GONUTS page
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