MOUSE:CLOCK

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Species (Taxon ID)	Mus musculus (Mouse). (taxon:10090)
Gene Name(s)	Clock
Protein Name(s)	Circadian locomoter output cycles protein kaput mCLOCK
External Links
UniProt Identifier	CLOCK_MOUSE
UniProt Accessions	O08785,
EMBL	AF000998, AF146793,
RefSeq	NP_031741.1,
IntAct	O08785,
Ensembl	ENSMUST00000075159, ENSMUST00000113497,
Pfam	PF00010, PF00989, PF08447,

Annotations

Qualifier	GO ID	GO term name	Reference	Evidence Code	with/from	Aspect	Notes	Status
	GO:0003677	DNA binding	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0238	F
	GO:0003700	sequence-specific DNA binding transcription factor activity	PMID:12024206^[1]	IDA: Inferred from Direct Assay		F
	GO:0003700	sequence-specific DNA binding transcription factor activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR001067	F
	GO:0004402	histone acetyltransferase activity	GO_REF:0000003	IEA: Inferred from Electronic Annotation	EC:2.3.1.48	F
	GO:0004871	signal transducer activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR000014	F
	GO:0005515	protein binding	PMID:18430226^[2]	IPI: Inferred from Physical Interaction	UniProtKB:O54943	F
	GO:0005515	protein binding	PMID:18662546^[3]	IPI: Inferred from Physical Interaction	UniProtKB:Q923E4	F
	GO:0005515	protein binding	PMID:18662546^[3]	IPI: Inferred from Physical Interaction	UniProtKB:Q9WTL8	F
	GO:0005634	nucleus	PMID:12897057^[4]	IDA: Inferred from Direct Assay		C
	GO:0005634	nucleus	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR001067	C
	GO:0005634	nucleus	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR011598	C
	GO:0005634	nucleus	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0539	C
	GO:0005634	nucleus	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000426983	C
	GO:0005634	nucleus	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0191	C
	GO:0005654	nucleoplasm	Reactome:REACT_24914	TAS: Traceable Author Statement		C
	GO:0005667	transcription factor complex	PMID:16606840^[5]	IDA: Inferred from Direct Assay		C
	GO:0005667	transcription factor complex	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000426983	C
	GO:0005737	cytoplasm	PMID:12897057^[4]	IDA: Inferred from Direct Assay		C
	GO:0005737	cytoplasm	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0963	C
	GO:0005737	cytoplasm	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0086	C
	GO:0005829	cytosol	Reactome:REACT_25019	TAS: Traceable Author Statement		C
	GO:0005829	cytosol	Reactome:REACT_25250	TAS: Traceable Author Statement		C
	GO:0006350	transcription	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0804	P
	GO:0006351	transcription, DNA-dependent	PMID:12024206^[1]	IDA: Inferred from Direct Assay		P
	GO:0006351	transcription, DNA-dependent		IEA: Inferred from Electronic Annotation	InterPro:IPR001067	P
	GO:0006355	regulation of transcription, DNA-dependent	PMID:12024206^[1]	IDA: Inferred from Direct Assay		P
	GO:0006355	regulation of transcription, DNA-dependent	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR001067	P
	GO:0006355	regulation of transcription, DNA-dependent	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR001610	P
	GO:0006355	regulation of transcription, DNA-dependent	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR013767	P
	GO:0007165	signal transduction	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR000014	P
	GO:0007165	signal transduction	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR001610	P
	GO:0007623	circadian rhythm	PMID:12897057^[4]	IDA: Inferred from Direct Assay		P
	GO:0007623	circadian rhythm	PMID:12024206^[1]	IMP: Inferred from Mutant Phenotype		P
	GO:0007623	circadian rhythm	PMID:8171325^[6]	IMP: Inferred from Mutant Phenotype		P
	GO:0008415	acyltransferase activity	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0012	F
	GO:0009649	entrainment of circadian clock	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000002976	P
	GO:0016740	transferase activity	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0808	F
	GO:0030528	transcription regulator activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR001092	F
	GO:0030528	transcription regulator activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR011598	F
	GO:0045449	regulation of transcription	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR001092	P
	GO:0045449	regulation of transcription	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR011598	P
	GO:0045449	regulation of transcription	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0805	P
	GO:0045944	positive regulation of transcription from RNA polymerase II promoter	PMID:19217292^[7]	IDA: Inferred from Direct Assay		P
	GO:0045944	positive regulation of transcription from RNA polymerase II promoter	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000426983	P
	GO:0045944	positive regulation of transcription from RNA polymerase II promoter	PMID:16606840^[5]	IGI: Inferred from Genetic Interaction		P
	GO:0048511	rhythmic process	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0090	P
Contributes to	GO:0016563	transcription activator activity	PMID:9616112^[8]	IMP: Inferred from Mutant Phenotype		F	Fig 4B to 4D show CLOCK, BMAL1, and the mutant CLOCK delta 19 assayed at transcriptional activation sites in the luciferase reporter derived from the 5' flanking region of the mper1 gene. Transcriptional activator activity is present when only when both CLOCK and BMAL1 are present, and transcriptional activator activity is not present with the mutant CLOCK delta 19.	complete
	GO:0005634	nucleus	PMID:12897057^[4]	IDA: Inferred from Direct Assay		C	Fig. 1 SCN extracts obtained from C57BL/6J mice at designated circadian times were fractionated and analyzed by Western blotting using CLOCK antibodies	complete
	GO:0005737	cytoplasm	PMID:12897057^[4]	IDA: Inferred from Direct Assay		C	Fig. 1 SCN extracts obtained from C57BL/6J mice at designated circadian times were fractionated and analyzed by Western blotting using CLOCK antibodies	complete
