MOUSE:ASIP

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Species (Taxon ID)	Mus musculus (Mouse). ([1])
Gene Name(s)	Asip (synonyms: a)
Protein Name(s)	Agouti-signaling protein ASP Agouti coat color protein Agouti switch protein
External Links
EMBL	L06451 L06941 AL805955 CH466551 CH466551 BC009122 S63413 S70320 S70326 S70394 S74479 S74489 S74493
IPI	IPI00130315
PIR	A46298
RefSeq	NP_056585.2
UniGene	Mm.218753 Mm.221440 Mm.315593
ProteinModelPortal	Q03288
STRING	Q03288
PRIDE	Q03288
Ensembl	ENSMUST00000029123 ENSMUST00000109697
GeneID	50518
MGI	MGI:87853
GeneTree	ENSGT00510000048661
HOGENOM	HBG446671
HOVERGEN	HBG050593
InParanoid	Q03288
OrthoDB	EOG4907BH
ArrayExpress	Q03288
Bgee	Q03288
CleanEx	MM_A
Genevestigator	Q03288
GermOnline	ENSMUSG00000027596
GO	GO:0005576 GO:0009755
InterPro	IPR007733
Gene3D	G3DSA:4.10.760.10
PANTHER	PTHR16551
Pfam	PF05039
SMART	SM00792
SUPFAM	SSF57055
PROSITE	PS60024 PS51150

Annotations

Qualifier	GO ID	GO term name	Reference	Evidence Code	with/from	Aspect	Notes	Status
	GO:0005515	protein binding	PMID:11137996^[1]	IPI: Inferred from Physical Interaction	UniProtKB:Q9WU60	F	Seeded From UniProt
	GO:0005576	extracellular region	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR007733	C	Seeded From UniProt
	GO:0005576	extracellular region	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0964	C	Seeded From UniProt
	GO:0005576	extracellular region	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0243	C	Seeded From UniProt
	GO:0006091	generation of precursor metabolites and energy	PMID:12177191^[2]	IGI: Inferred from Genetic Interaction	MGI:MGI:1343180	P	Seeded From UniProt
	GO:0008343	adult feeding behavior	PMID:17873059^[3]	IGI: Inferred from Genetic Interaction	MGI:MGI:2153518	P	Seeded From UniProt
	GO:0008343	adult feeding behavior	PMID:17873059^[3]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1855937	P	Seeded From UniProt
	GO:0008343	adult feeding behavior	PMID:17873059^[3]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1856798	P	Seeded From UniProt
	GO:0009755	hormone-mediated signaling pathway	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR007733	P	Seeded From UniProt
	GO:0031779	melanocortin receptor binding	PMID:9454589^[4]	IPI: Inferred from Physical Interaction	UniProtKB:Q01727	F	Seeded From UniProt
	GO:0031781	type 3 melanocortin receptor binding	PMID:9454589^[4]	IPI: Inferred from Physical Interaction	UniProtKB:P33033	F	Seeded From UniProt
	GO:0031782	type 4 melanocortin receptor binding	PMID:9454589^[4]	IPI: Inferred from Physical Interaction	UniProtKB:P56450	F	Seeded From UniProt
	GO:0032402	melanosome transport	PMID:9548375^[5]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1855937	P	Seeded From UniProt
	GO:0032438	melanosome organization	PMID:9548375^[5]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1855937	P	Seeded From UniProt
	GO:0040030	regulation of molecular function, epigenetic	PMID:12601169^[6]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1855930	P	Seeded From UniProt
	GO:0040030	regulation of molecular function, epigenetic	PMID:12601169^[6]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1855937	P	Seeded From UniProt
	GO:0042438	melanin biosynthetic process	PMID:7665913^[7]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1855937	P	Seeded From UniProt
	GO:0043473	pigmentation	PMID:17247639^[8]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1856798	P	Seeded From UniProt
	GO:0071514	genetic imprinting	PMID:12601169^[6]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1855930	P	Seeded From UniProt
	GO:0071514	genetic imprinting	PMID:12601169^[6]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1855937	P	Seeded From UniProt
	GO:0048023	positive regulation of melanin biosynthetic process	PMID:21949658^[9]	IGI: Inferred from Genetic Interaction	UniProtKB:P07147 UniProtKB:Q60696	P	Based on results in Table 2	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ He L et al. (2001) A biochemical function for attractin in agouti-induced pigmentation and obesity. Nat Genet 27: 40-7 PubMed GONUTS page
↑ Hahm S et al. (2002) VGF is required for obesity induced by diet, gold thioglucose treatment, and agouti and is differentially regulated in pro-opiomelanocortin- and neuropeptide Y-containing arcuate neurons in response to fasting. J Neurosci 22: 6929-38 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 Fujimoto W et al. (2007) Dmbx1 is essential in agouti-related protein action. Proc Natl Acad Sci U S A 104: 15514-9 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 Kiefer LL et al. (1998) Melanocortin receptor binding determinants in the agouti protein. Biochemistry 37: 991-7 PubMed GONUTS page
↑ ^5.0 ^5.1 Hirobe T et al. (1998) Effects of genic substitution at the agouti, brown, albino, dilute, and pink-eyed dilution loci on the proliferation and differentiation of mouse epidermal melanocytes in serum-free culture. Eur J Cell Biol 75: 184-91 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 ^6.3 Rakyan VK et al. (2003) Transgenerational inheritance of epigenetic states at the murine Axin(Fu) allele occurs after maternal and paternal transmission. Proc Natl Acad Sci U S A 100: 2538-43 PubMed GONUTS page
↑ Ozeki H et al. (1995) Chemical characterization of hair melanins in various coat-color mutants of mice. J Invest Dermatol 105: 361-6 PubMed GONUTS page
↑ Markert CL & Silvers WK (1956) The Effects of Genotype and Cell Environment on Melanoblast Differentiation in the House Mouse. Genetics 41: 429-50 PubMed GONUTS page
↑ Hellström AR et al. (2011) Inactivation of Pmel alters melanosome shape but has only a subtle effect on visible pigmentation. PLoS Genet 7: e1002285 PubMed GONUTS page

