MOUSE:BDNF

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Species (Taxon ID)	Mus musculus (Mouse). (taxon:10090)
Gene Name(s)	Bdnf
Protein Name(s)	Brain-derived neurotrophic factor BDNF
External Links
UniProt Identifier	BDNF_MOUSE
UniProt Accessions	P21237,
EMBL	X55573, BC034862,
PIR	S12555,
RefSeq	NP_001041604.1, NP_001041606.1, NP_001041607.1,
Ensembl	ENSMUST00000111042, ENSMUST00000111043, ENSMUST00000111044, ENSMUST00000111045, ENSMUST00000111046, ENSMUST00000111047, ENSMUST00000111049, ENSMUST00000111050, ENSMUST00000111051,
Pfam	PF00243,

Annotations

Qualifier	GO ID	GO term name	Reference	Evidence Code	with/from	Aspect	Notes	Status
	GO:0016023	cytoplasmic membrane-bounded vesicle		IDA: Inferred from Direct Assay		C	Source: MGI
	GO:0005788	endoplasmic reticulum lumen		EXP: Inferred from Experiment		C	Source: Reactome
	GO:0005576	extracellular region		EXP: Inferred from Experiment		C	Source: Reactome
	GO:0008083	growth factor activity		IEA: Inferred from Electronic Annotation		F	Source: UniProtKB-KW
	GO:0006916	anti-apoptosis		IDA: Inferred from Direct Assay		P	Source: MGI
	GO:0007411	axon guidance		IMP: Inferred from Mutant Phenotype		P	Source: MGI
	GO:0007412	axon target recognition		IMP: Inferred from Mutant Phenotype		P	Source: MGI
	GO:0016358	dendrite development		IMP: Inferred from Mutant Phenotype		P	Source: MGI
	GO:0042596	fear response		IMP: Inferred from Mutant Phenotype		P	Source: MGI
	GO:0007631	feeding behavior		IMP: Inferred from Mutant Phenotype		P	Source: MGI
	GO:0014047	glutamate secretion		IPI: Inferred from Physical Interaction		P	Source: MGI
	GO:0048839	inner ear development		IMP: Inferred from Mutant Phenotype		P	Source: MGI
	GO:0007611	learning or memory		IMP: Inferred from Mutant Phenotype		P	Source: MGI
	GO:0042490	mechanoreceptor differentiation		IGI: Inferred from Genetic Interaction		P	Source: MGI
	GO:0007406	negative regulation of neuroblast prolifera...		IDA: Inferred from Direct Assay		P	Source: MGI
	GO:0043524	negative regulation of neuron apoptosis		IMP: Inferred from Mutant Phenotype		P	Source: MGI
	GO:0021675	nerve development		IMP: Inferred from Mutant Phenotype		P	Source: MGI
	GO:0008038	neuron recognition		IMP: Inferred from Mutant Phenotype		P	Source: MGI
	GO:0045666	positive regulation of neuron differentiation		IDA: Inferred from Direct Assay		P	Source: MGI
	GO:0019222	regulation of metabolic process		IMP: Inferred from Mutant Phenotype		P	Source: MGI
	GO:0046668	regulation of retinal cell programmed cell ...		IDA: Inferred from Direct Assay		P	Source: MGI
	GO:0048167	regulation of synaptic plasticity		IDA: Inferred from Direct Assay		P	Source: MGI
	GO:0042493	response to drug		IMP: Inferred from Mutant Phenotype		P	Source: MGI
	GO:0043523	regulation of neuron apoptosis	PMID:20067784^[1]	IMP: Inferred from Mutant Phenotype		P	Table.1,2	complete
	GO:0001657	ureteric bud development		IDA: Inferred from Direct Assay		P	Source: MGI
	GO:0051930	regulation of sensory perception of pain	PMID:20067784^[1]	IMP: Inferred from Mutant Phenotype		P	Fig.1E,F	complete
	GO:0001657	ureteric bud development	PMID:16018995^[2]	IDA: Inferred from Direct Assay		P
	GO:0005102	receptor binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR002072	F
	GO:0005515	protein binding	PMID:11684666^[3]	IPI: Inferred from Physical Interaction	UniProtKB:Q9Z0W1	F
	GO:0005576	extracellular region	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0964	C
