MOUSE:CD36

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Species (Taxon ID)	Mus musculus (Mouse). (taxon:10090)
Gene Name(s)	Cd36
Protein Name(s)	Platelet glycoprotein 4 Glycoprotein IIIb GPIIIB PAS IV PAS-4 Platelet glycoprotein IV GPIV
External Links
UniProt Identifier	CD36_MOUSE
UniProt Accessions	Q08857,
EMBL	L23108, BC010262,
PIR	I49590,
RefSeq	NP_001153027.1, NP_001153028.1, NP_001153029.1, NP_001153030.1, NP_031669.3,
Ensembl	ENSMUST00000082367, ENSMUST00000165232, ENSMUST00000169095, ENSMUST00000170051,
Pfam	PF01130,

Annotations

Qualifier	GO ID	GO term name	Reference	Evidence Code	with/from	Aspect	Notes	Status
	GO:0009897	external side of plasma membrane		IDA: Inferred from Direct Assay		C	Source: MGI
	GO:0005794	Golgi apparatus		IDA: Inferred from Direct Assay		C	Source: MGI
	GO:0016021	integral to membrane		IEA: Inferred from Electronic Annotation		C	Source: UniProtKB-KW
	GO:0045121	membrane raft		IDA: Inferred from Direct Assay		C	Source: MGI
	GO:0051636	Gram-negative bacterial cell surface binding		IDA: Inferred from Direct Assay		F	Source: MGI
	GO:0051637	Gram-positive bacterial cell surface binding		IDA: Inferred from Direct Assay		F	Source: MGI
	GO:0008035	high-density lipoprotein binding		IDA: Inferred from Direct Assay		F	Source: MGI
	GO:0008289	lipid binding		ISS: Inferred from Sequence or Structural Similarity		F	Source: BHF-UCL
	GO:0070892	lipoteichoic acid receptor activity		IMP: Inferred from Mutant Phenotype		F	Source: MGI
	GO:0005041	low-density lipoprotein receptor activity		IMP: Inferred from Mutant Phenotype		F	Source: BHF-UCL
	GO:0043277	apoptotic cell clearance		IMP: Inferred from Mutant Phenotype		P	Source: MGI
	GO:0007155	cell adhesion		IEA: Inferred from Electronic Annotation		P	Source: UniProtKB-KW
	GO:0071221	cellular response to bacterial lipopeptide		IMP: Inferred from Mutant Phenotype		P	Source: MGI
	GO:0071222	cellular response to lipopolysaccharide		IMP: Inferred from Mutant Phenotype		P	Source: MGI
	GO:0071223	cellular response to lipoteichoic acid		IDA: Inferred from Direct Assay		P	Source: MGI
	GO:0030301	cholesterol transport		IMP: Inferred from Mutant Phenotype		P	Source: BHF-UCL
	GO:0050830	defense response to Gram-positive bacterium		IMP: Inferred from Mutant Phenotype		P	Source: MGI
	GO:0019915	lipid storage		IMP: Inferred from Mutant Phenotype		P	Source: BHF-UCL
	GO:0042953	lipoprotein transport		IMP: Inferred from Mutant Phenotype		P	Source: BHF-UCL
	GO:0034383	low-density lipoprotein particle clearance		IMP: Inferred from Mutant Phenotype		P	Source: BHF-UCL
	GO:0044130	negative regulation of growth of symbiont in host		IMP: Inferred from Mutant Phenotype		P	Source: MGI
	GO:0006910	phagocytosis, recognition		IDA: Inferred from Direct Assay		P	Source: MGI
	GO:0010886	positive regulation of cholesterol storage		IMP: Inferred from Mutant Phenotype		P	Source: BHF-UCL
	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB cascade		IMP: Inferred from Mutant Phenotype		P	Source: MGI
	GO:0032735	positive regulation of interleukin-12 production		IMP: Inferred from Mutant Phenotype		P	Source: MGI
	GO:0032755	positive regulation of interleukin-6 production		IMP: Inferred from Mutant Phenotype		P	Source: MGI
	GO:0060907	positive regulation of macrophage cytokine production		IMP: Inferred from Mutant Phenotype		P	Source: MGI
	GO:0010744	positive regulation of macrophage derived foam cell differentiation		IMP: Inferred from Mutant Phenotype		P	Source: BHF-UCL
	GO:0043410	positive regulation of MAPKKK cascade		IMP: Inferred from Mutant Phenotype		P	Source: MGI
	GO:0060100	positive regulation of phagocytosis, engulfment		IDA: Inferred from Direct Assay		P	Source: MGI
	GO:0032760	positive regulation of tumor necrosis factor production		IMP: Inferred from Mutant Phenotype		P	Source: MGI
