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MOUSE:CD28

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Species (Taxon ID) Mus musculus (Mouse). (10090)
Gene Name(s) Cd28
Protein Name(s) T-cell-specific surface glycoprotein CD28
External Links
UniProt P31041
EMBL M34563
AL646054
AL672024
CR936842
CH466548
BC064058
M74361
CCDS CCDS14992.1
PIR A43523
I49584
RefSeq NP_031668.3
UniGene Mm.255003
ProteinModelPortal P31041
SMR P31041
DIP DIP-60858N
IntAct P31041
STRING 10090.ENSMUSP00000027165
PhosphoSite P31041
PRIDE P31041
Ensembl ENSMUST00000027165
GeneID 12487
KEGG mmu:12487
UCSC uc007bev.2
uc007bew.2
CTD 940
MGI MGI:88327
eggNOG NOG48152
GeneTree ENSGT00530000063873
HOGENOM HOG000276892
HOVERGEN HBG004094
InParanoid P31041
KO K06470
OMA NHTDIYF
OrthoDB EOG7W6WMJ
TreeFam TF335679
Reactome REACT_196588
REACT_204081
REACT_226151
REACT_226341
REACT_261451
NextBio 281396
PRO PR:P31041
Proteomes UP000000589
CleanEx MM_CD28
Genevestigator P31041
GO GO:0009897
GO:0001772
GO:0016021
GO:0097190
GO:0006955
GO:0045060
GO:0046641
GO:0002863
GO:0045086
GO:0048304
GO:0045840
GO:0014068
GO:0051897
GO:0042102
GO:0045944
GO:0045066
GO:0031295
GO:0050852
Gene3D 2.60.40.10
InterPro IPR008093
IPR013783
IPR003599
IPR013106
Pfam PF07686
PRINTS PR01717
SMART SM00409

Annotations

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0001772

immunological synapse

PMID:23793062[1]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0002020

protease binding

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSP00000324890

F

Seeded From UniProt

complete

GO:0002020

protease binding

GO_REF:0000096

ISO: Inferred from Sequence Orthology

UniProtKB:P10747

F

Seeded From UniProt

complete

GO:0002863

positive regulation of inflammatory response to antigenic stimulus

PMID:10791997[2]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1857150

P

Seeded From UniProt

complete

GO:0005070

SH3/SH2 adaptor activity

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSP00000324890

F

Seeded From UniProt

complete

GO:0005070

SH3/SH2 adaptor activity

GO_REF:0000096

ISO: Inferred from Sequence Orthology

UniProtKB:P10747

F

Seeded From UniProt

complete

GO:0006955

immune response

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR008093

P

complete

GO:0005886

plasma membrane

GO_REF:0000008

ISO: Inferred from Sequence Orthology

UniProtKB:P10747

C

Seeded From UniProt

complete

GO:0016020

membrane

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR008093

C

complete

GO:0005886

plasma membrane

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSP00000324890

C

Seeded From UniProt

complete

GO:0006955

immune response

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR008093

P

Seeded From UniProt

complete

GO:0016020

membrane

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0472

C

complete

GO:0009897

external side of plasma membrane

GO_REF:0000008

ISO: Inferred from Sequence Orthology

UniProtKB:P10747

C

Seeded From UniProt

complete

GO:0016020

membrane

GO_REF:0000023

IEA: Inferred from Electronic Annotation

SP_SL:SL-0162

C

complete

GO:0009897

external side of plasma membrane

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSP00000324890

C

Seeded From UniProt

complete

GO:0016021

integral to membrane

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0812

C

complete

GO:0009897

external side of plasma membrane

PMID:12874832[3]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0042102

positive regulation of T cell proliferation

GO_REF:0000024

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:P10747

P

complete

GO:0009897

external side of plasma membrane

PMID:23793062[1]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0045086

positive regulation of interleukin-2 biosynthetic process

GO_REF:0000024

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:P10747

P

complete

GO:0009897

external side of plasma membrane

PMID:7688139[4]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1857150

C

Seeded From UniProt

complete

GO:0045840

positive regulation of mitosis

GO_REF:0000024

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:P10747

P

complete

GO:0009897

external side of plasma membrane

PMID:7790813[5]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0009897

external side of plasma membrane

PMID:8125140[6]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0010628

positive regulation of gene expression

GO_REF:0000096

ISO: Inferred from Sequence Orthology

UniProtKB:P10747

P

Seeded From UniProt

complete

GO:0010629

negative regulation of gene expression

GO_REF:0000096

ISO: Inferred from Sequence Orthology

UniProtKB:P10747

P

Seeded From UniProt

complete

GO:0014068

positive regulation of phosphatidylinositol 3-kinase signaling

PMID:23589618[7]

