MOUSE:CFLAR

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Species (Taxon ID)	Mus musculus (Mouse). (taxon:10090)
Gene Name(s)	Cflar ( synonyms: Cash )
Protein Name(s)	CASP8 and FADD-like apoptosis regulator Caspase homolog CASH Caspase-eight-related protein Casper Caspase-like apoptosis regulatory protein CLARP Cellular FLICE-like inhibitory protein c-FLIP FADD-like antiapoptotic molecule 1 FLAME-1 Inhibitor of FLICE I-FLICE MACH-related inducer of toxicity MRIT Usurpin CASP8 and FADD-like apoptosis regulator subunit p43 CASP8 and FADD-like apoptosis regulator subunit p12
External Links
UniProt Identifier	CFLAR_MOUSE
UniProt Accessions	O35732, O35707, O35733,
EMBL	Y14041, Y14042, U97076,
RefSeq	NP_997536.1,
IntAct	O35732,
Pfam	PF01335, PF00656,

Annotations

Qualifier	GO ID	GO term name	Reference	Evidence Code	with/from	Aspect	Notes	Status
	GO:0004197	cysteine-type endopeptidase activity		IEA: Inferred from Electronic Annotation		F	Source: InterPro
	GO:0005515	protein binding		IPI: Inferred from Physical Interaction		F	Source: IntAct
	GO:0006915	apoptosis		IEA: Inferred from Electronic Annotation		P	Source: UniProtKB-KW
	GO:0006508	proteolysis		IEA: Inferred from Electronic Annotation		P	Source: InterPro
	GO:0042981	regulation of apoptosis		IEA: Inferred from Electronic Annotation		P	Source: InterPro
	GO:0005737	cytoplasm	PMID:20100735^[1]	IDA: Inferred from Direct Assay		C	Fig.6A	complete
	GO:0004197	cysteine-type endopeptidase activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR001309	F
	GO:0004197	cysteine-type endopeptidase activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR002398	F
	GO:0004197	cysteine-type endopeptidase activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR011600	F
	GO:0005515	protein binding	PMID:16469705^[2]	IPI: Inferred from Physical Interaction	UniProtKB:Q61160	F
	GO:0005515	protein binding	PMID:16469705^[2]	IPI: Inferred from Physical Interaction	UniProtKB:Q8C863	F
	GO:0005737	cytoplasm	PMID:16263940^[3]	IDA: Inferred from Direct Assay		C
	GO:0006508	proteolysis	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR001309	P
	GO:0006508	proteolysis	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR002398	P
	GO:0006508	proteolysis	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR011600	P
	GO:0006915	apoptosis	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR015917	P
	GO:0006915	apoptosis	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0053	P
	GO:0006915	apoptosis	PMID:12819136^[4]	RCA: Inferred from Reviewed Computational Analysis		P
	GO:0006916	anti-apoptosis	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000312455	P
	GO:0008234	cysteine-type peptidase activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR015917	F
	GO:0042981	regulation of apoptosis	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR001875	P
	GO:0042981	regulation of apoptosis	PMID:12819136^[4]	RCA: Inferred from Reviewed Computational Analysis		P
	GO:0043066	negative regulation of apoptosis	PMID:16263940^[3]	IMP: Inferred from Mutant Phenotype		P
	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB cascade	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000312455	P
	GO:0043154	negative regulation of caspase activity	PMID:16263940^[3]	IMP: Inferred from Mutant Phenotype		P
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Lin YC et al. (2010) FasL gene-deficient mice display a limited disruption in spermatogenesis and inhibition of mono-(2-ethylhexyl) phthalate-induced germ cell apoptosis. Toxicol Sci 114: 335-45 PubMed GONUTS page
↑ ^2.0 ^2.1 Chang L et al. (2006) The E3 ubiquitin ligase itch couples JNK activation to TNFalpha-induced cell death by inducing c-FLIP(L) turnover. Cell 124: 601-13 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 Giampietri C et al. (2006) c-Flip expression and function in fetal mouse gonocytes. FASEB J 20: 124-6 PubMed GONUTS page
↑ ^4.0 ^4.1 Reed JC et al. (2003) Comparative analysis of apoptosis and inflammation genes of mice and humans. Genome Res 13: 1376-88 PubMed GONUTS page

[PMID:20100735-0] Lin YC et al. (2010) FasL gene-deficient mice display a limited disruption in spermatogenesis and inhibition of mono-(2-ethylhexyl) phthalate-induced germ cell apoptosis. Toxicol Sci 114: 335-45 PubMed GONUTS page

[PMID:16469705-1] 2.0 ^2.1 Chang L et al. (2006) The E3 ubiquitin ligase itch couples JNK activation to TNFalpha-induced cell death by inducing c-FLIP(L) turnover. Cell 124: 601-13 PubMed GONUTS page

[PMID:16263940-2] 3.0 ^3.1 ^3.2 Giampietri C et al. (2006) c-Flip expression and function in fetal mouse gonocytes. FASEB J 20: 124-6 PubMed GONUTS page

[PMID:12819136-3] 4.0 ^4.1 Reed JC et al. (2003) Comparative analysis of apoptosis and inflammation genes of mice and humans. Genome Res 13: 1376-88 PubMed GONUTS page

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MOUSE:CFLAR

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