MOUSE:ACVR1

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Acvr1 (synonyms: Acvrlk2, Tgfb1)
Protein Name(s)	Activin receptor type-1 Activin receptor type I ACTR-I Serine/threonine-protein kinase receptor R1 SKR1 TGF-B superfamily receptor type I TSR-I TSK-7L
External Links
UniProt	P37172
EMBL	L15436 AF332087 AF332088 AK150014 AK150075 BC058718
CCDS	CCDS16050.1
PIR	A37489
RefSeq	NP_001103674.1 NP_001103675.1 NP_031420.2 XP_006497685.1
UniGene	Mm.689
ProteinModelPortal	P37172
SMR	P37172
BioGrid	197953
DIP	DIP-5798N
MINT	MINT-1341279
BindingDB	P37172
PhosphoSite	P37172
PaxDb	P37172
PRIDE	P37172
Ensembl	ENSMUST00000056376 ENSMUST00000090935 ENSMUST00000112599 ENSMUST00000112601
GeneID	11477
KEGG	mmu:11477
UCSC	uc008jss.1
CTD	90
MGI	MGI:87911
eggNOG	COG0515
GeneTree	ENSGT00760000118876
HOGENOM	HOG000230587
HOVERGEN	HBG054502
InParanoid	P37172
KO	K04675
OMA	VCEGMSC
OrthoDB	EOG7Q8CN3
PhylomeDB	P37172
TreeFam	TF314724
BRENDA	2.7.10.2
ChiTaRS	Acvr1
NextBio	278820
PRO	PR:P37172
Proteomes	UP000000589
Bgee	P37172
CleanEx	MM_ACVR1 MM_TGFB1
ExpressionAtlas	P37172
Genevestigator	P37172
GO	GO:0048179 GO:0045177 GO:0005887 GO:0048185 GO:0016361 GO:0005524 GO:0019838 GO:0046872 GO:0004702 GO:0050431 GO:0005025 GO:0002526 GO:0003289 GO:0030509 GO:0060923 GO:0071385 GO:0007368 GO:0003143 GO:0061445 GO:0000082 GO:0007369 GO:0001702 GO:0007281 GO:0007507 GO:0001701 GO:0007498 GO:0001707 GO:0003183 GO:0032926 GO:2001237 GO:0001755 GO:0060389 GO:0001569 GO:0018107 GO:0060037 GO:0030501 GO:2000017 GO:0045669 GO:0010862 GO:0045944 GO:0048641 GO:0051145 GO:0007179 GO:0001655
InterPro	IPR000472 IPR011009 IPR000719 IPR017441 IPR008271 IPR003605 IPR000333
PANTHER	PTHR23255
Pfam	PF01064 PF00069 PF08515
PRINTS	PR00653
SMART	SM00467
SUPFAM	SSF56112
PROSITE	PS51256 PS00107 PS50011 PS00108

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
involved_in	GO:1905007	positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation	PMID:16140292^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:16140292^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(UBERON:0036067) has_regulation_target:(UniProtKB:P13297)\|occurs_in(UBERON:0036067) has_regulation_target:(UniProtKB:Q02085)	Seeded From UniProt	complete
involved_in	GO:0061312	BMP signaling pathway involved in heart development	PMID:16140292^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010862	positive regulation of pathway-restricted SMAD protein phosphorylation	PMID:16140292^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_regulation_target:(UniProtKB:Q62432) occurs_in:(UBERON:0003930)	Seeded From UniProt	complete
involved_in	GO:0003289	atrial septum primum morphogenesis	PMID:16140292^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0003181	atrioventricular valve morphogenesis	PMID:16140292^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0060412	ventricular septum morphogenesis	PMID:16140292^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
NOT\|involved_in	GO:0003148	outflow tract septum morphogenesis	PMID:16140292^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0003274	endocardial cushion fusion	PMID:16140292^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(UBERON:0002087)	Seeded From UniProt	complete
involved_in	GO:0003203	endocardial cushion morphogenesis	PMID:16140292^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0002526	acute inflammatory response	PMID:12151307^[2]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0098821	BMP receptor activity	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002356032 UniProtKB:P37023	F		Seeded From UniProt	complete
enables	GO:0048185	activin binding	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:87911 PANTHER:PTN002356032 UniProtKB:P37023 UniProtKB:Q04771	F		Seeded From UniProt	complete
part_of	GO:0048179	activin receptor complex	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002356032 RGD:620200 UniProtKB:Q04771	C		Seeded From UniProt	complete
enables	GO:0046332	SMAD binding	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:98728 MGI:MGI:98729 PANTHER:PTN000583675 RGD:621789 UniProtKB:O00238 UniProtKB:P36894 UniProtKB:P36896 UniProtKB:P36897 UniProtKB:P37023 UniProtKB:P37173 UniProtKB:Q04771	F		Seeded From UniProt	complete
part_of	GO:0043235	receptor complex	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000583675 UniProtKB:P27037 UniProtKB:P36896 UniProtKB:P36897 UniProtKB:P37173 UniProtKB:Q13705	C		Seeded From UniProt	complete
enables	GO:0019838	growth factor binding	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:102806 MGI:MGI:87911 MGI:MGI:87912 PANTHER:PTN000583675 RGD:71082 UniProtKB:P36896 UniProtKB:P36897 UniProtKB:Q13705 UniProtKB:Q8NER5	F		Seeded From UniProt	complete
contributes_to	GO:0016361	activin receptor activity, type I	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:87911 PANTHER:PTN002356032 RGD:620200 UniProtKB:P37023 UniProtKB:Q04771	F		Seeded From UniProt	complete
