MOUSE:BAX

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Species (Taxon ID)	Mus musculus (Mouse). (taxon:10090)
Gene Name(s)	Bax
Protein Name(s)	Apoptosis regulator BAX
External Links
UniProt Identifier	BAX_MOUSE
UniProt Accessions	Q07813,
EMBL	L22472, BC018228, BC053380,
PIR	D47538,
RefSeq	NP_031553.1,
PDB	2XA0,
IntAct	Q07813,
Ensembl	ENSMUST00000033093,
Pfam	PF00452,

Annotations

Qualifier	GO ID	GO term name	Reference	Evidence Code	with/from	Aspect	Notes	Status
	GO:0046982	protein heterodimerization activity	PMID:7650488^[1]	IPI: Inferred from Physical Interaction	UniProtKB:Q64373	F
	GO:0005739	mitochondrion	PMID:12847083^[2]	IDA: Inferred from Direct Assay		C
	GO:0048087	positive regulation of developmental pigmentation	PMID:9241272^[3]	IGI: Inferred from Genetic Interaction		P
	GO:0010212	response to ionizing radiation	PMID:15578100^[4]	IMP: Inferred from Mutant Phenotype		P
	GO:0007283	spermatogenesis	PMID:11906913^[5]	IMP: Inferred from Mutant Phenotype		P
	GO:0046902	regulation of mitochondrial membrane permeability	PMID:14963330^[6]	IGI: Inferred from Genetic Interaction		P
	GO:0031558	induction of apoptosis in response to chemical stimulus	PMID:14502238^[7]	IMP: Inferred from Mutant Phenotype		P
	GO:0009651	response to salt stress	PMID:16571598^[8]	IGI: Inferred from Genetic Interaction		P
	GO:0001844	protein insertion into mitochondrial membrane involved in induction of apoptosis	PMID:12952892^[9]	IMP: Inferred from Mutant Phenotype		P
	GO:0006808	regulation of nitrogen utilization	PMID:9241272^[3]	IGI: Inferred from Genetic Interaction		P
	GO:0008635	activation of caspase activity by cytochrome c	PMID:11836241^[10]	IMP: Inferred from Mutant Phenotype		P
	GO:0009566	fertilization	PMID:10894153^[11]	IGI: Inferred from Genetic Interaction		P
	GO:0006915	apoptosis	PMID:8358790^[12]	IDA: Inferred from Direct Assay		P
	GO:0043525	positive regulation of neuron apoptosis	PMID:17192424^[13]	IMP: Inferred from Mutant Phenotype		P
	GO:0009636	response to toxin	PMID:9454845^[14]	IMP: Inferred from Mutant Phenotype		P
	GO:0043065	positive regulation of apoptosis	PMID:15967824^[15]	IGI: Inferred from Genetic Interaction		P
	GO:0010212	response to ionizing radiation	PMID:10639175^[16]	IGI: Inferred from Genetic Interaction		P
	GO:0051402	neuron apoptosis	PMID:11226327^[17]	IMP: Inferred from Mutant Phenotype		P
	GO:0005622	intracellular	PMID:9008714^[18]	IDA: Inferred from Direct Assay		C
	GO:0051402	neuron apoptosis	PMID:12917363^[19]	IMP: Inferred from Mutant Phenotype		P
	GO:0005625	soluble fraction	PMID:9553144^[20]	IDA: Inferred from Direct Assay		C
	GO:0042803	protein homodimerization activity	PMID:8631771^[21]	IPI: Inferred from Physical Interaction	UniProtKB:Q07813	F
	GO:0033599	regulation of mammary gland epithelial cell proliferation	PMID:10363969^[22]	IMP: Inferred from Mutant Phenotype		P
	GO:0006974	response to DNA damage stimulus	PMID:12952892^[9]	IMP: Inferred from Mutant Phenotype		P
	GO:0006919	activation of caspase activity	PMID:15776018^[23]	IGI: Inferred from Genetic Interaction		P
	GO:0030264	nuclear fragmentation involved in apoptotic nuclear change	PMID:12925707^[24]	IDA: Inferred from Direct Assay		P
	GO:0051402	neuron apoptosis	PMID:15574493^[25]	IMP: Inferred from Mutant Phenotype		P
	GO:0005515	protein binding	PMID:9463381^[26]	IPI: Inferred from Physical Interaction	UniProtKB:P10415	F
	GO:0005829	cytosol	PMID:11369777^[27]	IDA: Inferred from Direct Assay		C
	GO:0006919	activation of caspase activity	PMID:12847083^[2]	IGI: Inferred from Genetic Interaction		P
	GO:0045136	development of secondary sexual characteristics	PMID:15944391^[28]	IMP: Inferred from Mutant Phenotype		P
	GO:0006915	apoptosis	PMID:9560217^[29]	IDA: Inferred from Direct Assay		P
	GO:0005739	mitochondrion	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0496	C
	GO:0051260	protein homooligomerization	PMID:12925707^[24]	IDA: Inferred from Direct Assay		P
	GO:0035234	germ cell programmed cell death	PMID:14660547^[30]	IGI: Inferred from Genetic Interaction		P
	GO:0008624	induction of apoptosis by extracellular signals	PMID:14507967^[31]	IMP: Inferred from Mutant Phenotype		P
	GO:0051402	neuron apoptosis	PMID:11717344^[32]	IGI: Inferred from Genetic Interaction		P
	GO:0043525	positive regulation of neuron apoptosis	PMID:10762311^[33]	IMP: Inferred from Mutant Phenotype		P
	GO:0043065	positive regulation of apoptosis	PMID:9988273^[34]	IMP: Inferred from Mutant Phenotype		P
	GO:0005737	cytoplasm	PMID:16469926^[35]	IDA: Inferred from Direct Assay		C
	GO:0005829	cytosol	PMID:11864976^[36]	IDA: Inferred from Direct Assay		C
	GO:0008053	mitochondrial fusion	PMID:17035996^[37]	IGI: Inferred from Genetic Interaction		P
	GO:0006915	apoptosis	PMID:14963330^[6]	IGI: Inferred from Genetic Interaction		P
	GO:0005739	mitochondrion	PMID:19139267^[38]	IDA: Inferred from Direct Assay		C
	GO:0006917	induction of apoptosis	PMID:10479688^[39]	IMP: Inferred from Mutant Phenotype		P
	GO:0043065	positive regulation of apoptosis	PMID:9241272^[3]	IMP: Inferred from Mutant Phenotype		P
	GO:0051434	BH3 domain binding	PMID:11060313^[40]	IPI: Inferred from Physical Interaction	UniProtKB:Q96BY2	F
	GO:0043525	positive regulation of neuron apoptosis	PMID:15947791^[41]	IMP: Inferred from Mutant Phenotype		P
	GO:0006974	response to DNA damage stimulus	PMID:9454845^[14]	IMP: Inferred from Mutant Phenotype		P
	GO:0070059	apoptosis in response to endoplasmic reticulum stress	PMID:12847083^[2]	IGI: Inferred from Genetic Interaction		P
	GO:0043065	positive regulation of apoptosis	PMID:11146002^[42]	IMP: Inferred from Mutant Phenotype		P
	GO:0043065	positive regulation of apoptosis	PMID:17107997^[43]	IGI: Inferred from Genetic Interaction		P
	GO:0005741	mitochondrial outer membrane	PMID:12925707^[24]	IDA: Inferred from Direct Assay		C
	GO:0060041	retina development in camera-type eye	PMID:9699561^[44]	IMP: Inferred from Mutant Phenotype		P
	GO:0043065	positive regulation of apoptosis	PMID:16571598^[8]	IGI: Inferred from Genetic Interaction		P
	GO:0005737	cytoplasm	PMID:15528359^[45]	IDA: Inferred from Direct Assay		C
	GO:0042981	regulation of apoptosis	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR002475	P
	GO:0006917	induction of apoptosis	PMID:8358790^[12]	IDA: Inferred from Direct Assay		P
	GO:0005783	endoplasmic reticulum	PMID:12847083^[2]	IDA: Inferred from Direct Assay		C
	GO:0007399	nervous system development	PMID:12810599^[46]	IMP: Inferred from Mutant Phenotype		P
	GO:0002352	B cell negative selection	PMID:16055554^[47]	IGI: Inferred from Genetic Interaction		P
	GO:0005739	mitochondrion	PMID:11864976^[36]	IDA: Inferred from Direct Assay		C
	GO:0002904	positive regulation of B cell apoptosis	PMID:11604501^[48]	IGI: Inferred from Genetic Interaction		P
	GO:0002262	myeloid cell homeostasis	PMID:15967824^[15]	IGI: Inferred from Genetic Interaction		P
	GO:0001782	B cell homeostasis	PMID:15967824^[15]	IGI: Inferred from Genetic Interaction		P
	GO:0001764	neuron migration	PMID:15590937^[49]	IMP: Inferred from Mutant Phenotype		P
	GO:0043525	positive regulation of neuron apoptosis	PMID:8816704^[50]	IMP: Inferred from Mutant Phenotype		P
	GO:0006687	glycosphingolipid metabolic process	PMID:18308723^[51]	IMP: Inferred from Mutant Phenotype		P
	GO:0043065	positive regulation of apoptosis	PMID:17068116^[52]	IMP: Inferred from Mutant Phenotype		P
	GO:0043525	positive regulation of neuron apoptosis	PMID:10683286^[53]	IMP: Inferred from Mutant Phenotype		P
	GO:0001836	release of cytochrome c from mitochondria	PMID:17052454^[54]	IGI: Inferred from Genetic Interaction		P
	GO:0001541	ovarian follicle development	PMID:17244737^[55]	IMP: Inferred from Mutant Phenotype		P
	GO:0001541	ovarian follicle development	PMID:10894153^[11]	IGI: Inferred from Genetic Interaction		P
	GO:0006915	apoptosis	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0053	P
	GO:0005737	cytoplasm	PMID:10931486^[56]	IDA: Inferred from Direct Assay		C
	GO:0007283	spermatogenesis	PMID:10894153^[11]	IGI: Inferred from Genetic Interaction		P
	GO:0048678	response to axon injury	PMID:16103918^[57]	IMP: Inferred from Mutant Phenotype		P
	GO:0007548	sex differentiation	PMID:15342910^[58]	IMP: Inferred from Mutant Phenotype		P
	GO:0010524	positive regulation of calcium ion transport into cytosol	PMID:15613488^[59]	IGI: Inferred from Genetic Interaction		P
	GO:0006915	apoptosis	PMID:10618441^[60]	IMP: Inferred from Mutant Phenotype		P
	GO:0048515	spermatid differentiation	PMID:16270031^[61]	IMP: Inferred from Mutant Phenotype		P
	GO:0033137	negative regulation of peptidyl-serine phosphorylation	PMID:15613488^[59]	IGI: Inferred from Genetic Interaction		P
	GO:0044445	cytosolic part	PMID:9553144^[20]	IDA: Inferred from Direct Assay		C
	GO:0009791	post-embryonic development	PMID:9241272^[3]	IGI: Inferred from Genetic Interaction		P
	GO:0043525	positive regulation of neuron apoptosis	PMID:10639175^[16]	IGI: Inferred from Genetic Interaction		P
	GO:0008285	negative regulation of cell proliferation	PMID:10762311^[33]	IMP: Inferred from Mutant Phenotype		P
	GO:0048872	homeostasis of number of cells	PMID:11163212^[62]	IGI: Inferred from Genetic Interaction		P
	GO:0070059	apoptosis in response to endoplasmic reticulum stress	PMID:15776018^[23]	IGI: Inferred from Genetic Interaction		P
	GO:0005737	cytoplasm	PMID:11226327^[17]	IDA: Inferred from Direct Assay		C
	GO:0008283	cell proliferation	PMID:9176392^[63]	IDA: Inferred from Direct Assay		P
	GO:0009611	response to wounding	PMID:14507967^[31]	IMP: Inferred from Mutant Phenotype		P
	GO:0043525	positive regulation of neuron apoptosis	PMID:10744634^[64]	IGI: Inferred from Genetic Interaction		P
	GO:0043525	positive regulation of neuron apoptosis	PMID:15944391^[28]	IMP: Inferred from Mutant Phenotype		P
	GO:0019987	negative regulation of anti-apoptosis	PMID:8798452^[65]	IGI: Inferred from Genetic Interaction		P
	GO:0006919	activation of caspase activity	PMID:14502238^[7]	IMP: Inferred from Mutant Phenotype		P
	GO:0005829	cytosol	PMID:12925707^[24]	IDA: Inferred from Direct Assay		C
	GO:0005737	cytoplasm	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0086	C
	GO:0001776	leukocyte homeostasis	PMID:11163212^[62]	IGI: Inferred from Genetic Interaction		P
	GO:0001836	release of cytochrome c from mitochondria	PMID:14614769^[66]	IDA: Inferred from Direct Assay		P
	GO:0007281	germ cell development	PMID:10894153^[11]	IGI: Inferred from Genetic Interaction		P
	GO:0001777	T cell homeostatic proliferation	PMID:9241272^[3]	IMP: Inferred from Mutant Phenotype		P
	GO:0001836	release of cytochrome c from mitochondria	PMID:9560217^[29]	IDA: Inferred from Direct Assay		P
	GO:0008629	induction of apoptosis by intracellular signals	PMID:12952892^[9]	IMP: Inferred from Mutant Phenotype		P
	GO:0001782	B cell homeostasis	PMID:16055554^[47]	IMP: Inferred from Mutant Phenotype		P