	GO:0010670	positive regulation of oxygen and reactive oxygen species metabolic process	PMID:20978343^[1]	IMP: Inferred from Mutant Phenotype		P	The level of ROS in the vessel walls of cd36–/– mice was similar to that seen in WT mice treated with edaravone (3-methyl-1 phenyl-2-pyrazoline-5-1), a potent free radical scavenger (Figure 1C).	complete
	GO:0032582	negative regulation of gene-specific transcription	PMID:20978343^[1]	IMP: Inferred from Mutant Phenotype		P	As shown in Figure 2A, Prdx2 levels were 3- to 4-fold higher in the cd36–/– mice than in the WT.	complete
	GO:0033159	negative regulation of protein import into nucleus, translocation	PMID:20978343^[1]	IMP: Inferred from Mutant Phenotype		P	Importantly, cellular fractionation studies showed that Nrf2 accumulated in the nuclei of cd36–/– cells to a far greater extent than in WT cells (Figure 5C).	complete
	GO:0000122	negative regulation of transcription from RNA polymerase II promoter	PMID:20978343^[1]	IMP: Inferred from Mutant Phenotype		P
	GO:0001954	positive regulation of cell-matrix adhesion	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000399421	P
	GO:0004872	receptor activity	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0675	F
	GO:0005041	low-density lipoprotein receptor activity	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000399421	F
	GO:0005041	low-density lipoprotein receptor activity	PMID:10772654^[2]	IMP: Inferred from Mutant Phenotype		F
	GO:0005794	Golgi apparatus	PMID:15496455^[3]	IDA: Inferred from Direct Assay		C
	GO:0005886	plasma membrane	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000399421	C
	GO:0005886	plasma membrane	PMID:15496455^[3]	IDA: Inferred from Direct Assay		C
	GO:0006810	transport	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0813	P
	GO:0006910	phagocytosis, recognition	PMID:16061696^[4]	IDA: Inferred from Direct Assay		P
	GO:0007155	cell adhesion	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR002159	P
	GO:0007155	cell adhesion	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR005428	P
	GO:0007155	cell adhesion	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0130	P
	GO:0007166	cell surface receptor linked signaling pathway	PMID:20978343^[1]	IDA: Inferred from Direct Assay		P
	GO:0007263	nitric oxide mediated signal transduction	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000399421	P
	GO:0008035	high-density lipoprotein particle binding	PMID:14729860^[5]	IDA: Inferred from Direct Assay		F
	GO:0008289	lipid binding	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000399421	F
	GO:0008289	lipid binding	PMID:10772654^[2]	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:P16671	F
	GO:0009897	external side of plasma membrane	PMID:15690042^[6]	IDA: Inferred from Direct Assay		C
	GO:0009897	external side of plasma membrane	PMID:16061696^[4]	IDA: Inferred from Direct Assay		C
	GO:0009986	cell surface	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000399421	C
	GO:0009986	cell surface	PMID:10772654^[2]	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:P16671	C
	GO:0010629	negative regulation of gene expression	PMID:20978343^[1]	IMP: Inferred from Mutant Phenotype		P
	GO:0010744	positive regulation of macrophage derived foam cell differentiation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000399421	P
	GO:0010744	positive regulation of macrophage derived foam cell differentiation	PMID:10772654^[2]	IMP: Inferred from Mutant Phenotype		P
	GO:0010744	positive regulation of macrophage derived foam cell differentiation	PMID:12376530^[7]	IMP: Inferred from Mutant Phenotype		P
	GO:0010886	positive regulation of cholesterol storage	PMID:12376530^[7]	IMP: Inferred from Mutant Phenotype		P
	GO:0015911	plasma membrane long-chain fatty acid transport	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000399421	P
	GO:0016020	membrane	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR002159	C
	GO:0016020	membrane	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0472	C
	GO:0016020	membrane	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0162	C
