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MOUSE:CD44

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Contents

Species (Taxon ID) Mus musculus (Mouse). ([1])
Gene Name(s) Cd44 (synonyms: Ly-24)
Protein Name(s) CD44 antigen

Extracellular matrix receptor III ECMR-III GP90 lymphocyte homing/adhesion receptor HUTCH-I Hermes antigen Hyaluronate receptor Lymphocyte antigen 24 Ly-24 Phagocytic glycoprotein 1 PGP-1 Phagocytic glycoprotein I PGP-I

External Links
EMBL X66084
X66083
X66082
X66081
M30655
M27129
M27130
AJ251594
BC005676
AK045226
J05163
X69724
L13611
U57610
U57611
U57612
U57612
IPI IPI00223770
IPI00223772
IPI00223773
IPI00265503
IPI00265504
IPI00265505
IPI00266152
IPI00266154
IPI00266155
IPI00410802
IPI00720073
IPI00828592
IPI00828623
PIR A34424
A37009
B44355
D44355
S30397
RefSeq NP_001034240.1
NP_001171256.1
NP_001171257.1
NP_001171258.1
NP_033981.2
UniGene Mm.423621
PDB 2JCP
2JCQ
2JCR
2ZPY
PDBsum 2JCP
2JCQ
2JCR
2ZPY
ProteinModelPortal P15379
SMR P15379
DIP DIP-29095N
STRING P15379
PhosphoSite P15379
PRIDE P15379
GeneID 12505
KEGG mmu:12505
CTD 960
MGI MGI:88338
GeneTree ENSGT00530000063822
HOVERGEN HBG003850
InParanoid P15379
OrthoDB EOG4PZJ66
NextBio 281466
ArrayExpress P15379
Bgee P15379
CleanEx MM_CD44
Genevestigator P15379
GermOnline ENSMUSG00000005087
GO GO:0016323
GO:0009897
GO:0016021
GO:0005540
GO:0005515
GO:0004872
GO:0060442
GO:0001658
GO:0007155
GO:0043518
GO:0002906
GO:0002821
GO:0070374
GO:0010628
GO:0033138
GO:0050731
GO:0016055
GO:0002246
InterPro IPR016186
IPR016187
IPR001231
IPR000538
Gene3D G3DSA:3.10.100.10
KO K06256
Pfam PF00193
PRINTS PR00658
PR01265
SMART SM00445
SUPFAM SSF56436
PROSITE PS01241
PS50963

Annotations

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0001658

branching involved in ureteric bud morphogenesis

PMID:10926769[1]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

GO:0002246

wound healing involved in inflammatory response

PMID:11935029[2]

IMP: Inferred from Mutant Phenotype

MGI:MGI:2181292

P

Seeded From UniProt

GO:0002821

positive regulation of adaptive immune response

PMID:18056708[3]

NAS: Non-traceable Author Statement

P

Seeded From UniProt

GO:0002906

negative regulation of mature B cell apoptosis

PMID:18056708[3]

IDA: Inferred from Direct Assay

P

Seeded From UniProt

GO:0004872

receptor activity

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0675

F

Seeded From UniProt

GO:0005488

binding

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR016186

F

Seeded From UniProt

GO:0005488

binding

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR016187

F

Seeded From UniProt

GO:0005515

protein binding

PMID:18056708[3]

IPI: Inferred from Physical Interaction

UniProtKB:P04441

F

Seeded From UniProt

GO:0005515

protein binding

PMID:7535771[4]

IPI: Inferred from Physical Interaction

UniProtKB:P13609

F

Seeded From UniProt

GO:0005540

hyaluronic acid binding

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR000538

F

Seeded From UniProt

GO:0005540

hyaluronic acid binding

PMID:10926769[1]

IMP: Inferred from Mutant Phenotype

F

Seeded From UniProt

GO:0005540

hyaluronic acid binding

PMID:1469058[5]