	GO:0005576	extracellular region	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0243	C
	GO:0005576	extracellular region	Reactome:REACT_13483	TAS: Traceable Author Statement		C
	GO:0005576	extracellular region	Reactome:REACT_13501	TAS: Traceable Author Statement		C
	GO:0005788	endoplasmic reticulum lumen	Reactome:REACT_11198	TAS: Traceable Author Statement		C
	GO:0005788	endoplasmic reticulum lumen	Reactome:REACT_11214	TAS: Traceable Author Statement		C
	GO:0006916	anti-apoptosis	PMID:12904469^[4]	IDA: Inferred from Direct Assay		P
	GO:0007406	negative regulation of neuroblast proliferation	PMID:12798291^[5]	IDA: Inferred from Direct Assay		P
	GO:0007411	axon guidance	PMID:15014133^[6]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1929986	P
	GO:0007412	axon target recognition	PMID:15464571^[7]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1930038	P
	GO:0007610	behavior	PMID:15249684^[8]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2176750	P
	GO:0007611	learning or memory	PMID:15249684^[8]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2176750	P
	GO:0007631	feeding behavior	PMID:12796784^[9]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2663046	P
	GO:0008038	neuron recognition	PMID:15844198^[10]	IMP: Inferred from Mutant Phenotype		P
	GO:0008083	growth factor activity	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0339	F
	GO:0014047	glutamate secretion	PMID:16819522^[11]	IPI: Inferred from Physical Interaction	UniProtKB:P15209	P
	GO:0016023	cytoplasmic membrane-bounded vesicle	PMID:14715936^[12]	IDA: Inferred from Direct Assay		C
	GO:0016023	cytoplasmic membrane-bounded vesicle	PMID:15242649^[13]	IDA: Inferred from Direct Assay		C
	GO:0016358	dendrite development	PMID:12890780^[14]	IMP: Inferred from Mutant Phenotype		P
	GO:0019222	regulation of metabolic process	PMID:12106019^[15]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2663046	P
	GO:0021675	nerve development	PMID:7605630^[16]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1857136	P
	GO:0042493	response to drug	PMID:15249684^[8]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2176750	P
	GO:0042596	fear response	PMID:15249684^[8]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2176750	P
	GO:0043523	regulation of neuron apoptosis	PMID:16516892^[17]	IDA: Inferred from Direct Assay		P
	GO:0043524	negative regulation of neuron apoptosis	PMID:15869495^[18]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1930038	P
	GO:0043524	negative regulation of neuron apoptosis	PMID:8861722^[19]	IMP: Inferred from Mutant Phenotype		P
	GO:0045666	positive regulation of neuron differentiation	PMID:12798291^[5]	IDA: Inferred from Direct Assay		P
	GO:0046668	regulation of retinal cell programmed cell death	PMID:11747369^[20]	IDA: Inferred from Direct Assay		P
	GO:0048167	regulation of synaptic plasticity	PMID:16819522^[11]	IDA: Inferred from Direct Assay		P
	GO:0048167	regulation of synaptic plasticity	PMID:17442827^[21]	IDA: Inferred from Direct Assay		P
	GO:0048839	inner ear development	PMID:7605630^[16]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1857136	P
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Valdés-Sánchez T et al. (2010) BDNF is essentially required for the early postnatal survival of nociceptors. Dev Biol 339: 465-76 PubMed GONUTS page