	GO:0016021	integral to membrane	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0812	C
	GO:0019915	lipid storage	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000399421	P
	GO:0019915	lipid storage	PMID:10772654^[2]	IMP: Inferred from Mutant Phenotype		P
	GO:0019934	cGMP-mediated signaling	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000399421	P
	GO:0030169	low-density lipoprotein particle binding	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000399421	F
	GO:0030169	low-density lipoprotein particle binding	PMID:10772654^[2]	IMP: Inferred from Mutant Phenotype		F
	GO:0030169	low-density lipoprotein particle binding	PMID:12376530^[7]	IMP: Inferred from Mutant Phenotype		F
	GO:0030194	positive regulation of blood coagulation	PMID:20978343^[1]	IMP: Inferred from Mutant Phenotype		P
	GO:0030301	cholesterol transport	PMID:12376530^[7]	IMP: Inferred from Mutant Phenotype		P
	GO:0031092	platelet alpha granule membrane	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000399421	C
	GO:0032735	positive regulation of interleukin-12 production	PMID:16061696^[4]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2447190	P
	GO:0032755	positive regulation of interleukin-6 production	PMID:16061696^[4]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2447190	P
	GO:0032760	positive regulation of tumor necrosis factor production	PMID:15690042^[6]	IMP: Inferred from Mutant Phenotype	MGI:MGI:3573941	P
	GO:0032760	positive regulation of tumor necrosis factor production	PMID:16061696^[4]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2447190	P
	GO:0034381	plasma lipoprotein particle clearance	PMID:12376530^[7]	IMP: Inferred from Mutant Phenotype		P
	GO:0034383	low-density lipoprotein particle clearance	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000399421	P
	GO:0034383	low-density lipoprotein particle clearance	PMID:10772654^[2]	IMP: Inferred from Mutant Phenotype		P
	GO:0035634	response to stilbenoid	PMID:17086191^[8]	IEP: Inferred from Expression Pattern		P
	GO:0042953	lipoprotein transport	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000399421	P
	GO:0042953	lipoprotein transport	PMID:10772654^[2]	IMP: Inferred from Mutant Phenotype		P
	GO:0042992	negative regulation of transcription factor import into nucleus	PMID:20978343^[1]	IMP: Inferred from Mutant Phenotype		P
	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB cascade	PMID:16061696^[4]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2447190	P
	GO:0043277	apoptotic cell clearance	PMID:15647754^[9]	IMP: Inferred from Mutant Phenotype		P
	GO:0043410	positive regulation of MAPKKK cascade	PMID:15690042^[6]	IMP: Inferred from Mutant Phenotype	MGI:MGI:3573941	P
	GO:0043619	regulation of transcription from RNA polymerase II promoter in response to oxidative stress	PMID:20978343^[1]	IC: Inferred by Curator	GO:0000122	P
	GO:0044130	negative regulation of growth of symbiont in host	PMID:15690042^[6]	IMP: Inferred from Mutant Phenotype	MGI:MGI:3573941	P
	GO:0044130	negative regulation of growth of symbiont in host	PMID:16061696^[4]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2447190	P
	GO:0045121	membrane raft	PMID:15496455^[3]	IDA: Inferred from Direct Assay		C
	GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	PMID:20978343^[1]	IDA: Inferred from Direct Assay		P
	GO:0050830	defense response to Gram-positive bacterium	PMID:15690042^[6]	IMP: Inferred from Mutant Phenotype	MGI:MGI:3573941	P
	GO:0050830	defense response to Gram-positive bacterium	PMID:16061696^[4]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2447190	P
	GO:0051636	Gram-negative bacterial cell surface binding	PMID:16061696^[4]	IDA: Inferred from Direct Assay		F
	GO:0051637	Gram-positive bacterial cell surface binding	PMID:16061696^[4]	IDA: Inferred from Direct Assay		F
	GO:0055096	low-density lipoprotein particle mediated signaling	PMID:20978343^[1]	IDA: Inferred from Direct Assay		P
