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MOUSE:CD44
Contents |
| Species (Taxon ID) | Mus musculus (Mouse). ([1]) | |
| Gene Name(s) | Cd44 (synonyms: Ly-24) | |
| Protein Name(s) | CD44 antigen
Extracellular matrix receptor III ECMR-III GP90 lymphocyte homing/adhesion receptor HUTCH-I Hermes antigen Hyaluronate receptor Lymphocyte antigen 24 Ly-24 Phagocytic glycoprotein 1 PGP-1 Phagocytic glycoprotein I PGP-I | |
| External Links | ||
| EMBL | X66084 X66083 X66082 X66081 M30655 M27129 M27130 AJ251594 BC005676 AK045226 J05163 X69724 L13611 U57610 U57611 U57612 U57612 | |
| IPI | IPI00223770 IPI00223772 IPI00223773 IPI00265503 IPI00265504 IPI00265505 IPI00266152 IPI00266154 IPI00266155 IPI00410802 IPI00720073 IPI00828592 IPI00828623 | |
| PIR | A34424 A37009 B44355 D44355 S30397 | |
| RefSeq | NP_001034240.1 NP_001171256.1 NP_001171257.1 NP_001171258.1 NP_033981.2 | |
| UniGene | Mm.423621 | |
| PDB | 2JCP 2JCQ 2JCR 2ZPY | |
| PDBsum | 2JCP 2JCQ 2JCR 2ZPY | |
| ProteinModelPortal | P15379 | |
| SMR | P15379 | |
| DIP | DIP-29095N | |
| STRING | P15379 | |
| PhosphoSite | P15379 | |
| PRIDE | P15379 | |
| GeneID | 12505 | |
| KEGG | mmu:12505 | |
| CTD | 960 | |
| MGI | MGI:88338 | |
| GeneTree | ENSGT00530000063822 | |
| HOVERGEN | HBG003850 | |
| InParanoid | P15379 | |
| OrthoDB | EOG4PZJ66 | |
| NextBio | 281466 | |
| ArrayExpress | P15379 | |
| Bgee | P15379 | |
| CleanEx | MM_CD44 | |
| Genevestigator | P15379 | |
| GermOnline | ENSMUSG00000005087 | |
| GO | GO:0016323 GO:0009897 GO:0016021 GO:0005540 GO:0005515 GO:0004872 GO:0060442 GO:0001658 GO:0007155 GO:0043518 GO:0002906 GO:0002821 GO:0070374 GO:0010628 GO:0033138 GO:0050731 GO:0016055 GO:0002246 | |
| InterPro | IPR016186 IPR016187 IPR001231 IPR000538 | |
| Gene3D | G3DSA:3.10.100.10 | |
| KO | K06256 | |
| Pfam | PF00193 | |
| PRINTS | PR00658 PR01265 | |
| SMART | SM00445 | |
| SUPFAM | SSF56436 | |
| PROSITE | PS01241 PS50963 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0001658 |
branching involved in ureteric bud morphogenesis |
IMP: Inferred from Mutant Phenotype |
|
P |
Seeded From UniProt |
|||
| GO:0002246 |
wound healing involved in inflammatory response |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2181292 |
P |
Seeded From UniProt |
|||
| GO:0002821 |
positive regulation of adaptive immune response |
NAS: Non-traceable Author Statement |
|
P |
Seeded From UniProt |
|||
| GO:0002906 |
negative regulation of mature B cell apoptosis |
IDA: Inferred from Direct Assay |
|
P |
Seeded From UniProt |
|||
| GO:0004872 |
receptor activity |
IEA: Inferred from Electronic Annotation |
F |
Seeded From UniProt |
||||
| GO:0005488 |
binding |
IEA: Inferred from Electronic Annotation |
F |
Seeded From UniProt |
||||
| GO:0005488 |
binding |
IEA: Inferred from Electronic Annotation |
F |
Seeded From UniProt |
||||
| GO:0005515 |
protein binding |
IPI: Inferred from Physical Interaction |
F |
Seeded From UniProt |
||||
| GO:0005515 |
protein binding |
IPI: Inferred from Physical Interaction |
F |
Seeded From UniProt |
||||
| GO:0005540 |
hyaluronic acid binding |
IEA: Inferred from Electronic Annotation |
F |
Seeded From UniProt |
||||
| GO:0005540 |
hyaluronic acid binding |
IMP: Inferred from Mutant Phenotype |
|
F |
Seeded From UniProt |
|||
| GO:0005540 |
hyaluronic acid binding |
IDA: Inferred from Direct Assay |
|
F |
Seeded From UniProt |
|||
| GO:0005886 |
plasma membrane |
IDA: Inferred from Direct Assay |
|
C |
Seeded From UniProt |
|||
| GO:0005886 |
plasma membrane |
IDA: Inferred from Direct Assay |
|
C |
Seeded From UniProt |
|||
| GO:0007155 |
cell adhesion |
IEA: Inferred from Electronic Annotation |
P |
Seeded From UniProt |
||||
| GO:0007155 |
cell adhesion |
IEA: Inferred from Electronic Annotation |
P |
Seeded From UniProt |