↑ Sajithlal G et al. (2005) Eya 1 acts as a critical regulator for specifying the metanephric mesenchyme. Dev Biol 284: 323-36 PubMed GONUTS page
↑ Coppola V et al. (2001) Dissection of NT3 functions in vivo by gene replacement strategy. Development 128: 4315-27 PubMed GONUTS page
↑ Schubert M et al. (2003) Insulin receptor substrate-2 deficiency impairs brain growth and promotes tau phosphorylation. J Neurosci 23: 7084-92 PubMed GONUTS page
↑ ^5.0 ^5.1 Cheng A et al. (2003) Nitric oxide acts in a positive feedback loop with BDNF to regulate neural progenitor cell proliferation and differentiation in the mammalian brain. Dev Biol 258: 319-33 PubMed GONUTS page
↑ Tessarollo L et al. (2004) NT-3 replacement with brain-derived neurotrophic factor redirects vestibular nerve fibers to the cochlea. J Neurosci 24: 2575-84 PubMed GONUTS page
↑ Hellard D et al. (2004) Cranial sensory neuron development in the absence of brain-derived neurotrophic factor in BDNF/Bax double null mice. Dev Biol 275: 34-43 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 ^8.3 Monteggia LM et al. (2004) Essential role of brain-derived neurotrophic factor in adult hippocampal function. Proc Natl Acad Sci U S A 101: 10827-32 PubMed GONUTS page
↑ Xu B et al. (2003) Brain-derived neurotrophic factor regulates energy balance downstream of melanocortin-4 receptor. Nat Neurosci 6: 736-42 PubMed GONUTS page
↑ Fritzsch B et al. (2005) Atoh1 null mice show directed afferent fiber growth to undifferentiated ear sensory epithelia followed by incomplete fiber retention. Dev Dyn 233: 570-83 PubMed GONUTS page
↑ ^11.0 ^11.1 Yano H et al. (2006) BDNF-mediated neurotransmission relies upon a myosin VI motor complex. Nat Neurosci 9: 1009-18 PubMed GONUTS page
↑ Sadakata T et al. (2004) The secretory granule-associated protein CAPS2 regulates neurotrophin release and cell survival. J Neurosci 24: 43-52 PubMed GONUTS page
↑ Gauthier LR et al. (2004) Huntingtin controls neurotrophic support and survival of neurons by enhancing BDNF vesicular transport along microtubules. Cell 118: 127-38 PubMed GONUTS page
↑ Gorski JA et al. (2003) Brain-derived neurotrophic factor is required for the maintenance of cortical dendrites. J Neurosci 23: 6856-65 PubMed GONUTS page
↑ Biffo S et al. (1990) B-50/GAP43 Expression Correlates with Process Outgrowth in the Embryonic Mouse Nervous System. Eur J Neurosci 2: 487-499 PubMed GONUTS page
↑ ^16.0 ^16.1 Ernfors P et al. (1995) Complementary roles of BDNF and NT-3 in vestibular and auditory development. Neuron 14: 1153-64 PubMed GONUTS page
↑ Li HL et al. (2006) The novel neurotrophin-regulated neuronal development-associated protein, NDAP, mediates apoptosis. FEBS Lett 580: 1723-8 PubMed GONUTS page
↑ Guo H et al. (2005) Development of pontine noradrenergic A5 neurons requires brain-derived neurotrophic factor. Eur J Neurosci 21: 2019-23 PubMed GONUTS page
↑ Staecker H et al. (1996) NGF, BDNF and NT-3 play unique roles in the in vitro development and patterning of innervation of the mammalian inner ear. Brain Res Dev Brain Res 92: 49-60 PubMed GONUTS page
↑ Wahlin KJ et al. (2001) Neurotrophic signaling in normal and degenerating rodent retinas. Exp Eye Res 73: 693-701 PubMed GONUTS page
↑ Lynch G et al. (2007) Brain-derived neurotrophic factor restores synaptic plasticity in a knock-in mouse model of Huntington's disease. J Neurosci 27: 4424-34 PubMed GONUTS page