	GO:0005667	transcription factor complex	PMID:9616112^[8]	IGI: Inferred from Genetic Interaction	UniProtKB:Q9WTL8	C	Fig 4B to 4D show CLOCK and BMAL1 assayed at transcriptional activation sites in the luciferase reporter derived from the 5' flanking region of the mper1 gene.	complete
	GO:0003677	DNA binding	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0238	F
	GO:0003700	sequence-specific DNA binding transcription factor activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR001067	F
	GO:0003700	sequence-specific DNA binding transcription factor activity	PMID:12024206^[1]	IDA: Inferred from Direct Assay		F
	GO:0004402	histone acetyltransferase activity	GO_REF:0000003	IEA: Inferred from Electronic Annotation	EC:2.3.1.48	F
	GO:0004871	signal transducer activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR000014	F
	GO:0005515	protein binding	PMID:18430226^[2]	IPI: Inferred from Physical Interaction	UniProtKB:O54943	F
	GO:0005515	protein binding	PMID:18662546^[3]	IPI: Inferred from Physical Interaction	UniProtKB:Q923E4	F
	GO:0005515	protein binding	PMID:18662546^[3]	IPI: Inferred from Physical Interaction	UniProtKB:Q9WTL8	F
	GO:0005515	protein binding	PMID:20832105^[9]	IPI: Inferred from Physical Interaction	UniProtKB:P09874	F
	GO:0005634	nucleus	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR001067	C
	GO:0005634	nucleus	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR011598	C
	GO:0005634	nucleus	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0539	C
	GO:0005634	nucleus	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000308741	C
	GO:0005634	nucleus	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0191	C
	GO:0005634	nucleus	PMID:12897057^[4]	IDA: Inferred from Direct Assay		C
	GO:0005654	nucleoplasm	Reactome:REACT_24913	TAS: Traceable Author Statement		C
	GO:0005654	nucleoplasm	Reactome:REACT_24914	TAS: Traceable Author Statement		C
	GO:0005654	nucleoplasm	Reactome:REACT_24950	TAS: Traceable Author Statement		C
	GO:0005654	nucleoplasm	Reactome:REACT_24955	TAS: Traceable Author Statement		C
	GO:0005654	nucleoplasm	Reactome:REACT_25007	TAS: Traceable Author Statement		C
	GO:0005654	nucleoplasm	Reactome:REACT_25033	TAS: Traceable Author Statement		C
	GO:0005654	nucleoplasm	Reactome:REACT_25038	TAS: Traceable Author Statement		C
	GO:0005654	nucleoplasm	Reactome:REACT_25062	TAS: Traceable Author Statement		C
	GO:0005654	nucleoplasm	Reactome:REACT_25112	TAS: Traceable Author Statement		C
	GO:0005654	nucleoplasm	Reactome:REACT_25175	TAS: Traceable Author Statement		C
	GO:0005654	nucleoplasm	Reactome:REACT_25248	TAS: Traceable Author Statement		C
	GO:0005654	nucleoplasm	Reactome:REACT_25263	TAS: Traceable Author Statement		C
	GO:0005667	transcription factor complex	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000308741	C
	GO:0005667	transcription factor complex	PMID:16606840^[5]	IDA: Inferred from Direct Assay		C
	GO:0005737	cytoplasm	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0963	C
	GO:0005737	cytoplasm	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0086	C
	GO:0005737	cytoplasm	PMID:12897057^[4]	IDA: Inferred from Direct Assay		C
	GO:0005829	cytosol	Reactome:REACT_25019	TAS: Traceable Author Statement		C
	GO:0005829	cytosol	Reactome:REACT_25250	TAS: Traceable Author Statement		C
	GO:0005829	cytosol	Reactome:REACT_25263	TAS: Traceable Author Statement		C
	GO:0006351	transcription, DNA-dependent	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0804	P
	GO:0006351	transcription, DNA-dependent	PMID:12024206^[1]	IDA: Inferred from Direct Assay		P
	GO:0006355	regulation of transcription, DNA-dependent	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR001067	P
	GO:0006355	regulation of transcription, DNA-dependent	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR001092	P
	GO:0006355	regulation of transcription, DNA-dependent	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR001610	P
	GO:0006355	regulation of transcription, DNA-dependent	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR011598	P
	GO:0006355	regulation of transcription, DNA-dependent	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR013767	P
	GO:0006355	regulation of transcription, DNA-dependent	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0805	P
	GO:0006355	regulation of transcription, DNA-dependent	PMID:12024206^[1]	IDA: Inferred from Direct Assay		P
	GO:0007165	signal transduction	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR000014	P
	GO:0007165	signal transduction	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR001610	P
	GO:0007623	circadian rhythm	PMID:12024206^[1]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1861634	P
	GO:0007623	circadian rhythm	PMID:12897057^[4]	IDA: Inferred from Direct Assay		P
	GO:0007623	circadian rhythm	PMID:8171325^[6]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1861634	P
	GO:0008415	acyltransferase activity	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0012	F
	GO:0009649	entrainment of circadian clock	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000002976	P
	GO:0016573	histone acetylation	GO_REF:0000003	IEA: Inferred from Electronic Annotation	EC:2.3.1.48	P
	GO:0016740	transferase activity	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0808	F
	GO:0043231	intracellular membrane-bounded organelle	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000308741	C
	GO:0045944	positive regulation of transcription from RNA polymerase II promoter	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000308741	P
	GO:0045944	positive regulation of transcription from RNA polymerase II promoter	PMID:16606840^[5]	IGI: Inferred from Genetic Interaction	MGI:MGI:1096381	P
	GO:0045944	positive regulation of transcription from RNA polymerase II promoter	PMID:19217292^[7]	IDA: Inferred from Direct Assay		P
	GO:0048511	rhythmic process	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0090	P
edit table

Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 ^1.6 ^1.7 Cheng MY et al. (2002) Prokineticin 2 transmits the behavioural circadian rhythm of the suprachiasmatic nucleus. Nature 417: 405-10 PubMed GONUTS page
↑ ^2.0 ^2.1 Langmesser S et al. (2008) Interaction of circadian clock proteins PER2 and CRY with BMAL1 and CLOCK. BMC Mol Biol 9: 41 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 Asher G et al. (2008) SIRT1 regulates circadian clock gene expression through PER2 deacetylation. Cell 134: 317-28 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 ^4.4 ^4.5 ^4.6 ^4.7 Kondratov RV et al. (2003) BMAL1-dependent circadian oscillation of nuclear CLOCK: posttranslational events induced by dimerization of transcriptional activators of the mammalian clock system. Genes Dev 17: 1921-32 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 ^5.3 Yujnovsky I et al. (2006) Signaling mediated by the dopamine D2 receptor potentiates circadian regulation by CLOCK:BMAL1. Proc Natl Acad Sci U S A 103: 6386-91 PubMed GONUTS page
↑ ^6.0 ^6.1 Vitaterna MH et al. (1994) Mutagenesis and mapping of a mouse gene, Clock, essential for circadian behavior. Science 264: 719-25 PubMed GONUTS page
↑ ^7.0 ^7.1 Duffield GE et al. (2009) A role for Id2 in regulating photic entrainment of the mammalian circadian system. Curr Biol 19: 297-304 PubMed GONUTS page
↑ ^8.0 ^8.1 Gekakis N et al. (1998) Role of the CLOCK protein in the mammalian circadian mechanism. Science 280: 1564-9 PubMed GONUTS page
↑ Asher G et al. (2010) Poly(ADP-ribose) polymerase 1 participates in the phase entrainment of circadian clocks to feeding. Cell 142: 943-53 PubMed GONUTS page