involved_in	GO:0007507	heart development	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:87911 PANTHER:PTN001907233 UniProtKB:Q90ZK6	P		Seeded From UniProt	complete
involved_in	GO:0007389	pattern specification process	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1338938 MGI:MGI:87912 PANTHER:PTN000583675	P		Seeded From UniProt	complete
involved_in	GO:0007179	transforming growth factor beta receptor signaling pathway	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0003716 MGI:MGI:1338946 MGI:MGI:87911 MGI:MGI:98728 MGI:MGI:98729 PANTHER:PTN000583675 RGD:3852 RGD:620200 RGD:69651 RGD:70964 UniProtKB:A0A0B4KG59 UniProtKB:P36897 UniProtKB:P37023 UniProtKB:P37173 UniProtKB:Q04771 UniProtKB:Q06900 UniProtKB:Q90ZK6	P		Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:87911 PANTHER:PTN000583675 RGD:69651 RGD:70964 UniProtKB:P36896 UniProtKB:P37023 UniProtKB:Q04771 UniProtKB:Q13873	C		Seeded From UniProt	complete
enables	GO:0005025	transforming growth factor beta receptor activity, type I	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:87911 PANTHER:PTN002356032 UniProtKB:A0A0B4K7J3 UniProtKB:P37023 UniProtKB:Q90ZK6	F		Seeded From UniProt	complete
enables	GO:0005024	transforming growth factor beta-activated receptor activity	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:98728 MGI:MGI:98729 PANTHER:PTN000583675 UniProtKB:A0A0B4KG59 UniProtKB:P36897 UniProtKB:P37023 UniProtKB:P37173 ZFIN:ZDB-GENE-070618-1	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:2001237	negative regulation of extrinsic apoptotic signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q04771	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:2000017	positive regulation of determination of dorsal identity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q04771	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071773	cellular response to BMP stimulus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q04771	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0061445	endocardial cushion cell fate commitment	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q04771	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060923	cardiac muscle cell fate commitment	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q04771	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060389	pathway-restricted SMAD protein phosphorylation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q04771	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060037	pharyngeal system development	PMID:17078885^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2386570,MGI:MGI:2651395	P	results_in_development_of:(EMAPA:16684)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051145	smooth muscle cell differentiation	PMID:17078885^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2386570,MGI:MGI:2651395	P	occurs_in:(EMAPA:16346)\|occurs_in:(EMAPA:16827)	Seeded From UniProt	complete
enables	GO:0050431	transforming growth factor beta binding	PMID:12054694^[5]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0050431	transforming growth factor beta binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q04771	F		Seeded From UniProt	complete
enables	GO:0048185	activin binding	PMID:7577669^[6]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q04998	F		Seeded From UniProt	complete
enables	GO:0048185	activin binding	PMID:1646080^[7]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P27038	F		Seeded From UniProt	complete
enables	GO:0048185	activin binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q04771	F		Seeded From UniProt	complete
part_of	GO:0048179	activin receptor complex	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q04771	C		Seeded From UniProt	complete
part_of	GO:0048179	activin receptor complex	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620200	C		Seeded From UniProt	complete
enables	GO:0046332	SMAD binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q04771	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q04771	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045893	positive regulation of transcription, DNA-templated	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q04771	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045669	positive regulation of osteoblast differentiation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q04771	P		Seeded From UniProt	complete
part_of	GO:0045177	apical part of cell	PMID:11290335^[8]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0045177	apical part of cell	PMID:10704880^[9]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0042803	protein homodimerization activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q04771	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032926	negative regulation of activin receptor signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q04771	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032924	activin receptor signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q04771	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030509	BMP signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q04771	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030501	positive regulation of bone mineralization	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q04771	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030335	positive regulation of cell migration	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q04771	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030278	regulation of ossification	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q04771	P		Seeded From UniProt	complete