IDA: Inferred from Direct Assay

F

Seeded From UniProt

GO:0005886

plasma membrane

PMID:18085615[6]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

GO:0005886

plasma membrane

PMID:9374396[7]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

GO:0007155

cell adhesion

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR000538

P

Seeded From UniProt

GO:0007155

cell adhesion

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR001231

P

Seeded From UniProt

GO:0007155

cell adhesion

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0130

P

Seeded From UniProt

GO:0007155

cell adhesion

PMID:1469058[5]

IDA: Inferred from Direct Assay

P

Seeded From UniProt

GO:0009897

external side of plasma membrane

PMID:10072077[8]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

GO:0009897

external side of plasma membrane

PMID:10704459[9]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

GO:0009897

external side of plasma membrane

PMID:10848813[10]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

GO:0009897

external side of plasma membrane

PMID:10943842[11]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

GO:0009897

external side of plasma membrane

PMID:14609575[12]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

GO:0009897

external side of plasma membrane

PMID:14764662[13]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

GO:0009897

external side of plasma membrane

PMID:15294943[14]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

GO:0009897

external side of plasma membrane

PMID:15477346[15]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

GO:0009897

external side of plasma membrane

PMID:15728238[16]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

GO:0009897

external side of plasma membrane

PMID:16203996[17]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

GO:0009897

external side of plasma membrane

PMID:16301745[18]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

GO:0009897

external side of plasma membrane

PMID:16973387[19]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

GO:0009897

external side of plasma membrane

PMID:17082577[20]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

GO:0009897

external side of plasma membrane

PMID:18958875[21]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

GO:0009897

external side of plasma membrane

PMID:19008373[22]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

GO:0009897

external side of plasma membrane

PMID:19723499[23]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

GO:0009897

external side of plasma membrane

PMID:19934022[24]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

GO:0009897

external side of plasma membrane

PMID:21460847[25]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

GO:0009897

external side of plasma membrane

PMID:21508411[26]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

GO:0009897

external side of plasma membrane

PMID:7538697[27]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

GO:0009897

external side of plasma membrane

PMID:7584142[28]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

GO:0009897

external side of plasma membrane

PMID:8043862[29]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

GO:0009897

external side of plasma membrane

PMID:8769481[30]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

GO:0009897

external side of plasma membrane

PMID:9133426[31]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

GO:0009986

cell surface

PMID:1469058[5]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

GO:0009986

cell surface

PMID:9324354[32]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

GO:0010628

positive regulation of gene expression

PMID:9847236[33]

IGI: Inferred from Genetic Interaction

MGI:MGI:99604

P

Seeded From UniProt

GO:0016020

membrane

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR001231

C

Seeded From UniProt

GO:0016020

membrane

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0472

C

Seeded From UniProt

GO:0016020

membrane

GO_REF:0000023

IEA: Inferred from Electronic Annotation

SP_SL:SL-0162

C

Seeded From UniProt

GO:0016021

integral to membrane

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0812

C

Seeded From UniProt

GO:0016055

Wnt receptor signaling pathway

PMID:19056892[34]

IDA: Inferred from Direct Assay

P

Seeded From UniProt

GO:0016323

basolateral plasma membrane

PMID:10027409[35]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

GO:0033138

positive regulation of peptidyl-serine phosphorylation

PMID:17045821[36]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

GO:0043066

negative regulation of apoptosis

PMID:17045821[36]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

GO:0043518

negative regulation of DNA damage response, signal transduction by p53 class mediator

PMID:17045821[36]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

GO:0050731

positive regulation of peptidyl-tyrosine phosphorylation

PMID:17045821[36]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

GO:0060442

branching involved in prostate gland morphogenesis

PMID:9374396[7]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

GO:0070374

positive regulation of ERK1 and ERK2 cascade

PMID:17045821[36]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

GO:0004888

transmembrane signaling receptor activity

PMID:17045821[36]

IDA: Inferred from Direct Assay

F

Seeded From UniProt

GO:0019955

cytokine binding

PMID:18056708[3]

IDA: Inferred from Direct Assay

F

Seeded From UniProt

GO:0044425

cell adhesion

PMID:7528778[37]

IDA: Inferred from Direct Assay

P

CD44 is a transmembrane glycoprotein expressed in leukocytes.