	GO:0043525	positive regulation of neuron apoptosis	PMID:15590937^[49]	IMP: Inferred from Mutant Phenotype		P
	GO:0005829	cytosol	PMID:12847083^[2]	IDA: Inferred from Direct Assay		C
	GO:0005739	mitochondrion	PMID:11369777^[27]	IDA: Inferred from Direct Assay		C
	GO:0048873	homeostasis of number of cells within a tissue	PMID:15342910^[58]	IMP: Inferred from Mutant Phenotype		P
	GO:0043065	positive regulation of apoptosis	PMID:10995754^[67]	IMP: Inferred from Mutant Phenotype		P
	GO:0048597	post-embryonic camera-type eye morphogenesis	PMID:15955981^[68]	IGI: Inferred from Genetic Interaction		P
	GO:0032471	reduction of endoplasmic reticulum calcium ion concentration	PMID:15613488^[59]	IGI: Inferred from Genetic Interaction		P
	GO:0042981	regulation of apoptosis	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR020717	P
	GO:0043525	positive regulation of neuron apoptosis	PMID:14502238^[7]	IMP: Inferred from Mutant Phenotype		P
	GO:0042803	protein homodimerization activity	PMID:8631771^[21]	IMP: Inferred from Mutant Phenotype		F
	GO:0008635	activation of caspase activity by cytochrome c	PMID:9560217^[29]	IDA: Inferred from Direct Assay		P
	GO:0043525	positive regulation of neuron apoptosis	PMID:16103918^[57]	IMP: Inferred from Mutant Phenotype		P
	GO:0043525	positive regulation of neuron apoptosis	PMID:9699561^[44]	IMP: Inferred from Mutant Phenotype		P
	GO:0046666	retinal cell programmed cell death	PMID:14517994^[69]	IMP: Inferred from Mutant Phenotype		P
	GO:0006919	activation of caspase activity	PMID:14561915^[70]	IMP: Inferred from Mutant Phenotype		P
	GO:0005739	mitochondrion	PMID:15528359^[45]	IDA: Inferred from Direct Assay		C
	GO:0005737	cytoplasm	PMID:10486519^[71]	IDA: Inferred from Direct Assay		C
	GO:0043525	positive regulation of neuron apoptosis	PMID:11150333^[72]	IMP: Inferred from Mutant Phenotype		P
	GO:0006915	apoptosis	PMID:10201940^[73]	IMP: Inferred from Mutant Phenotype		P
	GO:0016020	membrane	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0472	C
	GO:0042981	regulation of apoptosis	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR020728	P
	GO:0021987	cerebral cortex development	PMID:15342910^[58]	IMP: Inferred from Mutant Phenotype		P
	GO:0007283	spermatogenesis	PMID:7569956^[74]	IMP: Inferred from Mutant Phenotype		P
	GO:0005515	protein binding	PMID:9843949^[75]	IPI: Inferred from Physical Interaction	UniProtKB:P21796	F
	GO:0046982	protein heterodimerization activity	PMID:11226327^[17]	IPI: Inferred from Physical Interaction	UniProtKB:P10417	F
	GO:0005741	mitochondrial outer membrane	PMID:12910269^[76]	IDA: Inferred from Direct Assay		C
	GO:0006915	apoptosis	PMID:15967824^[15]	IGI: Inferred from Genetic Interaction		P
	GO:0005829	cytosol	PMID:15989966^[77]	IDA: Inferred from Direct Assay		C
	GO:0048872	homeostasis of number of cells	PMID:10931486^[56]	IMP: Inferred from Mutant Phenotype		P
	GO:0005741	mitochondrial outer membrane	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0172	C
	GO:0043065	positive regulation of apoptosis	PMID:15955981^[68]	IGI: Inferred from Genetic Interaction		P
	GO:0005829	cytosol	PMID:11980919^[78]	IDA: Inferred from Direct Assay		C
	GO:0060058	positive regulation of apoptosis involved in mammary gland involution	PMID:10363969^[22]	IMP: Inferred from Mutant Phenotype		P
	GO:0051281	positive regulation of release of sequestered calcium ion into cytosol	PMID:15947791^[41]	IMP: Inferred from Mutant Phenotype		P
	GO:0051726	regulation of cell cycle	PMID:16055554^[47]	IGI: Inferred from Genetic Interaction		P
	GO:0005737	cytoplasm	PMID:10464378^[79]	IDA: Inferred from Direct Assay		C
	GO:0043525	positive regulation of neuron apoptosis	PMID:10884318^[80]	IGI: Inferred from Genetic Interaction		P
	GO:0048873	homeostasis of number of cells within a tissue	PMID:11413548^[81]	IMP: Inferred from Mutant Phenotype		P
	GO:0043524	negative regulation of neuron apoptosis	PMID:8625820^[82]	IDA: Inferred from Direct Assay		P
	GO:0035234	germ cell programmed cell death	PMID:17107997^[43]	IGI: Inferred from Genetic Interaction		P
	GO:0051881	regulation of mitochondrial membrane potential	PMID:14614769^[66]	IDA: Inferred from Direct Assay		P
	GO:0031966	mitochondrial membrane	PMID:11369777^[27]	IDA: Inferred from Direct Assay		C
	GO:0042981	regulation of apoptosis	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR000712	P
	GO:0060011	Sertoli cell proliferation	PMID:11784036^[83]	IGI: Inferred from Genetic Interaction		P
	GO:0008584	male gonad development	PMID:9241272^[3]	IGI: Inferred from Genetic Interaction		P
	GO:0005737	cytoplasm	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0963	C
	GO:0043525	positive regulation of neuron apoptosis	PMID:9096145^[84]	IGI: Inferred from Genetic Interaction		P
	GO:0043065	positive regulation of apoptosis	PMID:15753097^[85]	IDA: Inferred from Direct Assay		P
	GO:0043065	positive regulation of apoptosis	PMID:15578100^[4]	IMP: Inferred from Mutant Phenotype		P
	GO:0031966	mitochondrial membrane	PMID:11980919^[78]	IDA: Inferred from Direct Assay		C
	GO:0042803	protein homodimerization activity	PMID:10582606^[86]	IPI: Inferred from Physical Interaction	UniProtKB:P10417	F
	GO:0043525	positive regulation of neuron apoptosis	PMID:9454852^[87]	IMP: Inferred from Mutant Phenotype		P
	GO:0008584	male gonad development	PMID:16270031^[61]	IMP: Inferred from Mutant Phenotype		P
	GO:0042981	regulation of apoptosis	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR020726	P
	GO:0043065	positive regulation of apoptosis	PMID:11906913^[5]	IMP: Inferred from Mutant Phenotype		P
	GO:0051402	neuron apoptosis	PMID:17077143^[88]	IGI: Inferred from Genetic Interaction		P
	GO:0043525	positive regulation of neuron apoptosis	PMID:15869495^[89]	IMP: Inferred from Mutant Phenotype		P
	GO:0008053	mitochondrial fusion	PMID:16893972^[90]	IGI: Inferred from Genetic Interaction		P
	GO:0043281	regulation of caspase activity	PMID:14507967^[31]	IMP: Inferred from Mutant Phenotype		P
	GO:0005739	mitochondrion	PMID:18614015^[91]	IDA: Inferred from Direct Assay		C
	GO:0042475	odontogenesis of dentine-containing tooth	PMID:15967824^[15]	IGI: Inferred from Genetic Interaction		P
	GO:0005622	intracellular	PMID:11146504^[92]	IDA: Inferred from Direct Assay		C
	GO:0008624	induction of apoptosis by extracellular signals	PMID:12925707^[24]	IMP: Inferred from Mutant Phenotype		P
	GO:0001836	release of cytochrome c from mitochondria	PMID:14963330^[6]	IGI: Inferred from Genetic Interaction		P
	GO:0001776	leukocyte homeostasis	PMID:15967824^[15]	IGI: Inferred from Genetic Interaction		P
	GO:0001783	B cell apoptosis	PMID:16055554^[47]	IGI: Inferred from Genetic Interaction		P
	GO:0001836	release of cytochrome c from mitochondria	PMID:12925707^[24]	IDA: Inferred from Direct Assay		P
	GO:0005829	cytosol	PMID:16227588^[93]	IDA: Inferred from Direct Assay		C
	GO:0001777	T cell homeostatic proliferation	PMID:7569956^[74]	IMP: Inferred from Mutant Phenotype		P
	GO:0001974	blood vessel remodeling	PMID:15955981^[68]	IGI: Inferred from Genetic Interaction		P
	GO:0005739	mitochondrion	PMID:14651853^[94]	IDA: Inferred from Direct Assay		C
	GO:0002358	B cell homeostatic proliferation	PMID:7569956^[74]	IMP: Inferred from Mutant Phenotype		P
	GO:0001101	response to acid	PMID:7675327^[95]	IDA: Inferred from Direct Assay		P
	GO:0001822	kidney development	PMID:9241272^[3]	IGI: Inferred from Genetic Interaction		P
	GO:0051402	neuron apoptosis	PMID:10762311^[33]	IGI: Inferred from Genetic Interaction		P
	GO:0005739	mitochondrion	PMID:16469926^[35]	IDA: Inferred from Direct Assay		C
	GO:0021854	hypothalamus development	PMID:15342910^[58]	IMP: Inferred from Mutant Phenotype		P
	GO:0034644	cellular response to UV	PMID:14963330^[6]	IGI: Inferred from Genetic Interaction		P
	GO:0005741	mitochondrial outer membrane	PMID:16227588^[93]	IDA: Inferred from Direct Assay		C
	GO:0010332	response to gamma radiation	PMID:17068116^[52]	IMP: Inferred from Mutant Phenotype		P
	GO:0035108	limb morphogenesis	PMID:11163212^[62]	IGI: Inferred from Genetic Interaction		P
	GO:0016021	integral to membrane	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0812	C
	GO:0008283	cell proliferation	PMID:10762311^[33]	IGI: Inferred from Genetic Interaction		P
	GO:0046982	protein heterodimerization activity	PMID:8798452^[65]	IPI: Inferred from Physical Interaction	UniProtKB:Q64373-1	F
	GO:0005829	cytosol	PMID:19139267^[38]	IDA: Inferred from Direct Assay		C
	GO:0005741	mitochondrial outer membrane	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-1000	C
	GO:0031966	mitochondrial membrane	PMID:14614769^[66]	IDA: Inferred from Direct Assay		C
	GO:0043065	positive regulation of apoptosis	PMID:9056387^[96]	IGI: Inferred from Genetic Interaction		P
	GO:0060068	vagina development	PMID:11163212^[62]	IGI: Inferred from Genetic Interaction		P
	GO:0008637	apoptotic mitochondrial changes	PMID:12925707^[24]	IDA: Inferred from Direct Assay		P
	GO:0048147	negative regulation of fibroblast proliferation	PMID:12952892^[9]	IMP: Inferred from Mutant Phenotype		P
	GO:0007283	spermatogenesis	PMID:7569956^[74]	IMP: Inferred from Mutant Phenotype		P	Fig 2 A, C-J, Fig 3) Bax- mutants were incapable of spermatogenesis.	complete
	GO:0001101	response to acid	PMID:7675327^[95]	IDA: Inferred from Direct Assay		P
	GO:0001541	ovarian follicle development	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000028328	P
	GO:0001541	ovarian follicle development	PMID:10894153^[11]	IGI: Inferred from Genetic Interaction	MGI:MGI:2176699	P
	GO:0001541	ovarian follicle development	PMID:17244737^[55]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1857429	P
	GO:0001764	neuron migration	PMID:15590937^[49]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1857429	P
	GO:0001776	leukocyte homeostasis	PMID:11163212^[62]	IGI: Inferred from Genetic Interaction	MGI:MGI:1097161	P
	GO:0001776	leukocyte homeostasis	PMID:15967824^[15]	IGI: Inferred from Genetic Interaction	MGI:MGI:1197519	P
	GO:0001777	T cell homeostatic proliferation	PMID:7569956^[74]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1857429	P
	GO:0001777	T cell homeostatic proliferation	PMID:9241272^[3]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1857429	P
	GO:0001782	B cell homeostasis	PMID:15967824^[15]	IGI: Inferred from Genetic Interaction	MGI:MGI:1197519	P
	GO:0001782	B cell homeostasis	PMID:16055554^[47]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1857429	P
	GO:0001783	B cell apoptosis	PMID:16055554^[47]	IGI: Inferred from Genetic Interaction	MGI:MGI:1097161	P
	GO:0001822	kidney development	PMID:9241272^[3]	IGI: Inferred from Genetic Interaction	MGI:MGI:88138	P
	GO:0001836	release of cytochrome c from mitochondria	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000028328	P