enables	GO:0019838	growth factor binding	PMID:8388127^[10]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0018107	peptidyl-threonine phosphorylation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q04771	P		Seeded From UniProt	complete
enables	GO:0016361	activin receptor activity, type I	PMID:11376112^[11]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0016361	activin receptor activity, type I	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620200	F		Seeded From UniProt	complete
contributes_to	GO:0016361	activin receptor activity, type I	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q04771	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010862	positive regulation of pathway-restricted SMAD protein phosphorylation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q04771	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0009968	negative regulation of signal transduction	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q04771	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007507	heart development	PMID:17078885^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2386570,MGI:MGI:2651395	P	results_in_development_of:(EMAPA:16346)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007507	heart development	PMID:16140292^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2136412,MGI:MGI:2651395	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007507	heart development	PMID:15226263^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2651395	P	results_in_development_of:(EMAPA:16346)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007498	mesoderm development	PMID:17117439^[13]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1931734 MGI:MGI:3696672	P	results_in_development_of:(EMAPA:16039)\|results_in_development_of:(EMAPA:16039)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007369	gastrulation	PMID:10226013^[14]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857711	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007368	determination of left/right symmetry	PMID:15531373^[15]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1931734	P	has_participant:(EMAPA:16039)\|has_participant:(EMAPA:16105)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007281	germ cell development	PMID:15289457^[16]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857711	P	occurs_in:(EMAPA:16116)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007179	transforming growth factor beta receptor signaling pathway	PMID:11376112^[11]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007179	transforming growth factor beta receptor signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q04771	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007179	transforming growth factor beta receptor signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620200	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006468	protein phosphorylation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q04771	P		Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	PMID:11376112^[11]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q04771	C		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q04771	F		Seeded From UniProt	complete
enables	GO:0005025	transforming growth factor beta receptor activity, type I	PMID:8388127^[10]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q04771	F		Seeded From UniProt	complete
enables	GO:0004672	protein kinase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q04771	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0003289	atrial septum primum morphogenesis	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q04771	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0003183	mitral valve morphogenesis	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q04771	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0003143	embryonic heart tube morphogenesis	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q04771	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001755	neural crest cell migration	PMID:15226263^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2651395	P	occurs_in:(EMAPA:16346)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001707	mesoderm formation	PMID:17117439^[13]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1931734 MGI:MGI:3696672	P	results_in_formation_of:(EMAPA:16039)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001707	