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 Pohl M et al. (2000) Role of hyaluronan and CD44 in in vitro branching morphogenesis of ureteric bud cells. Dev Biol 224: 312-25 PubMed GONUTS page
  2. Teder P et al. (2002) Resolution of lung inflammation by CD44. Science 296: 155-8 PubMed GONUTS page
  3. 3.0 3.1 3.2 3.3 Gore Y et al. (2008) Macrophage migration inhibitory factor induces B cell survival by activation of a CD74-CD44 receptor complex. J Biol Chem 283: 2784-92 PubMed GONUTS page
  4. Toyama-Sorimachi N et al. (1995) A novel ligand for CD44 is serglycin, a hematopoietic cell lineage-specific proteoglycan. Possible involvement in lymphoid cell adherence and activation. J Biol Chem 270: 7437-44 PubMed GONUTS page
  5. 5.0 5.1 5.2 He Q et al. (1992) Molecular isoforms of murine CD44 and evidence that the membrane proximal domain is not critical for hyaluronate recognition. J Cell Biol 119: 1711-9 PubMed GONUTS page
  6. Preston SL et al. (2008) The development of duodenal microadenomas in FAP patients: the human correlate of the Min mouse. J Pathol 214: 294-301 PubMed GONUTS page
  7. 7.0 7.1 Gakunga P et al. (1997) Hyaluronan is a prerequisite for ductal branching morphogenesis. Development 124: 3987-97 PubMed GONUTS page
  8. Moriggl R et al. (1999) Stat5 is required for IL-2-induced cell cycle progression of peripheral T cells. Immunity 10: 249-59 PubMed GONUTS page
  9. Kennedy MK et al. (2000) Reversible defects in natural killer and memory CD8 T cell lineages in interleukin 15-deficient mice. J Exp Med 191: 771-80 PubMed GONUTS page
  10. Kina T et al. (2000) The monoclonal antibody TER-119 recognizes a molecule associated with glycophorin A and specifically marks the late stages of murine erythroid lineage. Br J Haematol 109: 280-7 PubMed GONUTS page
  11. Tamura K et al. (2000) Requirement for p38alpha in erythropoietin expression: a role for stress kinases in erythropoiesis. Cell 102: 221-31 PubMed GONUTS page
  12. Matsuzaki J et al. (2003) Successful elimination of memory-type CD8+ T cell subsets by the administration of anti-Gr-1 monoclonal antibody in vivo. Cell Immunol 224: 98-105 PubMed GONUTS page
  13. Hamerman JA et al. (2004) Cutting edge: Toll-like receptor signaling in macrophages induces ligands for the NKG2D receptor. J Immunol 172: 2001-5 PubMed GONUTS page
  14. Kang J et al. (2004) STAT5 is required for thymopoiesis in a development stage-specific manner. J Immunol 173: 2307-14 PubMed GONUTS page
  15. Li O et al. (2004) CD24 expression on T cells is required for optimal T cell proliferation in lymphopenic host. J Exp Med 200: 1083-9 PubMed GONUTS page
  16. Mandal M et al. (2005) The BCL2A1 gene as a pre-T cell receptor-induced regulator of thymocyte survival. J Exp Med 201: 603-14 PubMed GONUTS page
  17. Chen Z et al. (2005) How defects in central tolerance impinge on a deficiency in regulatory T cells. Proc Natl Acad Sci U S A 102: 14735-40 PubMed GONUTS page
  18. Chen Z et al. (2005) Where CD4+CD25+ T reg cells impinge on autoimmune diabetes. J Exp Med 202: 1387-97 PubMed GONUTS page