[PMID:12024206-0] 1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 ^1.6 ^1.7 Cheng MY et al. (2002) Prokineticin 2 transmits the behavioural circadian rhythm of the suprachiasmatic nucleus. Nature 417: 405-10 PubMed GONUTS page

[PMID:18430226-1] 2.0 ^2.1 Langmesser S et al. (2008) Interaction of circadian clock proteins PER2 and CRY with BMAL1 and CLOCK. BMC Mol Biol 9: 41 PubMed GONUTS page

[PMID:18662546-2] 3.0 ^3.1 ^3.2 ^3.3 Asher G et al. (2008) SIRT1 regulates circadian clock gene expression through PER2 deacetylation. Cell 134: 317-28 PubMed GONUTS page

[PMID:12897057-3] 4.0 ^4.1 ^4.2 ^4.3 ^4.4 ^4.5 ^4.6 ^4.7 Kondratov RV et al. (2003) BMAL1-dependent circadian oscillation of nuclear CLOCK: posttranslational events induced by dimerization of transcriptional activators of the mammalian clock system. Genes Dev 17: 1921-32 PubMed GONUTS page

[PMID:16606840-4] 5.0 ^5.1 ^5.2 ^5.3 Yujnovsky I et al. (2006) Signaling mediated by the dopamine D2 receptor potentiates circadian regulation by CLOCK:BMAL1. Proc Natl Acad Sci U S A 103: 6386-91 PubMed GONUTS page

[PMID:8171325-5] 6.0 ^6.1 Vitaterna MH et al. (1994) Mutagenesis and mapping of a mouse gene, Clock, essential for circadian behavior. Science 264: 719-25 PubMed GONUTS page

[PMID:19217292-6] 7.0 ^7.1 Duffield GE et al. (2009) A role for Id2 in regulating photic entrainment of the mammalian circadian system. Curr Biol 19: 297-304 PubMed GONUTS page

[PMID:9616112-7] 8.0 ^8.1 Gekakis N et al. (1998) Role of the CLOCK protein in the mammalian circadian mechanism. Science 280: 1564-9 PubMed GONUTS page

[PMID:20832105-8] Asher G et al. (2010) Poly(ADP-ribose) polymerase 1 participates in the phase entrainment of circadian clocks to feeding. Cell 142: 943-53 PubMed GONUTS page

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MOUSE:CLOCK

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