||||
| GO:0007155 |
cell adhesion |
IEA: Inferred from Electronic Annotation |
P |
Seeded From UniProt |
||||
| GO:0007155 |
cell adhesion |
IDA: Inferred from Direct Assay |
|
P |
Seeded From UniProt |
|||
| GO:0009897 |
external side of plasma membrane |
IDA: Inferred from Direct Assay |
|
C |
Seeded From UniProt |
|||
| GO:0009897 |
external side of plasma membrane |
IDA: Inferred from Direct Assay |
|
C |
Seeded From UniProt |
|||
| GO:0009897 |
external side of plasma membrane |
IDA: Inferred from Direct Assay |
|
C |
Seeded From UniProt |
|||
| GO:0009897 |
external side of plasma membrane |
IDA: Inferred from Direct Assay |
|
C |
Seeded From UniProt |
|||
| GO:0009897 |
external side of plasma membrane |
IDA: Inferred from Direct Assay |
|
C |
Seeded From UniProt |
|||
| GO:0009897 |
external side of plasma membrane |
IDA: Inferred from Direct Assay |
|
C |
Seeded From UniProt |
|||
| GO:0009897 |
external side of plasma membrane |
IDA: Inferred from Direct Assay |
|
C |
Seeded From UniProt |
|||
| GO:0009897 |
external side of plasma membrane |
IDA: Inferred from Direct Assay |
|
C |
Seeded From UniProt |
|||
| GO:0009897 |
external side of plasma membrane |
IDA: Inferred from Direct Assay |
|
C |
Seeded From UniProt |
|||
| GO:0009897 |
external side of plasma membrane |
IDA: Inferred from Direct Assay |
|
C |
Seeded From UniProt |
|||
| GO:0009897 |
external side of plasma membrane |
IDA: Inferred from Direct Assay |
|
C |
Seeded From UniProt |
|||
| GO:0009897 |
external side of plasma membrane |
IDA: Inferred from Direct Assay |
|
C |
Seeded From UniProt |
|||
| GO:0009897 |
external side of plasma membrane |
IDA: Inferred from Direct Assay |
|
C |
Seeded From UniProt |
|||
| GO:0009897 |
external side of plasma membrane |
IDA: Inferred from Direct Assay |
|
C |
Seeded From UniProt |
|||
| GO:0009897 |
external side of plasma membrane |
IDA: Inferred from Direct Assay |
|
C |
Seeded From UniProt |
|||
| GO:0009897 |
external side of plasma membrane |
IDA: Inferred from Direct Assay |
|
C |
Seeded From UniProt |
|||
| GO:0009897 |
external side of plasma membrane |
IDA: Inferred from Direct Assay |
|
C |
Seeded From UniProt |
|||
| GO:0009897 |
external side of plasma membrane |
IDA: Inferred from Direct Assay |
|
C |
Seeded From UniProt |
|||
| GO:0009897 |
external side of plasma membrane |
IDA: Inferred from Direct Assay |
|
C |
Seeded From UniProt |
|||
| GO:0009897 |
external side of plasma membrane |
IDA: Inferred from Direct Assay |
|
C |
Seeded From UniProt |
|||
| GO:0009897 |
external side of plasma membrane |
IDA: Inferred from Direct Assay |
|
C |
Seeded From UniProt |
|||
| GO:0009897 |
external side of plasma membrane |
IDA: Inferred from Direct Assay |
|
C |
Seeded From UniProt |
|||
| GO:0009897 |
external side of plasma membrane |
IDA: Inferred from Direct Assay |
|
C |
Seeded From UniProt |
|||
| GO:0009897 |
external side of plasma membrane |
IDA: Inferred from Direct Assay |
|
C |
Seeded From UniProt |
|||
| GO:0009986 |
cell surface |
IDA: Inferred from Direct Assay |
|
C |
Seeded From UniProt |
|||
| GO:0009986 |
cell surface |
IDA: Inferred from Direct Assay |
|
C |
Seeded From UniProt |
|||
| GO:0010628 |
positive regulation of gene expression |
IGI: Inferred from Genetic Interaction |
MGI:MGI:99604 |
P |
Seeded From UniProt |
|||
| GO:0016020 |
membrane |
IEA: Inferred from Electronic Annotation |
C |
Seeded From UniProt |
||||
| GO:0016020 |
membrane |
IEA: Inferred from Electronic Annotation |
C |
Seeded From UniProt |
||||
| GO:0016020 |
membrane |
IEA: Inferred from Electronic Annotation |
SP_SL:SL-0162 |
C |
Seeded From UniProt |
|||
| GO:0016021 |
integral to membrane |
IEA: Inferred from Electronic Annotation |
C |
Seeded From UniProt |
||||
| GO:0016055 |
Wnt receptor signaling pathway |