	GO:0001836	release of cytochrome c from mitochondria	PMID:12925707^[24]	IDA: Inferred from Direct Assay		P
	GO:0001836	release of cytochrome c from mitochondria	PMID:14614769^[66]	IDA: Inferred from Direct Assay		P
	GO:0001836	release of cytochrome c from mitochondria	PMID:14963330^[6]	IGI: Inferred from Genetic Interaction	MGI:MGI:98834	P
	GO:0001836	release of cytochrome c from mitochondria	PMID:17052454^[54]	IGI: Inferred from Genetic Interaction	MGI:MGI:108093	P
	GO:0001836	release of cytochrome c from mitochondria	PMID:9560217^[29]	IDA: Inferred from Direct Assay		P
	GO:0001844	protein insertion into mitochondrial membrane involved in induction of apoptosis	PMID:12952892^[9]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1857429	P
	GO:0001974	blood vessel remodeling	PMID:15955981^[68]	IGI: Inferred from Genetic Interaction	MGI:MGI:1097161	P
	GO:0002262	myeloid cell homeostasis	PMID:15967824^[15]	IGI: Inferred from Genetic Interaction	MGI:MGI:1197519	P
	GO:0002352	B cell negative selection	PMID:16055554^[47]	IGI: Inferred from Genetic Interaction	MGI:MGI:1097161	P
	GO:0002358	B cell homeostatic proliferation	PMID:7569956^[74]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1857429	P
	GO:0002904	positive regulation of B cell apoptosis	PMID:11604501^[48]	IGI: Inferred from Genetic Interaction	MGI:MGI:97250	P
	GO:0005515	protein binding	PMID:9463381^[26]	IPI: Inferred from Physical Interaction	UniProtKB:P10415	F
	GO:0005515	protein binding	PMID:9843949^[75]	IPI: Inferred from Physical Interaction	UniProtKB:P21796	F
	GO:0005622	intracellular	PMID:11146504^[92]	IDA: Inferred from Direct Assay		C
	GO:0005622	intracellular	PMID:9008714^[18]	IDA: Inferred from Direct Assay		C
	GO:0005625	soluble fraction	PMID:9553144^[20]	IDA: Inferred from Direct Assay		C
	GO:0005737	cytoplasm	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0963	C
	GO:0005737	cytoplasm	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000028328	C
	GO:0005737	cytoplasm	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0086	C
	GO:0005737	cytoplasm	PMID:10464378^[79]	IDA: Inferred from Direct Assay		C
	GO:0005737	cytoplasm	PMID:10486519^[71]	IDA: Inferred from Direct Assay		C
	GO:0005737	cytoplasm	PMID:10931486^[56]	IDA: Inferred from Direct Assay		C
	GO:0005737	cytoplasm	PMID:11226327^[17]	IDA: Inferred from Direct Assay		C
	GO:0005737	cytoplasm	PMID:15528359^[45]	IDA: Inferred from Direct Assay		C
	GO:0005737	cytoplasm	PMID:16469926^[35]	IDA: Inferred from Direct Assay		C
	GO:0005739	mitochondrion	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0496	C
	GO:0005739	mitochondrion	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000028328	C
	GO:0005739	mitochondrion	PMID:11369777^[27]	IDA: Inferred from Direct Assay		C
	GO:0005739	mitochondrion	PMID:11864976^[36]	IDA: Inferred from Direct Assay		C
	GO:0005739	mitochondrion	PMID:12847083^[2]	IDA: Inferred from Direct Assay		C
	GO:0005739	mitochondrion	PMID:14651853^[94]	IDA: Inferred from Direct Assay		C
	GO:0005739	mitochondrion	PMID:15528359^[45]	IDA: Inferred from Direct Assay		C
	GO:0005739	mitochondrion	PMID:16469926^[35]	IDA: Inferred from Direct Assay		C
	GO:0005739	mitochondrion	PMID:18614015^[91]	IDA: Inferred from Direct Assay		C
	GO:0005739	mitochondrion	PMID:19139267^[38]	IDA: Inferred from Direct Assay		C
	GO:0005741	mitochondrial outer membrane	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-1000	C
	GO:0005741	mitochondrial outer membrane	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0172	C
	GO:0005741	mitochondrial outer membrane	PMID:12910269^[76]	IDA: Inferred from Direct Assay		C
	GO:0005741	mitochondrial outer membrane	PMID:12925707^[24]	IDA: Inferred from Direct Assay		C
	GO:0005741	mitochondrial outer membrane	PMID:16227588^[93]	IDA: Inferred from Direct Assay		C
	GO:0005783	endoplasmic reticulum	PMID:12847083^[2]	IDA: Inferred from Direct Assay		C
	GO:0005829	cytosol	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000028328	C
	GO:0005829	cytosol	PMID:11369777^[27]	IDA: Inferred from Direct Assay		C
	GO:0005829	cytosol	PMID:11864976^[36]	IDA: Inferred from Direct Assay		C
	GO:0005829	cytosol	PMID:11980919^[78]	IDA: Inferred from Direct Assay		C
	GO:0005829	cytosol	PMID:12847083^[2]	IDA: Inferred from Direct Assay		C
	GO:0005829	cytosol	PMID:12925707^[24]	IDA: Inferred from Direct Assay		C
	GO:0005829	cytosol	PMID:15989966^[77]	IDA: Inferred from Direct Assay		C
	GO:0005829	cytosol	PMID:16227588^[93]	IDA: Inferred from Direct Assay		C
	GO:0005829	cytosol	PMID:19139267^[38]	IDA: Inferred from Direct Assay		C
	GO:0006687	glycosphingolipid metabolic process	PMID:18308723^[51]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1857429	P
	GO:0006808	regulation of nitrogen utilization	PMID:9241272^[3]	IGI: Inferred from Genetic Interaction	MGI:MGI:88138	P
	GO:0006915	apoptosis	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0053	P
	GO:0006915	apoptosis	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000028328	P
	GO:0006915	apoptosis	PMID:10201940^[73]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1857429	P
	GO:0006915	apoptosis	PMID:10618441^[60]	IMP: Inferred from Mutant Phenotype		P
	GO:0006915	apoptosis	PMID:14963330^[6]	IGI: Inferred from Genetic Interaction	MGI:MGI:98834	P
	GO:0006915	apoptosis	PMID:15967824^[15]	IGI: Inferred from Genetic Interaction	MGI:MGI:1197519	P
	GO:0006915	apoptosis	PMID:8358790^[12]	IDA: Inferred from Direct Assay		P
	GO:0006915	apoptosis	PMID:9560217^[29]	IDA: Inferred from Direct Assay		P
	GO:0006917	induction of apoptosis	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000028328	P
	GO:0006917	induction of apoptosis	PMID:10479688^[39]	IMP: Inferred from Mutant Phenotype		P
	GO:0006917	induction of apoptosis	PMID:8358790^[12]	IDA: Inferred from Direct Assay		P
	GO:0006919	activation of caspase activity	PMID:12847083^[2]	IGI: Inferred from Genetic Interaction	MGI:MGI:1097161	P
	GO:0006919	activation of caspase activity	PMID:14502238^[7]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2158306	P
	GO:0006919	activation of caspase activity	PMID:14561915^[70]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1857429	P
	GO:0006919	activation of caspase activity	PMID:15776018^[23]	IGI: Inferred from Genetic Interaction	MGI:MGI:1097161	P
	GO:0006919	activation of caspase activity	PMID:16735463^[97]	IDA: Inferred from Direct Assay		P
	GO:0006974	response to DNA damage stimulus	PMID:12952892^[9]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1857429	P
	GO:0006974	response to DNA damage stimulus	PMID:9454845^[14]	IMP: Inferred from Mutant Phenotype		P
	GO:0007007	inner mitochondrial membrane organization	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000028328	P
	GO:0007008	outer mitochondrial membrane organization	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000028328	P
	GO:0007281	germ cell development	PMID:10894153^[11]	IGI: Inferred from Genetic Interaction	MGI:MGI:2176699	P
	GO:0007283	spermatogenesis	PMID:10894153^[11]	IGI: Inferred from Genetic Interaction	MGI:MGI:2176699	P
	GO:0007283	spermatogenesis	PMID:11906913^[5]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1857429	P
	GO:0007283	spermatogenesis	PMID:7569956^[74]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1857429	P
	GO:0007399	nervous system development	PMID:12810599^[46]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2387665	P
	GO:0007420	brain development	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000028328	P
	GO:0007548	sex differentiation	PMID:15342910^[58]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1857429	P
	GO:0008283	cell proliferation	PMID:10762311^[33]	IGI: Inferred from Genetic Interaction	MGI:MGI:88138	P
	GO:0008283	cell proliferation	PMID:9176392^[63]	IDA: Inferred from Direct Assay		P
	GO:0008285	negative regulation of cell proliferation	PMID:10762311^[33]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1857429	P
	GO:0008584	male gonad development	PMID:16270031^[61]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1857429	P
	GO:0008584	male gonad development	PMID:9241272^[3]	IGI: Inferred from Genetic Interaction	MGI:MGI:88138	P
	GO:0008624	induction of apoptosis by extracellular signals	PMID:12925707^[24]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1857429	P
	GO:0008624	induction of apoptosis by extracellular signals	PMID:14507967^[31]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1857429	P
	GO:0008629	induction of apoptosis by intracellular signals	PMID:12952892^[9]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1857429	P
	GO:0008635	activation of caspase activity by cytochrome c	PMID:11836241^[10]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1857429	P
	GO:0008635	activation of caspase activity by cytochrome c	PMID:9560217^[29]	IDA: Inferred from Direct Assay		P
	GO:0008637	apoptotic mitochondrial changes	PMID:12925707^[24]	IDA: Inferred from Direct Assay		P
	GO:0009566	fertilization	PMID:10894153^[11]	IGI: Inferred from Genetic Interaction	MGI:MGI:2176699	P
	GO:0009611	response to wounding	PMID:14507967^[31]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1857429	P
	GO:0009636	response to toxin	PMID:9454845^[14]	IMP: Inferred from Mutant Phenotype		P
	GO:0009791	post-embryonic development	PMID:9241272^[3]	IGI: Inferred from Genetic Interaction	MGI:MGI:88138	P
	GO:0010212	response to ionizing radiation	PMID:10639175^[16]	IGI: Inferred from Genetic Interaction	MGI:MGI:107202	P
	GO:0010212	response to ionizing radiation	PMID:15578100^[4]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1857429	P
	GO:0010332	response to gamma radiation	PMID:17068116^[52]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1857429	P
	GO:0010524	positive regulation of calcium ion transport into cytosol	PMID:15613488^[59]	IGI: Inferred from Genetic Interaction	MGI:MGI:1097161	P
	GO:0016020	membrane	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0472	C
	GO:0016021	integral to membrane	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0812	C
	GO:0019987	negative regulation of anti-apoptosis	PMID:8798452^[65]	IGI: Inferred from Genetic Interaction	MGI:MGI:88139	P
	GO:0021854	hypothalamus development	PMID:15342910^[58]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1857429	P
	GO:0021987	cerebral cortex development	PMID:15342910^[58]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1857429	P
	GO:0030264	nuclear fragmentation involved in apoptotic nuclear change	PMID:12925707^[24]	IDA: Inferred from Direct Assay		P
	GO:0031072	heat shock protein binding	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000028328	F
	GO:0031558	induction of apoptosis in response to chemical stimulus	PMID:14502238^[7]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2158306	P
	GO:0031966	mitochondrial membrane	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000028328	C