mesoderm formation	PMID:10479450^[17]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1931734	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001702	gastrulation with mouth forming second	PMID:17117439^[13]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1931734 MGI:MGI:3696672	P	has_participant:(EMAPA:16039)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001701	in utero embryonic development	PMID:17117439^[13]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1931734 MGI:MGI:3696672	P	has_participant:(EMAPA:16039)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001701	in utero embryonic development	PMID:15037318^[18]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2447280 MGI:MGI:2651395	P	has_participant:(EMAPA:17930)\|has_participant:(EMAPA:17907)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001701	in utero embryonic development	PMID:14729481^[19]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_participant:(EMAPA:17930)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001655	urogenital system development	GO_REF:0000008	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P80201	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001569	branching involved in blood vessel morphogenesis	PMID:17078885^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2386570,MGI:MGI:2651395	P	occurs_in:(EMAPA:16346)\|occurs_in:(EMAPA:16827)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0000082	G1/S transition of mitotic cell cycle	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q04771	P		Seeded From UniProt	complete
involved_in	GO:2001237	negative regulation of extrinsic apoptotic signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q04771 ensembl:ENSP00000263640	P		Seeded From UniProt	complete
involved_in	GO:2000017	positive regulation of determination of dorsal identity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q04771 ensembl:ENSP00000263640	P		Seeded From UniProt	complete
involved_in	GO:0071773	cellular response to BMP stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q04771 ensembl:ENSP00000263640	P		Seeded From UniProt	complete
involved_in	GO:0061445	endocardial cushion cell fate commitment	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q04771 ensembl:ENSP00000263640	P		Seeded From UniProt	complete
involved_in	GO:0060923	cardiac muscle cell fate commitment	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q04771 ensembl:ENSP00000263640	P		Seeded From UniProt	complete
involved_in	GO:0060389	pathway-restricted SMAD protein phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q04771 ensembl:ENSP00000263640	P		Seeded From UniProt	complete
enables	GO:0050431	transforming growth factor beta binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q04771 ensembl:ENSP00000263640	F		Seeded From UniProt	complete
enables	GO:0048185	activin binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q04771 ensembl:ENSP00000263640	F		Seeded From UniProt	complete
part_of	GO:0048179	activin receptor complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q04771 ensembl:ENSP00000263640	C		Seeded From UniProt	complete
enables	GO:0046332	SMAD binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q04771 ensembl:ENSP00000263640	F		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q04771 ensembl:ENSP00000263640	P		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q04771 ensembl:ENSP00000263640	P		Seeded From UniProt	complete
involved_in	GO:0045669	positive regulation of osteoblast differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q04771 ensembl:ENSP00000263640	P		Seeded From UniProt	complete
enables	GO:0042803	protein homodimerization activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q04771 ensembl:ENSP00000263640	F		Seeded From UniProt	complete
involved_in	GO:0032926	negative regulation of activin receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q04771 ensembl:ENSP00000263640	P		Seeded From UniProt	complete
involved_in	GO:0032924	activin receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q04771 ensembl:ENSP00000263640	P		Seeded From UniProt	complete
involved_in	GO:0030509	BMP signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q04771 ensembl:ENSP00000263640	P		Seeded From UniProt	complete
involved_in	GO:0030501	positive regulation of bone mineralization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q04771 ensembl:ENSP00000263640	P		Seeded From UniProt	complete
involved_in	GO:0030335	positive regulation of cell migration	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q04771 ensembl:ENSP00000263640	P		Seeded From UniProt	complete
involved_in	GO:0030278	regulation of ossification	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q04771 ensembl:ENSP00000263640	P		Seeded From UniProt	complete
involved_in	GO:0018107	peptidyl-threonine phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q04771 ensembl:ENSP00000263640	P		Seeded From UniProt	complete