IDA: Inferred from Direct Assay |
|
P |
Seeded From UniProt |
|||
| GO:0016323 |
basolateral plasma membrane |
IDA: Inferred from Direct Assay |
|
C |
Seeded From UniProt |
|||
| GO:0033138 |
positive regulation of peptidyl-serine phosphorylation |
IMP: Inferred from Mutant Phenotype |
|
P |
Seeded From UniProt |
|||
| GO:0043066 |
negative regulation of apoptosis |
IMP: Inferred from Mutant Phenotype |
|
P |
Seeded From UniProt |
|||
| GO:0043518 |
negative regulation of DNA damage response, signal transduction by p53 class mediator |
IMP: Inferred from Mutant Phenotype |
|
P |
Seeded From UniProt |
|||
| GO:0050731 |
positive regulation of peptidyl-tyrosine phosphorylation |
IMP: Inferred from Mutant Phenotype |
|
P |
Seeded From UniProt |
|||
| GO:0060442 |
branching involved in prostate gland morphogenesis |
IMP: Inferred from Mutant Phenotype |
|
P |
Seeded From UniProt |
|||
| GO:0070374 |
positive regulation of ERK1 and ERK2 cascade |
IMP: Inferred from Mutant Phenotype |
|
P |
Seeded From UniProt |
|||
| GO:0004888 |
transmembrane signaling receptor activity |
IDA: Inferred from Direct Assay |
|
F |
Seeded From UniProt |
|||
| GO:0019955 |
cytokine binding |
IDA: Inferred from Direct Assay |
|
F |
Seeded From UniProt |
|||
| GO:0044425 |
cell adhesion |
IDA: Inferred from Direct Assay |
P |
CD44 is a transmembrane glycoprotein expressed in leukocytes. |
complete | |||
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 Pohl M et al. (2000) Role of hyaluronan and CD44 in in vitro branching morphogenesis of ureteric bud cells. Dev Biol 224: 312-25 PubMed GONUTS page
- ↑ Teder P et al. (2002) Resolution of lung inflammation by CD44. Science 296: 155-8 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 3.3 Gore Y et al. (2008) Macrophage migration inhibitory factor induces B cell survival by activation of a CD74-CD44 receptor complex. J Biol Chem 283: 2784-92 PubMed GONUTS page
- ↑ Toyama-Sorimachi N et al. (1995) A novel ligand for CD44 is serglycin, a hematopoietic cell lineage-specific proteoglycan. Possible involvement in lymphoid cell adherence and activation. J Biol Chem 270: 7437-44 PubMed GONUTS page
- ↑ 5.0 5.1 5.2 He Q et al. (1992) Molecular isoforms of murine CD44 and evidence that the membrane proximal domain is not critical for hyaluronate recognition. J Cell Biol 119: 1711-9 PubMed GONUTS page
- ↑ Preston SL et al. (2008) The development of duodenal microadenomas in FAP patients: the human correlate of the Min mouse. J Pathol 214: 294-301 PubMed GONUTS page
- ↑ 7.0 7.1 Gakunga P et al. (1997) Hyaluronan is a prerequisite for ductal branching morphogenesis. Development 124: 3987-97 PubMed GONUTS page
- ↑ Moriggl R et al. (1999) Stat5 is required for IL-2-induced cell cycle progression of peripheral T cells. Immunity 10: 249-59 PubMed GONUTS page
- ↑ Kennedy MK et al. (2000) Reversible defects in natural killer and memory CD8 T cell lineages in interleukin 15-deficient mice. J Exp Med 191: 771-80 PubMed GONUTS page
- ↑ Kina T et al. (2000) The monoclonal antibody TER-119 recognizes a molecule associated with glycophorin A and specifically marks the late stages of murine erythroid lineage. Br J Haematol 109: 280-7 PubMed GONUTS page
- ↑ Tamura K et al. (2000) Requirement for p38alpha in erythropoietin expression: a role for stress kinases in erythropoiesis. Cell 102: 221-31 PubMed GONUTS page
- ↑ Matsuzaki J et al. (2003) Successful elimination of memory-type CD8+ T cell subsets by the administration of anti-Gr-1 monoclonal antibody in vivo. Cell Immunol 224: 98-105 PubMed GONUTS page
- ↑ Hamerman JA et al. (2004) Cutting edge: Toll-like receptor signaling in macrophages induces ligands for the NKG2D receptor. J Immunol 172: 2001-5 PubMed GONUTS page