	GO:0031966	mitochondrial membrane	PMID:11369777^[27]	IDA: Inferred from Direct Assay		C
	GO:0031966	mitochondrial membrane	PMID:11980919^[78]	IDA: Inferred from Direct Assay		C
	GO:0031966	mitochondrial membrane	PMID:14614769^[66]	IDA: Inferred from Direct Assay		C
	GO:0032471	reduction of endoplasmic reticulum calcium ion concentration	PMID:15613488^[59]	IGI: Inferred from Genetic Interaction	MGI:MGI:1097161	P
	GO:0033137	negative regulation of peptidyl-serine phosphorylation	PMID:15613488^[59]	IGI: Inferred from Genetic Interaction	MGI:MGI:1097161	P
	GO:0033599	regulation of mammary gland epithelial cell proliferation	PMID:10363969^[22]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1857429	P
	GO:0034349	glial cell apoptosis	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000028328	P
	GO:0034644	cellular response to UV	PMID:14963330^[6]	IGI: Inferred from Genetic Interaction	MGI:MGI:98834	P
	GO:0035108	limb morphogenesis	PMID:11163212^[62]	IGI: Inferred from Genetic Interaction	MGI:MGI:1097161	P
	GO:0035234	germ cell programmed cell death	PMID:14660547^[30]	IGI: Inferred from Genetic Interaction	MGI:MGI:96677	P
	GO:0035234	germ cell programmed cell death	PMID:14660547^[30]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1857429	P
	GO:0035234	germ cell programmed cell death	PMID:17107997^[43]	IGI: Inferred from Genetic Interaction	MGI:MGI:96974	P
	GO:0042220	response to cocaine	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000028328	P
	GO:0042475	odontogenesis of dentine-containing tooth	PMID:15967824^[15]	IGI: Inferred from Genetic Interaction	MGI:MGI:1197519	P
	GO:0042493	response to drug	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000028328	P
	GO:0042803	protein homodimerization activity	PMID:10582606^[86]	IPI: Inferred from Physical Interaction	UniProtKB:P10417	F
	GO:0042803	protein homodimerization activity	PMID:8631771^[21]	IMP: Inferred from Mutant Phenotype		F
	GO:0042803	protein homodimerization activity	PMID:8631771^[21]	IPI: Inferred from Physical Interaction	UniProtKB:Q07813	F
	GO:0042981	regulation of apoptosis	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR000712	P
	GO:0042981	regulation of apoptosis	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR002475	P
	GO:0042981	regulation of apoptosis	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR020717	P
	GO:0042981	regulation of apoptosis	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR020726	P
	GO:0042981	regulation of apoptosis	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR020728	P
	GO:0043065	positive regulation of apoptosis	PMID:10995754^[67]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1857429	P
	GO:0043065	positive regulation of apoptosis	PMID:11146002^[42]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1857429	P
	GO:0043065	positive regulation of apoptosis	PMID:11906913^[5]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1857429	P
	GO:0043065	positive regulation of apoptosis	PMID:15578100^[4]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1857429	P
	GO:0043065	positive regulation of apoptosis	PMID:15753097^[85]	IDA: Inferred from Direct Assay		P
	GO:0043065	positive regulation of apoptosis	PMID:15955981^[68]	IGI: Inferred from Genetic Interaction	MGI:MGI:1097161	P
	GO:0043065	positive regulation of apoptosis	PMID:15967824^[15]	IGI: Inferred from Genetic Interaction	MGI:MGI:1197519	P
	GO:0043065	positive regulation of apoptosis	PMID:17068116^[52]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1857429	P
	GO:0043065	positive regulation of apoptosis	PMID:17107997^[43]	IGI: Inferred from Genetic Interaction	MGI:MGI:96974	P
	GO:0043065	positive regulation of apoptosis	PMID:9056387^[96]	IGI: Inferred from Genetic Interaction	MGI:MGI:98834	P
	GO:0043065	positive regulation of apoptosis	PMID:9241272^[3]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1857429	P
	GO:0043065	positive regulation of apoptosis	PMID:9988273^[34]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1857429	P
	GO:0043281	regulation of caspase activity	PMID:14507967^[31]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1857429	P
	GO:0043524	negative regulation of neuron apoptosis	PMID:8625820^[82]	IDA: Inferred from Direct Assay		P
	GO:0043525	positive regulation of neuron apoptosis	PMID:10639175^[16]	IGI: Inferred from Genetic Interaction	MGI:MGI:107202	P
	GO:0043525	positive regulation of neuron apoptosis	PMID:10683286^[53]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1857429	P
	GO:0043525	positive regulation of neuron apoptosis	PMID:10744634^[64]	IGI: Inferred from Genetic Interaction	MGI:MGI:95824	P
	GO:0043525	positive regulation of neuron apoptosis	PMID:10762311^[33]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1857429	P
	GO:0043525	positive regulation of neuron apoptosis	PMID:10884318^[80]	IGI: Inferred from Genetic Interaction	MGI:MGI:95813	P
	GO:0043525	positive regulation of neuron apoptosis	PMID:11150333^[72]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2158306	P
	GO:0043525	positive regulation of neuron apoptosis	PMID:14502238^[7]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2158306	P
	GO:0043525	positive regulation of neuron apoptosis	PMID:15590937^[49]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1857429	P
	GO:0043525	positive regulation of neuron apoptosis	PMID:15869495^[89]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1857429	P
	GO:0043525	positive regulation of neuron apoptosis	PMID:15944391^[28]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1857429	P
	GO:0043525	positive regulation of neuron apoptosis	PMID:15947791^[41]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1857429	P
	GO:0043525	positive regulation of neuron apoptosis	PMID:16103918^[57]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1857429	P
	GO:0043525	positive regulation of neuron apoptosis	PMID:17192424^[13]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1857429	P
	GO:0043525	positive regulation of neuron apoptosis	PMID:8816704^[50]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1857429	P
	GO:0043525	positive regulation of neuron apoptosis	PMID:9096145^[84]	IGI: Inferred from Genetic Interaction	MGI:MGI:88139	P
	GO:0043525	positive regulation of neuron apoptosis	PMID:9454852^[87]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1857429	P
	GO:0043525	positive regulation of neuron apoptosis	PMID:9699561^[44]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1857429	P
	GO:0044445	cytosolic part	PMID:9553144^[20]	IDA: Inferred from Direct Assay		C
	GO:0045136	development of secondary sexual characteristics	PMID:15944391^[28]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1857429	P
	GO:0045333	cellular respiration	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000028328	P
	GO:0046666	retinal cell programmed cell death	PMID:14517994^[69]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1857429	P
	GO:0046688	response to copper ion	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000028328	P
	GO:0046982	protein heterodimerization activity	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000028328	F
	GO:0046982	protein heterodimerization activity	PMID:11226327^[17]	IPI: Inferred from Physical Interaction	UniProtKB:P10417	F
	GO:0046982	protein heterodimerization activity	PMID:7650488^[1]	IPI: Inferred from Physical Interaction	UniProtKB:Q64373	F
	GO:0046982	protein heterodimerization activity	PMID:7834748^[98]	IPI: Inferred from Physical Interaction	UniProtKB:Q64373	F
	GO:0046982	protein heterodimerization activity	PMID:8798452^[65]	IPI: Inferred from Physical Interaction	UniProtKB:Q64373-1	F
	GO:0048087	positive regulation of developmental pigmentation	PMID:9241272^[3]	IGI: Inferred from Genetic Interaction	MGI:MGI:99702	P
	GO:0048147	negative regulation of fibroblast proliferation	PMID:12952892^[9]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1857429	P
	GO:0048515	spermatid differentiation	PMID:16270031^[61]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1857429	P
	GO:0048597	post-embryonic camera-type eye morphogenesis	PMID:15955981^[68]	IGI: Inferred from Genetic Interaction	MGI:MGI:1097161	P
	GO:0048678	response to axon injury	PMID:16103918^[57]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1857429	P
	GO:0048872	homeostasis of number of cells	PMID:10931486^[56]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1857429	P
	GO:0048872	homeostasis of number of cells	PMID:11163212^[62]	IGI: Inferred from Genetic Interaction	MGI:MGI:1097161	P
	GO:0048873	homeostasis of number of cells within a tissue	PMID:11413548^[81]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1857429	P
	GO:0048873	homeostasis of number of cells within a tissue	PMID:15342910^[58]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1857249	P
	GO:0051087	chaperone binding	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000028328	F
	GO:0051260	protein homooligomerization	PMID:12925707^[24]	IDA: Inferred from Direct Assay		P
	GO:0051281	positive regulation of release of sequestered calcium ion into cytosol	PMID:15947791^[41]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1857429	P
	GO:0051400	BH domain binding	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000028328	F
	GO:0051402	neuron apoptosis	PMID:10762311^[33]	IGI: Inferred from Genetic Interaction	MGI:MGI:88138	P
	GO:0051402	neuron apoptosis	PMID:11226327^[17]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1857429	P
	GO:0051402	neuron apoptosis	PMID:12917363^[19]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1857429	P
	GO:0051402	neuron apoptosis	PMID:15574493^[25]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1857429	P
	GO:0051402	neuron apoptosis	PMID:17077143^[88]	IGI: Inferred from Genetic Interaction	MGI:MGI:95819	P
	GO:0051412	response to corticosterone stimulus	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000028328	P
	GO:0051434	BH3 domain binding	PMID:11060313^[40]	IPI: Inferred from Physical Interaction	UniProtKB:Q96BY2	F
	GO:0051726	regulation of cell cycle	PMID:16055554^[47]	IGI: Inferred from Genetic Interaction	MGI:MGI:1097161	P
	GO:0060041	retina development in camera-type eye	PMID:9699561^[44]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1857429	P
	GO:0060058	positive regulation of apoptosis involved in mammary gland involution	PMID:10363969^[22]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1857429	P
	GO:0060068	vagina development	PMID:11163212^[62]	IGI: Inferred from Genetic Interaction	MGI:MGI:1097161	P
	GO:0070059	apoptosis in response to endoplasmic reticulum stress	PMID:12847083^[2]	IGI: Inferred from Genetic Interaction	MGI:MGI:1097161	P
NOT	GO:0051881	regulation of mitochondrial membrane potential	PMID:14614769^[66]	IDA: Inferred from Direct Assay		P
edit table

Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Chao DT et al. (1995) Bcl-XL and Bcl-2 repress a common pathway of cell death. J Exp Med 182: 821-8 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 ^2.6 ^2.7 ^2.8 ^2.9 Zong WX et al. (2003) Bax and Bak can localize to the endoplasmic reticulum to initiate apoptosis. J Cell Biol 162: 59-69 PubMed GONUTS page
↑ ^3.00 ^3.01 ^3.02 ^3.03 ^3.04 ^3.05 ^3.06 ^3.07 ^3.08 ^3.09 ^3.10 ^3.11 ^3.12 ^3.13 Knudson CM & Korsmeyer SJ (1997) Bcl-2 and Bax function independently to regulate cell death. Nat Genet 16: 358-63 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 Tessner TG et al. (2004) Prostaglandin E2 reduces radiation-induced epithelial apoptosis through a mechanism involving AKT activation and bax translocation. J Clin Invest 114: 1676-85 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 ^5.3 Russell LD et al. (2002) Bax-dependent spermatogonia apoptosis is required for testicular development and spermatogenesis. Biol Reprod 66: 950-8 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 ^6.3 ^6.4 ^6.5 ^6.6 Chipuk JE et al. (2004) Direct activation of Bax by p53 mediates mitochondrial membrane permeabilization and apoptosis. Science 303: 1010-4 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 ^7.3 ^7.4 ^7.5 Young C et al. (2003) Ethanol-induced neuronal apoptosis in vivo requires BAX in the developing mouse brain. Cell Death Differ 10: 1148-55 PubMed GONUTS page
↑ ^8.0 ^8.1 Fan H et al. (2006) Susceptibility to metanephric apoptosis in bradykinin B2 receptor null mice via the p53-Bax pathway. Am J Physiol Renal Physiol 291: F670-82 PubMed GONUTS page
↑ ^9.0 ^9.1 ^9.2 ^9.3 ^9.4 ^9.5 ^9.6 ^9.7 Shibue T et al. (2003) Integral role of Noxa in p53-mediated apoptotic response. Genes Dev 17: 2233-8 PubMed GONUTS page
↑ ^10.0 ^10.1 Degenhardt K et al. (2002) Bax and Bak independently promote cytochrome C release from mitochondria. J Biol Chem 277: 14127-34 PubMed GONUTS page
↑ ^11.0 ^11.1 ^11.2 ^11.3 ^11.4 ^11.5 ^11.6 ^11.7 Rucker EB 3rd et al. (2000) Bcl-x and Bax regulate mouse primordial germ cell survival and apoptosis during embryogenesis. Mol Endocrinol 14: 1038-52 PubMed GONUTS page
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↑ ^13.0 ^13.1 Buss RR et al. (2006) Neuromuscular development in the absence of programmed cell death: phenotypic alteration of motoneurons and muscle. J Neurosci 26: 13413-27 PubMed GONUTS page
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↑ ^15.00 ^15.01 ^15.02 ^15.03 ^15.04 ^15.05 ^15.06 ^15.07 ^15.08 ^15.09 ^15.10 ^15.11 Hutcheson J et al. (2005) Combined loss of proapoptotic genes Bak or Bax with Bim synergizes to cause defects in hematopoiesis and in thymocyte apoptosis. J Exp Med 201: 1949-60 PubMed GONUTS page
↑ ^16.0 ^16.1 ^16.2 ^16.3 Chong MJ et al. (2000) Atm and Bax cooperate in ionizing radiation-induced apoptosis in the central nervous system. Proc Natl Acad Sci U S A 97: 889-94 PubMed GONUTS page
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[PMID:7650488-0] 1.0 ^1.1 Chao DT et al. (1995) Bcl-XL and Bcl-2 repress a common pathway of cell death. J Exp Med 182: 821-8 PubMed GONUTS page