[PMID:11137996-0] He L et al. (2001) A biochemical function for attractin in agouti-induced pigmentation and obesity. Nat Genet 27: 40-7 PubMed GONUTS page

[PMID:12177191-1] Hahm S et al. (2002) VGF is required for obesity induced by diet, gold thioglucose treatment, and agouti and is differentially regulated in pro-opiomelanocortin- and neuropeptide Y-containing arcuate neurons in response to fasting. J Neurosci 22: 6929-38 PubMed GONUTS page

[PMID:17873059-2] 3.0 ^3.1 ^3.2 Fujimoto W et al. (2007) Dmbx1 is essential in agouti-related protein action. Proc Natl Acad Sci U S A 104: 15514-9 PubMed GONUTS page

[PMID:9454589-3] 4.0 ^4.1 ^4.2 Kiefer LL et al. (1998) Melanocortin receptor binding determinants in the agouti protein. Biochemistry 37: 991-7 PubMed GONUTS page

[PMID:9548375-4] 5.0 ^5.1 Hirobe T et al. (1998) Effects of genic substitution at the agouti, brown, albino, dilute, and pink-eyed dilution loci on the proliferation and differentiation of mouse epidermal melanocytes in serum-free culture. Eur J Cell Biol 75: 184-91 PubMed GONUTS page

[PMID:12601169-5] 6.0 ^6.1 ^6.2 ^6.3 Rakyan VK et al. (2003) Transgenerational inheritance of epigenetic states at the murine Axin(Fu) allele occurs after maternal and paternal transmission. Proc Natl Acad Sci U S A 100: 2538-43 PubMed GONUTS page

[PMID:7665913-6] Ozeki H et al. (1995) Chemical characterization of hair melanins in various coat-color mutants of mice. J Invest Dermatol 105: 361-6 PubMed GONUTS page

[PMID:17247639-7] Markert CL & Silvers WK (1956) The Effects of Genotype and Cell Environment on Melanoblast Differentiation in the House Mouse. Genetics 41: 429-50 PubMed GONUTS page

[PMID:21949658-8] Hellström AR et al. (2011) Inactivation of Pmel alters melanosome shape but has only a subtle effect on visible pigmentation. PLoS Genet 7: e1002285 PubMed GONUTS page

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MOUSE:ASIP

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