MOUSE:CFTR

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Species (Taxon ID)	Mus musculus (Mouse). (taxon:10090)
Gene Name(s)	Cftr ( synonyms: Abcc7 )
Protein Name(s)	Cystic fibrosis transmembrane conductance regulator CFTR ATP-binding cassette sub-family C member 7 Channel conductance-controlling ATPase cAMP-dependent chloride channel
External Links
UniProt Identifier	CFTR_MOUSE
UniProt Accessions	P26361, Q63893, Q63894, Q9JKQ6,
EMBL	M69298, M60493, AF162137, L04873, S65942, S65940, S65941, S65942, S65941, S65940,
PIR	A39901, A40303, I49593, I58115, I78527,
RefSeq	NP_066388.1,
PDB	1Q3H, 1R0W, 1R0X, 1R0Y, 1R0Z, 1R10, 1XF9, 1XFA,
Ensembl	ENSMUST00000045706, ENSMUST00000115405, ENSMUST00000140407,
Pfam	PF00664, PF00005,

Annotations

Qualifier	GO ID	GO term name	Reference	Evidence Code	with/from	Aspect
	GO:0000166	nucleotide binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR003593	F
	GO:0000166	nucleotide binding	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0547	F
	GO:0005216	ion channel activity	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0407	F
	GO:0005254	chloride channel activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR005291	F
	GO:0005254	chloride channel activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR009147	F
	GO:0005254	chloride channel activity	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0869	F
	GO:0005260	channel-conductance-controlling ATPase activity	GO_REF:0000003	IEA: Inferred from Electronic Annotation	EC:3.6.3.49	F
	GO:0005524	ATP binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR001140	F
	GO:0005524	ATP binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR003439	F
	GO:0005524	ATP binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR011527	F
	GO:0005524	ATP binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR017871	F
	GO:0005524	ATP binding	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0067	F
	GO:0005737	cytoplasm	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000010981	C
	GO:0005768	endosome	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0967	C
	GO:0005769	early endosome	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000003084	C
	GO:0005769	early endosome	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:P13569	C
	GO:0005902	microvillus	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000010981	C
	GO:0006200	ATP catabolic process	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR003439	P
	GO:0006200	ATP catabolic process	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR017871	P
	GO:0006695	cholesterol biosynthetic process	PMID:17085523^[1]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1856709	P
	GO:0006810	transport	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR001140	P
	GO:0006810	transport	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR011527	P
	GO:0006810	transport	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0813	P
	GO:0006811	ion transport	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR005291	P
	GO:0006811	ion transport	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR009147	P
	GO:0006811	ion transport	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0406	P
	GO:0006821	chloride transport	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0869	P
	GO:0006821	chloride transport	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000010981	P
	GO:0006833	water transport	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000010981	P
	GO:0015701	bicarbonate transport	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000010981	P
	GO:0015705	iodide transport	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000010981	P
	GO:0016020	membrane	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR005291	C
	GO:0016020	membrane	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR009147	C
	GO:0016020	membrane	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0472	C
	GO:0016021	integral to membrane	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR001140	C
	GO:0016021	integral to membrane	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR011527	C
	GO:0016021	integral to membrane	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0812	C
	GO:0016323	basolateral plasma membrane	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000010981	C
	GO:0016324	apical plasma membrane	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000003084	C
	GO:0016324	apical plasma membrane	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000010981	C
	GO:0016787	hydrolase activity	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0378	F
	GO:0016887	ATPase activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR003439	F
	GO:0016887	ATPase activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR017871	F
	GO:0017111	nucleoside-triphosphatase activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR003593	F
	GO:0019899	enzyme binding	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000003084	F
	GO:0030165	PDZ domain binding	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000003084	F
	GO:0030301	cholesterol transport	PMID:17085523^[1]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1856709	P
	GO:0030321	transepithelial chloride transport	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000010981	P
	GO:0030324	lung development	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000010981	P
	GO:0030659	cytoplasmic vesicle membrane	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000010981	C
	GO:0031205	endoplasmic reticulum Sec complex	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000003084	C
	GO:0031901	early endosome membrane	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0093	C
	GO:0032870	cellular response to hormone stimulus	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000010981	P
	GO:0034097	response to cytokine stimulus	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000010981	P
	GO:0034707	chloride channel complex	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0869	C
	GO:0042311	vasodilation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000010981	P
	GO:0042493	response to drug	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000010981	P
	GO:0042626	ATPase activity, coupled to transmembrane movement of substances	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR001140	F
	GO:0042626	ATPase activity, coupled to transmembrane movement of substances	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR011527	F
	GO:0043434	response to peptide hormone stimulus	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000010981	P
	GO:0043627	response to estrogen stimulus	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000010981	P
	GO:0045909	positive regulation of vasodilation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000010981	P
	GO:0055085	transmembrane transport	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR001140	P
	GO:0055085	transmembrane transport	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR011527	P
	GO:0000166	nucleotide binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR003593	F