[PMID:12847083-1] 2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 ^2.6 ^2.7 ^2.8 ^2.9 Zong WX et al. (2003) Bax and Bak can localize to the endoplasmic reticulum to initiate apoptosis. J Cell Biol 162: 59-69 PubMed GONUTS page

[PMID:9241272-2] 3.00 ^3.01 ^3.02 ^3.03 ^3.04 ^3.05 ^3.06 ^3.07 ^3.08 ^3.09 ^3.10 ^3.11 ^3.12 ^3.13 Knudson CM & Korsmeyer SJ (1997) Bcl-2 and Bax function independently to regulate cell death. Nat Genet 16: 358-63 PubMed GONUTS page

[PMID:15578100-3] 4.0 ^4.1 ^4.2 ^4.3 Tessner TG et al. (2004) Prostaglandin E2 reduces radiation-induced epithelial apoptosis through a mechanism involving AKT activation and bax translocation. J Clin Invest 114: 1676-85 PubMed GONUTS page

[PMID:11906913-4] 5.0 ^5.1 ^5.2 ^5.3 Russell LD et al. (2002) Bax-dependent spermatogonia apoptosis is required for testicular development and spermatogenesis. Biol Reprod 66: 950-8 PubMed GONUTS page

[PMID:14963330-5] 6.0 ^6.1 ^6.2 ^6.3 ^6.4 ^6.5 ^6.6 Chipuk JE et al. (2004) Direct activation of Bax by p53 mediates mitochondrial membrane permeabilization and apoptosis. Science 303: 1010-4 PubMed GONUTS page

[PMID:14502238-6] 7.0 ^7.1 ^7.2 ^7.3 ^7.4 ^7.5 Young C et al. (2003) Ethanol-induced neuronal apoptosis in vivo requires BAX in the developing mouse brain. Cell Death Differ 10: 1148-55 PubMed GONUTS page

[PMID:16571598-7] 8.0 ^8.1 Fan H et al. (2006) Susceptibility to metanephric apoptosis in bradykinin B2 receptor null mice via the p53-Bax pathway. Am J Physiol Renal Physiol 291: F670-82 PubMed GONUTS page

[PMID:12952892-8] 9.0 ^9.1 ^9.2 ^9.3 ^9.4 ^9.5 ^9.6 ^9.7 Shibue T et al. (2003) Integral role of Noxa in p53-mediated apoptotic response. Genes Dev 17: 2233-8 PubMed GONUTS page

[PMID:11836241-9] 10.0 ^10.1 Degenhardt K et al. (2002) Bax and Bak independently promote cytochrome C release from mitochondria. J Biol Chem 277: 14127-34 PubMed GONUTS page

[PMID:10894153-10] 11.0 ^11.1 ^11.2 ^11.3 ^11.4 ^11.5 ^11.6 ^11.7 Rucker EB 3rd et al. (2000) Bcl-x and Bax regulate mouse primordial germ cell survival and apoptosis during embryogenesis. Mol Endocrinol 14: 1038-52 PubMed GONUTS page

[PMID:8358790-11] 12.0 ^12.1 ^12.2 ^12.3 Oltvai ZN et al. (1993) Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death. Cell 74: 609-19 PubMed GONUTS page

[PMID:17192424-12] 13.0 ^13.1 Buss RR et al. (2006) Neuromuscular development in the absence of programmed cell death: phenotypic alteration of motoneurons and muscle. J Neurosci 26: 13413-27 PubMed GONUTS page

[PMID:9454845-13] 14.0 ^14.1 ^14.2 ^14.3 Xiang H et al. (1998) Bax involvement in p53-mediated neuronal cell death. J Neurosci 18: 1363-73 PubMed GONUTS page

[PMID:15967824-14] 15.00 ^15.01 ^15.02 ^15.03 ^15.04 ^15.05 ^15.06 ^15.07 ^15.08 ^15.09 ^15.10 ^15.11 Hutcheson J et al. (2005) Combined loss of proapoptotic genes Bak or Bax with Bim synergizes to cause defects in hematopoiesis and in thymocyte apoptosis. J Exp Med 201: 1949-60 PubMed GONUTS page

[PMID:10639175-15] 16.0 ^16.1 ^16.2 ^16.3 Chong MJ et al. (2000) Atm and Bax cooperate in ionizing radiation-induced apoptosis in the central nervous system. Proc Natl Acad Sci U S A 97: 889-94 PubMed GONUTS page

[PMID:11226327-16] 17.0 ^17.1 ^17.2 ^17.3 ^17.4 ^17.5 Vila M et al. (2001) Bax ablation prevents dopaminergic neurodegeneration in the 1-methyl- 4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson's disease. Proc Natl Acad Sci U S A 98: 2837-42 PubMed GONUTS page

[PMID:9008714-17] 18.0 ^18.1 Amling M et al. (1997) Bcl-2 lies downstream of parathyroid hormone-related peptide in a signaling pathway that regulates chondrocyte maturation during skeletal development. J Cell Biol 136: 205-13 PubMed GONUTS page

[PMID:12917363-18] 19.0 ^19.1 Sun W et al. (2003) Neuromuscular development after the prevention of naturally occurring neuronal death by Bax deletion. J Neurosci 23: 7298-310 PubMed GONUTS page

[PMID:9553144-19] 20.0 ^20.1 ^20.2 ^20.3 Hsu YT & Youle RJ (1998) Bax in murine thymus is a soluble monomeric protein that displays differential detergent-induced conformations. J Biol Chem 273: 10777-83 PubMed GONUTS page

[PMID:8631771-20] 21.0 ^21.1 ^21.2 ^21.3 Zha H et al. (1996) Proapoptotic protein Bax heterodimerizes with Bcl-2 and homodimerizes with Bax via a novel domain (BH3) distinct from BH1 and BH2. J Biol Chem 271: 7440-4 PubMed GONUTS page

[PMID:10363969-21] 22.0 ^22.1 ^22.2 ^22.3 Schorr K et al. (1999) Gain of Bcl-2 is more potent than bax loss in regulating mammary epithelial cell survival in vivo. Cancer Res 59: 2541-5 PubMed GONUTS page

[PMID:15776018-22] 23.0 ^23.1 ^23.2 Ruiz-Vela A et al. (2005) Proapoptotic BAX and BAK control multiple initiator caspases. EMBO Rep 6: 379-85 PubMed GONUTS page

[PMID:12925707-23] 24.00 ^24.01 ^24.02 ^24.03 ^24.04 ^24.05 ^24.06 ^24.07 ^24.08 ^24.09 ^24.10 ^24.11 ^24.12 ^24.13 Valentijn AJ et al. (2003) Spatial and temporal changes in Bax subcellular localization during anoikis. J Cell Biol 162: 599-612 PubMed GONUTS page

