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MOUSE:B1AVP8
Contents |
| Species (Taxon ID) | Mus musculus (Mouse). (taxon:10090) | |
| Gene Name(s) | Rgs2 | |
| Protein Name(s) |
| |
| External Links | ||
| UniProt Identifier | B1AVP8_MOUSE | |
| UniProt Accessions | B1AVP8, | |
| EMBL | AL713991, CH466520, | |
| RefSeq | NP_033087.2, | |
| Ensembl | ENSMUST00000127206, | |
| Pfam | PF00615, | |
Annotations
| Qualifier | GO ID | GO term name | Reference(s) | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0005634 |
nucleus |
TAS: Traceable Author Statement |
C |
Source: MGI |
||||
| GO:0005096 |
GTPase activator activity |
TAS: Traceable Author Statement |
F |
Source: MGI |
||||
| GO:0004871 |
signal transducer activity |
IEA: Inferred from Electronic Annotation |
F |
Source: InterPro |
||||
| GO:0050873 |
brown fat cell differentiation |
IDA: Inferred from Direct Assay |
P |
Source: MGI |
||||
| GO:0007186 |
G-protein coupled receptor protein signaling pathway |
TAS: Traceable Author Statement |
P |
Source: MGI |
||||
| GO:0045744 |
regulation of G-protein coupled receptor protein signaling pathway |
IMP: Inferred from Mutant Phenotype |
P |
Figure 1B:Treatment of RGS2 -/- mice and RGS2 +/+ mice with Gq agonist showed enhanced protein synthesis, especially in RGS2 -/- mice. |
complete | |||
| GO:0010614 |
negative regulation of cardiac muscle hypertrophy |
IMP: Inferred from Mutant Phenotype |
P |
Figure 1C - 1E: After TAC, RGS2 -/- mice developed increased hypertrophy and had a higher mortality rate than RGS2 +/+ mice. |
complete | |||
| GO:0055118 |
negative regulation of cardiac muscle contraction |
IMP: Inferred from Mutant Phenotype |
P |
Figure 2D: TAC treated RGS2 -/- mice hearts failed to compensate by increasing contractibility like RGS2 +/+ hearts. |
complete | |||
| GO:0005829 |
cytosol |
IDA: Inferred from Direct Assay |
C |
Figure 7B+D:Immunohistochemtistry showed diffuse of RGS2 to the cytosol. |
complete | |||
| GO:0009279 |
cell outer membrane |
IDA: Inferred from Direct Assay |
C |
Figure 7B+D: Immunohistochemistry shows RGS2 localizes to outer membrane. |
complete | |||
| GO:0004871 |
signal transducer activity |
IEA: Inferred from Electronic Annotation |
F |
|||||
| GO:0005096 |
GTPase activator activity |
TAS: Traceable Author Statement |
F |
|||||
| GO:0005634 |
nucleus |
TAS: Traceable Author Statement |
C |
|||||
| GO:0007165 |
signal transduction |
IEA: Inferred from Electronic Annotation |
P |
|||||
| GO:0007186 |
G-protein coupled receptor protein signaling pathway |
TAS: Traceable Author Statement |
P |
|||||
| GO:0043547 |
positive regulation of GTPase activity |
TAS: Traceable Author Statement |
P |
|||||
| GO:0050873 |
brown fat cell differentiation |
IDA: Inferred from Direct Assay |
P |
| ||||
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 1.3 1.4 Takimoto E et al. (2009) Regulator of G protein signaling 2 mediates cardiac compensation to pressure overload and antihypertrophic effects of PDE5 inhibition in mice. J Clin Invest 119: 408-20 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 2.3 Nagata Y et al. (2001) A novel regulator of G-protein signaling bearing GAP activity for Galphai and Galphaq in megakaryocytes. Blood 97: 3051-60 PubMed GONUTS page
- ↑ Wu Y & Smas CM (2008) Wdnm1-like, a new adipokine with a role in MMP-2 activation. Am J Physiol Endocrinol Metab 295: E205-15 PubMed GONUTS page