	GO:0060100	positive regulation of phagocytosis, engulfment	PMID:16061696^[4]	IDA: Inferred from Direct Assay		P
	GO:0060100	positive regulation of phagocytosis, engulfment	PMID:16061696^[4]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2447190	P
	GO:0060907	positive regulation of macrophage cytokine production	PMID:16061696^[4]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2447190	P
	GO:0070892	lipoteichoic acid receptor activity	PMID:16061696^[4]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2447190	F
	GO:0071221	cellular response to bacterial lipopeptide	PMID:15690042^[6]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1931790	P
	GO:0071221	cellular response to bacterial lipopeptide	PMID:15690042^[6]	IMP: Inferred from Mutant Phenotype	MGI:MGI:3573941	P
	GO:0071222	cellular response to lipopolysaccharide	PMID:16061696^[4]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2447190	P
	GO:0071223	cellular response to lipoteichoic acid	PMID:15690042^[6]	IDA: Inferred from Direct Assay		P
	GO:0071223	cellular response to lipoteichoic acid	PMID:15690042^[6]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1931790	P
	GO:0071223	cellular response to lipoteichoic acid	PMID:15690042^[6]	IMP: Inferred from Mutant Phenotype	MGI:MGI:3573941	P
	GO:0071223	cellular response to lipoteichoic acid	PMID:16061696^[4]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2447190	P
	GO:0071447	cellular response to hydroperoxide	PMID:20978343^[1]	IMP: Inferred from Mutant Phenotype		P
	GO:0071813	lipoprotein particle binding	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000399421	F
	GO:2000121	regulation of removal of superoxide radicals	PMID:20978343^[1]	IMP: Inferred from Mutant Phenotype		P
	GO:2000334	positive regulation of blood microparticle formation	PMID:20978343^[1]	IMP: Inferred from Mutant Phenotype		P
	GO:2000379	positive regulation of reactive oxygen species metabolic process	PMID:20978343^[1]	IMP: Inferred from Mutant Phenotype		P
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.00 ^1.01 ^1.02 ^1.03 ^1.04 ^1.05 ^1.06 ^1.07 ^1.08 ^1.09 ^1.10 ^1.11 ^1.12 ^1.13 ^1.14 Li W et al. (2010) CD36 participates in a signaling pathway that regulates ROS formation in murine VSMCs. J Clin Invest 120: 3996-4006 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 ^2.6 ^2.7 Podrez EA et al. (2000) Macrophage scavenger receptor CD36 is the major receptor for LDL modified by monocyte-generated reactive nitrogen species. J Clin Invest 105: 1095-108 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 Pohl J et al. (2005) FAT/CD36-mediated long-chain fatty acid uptake in adipocytes requires plasma membrane rafts. Mol Biol Cell 16: 24-31 PubMed GONUTS page
↑ ^4.00 ^4.01 ^4.02 ^4.03 ^4.04 ^4.05 ^4.06 ^4.07 ^4.08 ^4.09 ^4.10 ^4.11 ^4.12 ^4.13 ^4.14 ^4.15 Stuart LM et al. (2005) Response to Staphylococcus aureus requires CD36-mediated phagocytosis triggered by the COOH-terminal cytoplasmic domain. J Cell Biol 170: 477-85 PubMed GONUTS page
↑ de Beer MC et al. (2004) ApoA-II modulates the association of HDL with class B scavenger receptors SR-BI and CD36. J Lipid Res 45: 706-15 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 ^6.3 ^6.4 ^6.5 ^6.6 ^6.7 ^6.8 ^6.9 Hoebe K et al. (2005) CD36 is a sensor of diacylglycerides. Nature 433: 523-7 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 ^7.3 ^7.4 Kunjathoor VV et al. (2002) Scavenger receptors class A-I/II and CD36 are the principal receptors responsible for the uptake of modified low density lipoprotein leading to lipid loading in macrophages. J Biol Chem 277: 49982-8 PubMed GONUTS page
↑ Baur JA et al. (2006) Resveratrol improves health and survival of mice on a high-calorie diet. Nature 444: 337-42 PubMed GONUTS page
↑ Monks J et al. (2005) Epithelial cells as phagocytes: apoptotic epithelial cells are engulfed by mammary alveolar epithelial cells and repress inflammatory mediator release. Cell Death Differ 12: 107-14 PubMed GONUTS page