[PMID:15574493-24] 25.0 ^25.1 Weiner JA et al. (2005) Gamma protocadherins are required for synaptic development in the spinal cord. Proc Natl Acad Sci U S A 102: 8-14 PubMed GONUTS page

[PMID:9463381-25] 26.0 ^26.1 Huang DC et al. (1998) The conserved N-terminal BH4 domain of Bcl-2 homologues is essential for inhibition of apoptosis and interaction with CED-4. EMBO J 17: 1029-39 PubMed GONUTS page

[PMID:11369777-26] 27.0 ^27.1 ^27.2 ^27.3 ^27.4 ^27.5 Zhao Y et al. (2001) Activation of pro-death Bcl-2 family proteins and mitochondria apoptosis pathway in tumor necrosis factor-alpha-induced liver injury. J Biol Chem 276: 27432-40 PubMed GONUTS page

[PMID:15944391-27] 28.0 ^28.1 ^28.2 ^28.3 Jacob DA et al. (2005) Effects of Bax gene deletion on muscle and motoneuron degeneration in a sexually dimorphic neuromuscular system. J Neurosci 25: 5638-44 PubMed GONUTS page

[PMID:9560217-28] 29.0 ^29.1 ^29.2 ^29.3 ^29.4 ^29.5 Jürgensmeier JM et al. (1998) Bax directly induces release of cytochrome c from isolated mitochondria. Proc Natl Acad Sci U S A 95: 4997-5002 PubMed GONUTS page

[PMID:14660547-29] 30.0 ^30.1 ^30.2 Stallock J et al. (2003) The pro-apoptotic gene Bax is required for the death of ectopic primordial germ cells during their migration in the mouse embryo. Development 130: 6589-97 PubMed GONUTS page

[PMID:14507967-30] 31.0 ^31.1 ^31.2 ^31.3 ^31.4 ^31.5 Dong H et al. (2003) Enhanced oligodendrocyte survival after spinal cord injury in Bax-deficient mice and mice with delayed Wallerian degeneration. J Neurosci 23: 8682-91 PubMed GONUTS page

[PMID:11717344-31] Laforet GA et al. (2001) Changes in cortical and striatal neurons predict behavioral and electrophysiological abnormalities in a transgenic murine model of Huntington's disease. J Neurosci 21: 9112-23 PubMed GONUTS page

[PMID:10762311-32] 33.0 ^33.1 ^33.2 ^33.3 ^33.4 ^33.5 ^33.6 ^33.7 Middleton G et al. (2000) Differences in bcl-2- and bax-independent function in regulating apoptosis in sensory neuron populations. Eur J Neurosci 12: 819-27 PubMed GONUTS page

[PMID:9988273-33] 34.0 ^34.1 Perez GI et al. (1999) Prolongation of ovarian lifespan into advanced chronological age by Bax-deficiency. Nat Genet 21: 200-3 PubMed GONUTS page

[PMID:16469926-34] 35.0 ^35.1 ^35.2 ^35.3 Lakhani SA et al. (2006) Caspases 3 and 7: key mediators of mitochondrial events of apoptosis. Science 311: 847-51 PubMed GONUTS page

[PMID:11864976-35] 36.0 ^36.1 ^36.2 ^36.3 Karpinich NO et al. (2002) The course of etoposide-induced apoptosis from damage to DNA and p53 activation to mitochondrial release of cytochrome c. J Biol Chem 277: 16547-52 PubMed GONUTS page

[PMID:17035996-36] Karbowski M et al. (2006) Role of Bax and Bak in mitochondrial morphogenesis. Nature 443: 658-62 PubMed GONUTS page

[PMID:19139267-37] 38.0 ^38.1 ^38.2 ^38.3 Wang X et al. (2009) Mitochondrial degeneration and not apoptosis is the primary cause of embryonic lethality in ceramide transfer protein mutant mice. J Cell Biol 184: 143-58 PubMed GONUTS page

[PMID:10479688-38] 39.0 ^39.1 Cregan SP et al. (1999) Bax-dependent caspase-3 activation is a key determinant in p53-induced apoptosis in neurons. J Neurosci 19: 7860-9 PubMed GONUTS page

[PMID:11060313-39] 40.0 ^40.1 Tan KO et al. (2001) MAP-1, a novel proapoptotic protein containing a BH3-like motif that associates with Bax through its Bcl-2 homology domains. J Biol Chem 276: 2802-7 PubMed GONUTS page

[PMID:15947791-40] 41.0 ^41.1 ^41.2 ^41.3 Shi J et al. (2005) Bax limits adult neural stem cell persistence through caspase and IP3 receptor activation. Cell Death Differ 12: 1601-12 PubMed GONUTS page

[PMID:11146002-41] 42.0 ^42.1 Dargusch R et al. (2001) The role of Bax in glutamate-induced nerve cell death. J Neurochem 76: 295-301 PubMed GONUTS page

[PMID:17107997-42] 43.0 ^43.1 ^43.2 ^43.3 Runyan C et al. (2006) Steel factor controls midline cell death of primordial germ cells and is essential for their normal proliferation and migration. Development 133: 4861-9 PubMed GONUTS page

[PMID:9699561-43] 44.0 ^44.1 ^44.2 ^44.3 Mosinger Ogilvie J et al. (1998) Suppression of developmental retinal cell death but not of photoreceptor degeneration in Bax-deficient mice. Invest Ophthalmol Vis Sci 39: 1713-20 PubMed GONUTS page

[PMID:15528359-44] 45.0 ^45.1 ^45.2 ^45.3 Parikh N et al. (2004) The Bax N terminus is required for negative regulation by the mitogen-activated protein kinase kinase and Akt signaling pathways in T cells. J Immunol 173: 6220-7 PubMed GONUTS page

[PMID:12810599-45] 46.0 ^46.1 Ma L et al. (2003) Brn3a regulation of TrkA/NGF receptor expression in developing sensory neurons. Development 130: 3525-34 PubMed GONUTS page

[PMID:16055554-46] 47.0 ^47.1 ^47.2 ^47.3 ^47.4 ^47.5 ^47.6 ^47.7 Takeuchi O et al. (2005) Essential role of BAX,BAK in B cell homeostasis and prevention of autoimmune disease. Proc Natl Acad Sci U S A 102: 11272-7 PubMed GONUTS page

[PMID:11604501-47] 48.0 ^48.1 Eischen CM et al. (2001) Bax loss impairs Myc-induced apoptosis and circumvents the selection of p53 mutations during Myc-mediated lymphomagenesis. Mol Cell Biol 21: 7653-62 PubMed GONUTS page

[PMID:15590937-48] 49.0 ^49.1 ^49.2 ^49.3 Sun W et al. (2004) Programmed cell death of adult-generated hippocampal neurons is mediated by the proapoptotic gene Bax. J Neurosci 24: 11205-13 PubMed GONUTS page

[PMID:8816704-49] 50.0 ^50.1 Deckwerth TL et al. (1996) BAX is required for neuronal death after trophic factor deprivation and during development. Neuron 17: 401-11 PubMed GONUTS page

[PMID:18308723-50] 51.0 ^51.1 Rabionet M et al. (2008) Male germ cells require polyenoic sphingolipids with complex glycosylation for completion of meiosis: a link to ceramide synthase-3. J Biol Chem 283: 13357-69 PubMed GONUTS page

[PMID:17068116-51] 52.0 ^52.1 ^52.2 ^52.3 Przemeck SM et al. (2007) Radiation-induced gastric epithelial apoptosis occurs in the proliferative zone and is regulated by p53, bak, bax, and bcl-2. Am J Physiol Gastrointest Liver Physiol 292: G620-7 PubMed GONUTS page

[PMID:10683286-52] 53.0 ^53.1 Werth JL et al. (2000) Reversible physiological alterations in sympathetic neurons deprived of NGF but protected from apoptosis by caspase inhibition or Bax deletion. Exp Neurol 161: 203-11 PubMed GONUTS page

[PMID:17052454-53] 54.0 ^54.1 Walensky LD et al. (2006) A stapled BID BH3 helix directly binds and activates BAX. Mol Cell 24: 199-210 PubMed GONUTS page

[PMID:17244737-54] 55.0 ^55.1 Greenfeld CR et al. (2007) BAX is involved in regulating follicular growth, but is dispensable for follicle atresia in adult mouse ovaries. Reproduction 133: 107-16 PubMed GONUTS page

[PMID:10931486-55] 56.0 ^56.1 ^56.2 ^56.3 Zeng Q et al. (2000) Gustatory innervation and bax-dependent caspase-2: participants in the life and death pathways of mouse taste receptor cells. J Comp Neurol 424: 640-50 PubMed GONUTS page

[PMID:16103918-56] 57.0 ^57.1 ^57.2 ^57.3 Libby RT et al. (2005) Susceptibility to neurodegeneration in a glaucoma is modified by Bax gene dosage. PLoS Genet 1: 17-26 PubMed GONUTS page

[PMID:15342910-57] 58.0 ^58.1 ^58.2 ^58.3 ^58.4 ^58.5 ^58.6 ^58.7 Forger NG et al. (2004) Deletion of Bax eliminates sex differences in the mouse forebrain. Proc Natl Acad Sci U S A 101: 13666-71 PubMed GONUTS page

[PMID:15613488-58] 59.0 ^59.1 ^59.2 ^59.3 ^59.4 ^59.5 Oakes SA et al. (2005) Proapoptotic BAX and BAK regulate the type 1 inositol trisphosphate receptor and calcium leak from the endoplasmic reticulum. Proc Natl Acad Sci U S A 102: 105-10 PubMed GONUTS page