	GO:0000166	nucleotide binding	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0547	F
	GO:0005216	ion channel activity	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0407	F
	GO:0005254	chloride channel activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR005291	F
	GO:0005254	chloride channel activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR009147	F
	GO:0005254	chloride channel activity	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0869	F
	GO:0005260	channel-conductance-controlling ATPase activity	GO_REF:0000003	IEA: Inferred from Electronic Annotation	EC:3.6.3.49	F
	GO:0005524	ATP binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR001140	F
	GO:0005524	ATP binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR003439	F
	GO:0005524	ATP binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR011527	F
	GO:0005524	ATP binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR017871	F
	GO:0005524	ATP binding	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0067	F
	GO:0005737	cytoplasm	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000010981	C
	GO:0005768	endosome	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0967	C
	GO:0005769	early endosome	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000003084	C
	GO:0005769	early endosome	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:P13569	C
	GO:0005902	microvillus	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000010981	C
	GO:0006200	ATP catabolic process	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR003439	P
	GO:0006200	ATP catabolic process	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR017871	P
	GO:0006695	cholesterol biosynthetic process	PMID:17085523^[1]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1856709	P
	GO:0006810	transport	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR001140	P
	GO:0006810	transport	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR011527	P
	GO:0006810	transport	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0813	P
	GO:0006811	ion transport	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR005291	P
	GO:0006811	ion transport	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR009147	P
	GO:0006811	ion transport	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0406	P
	GO:0006821	chloride transport	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0869	P
	GO:0006821	chloride transport	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000010981	P
	GO:0006821	chloride transport	PMID:19033647^[2]	IGI: Inferred from Genetic Interaction	MGI:MGI:2385184	P
	GO:0006833	water transport	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000010981	P
	GO:0015701	bicarbonate transport	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000010981	P
	GO:0015705	iodide transport	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000010981	P
	GO:0016020	membrane	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR005291	C
	GO:0016020	membrane	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR009147	C
	GO:0016020	membrane	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0472	C
	GO:0016021	integral to membrane	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR001140	C
	GO:0016021	integral to membrane	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR011527	C
	GO:0016021	integral to membrane	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0812	C
	GO:0016323	basolateral plasma membrane	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000010981	C
	GO:0016324	apical plasma membrane	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000003084	C
	GO:0016324	apical plasma membrane	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000010981	C
	GO:0016787	hydrolase activity	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0378	F
	GO:0016887	ATPase activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR003439	F
	GO:0016887	ATPase activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR017871	F
	GO:0017111	nucleoside-triphosphatase activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR003593	F
	GO:0019899	enzyme binding	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000003084	F
	GO:0030165	PDZ domain binding	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000003084	F
	GO:0030301	cholesterol transport	PMID:17085523^[1]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1856709	P
	GO:0030321	transepithelial chloride transport	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000010981	P
	GO:0030324	lung development	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000010981	P
	GO:0030659	cytoplasmic vesicle membrane	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000010981	C
	GO:0031205	endoplasmic reticulum Sec complex	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000003084	C
	GO:0031901	early endosome membrane	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0093	C
	GO:0032870	cellular response to hormone stimulus	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000010981	P
	GO:0034097	response to cytokine stimulus	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000010981	P
	GO:0034707	chloride channel complex	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0869	C
	GO:0042311	vasodilation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000010981	P
	GO:0042493	response to drug	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000010981	P
	GO:0042626	ATPase activity, coupled to transmembrane movement of substances	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR001140	F
	GO:0042626	ATPase activity, coupled to transmembrane movement of substances	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR011527	F
	GO:0043434	response to peptide hormone stimulus	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000010981	P
	GO:0043627	response to estrogen stimulus	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000010981	P
	GO:0045909	positive regulation of vasodilation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000010981	P
	GO:0055085	transmembrane transport	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR001140	P
	GO:0055085	transmembrane transport	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR011527	P
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 White NM et al. (2007) Altered cholesterol homeostasis in cultured and in vivo models of cystic fibrosis. Am J Physiol Lung Cell Mol Physiol 292: L476-86 PubMed GONUTS page
↑ Yang D et al. (2009) IRBIT coordinates epithelial fluid and HCO3- secretion by stimulating the transporters pNBC1 and CFTR in the murine pancreatic duct. J Clin Invest 119: 193-202 PubMed GONUTS page

[PMID:17085523-0] 1.0 ^1.1 ^1.2 ^1.3 White NM et al. (2007) Altered cholesterol homeostasis in cultured and in vivo models of cystic fibrosis. Am J Physiol Lung Cell Mol Physiol 292: L476-86 PubMed GONUTS page

[PMID:19033647-1] Yang D et al. (2009) IRBIT coordinates epithelial fluid and HCO3- secretion by stimulating the transporters pNBC1 and CFTR in the murine pancreatic duct. J Clin Invest 119: 193-202 PubMed GONUTS page

[1]

[2]

MOUSE:CFTR

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