[PMID:20978343-0] 1.00 ^1.01 ^1.02 ^1.03 ^1.04 ^1.05 ^1.06 ^1.07 ^1.08 ^1.09 ^1.10 ^1.11 ^1.12 ^1.13 ^1.14 Li W et al. (2010) CD36 participates in a signaling pathway that regulates ROS formation in murine VSMCs. J Clin Invest 120: 3996-4006 PubMed GONUTS page

[PMID:10772654-1] 2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 ^2.6 ^2.7 Podrez EA et al. (2000) Macrophage scavenger receptor CD36 is the major receptor for LDL modified by monocyte-generated reactive nitrogen species. J Clin Invest 105: 1095-108 PubMed GONUTS page

[PMID:15496455-2] 3.0 ^3.1 ^3.2 Pohl J et al. (2005) FAT/CD36-mediated long-chain fatty acid uptake in adipocytes requires plasma membrane rafts. Mol Biol Cell 16: 24-31 PubMed GONUTS page

[PMID:16061696-3] 4.00 ^4.01 ^4.02 ^4.03 ^4.04 ^4.05 ^4.06 ^4.07 ^4.08 ^4.09 ^4.10 ^4.11 ^4.12 ^4.13 ^4.14 ^4.15 Stuart LM et al. (2005) Response to Staphylococcus aureus requires CD36-mediated phagocytosis triggered by the COOH-terminal cytoplasmic domain. J Cell Biol 170: 477-85 PubMed GONUTS page

[PMID:14729860-4] Beer MC et al. (2004) ApoA-II modulates the association of HDL with class B scavenger receptors SR-BI and CD36. J Lipid Res 45: 706-15 PubMed GONUTS page

[PMID:15690042-5] 6.0 ^6.1 ^6.2 ^6.3 ^6.4 ^6.5 ^6.6 ^6.7 ^6.8 ^6.9 Hoebe K et al. (2005) CD36 is a sensor of diacylglycerides. Nature 433: 523-7 PubMed GONUTS page

[PMID:12376530-6] 7.0 ^7.1 ^7.2 ^7.3 ^7.4 Kunjathoor VV et al. (2002) Scavenger receptors class A-I/II and CD36 are the principal receptors responsible for the uptake of modified low density lipoprotein leading to lipid loading in macrophages. J Biol Chem 277: 49982-8 PubMed GONUTS page

[PMID:17086191-7] Baur JA et al. (2006) Resveratrol improves health and survival of mice on a high-calorie diet. Nature 444: 337-42 PubMed GONUTS page

[PMID:15647754-8] Monks J et al. (2005) Epithelial cells as phagocytes: apoptotic epithelial cells are engulfed by mammary alveolar epithelial cells and repress inflammatory mediator release. Cell Death Differ 12: 107-14 PubMed GONUTS page

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MOUSE:CD36

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