[PMID:10618441-59] 60.0 ^60.1 Roth KA et al. (2000) Epistatic and independent functions of caspase-3 and Bcl-X(L) in developmental programmed cell death. Proc Natl Acad Sci U S A 97: 466-71 PubMed GONUTS page

[PMID:16270031-60] 61.0 ^61.1 ^61.2 ^61.3 Coultas L et al. (2005) Concomitant loss of proapoptotic BH3-only Bcl-2 antagonists Bik and Bim arrests spermatogenesis. EMBO J 24: 3963-73 PubMed GONUTS page

[PMID:11163212-61] 62.0 ^62.1 ^62.2 ^62.3 ^62.4 ^62.5 ^62.6 ^62.7 Lindsten T et al. (2000) The combined functions of proapoptotic Bcl-2 family members bak and bax are essential for normal development of multiple tissues. Mol Cell 6: 1389-99 PubMed GONUTS page

[PMID:9176392-62] 63.0 ^63.1 Tzung SP et al. (1997) Expression of Bcl-2 family during liver regeneration and identification of Bcl-x as a delayed early response gene. Am J Pathol 150: 1985-95 PubMed GONUTS page

[PMID:10744634-63] 64.0 ^64.1 Almeida OF et al. (2000) Subtle shifts in the ratio between pro- and antiapoptotic molecules after activation of corticosteroid receptors decide neuronal fate. FASEB J 14: 779-90 PubMed GONUTS page

[PMID:8798452-64] 65.0 ^65.1 ^65.2 ^65.3 Simonian PL et al. (1996) Bax can antagonize Bcl-XL during etoposide and cisplatin-induced cell death independently of its heterodimerization with Bcl-XL. J Biol Chem 271: 22764-72 PubMed GONUTS page

[PMID:14614769-65] 66.0 ^66.1 ^66.2 ^66.3 ^66.4 ^66.5 Heimlich G et al. (2004) Bax-induced cytochrome c release from mitochondria depends on alpha-helices-5 and -6. Biochem J 378: 247-55 PubMed GONUTS page

[PMID:10995754-66] 67.0 ^67.1 Chi MM et al. (2000) Decreased glucose transporter expression triggers BAX-dependent apoptosis in the murine blastocyst. J Biol Chem 275: 40252-7 PubMed GONUTS page

[PMID:15955981-67] 68.0 ^68.1 ^68.2 ^68.3 ^68.4 ^68.5 Hahn P et al. (2005) Persistent fetal ocular vasculature in mice deficient in bax and bak. Arch Ophthalmol 123: 797-802 PubMed GONUTS page

[PMID:14517994-68] 69.0 ^69.1 Péquignot MO et al. (2003) Major role of BAX in apoptosis during retinal development and in establishment of a functional postnatal retina. Dev Dyn 228: 231-8 PubMed GONUTS page

[PMID:14561915-69] 70.0 ^70.1 Robinson AM et al. (2003) Olfactory neurons in bax knockout mice are protected from bulbectomy-induced apoptosis. Neuroreport 14: 1891-4 PubMed GONUTS page

[PMID:10486519-70] 71.0 ^71.1 Abdelwahid E et al. (1999) Apoptosis in the pattern formation of the ventricular wall during mouse heart organogenesis. Anat Rec 256: 208-17 PubMed GONUTS page

[PMID:11150333-71] 72.0 ^72.1 Zaidi AU et al. (2001) Bcl-X(L)-caspase-9 interactions in the developing nervous system: evidence for multiple death pathways. J Neurosci 21: 169-75 PubMed GONUTS page

[PMID:10201940-72] 73.0 ^73.1 Hotchkiss RS et al. (1999) Overexpression of Bcl-2 in transgenic mice decreases apoptosis and improves survival in sepsis. J Immunol 162: 4148-56 PubMed GONUTS page

[PMID:7569956-73] 74.0 ^74.1 ^74.2 ^74.3 ^74.4 ^74.5 ^74.6 Knudson CM et al. (1995) Bax-deficient mice with lymphoid hyperplasia and male germ cell death. Science 270: 96-9 PubMed GONUTS page

[PMID:9843949-74] 75.0 ^75.1 Narita M et al. (1998) Bax interacts with the permeability transition pore to induce permeability transition and cytochrome c release in isolated mitochondria. Proc Natl Acad Sci U S A 95: 14681-6 PubMed GONUTS page

[PMID:12910269-75] 76.0 ^76.1 Zhou Z et al. (2003) Cidea-deficient mice have lean phenotype and are resistant to obesity. Nat Genet 35: 49-56 PubMed GONUTS page

[PMID:15989966-76] 77.0 ^77.1 Yuan X et al. (2005) Genetic inactivation of the transcription factor TIF-IA leads to nucleolar disruption, cell cycle arrest, and p53-mediated apoptosis. Mol Cell 19: 77-87 PubMed GONUTS page

[PMID:11980919-77] 78.0 ^78.1 ^78.2 ^78.3 Putcha GV et al. (2002) Intrinsic and extrinsic pathway signaling during neuronal apoptosis: lessons from the analysis of mutant mice. J Cell Biol 157: 441-53 PubMed GONUTS page

[PMID:10464378-78] 79.0 ^79.1 Zeng Q & Oakley B (1999) p53 and Bax: putative death factors in taste cell turnover. J Comp Neurol 413: 168-80 PubMed GONUTS page

[PMID:10884318-79] 80.0 ^80.1 Selimi F et al. (2000) Bax inactivation in lurcher mutants rescues cerebellar granule cells but not purkinje cells or inferior olivary neurons. J Neurosci 20: 5339-45 PubMed GONUTS page

[PMID:11413548-80] 81.0 ^81.1 Fan H et al. (2001) Elimination of Bax expression in mice increases cerebellar purkinje cell numbers but not the number of granule cells. J Comp Neurol 436: 82-91 PubMed GONUTS page

[PMID:8625820-81] 82.0 ^82.1 Middleton G et al. (1996) Bax promotes neuronal survival and antagonises the survival effects of neurotrophic factors. Development 122: 695-701 PubMed GONUTS page

[PMID:11784036-82] Ross AJ et al. (2001) BCLW mediates survival of postmitotic Sertoli cells by regulating BAX activity. Dev Biol 239: 295-308 PubMed GONUTS page

[PMID:9096145-83] 84.0 ^84.1 Shindler KS et al. (1997) Bax deficiency prevents the increased cell death of immature neurons in bcl-x-deficient mice. J Neurosci 17: 3112-9 PubMed GONUTS page

[PMID:15753097-84] 85.0 ^85.1 Li A & Harris DA (2005) Mammalian prion protein suppresses Bax-induced cell death in yeast. J Biol Chem 280: 17430-4 PubMed GONUTS page

[PMID:10582606-85] 86.0 ^86.1 Vukosavic S et al. (1999) Bax and Bcl-2 interaction in a transgenic mouse model of familial amyotrophic lateral sclerosis. J Neurochem 73: 2460-8 PubMed GONUTS page

[PMID:9454852-86] 87.0 ^87.1 White FA et al. (1998) Widespread elimination of naturally occurring neuronal death in Bax-deficient mice. J Neurosci 18: 1428-39 PubMed GONUTS page

[PMID:17077143-87] 88.0 ^88.1 de Rivero Vaccari JC et al. (2006) NMDA receptors promote survival in somatosensory relay nuclei by inhibiting Bax-dependent developmental cell death. Proc Natl Acad Sci U S A 103: 16971-6 PubMed GONUTS page

[PMID:15869495-88] 89.0 ^89.1 Guo H et al. (2005) Development of pontine noradrenergic A5 neurons requires brain-derived neurotrophic factor. Eur J Neurosci 21: 2019-23 PubMed GONUTS page

[PMID:16893972-89] Pardo J et al. (2006) The mitochondrial protein Bak is pivotal for gliotoxin-induced apoptosis and a critical host factor of Aspergillus fumigatus virulence in mice. J Cell Biol 174: 509-19 PubMed GONUTS page

[PMID:18614015-90] 91.0 ^91.1 Pagliarini DJ et al. (2008) A mitochondrial protein compendium elucidates complex I disease biology. Cell 134: 112-23 PubMed GONUTS page

[PMID:11146504-91] 92.0 ^92.1 Dominov JA et al. (2001) Pro- and anti-apoptotic members of the Bcl-2 family in skeletal muscle: a distinct role for Bcl-2 in later stages of myogenesis. Dev Dyn 220: 18-26 PubMed GONUTS page

[PMID:16227588-92] 93.0 ^93.1 ^93.2 ^93.3 Takahashi Y et al. (2005) Loss of Bif-1 suppresses Bax/Bak conformational change and mitochondrial apoptosis. Mol Cell Biol 25: 9369-82 PubMed GONUTS page

[PMID:14651853-93] 94.0 ^94.1 Mootha VK et al. (2003) Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria. Cell 115: 629-40 PubMed GONUTS page

[PMID:7675327-94] 95.0 ^95.1 Gillardon F et al. (1995) Up-regulation of bax and down-regulation of bcl-2 is associated with kainate-induced apoptosis in mouse brain. Neurosci Lett 192: 85-8 PubMed GONUTS page

[PMID:9056387-95] 96.0 ^96.1 Popper P et al. (1997) TRPM-2 expression and tunel staining in neurodegenerative diseases: studies in wobbler and rd mice. Exp Neurol 143: 246-54 PubMed GONUTS page

[PMID:16735463-96] Dziarmaga A et al. (2006) Neuronal apoptosis inhibitory protein is expressed in developing kidney and is regulated by PAX2. Am J Physiol Renal Physiol 291: F913-20 PubMed GONUTS page

[PMID:7834748-97] Yang E et al. (1995) Bad, a heterodimeric partner for Bcl-XL and Bcl-2, displaces Bax and promotes cell death. Cell 80: 285-91 PubMed GONUTS page

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MOUSE:BAX

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