- ↑ Kang J et al. (2004) STAT5 is required for thymopoiesis in a development stage-specific manner. J Immunol 173: 2307-14 PubMed GONUTS page
- ↑ Li O et al. (2004) CD24 expression on T cells is required for optimal T cell proliferation in lymphopenic host. J Exp Med 200: 1083-9 PubMed GONUTS page
- ↑ Mandal M et al. (2005) The BCL2A1 gene as a pre-T cell receptor-induced regulator of thymocyte survival. J Exp Med 201: 603-14 PubMed GONUTS page
- ↑ Chen Z et al. (2005) How defects in central tolerance impinge on a deficiency in regulatory T cells. Proc Natl Acad Sci U S A 102: 14735-40 PubMed GONUTS page
- ↑ Chen Z et al. (2005) Where CD4+CD25+ T reg cells impinge on autoimmune diabetes. J Exp Med 202: 1387-97 PubMed GONUTS page
- ↑ Marie JC et al. (2006) Cellular mechanisms of fatal early-onset autoimmunity in mice with the T cell-specific targeting of transforming growth factor-beta receptor. Immunity 25: 441-54 PubMed GONUTS page
- ↑ Kim PJ et al. (2006) GATA-3 regulates the development and function of invariant NKT cells. J Immunol 177: 6650-9 PubMed GONUTS page
- ↑ Jia J et al. (2008) E proteins are required to activate germline transcription of the TCR Vbeta8.2 gene. Eur J Immunol 38: 2806-20 PubMed GONUTS page
- ↑ Abe J et al. (2008) Increased Foxp3(+) CD4(+) regulatory T cells with intact suppressive activity but altered cellular localization in murine lupus. Am J Pathol 173: 1682-92 PubMed GONUTS page
- ↑ Terauchi M et al. (2009) T lymphocytes amplify the anabolic activity of parathyroid hormone through Wnt10b signaling. Cell Metab 10: 229-40 PubMed GONUTS page
- ↑ Hosoya T et al. (2009) GATA-3 is required for early T lineage progenitor development. J Exp Med 206: 2987-3000 PubMed GONUTS page
- ↑ Motomura Y et al. (2011) The transcription factor E4BP4 regulates the production of IL-10 and IL-13 in CD4+ T cells. Nat Immunol 12: 450-9 PubMed GONUTS page
- ↑ Hu MG et al. (2011) CDK6 kinase activity is required for thymocyte development. Blood 117: 6120-31 PubMed GONUTS page
- ↑ Bendelac A et al. (1995) CD1 recognition by mouse NK1+ T lymphocytes. Science 268: 863-5 PubMed GONUTS page
- ↑ Willerford DM et al. (1995) Interleukin-2 receptor alpha chain regulates the size and content of the peripheral lymphoid compartment. Immunity 3: 521-30 PubMed GONUTS page
- ↑ Coombe DR et al. (1994) Mac-1 (CD11b/CD18) and CD45 mediate the adhesion of hematopoietic progenitor cells to stromal cell elements via recognition of stromal heparan sulfate. Blood 84: 739-52 PubMed GONUTS page
- ↑ Hazenbos WL et al. (1996) Impaired IgG-dependent anaphylaxis and Arthus reaction in Fc gamma RIII (CD16) deficient mice. Immunity 5: 181-8 PubMed GONUTS page
- ↑ Mendiratta SK et al. (1997) CD1d1 mutant mice are deficient in natural T cells that promptly produce IL-4. Immunity 6: 469-77 PubMed GONUTS page
- ↑ Yoder MC et al. (1997) Characterization of definitive lymphohematopoietic stem cells in the day 9 murine yolk sac. Immunity 7: 335-44 PubMed GONUTS page
- ↑ Tucker AS et al. (1999) Conserved regulation of mesenchymal gene expression by Fgf-8 in face and limb development. Development 126: 221-8 PubMed GONUTS page
- ↑ Miranda-Carboni GA et al. (2008) A functional link between Wnt signaling and SKP2-independent p27 turnover in mammary tumors. Genes Dev 22: 3121-34 PubMed GONUTS page
- ↑ Wielenga VJ et al. (1999) Expression of CD44 in Apc and Tcf mutant mice implies regulation by the WNT pathway. Am J Pathol 154: 515-23 PubMed GONUTS page
- ↑ 36.0 36.1 36.2 36.3 36.4 36.5 Shi X et al. (2006) CD44 is the signaling component of the macrophage migration inhibitory factor-CD74 receptor complex. Immunity 25: 595-606 PubMed GONUTS page
- ↑ Puré E et al. (1995) Defective phosphorylation and hyaluronate binding of CD44 with point mutations in the cytoplasmic domain. J Exp Med 181: 55-62 PubMed GONUTS page