IDA: Inferred from Direct Assay

P

Seeded From UniProt

complete

GO:0016020

membrane

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR008093

C

Seeded From UniProt

complete

GO:0016020

membrane

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0472

C

Seeded From UniProt

complete

GO:0016020

membrane

GO_REF:0000039

IEA: Inferred from Electronic Annotation

UniProtKB-SubCell:SL-0162

C

Seeded From UniProt

complete

GO:0016021

integral component of membrane

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0812

C

Seeded From UniProt

complete

GO:0031295

T cell costimulation

PMID:10429671[8]

IDA: Inferred from Direct Assay

P

Seeded From UniProt

complete

GO:0031295

T cell costimulation

PMID:12925852[9]

IDA: Inferred from Direct Assay

P

Seeded From UniProt

complete

GO:0031295

T cell costimulation

PMID:15240667[10]

IDA: Inferred from Direct Assay

P

Seeded From UniProt

complete

GO:0031295

T cell costimulation

PMID:23793062[1]

IGI: Inferred from Genetic Interaction

MGI:MGI:88332

P

Seeded From UniProt

complete

GO:0031295

T cell costimulation

PMID:7688139[4]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1857150

P

Seeded From UniProt

complete

GO:0031295

T cell costimulation

PMID:8125140[6]

IDA: Inferred from Direct Assay

P

Seeded From UniProt

complete

GO:0031295

T cell costimulation

PMID:9368605[11]

IDA: Inferred from Direct Assay

P

Seeded From UniProt

complete

GO:0031295

T cell costimulation

PMID:9368605[11]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1857150

P

Seeded From UniProt

complete

GO:0042102

positive regulation of T cell proliferation

GO_REF:0000024

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:P10747

P

Seeded From UniProt

complete

GO:0042102

positive regulation of T cell proliferation

GO_REF:0000096

ISO: Inferred from Sequence Orthology

UniProtKB:P10747

P

Seeded From UniProt

complete

GO:0042102

positive regulation of T cell proliferation

PMID:10791997[2]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1857150

P

Seeded From UniProt

complete

GO:0042102

positive regulation of T cell proliferation

PMID:12867038[12]

IDA: Inferred from Direct Assay

P

Seeded From UniProt

complete

GO:0042102

positive regulation of T cell proliferation

PMID:12925852[9]

IDA: Inferred from Direct Assay

P

Seeded From UniProt

complete

GO:0042102

positive regulation of T cell proliferation

PMID:15240667[10]

IDA: Inferred from Direct Assay

P

Seeded From UniProt

complete

GO:0042102

positive regulation of T cell proliferation

PMID:7688139[4]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1857150

P

Seeded From UniProt

complete

GO:0045060

negative thymic T cell selection

PMID:10429671[8]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1857150

P

Seeded From UniProt

complete

GO:0045066

regulatory T cell differentiation

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSP00000324890

P

Seeded From UniProt

complete

GO:0045066

regulatory T cell differentiation

GO_REF:0000096

ISO: Inferred from Sequence Orthology

UniProtKB:P10747

P

Seeded From UniProt

complete

GO:0045086

positive regulation of interleukin-2 biosynthetic process

GO_REF:0000024

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:P10747

P

Seeded From UniProt

complete

GO:0045086

positive regulation of interleukin-2 biosynthetic process

GO_REF:0000096

ISO: Inferred from Sequence Orthology

UniProtKB:P10747

P

Seeded From UniProt

complete

GO:0045086

positive regulation of interleukin-2 biosynthetic process

PMID:7688139[4]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1857150

P

Seeded From UniProt

complete

GO:0045840

positive regulation of mitotic nuclear division

GO_REF:0000024

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:P10747

P

Seeded From UniProt

complete

GO:0045840

positive regulation of mitotic nuclear division

GO_REF:0000096

ISO: Inferred from Sequence Orthology

UniProtKB:P10747

P

Seeded From UniProt

complete

GO:0045944

positive regulation of transcription from RNA polymerase II promoter

PMID:16809611[13]

IGI: Inferred from Genetic Interaction

MGI:MGI:1929913

P

Seeded From UniProt

complete

GO:0046641

positive regulation of alpha-beta T cell proliferation

PMID:14973438[14]