  19. Marie JC et al. (2006) Cellular mechanisms of fatal early-onset autoimmunity in mice with the T cell-specific targeting of transforming growth factor-beta receptor. Immunity 25: 441-54 PubMed GONUTS page
  20. Kim PJ et al. (2006) GATA-3 regulates the development and function of invariant NKT cells. J Immunol 177: 6650-9 PubMed GONUTS page
  21. Jia J et al. (2008) E proteins are required to activate germline transcription of the TCR Vbeta8.2 gene. Eur J Immunol 38: 2806-20 PubMed GONUTS page
  22. Abe J et al. (2008) Increased Foxp3(+) CD4(+) regulatory T cells with intact suppressive activity but altered cellular localization in murine lupus. Am J Pathol 173: 1682-92 PubMed GONUTS page
  23. Terauchi M et al. (2009) T lymphocytes amplify the anabolic activity of parathyroid hormone through Wnt10b signaling. Cell Metab 10: 229-40 PubMed GONUTS page
  24. Hosoya T et al. (2009) GATA-3 is required for early T lineage progenitor development. J Exp Med 206: 2987-3000 PubMed GONUTS page
  25. Motomura Y et al. (2011) The transcription factor E4BP4 regulates the production of IL-10 and IL-13 in CD4+ T cells. Nat Immunol 12: 450-9 PubMed GONUTS page
  26. Hu MG et al. (2011) CDK6 kinase activity is required for thymocyte development. Blood 117: 6120-31 PubMed GONUTS page
  27. Bendelac A et al. (1995) CD1 recognition by mouse NK1+ T lymphocytes. Science 268: 863-5 PubMed GONUTS page
  28. Willerford DM et al. (1995) Interleukin-2 receptor alpha chain regulates the size and content of the peripheral lymphoid compartment. Immunity 3: 521-30 PubMed GONUTS page
  29. Coombe DR et al. (1994) Mac-1 (CD11b/CD18) and CD45 mediate the adhesion of hematopoietic progenitor cells to stromal cell elements via recognition of stromal heparan sulfate. Blood 84: 739-52 PubMed GONUTS page
  30. Hazenbos WL et al. (1996) Impaired IgG-dependent anaphylaxis and Arthus reaction in Fc gamma RIII (CD16) deficient mice. Immunity 5: 181-8 PubMed GONUTS page
  31. Mendiratta SK et al. (1997) CD1d1 mutant mice are deficient in natural T cells that promptly produce IL-4. Immunity 6: 469-77 PubMed GONUTS page
  32. Yoder MC et al. (1997) Characterization of definitive lymphohematopoietic stem cells in the day 9 murine yolk sac. Immunity 7: 335-44 PubMed GONUTS page
  33. Tucker AS et al. (1999) Conserved regulation of mesenchymal gene expression by Fgf-8 in face and limb development. Development 126: 221-8 PubMed GONUTS page
  34. Miranda-Carboni GA et al. (2008) A functional link between Wnt signaling and SKP2-independent p27 turnover in mammary tumors. Genes Dev 22: 3121-34 PubMed GONUTS page
  35. Wielenga VJ et al. (1999) Expression of CD44 in Apc and Tcf mutant mice implies regulation by the WNT pathway. Am J Pathol 154: 515-23 PubMed GONUTS page
  36. 36.0 36.1 36.2 36.3 36.4 36.5 Shi X et al. (2006) CD44 is the signaling component of the macrophage migration inhibitory factor-CD74 receptor complex. Immunity 25: 595-606 PubMed GONUTS page
  37. Puré E et al. (1995) Defective phosphorylation and hyaluronate binding of CD44 with point mutations in the cytoplasmic domain. J Exp Med 181: 55-62 PubMed GONUTS page
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