[PMID:20067784-0] 1.0 ^1.1 Valdés-Sánchez T et al. (2010) BDNF is essentially required for the early postnatal survival of nociceptors. Dev Biol 339: 465-76 PubMed GONUTS page

[PMID:16018995-1] Sajithlal G et al. (2005) Eya 1 acts as a critical regulator for specifying the metanephric mesenchyme. Dev Biol 284: 323-36 PubMed GONUTS page

[PMID:11684666-2] Coppola V et al. (2001) Dissection of NT3 functions in vivo by gene replacement strategy. Development 128: 4315-27 PubMed GONUTS page

[PMID:12904469-3] Schubert M et al. (2003) Insulin receptor substrate-2 deficiency impairs brain growth and promotes tau phosphorylation. J Neurosci 23: 7084-92 PubMed GONUTS page

[PMID:12798291-4] 5.0 ^5.1 Cheng A et al. (2003) Nitric oxide acts in a positive feedback loop with BDNF to regulate neural progenitor cell proliferation and differentiation in the mammalian brain. Dev Biol 258: 319-33 PubMed GONUTS page

[PMID:15014133-5] Tessarollo L et al. (2004) NT-3 replacement with brain-derived neurotrophic factor redirects vestibular nerve fibers to the cochlea. J Neurosci 24: 2575-84 PubMed GONUTS page

[PMID:15464571-6] Hellard D et al. (2004) Cranial sensory neuron development in the absence of brain-derived neurotrophic factor in BDNF/Bax double null mice. Dev Biol 275: 34-43 PubMed GONUTS page

[PMID:15249684-7] 8.0 ^8.1 ^8.2 ^8.3 Monteggia LM et al. (2004) Essential role of brain-derived neurotrophic factor in adult hippocampal function. Proc Natl Acad Sci U S A 101: 10827-32 PubMed GONUTS page

[PMID:12796784-8] Xu B et al. (2003) Brain-derived neurotrophic factor regulates energy balance downstream of melanocortin-4 receptor. Nat Neurosci 6: 736-42 PubMed GONUTS page

[PMID:15844198-9] Fritzsch B et al. (2005) Atoh1 null mice show directed afferent fiber growth to undifferentiated ear sensory epithelia followed by incomplete fiber retention. Dev Dyn 233: 570-83 PubMed GONUTS page

[PMID:16819522-10] 11.0 ^11.1 Yano H et al. (2006) BDNF-mediated neurotransmission relies upon a myosin VI motor complex. Nat Neurosci 9: 1009-18 PubMed GONUTS page

[PMID:14715936-11] Sadakata T et al. (2004) The secretory granule-associated protein CAPS2 regulates neurotrophin release and cell survival. J Neurosci 24: 43-52 PubMed GONUTS page

[PMID:15242649-12] Gauthier LR et al. (2004) Huntingtin controls neurotrophic support and survival of neurons by enhancing BDNF vesicular transport along microtubules. Cell 118: 127-38 PubMed GONUTS page

[PMID:12890780-13] Gorski JA et al. (2003) Brain-derived neurotrophic factor is required for the maintenance of cortical dendrites. J Neurosci 23: 6856-65 PubMed GONUTS page

[PMID:12106019-14] Biffo S et al. (1990) B-50/GAP43 Expression Correlates with Process Outgrowth in the Embryonic Mouse Nervous System. Eur J Neurosci 2: 487-499 PubMed GONUTS page

[PMID:7605630-15] 16.0 ^16.1 Ernfors P et al. (1995) Complementary roles of BDNF and NT-3 in vestibular and auditory development. Neuron 14: 1153-64 PubMed GONUTS page

[PMID:16516892-16] Li HL et al. (2006) The novel neurotrophin-regulated neuronal development-associated protein, NDAP, mediates apoptosis. FEBS Lett 580: 1723-8 PubMed GONUTS page

[PMID:15869495-17] Guo H et al. (2005) Development of pontine noradrenergic A5 neurons requires brain-derived neurotrophic factor. Eur J Neurosci 21: 2019-23 PubMed GONUTS page

[PMID:8861722-18] Staecker H et al. (1996) NGF, BDNF and NT-3 play unique roles in the in vitro development and patterning of innervation of the mammalian inner ear. Brain Res Dev Brain Res 92: 49-60 PubMed GONUTS page

[PMID:11747369-19] Wahlin KJ et al. (2001) Neurotrophic signaling in normal and degenerating rodent retinas. Exp Eye Res 73: 693-701 PubMed GONUTS page

[PMID:17442827-20] Lynch G et al. (2007) Brain-derived neurotrophic factor restores synaptic plasticity in a knock-in mouse model of Huntington's disease. J Neurosci 27: 4424-34 PubMed GONUTS page

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MOUSE:BDNF

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