IDA: Inferred from Direct Assay

P

Seeded From UniProt

complete

GO:0046641

positive regulation of alpha-beta T cell proliferation

PMID:8125140[6]

IDA: Inferred from Direct Assay

P

Seeded From UniProt

complete

GO:0046641

positive regulation of alpha-beta T cell proliferation

PMID:9368605[11]

IDA: Inferred from Direct Assay

P

Seeded From UniProt

complete

GO:0046641

positive regulation of alpha-beta T cell proliferation

PMID:9368605[11]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1857150

P

Seeded From UniProt

complete

GO:0048304

positive regulation of isotype switching to IgG isotypes

PMID:7688139[4]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1857150

P

Seeded From UniProt

complete

GO:0050852

T cell receptor signaling pathway

PMID:23793062[1]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1857150

P

Seeded From UniProt

complete

GO:0051897

positive regulation of protein kinase B signaling

PMID:23589618[7]

IDA: Inferred from Direct Assay

P

Seeded From UniProt

complete

GO:0097190

apoptotic signaling pathway

PMID:10429671[8]

IDA: Inferred from Direct Assay

P

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 1.2 1.3 Liang, Y et al. (2013) The lymphoid lineage-specific actin-uncapping protein Rltpr is essential for costimulation via CD28 and the development of regulatory T cells. Nat. Immunol. 14 858-66 PubMed GONUTS page
  2. 2.0 2.1 Bai, XF et al. (2000) The heat-stable antigen determines pathogenicity of self-reactive T cells in experimental autoimmune encephalomyelitis. J. Clin. Invest. 105 1227-32 PubMed GONUTS page
  3. Butler, JJ et al. (2003) Adenosine inhibits activation-induced T cell expression of CD2 and CD28 co-stimulatory molecules: role of interleukin-2 and cyclic AMP signaling pathways. J. Cell. Biochem. 89 975-91 PubMed GONUTS page
  4. 4.0 4.1 4.2 4.3 4.4 Shahinian, A et al. (1993) Differential T cell costimulatory requirements in CD28-deficient mice. Science 261 609-12 PubMed GONUTS page
  5. Sperling, AI et al. (1995) CD43 is a murine T cell costimulatory receptor that functions independently of CD28. J. Exp. Med. 182 139-46 PubMed GONUTS page
  6. 6.0 6.1 6.2 Hubbe, M & Altevogt, P (1994) Heat-stable antigen/CD24 on mouse T lymphocytes: evidence for a costimulatory function. Eur. J. Immunol. 24 731-7 PubMed GONUTS page
  7. 7.0 7.1 Ammann, JU et al. (2013) Butyrophilin Btn2a2 inhibits TCR activation and phosphatidylinositol 3-kinase/Akt pathway signaling and induces Foxp3 expression in T lymphocytes. J. Immunol. 190 5030-6 PubMed GONUTS page
  8. 8.0 8.1 8.2 Kishimoto, H & Sprent, J (1999) Several different cell surface molecules control negative selection of medullary thymocytes. J. Exp. Med. 190 65-73 PubMed GONUTS page
  9. 9.0 9.1 Suh, WK et al. (2003) The B7 family member B7-H3 preferentially down-regulates T helper type 1-mediated immune responses. Nat. Immunol. 4 899-906 PubMed GONUTS page
  10. 10.0 10.1 Ng, LG et al. (2004) B cell-activating factor belonging to the TNF family (BAFF)-R is the principal BAFF receptor facilitating BAFF costimulation of circulating T and B cells. J. Immunol. 173 807-17 PubMed GONUTS page
  11. 11.0 11.1 11.2 11.3 Zhou, Q et al. (1997) Homotypic interaction of the heat-stable antigen is not responsible for its co-stimulatory activity for T cell clonal expansion. Eur. J. Immunol. 27 2524-8 PubMed GONUTS page
  12. Egawa, T et al. (2003) Requirement for CARMA1 in antigen receptor-induced NF-kappa B activation and lymphocyte proliferation. Curr. Biol. 13 1252-8 PubMed GONUTS page
  13. Cismasiu, VB et al. (2006) BCL11B participates in the activation of IL2 gene expression in CD4+ T lymphocytes. Blood 108 2695-702 PubMed GONUTS page
  14. Heissmeyer, V et al. (2004) Calcineurin imposes T cell unresponsiveness through targeted proteolysis of signaling proteins. Nat. Immunol. 5 255-65 PubMed GONUTS page