enables	GO:0016361	activin receptor activity, type I	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q04771 ensembl:ENSP00000263640	F		Seeded From UniProt	complete
involved_in	GO:0010862	positive regulation of pathway-restricted SMAD protein phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q04771 ensembl:ENSP00000263640	P		Seeded From UniProt	complete
involved_in	GO:0009968	negative regulation of signal transduction	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q04771 ensembl:ENSP00000263640	P		Seeded From UniProt	complete
involved_in	GO:0007179	transforming growth factor beta receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q04771 ensembl:ENSP00000263640	P		Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q04771 ensembl:ENSP00000263640	P		Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q04771 ensembl:ENSP00000263640	C		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q04771 ensembl:ENSP00000263640	F		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q04771 ensembl:ENSP00000263640	F		Seeded From UniProt	complete
enables	GO:0004672	protein kinase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q04771 ensembl:ENSP00000263640	F		Seeded From UniProt	complete
involved_in	GO:0003289	atrial septum primum morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q04771 ensembl:ENSP00000263640	P		Seeded From UniProt	complete
involved_in	GO:0003183	mitral valve morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q04771 ensembl:ENSP00000263640	P		Seeded From UniProt	complete
involved_in	GO:0003143	embryonic heart tube morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q04771 ensembl:ENSP00000263640	P		Seeded From UniProt	complete
involved_in	GO:0000082	G1/S transition of mitotic cell cycle	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q04771 ensembl:ENSP00000263640	P		Seeded From UniProt	complete
enables	GO:0004672	protein kinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR001245 InterPro:IPR008271	F		Seeded From UniProt	complete
enables	GO:0004675	transmembrane receptor protein serine/threonine kinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000333 InterPro:IPR000472 InterPro:IPR003605	F		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000333 InterPro:IPR000719 InterPro:IPR003605 InterPro:IPR017441	F		Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR001245 InterPro:IPR003605 InterPro:IPR008271	P		Seeded From UniProt	complete
involved_in	GO:0007178	transmembrane receptor protein serine/threonine kinase signaling pathway	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000333	P		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000333 InterPro:IPR000472 InterPro:IPR003605	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007179	transforming growth factor beta receptor signaling pathway	PMID:12054694^[5]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0723	F		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C		Seeded From UniProt	complete
enables	GO:0000166	nucleotide binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0547	F		Seeded From UniProt	complete
involved_in	GO:0016310	phosphorylation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	P		Seeded From UniProt	complete
enables	GO:0016301	kinase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	F		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472 UniProtKB-SubCell:SL-0162	C		Seeded From UniProt	complete
enables	GO:0016740	transferase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0808	F		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0067	F		Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.00 ^1.01 ^1.02 ^1.03 ^1.04 ^1.05 ^1.06 ^1.07 ^1.08 ^1.09 ^1.10 Wang, J et al. (2005) Atrioventricular cushion transformation is mediated by ALK2 in the developing mouse heart. Dev. Biol. 286 299-310 PubMed GONUTS page
↑ Rosendahl, A et al. (2002) Activation of bone morphogenetic protein/Smad signaling in bronchial epithelial cells during airway inflammation. Am. J. Respir. Cell Mol. Biol. 27 160-9 PubMed GONUTS page
↑ ^3.00 ^3.01 ^3.02 ^3.03 ^3.04 ^3.05 ^3.06 ^3.07 ^3.08 ^3.09 ^3.10 ^3.11 ^3.12 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 Wang, J et al. (2006) Defective ALK5 signaling in the neural crest leads to increased postmigratory neural crest cell apoptosis and severe outflow tract defects. BMC Dev. Biol. 6 51 PubMed GONUTS page
↑ ^5.0 ^5.1 de Caestecker, MP et al. (2002) The novel type I serine-threonine kinase receptor Alk8 binds TGF-beta in the presence of TGF-betaRII. Biochem. Biophys. Res. Commun. 293 1556-65 PubMed GONUTS page
↑ Verschueren, K et al. (1995) Expression of type I and type IB receptors for activin in midgestation mouse embryos suggests distinct functions in organogenesis. Mech. Dev. 52 109-23 PubMed GONUTS page
↑ Mathews, LS & Vale, WW (1991) Expression cloning of an activin receptor, a predicted transmembrane serine kinase. Cell 65 973-82 PubMed GONUTS page
↑ Izon, DJ et al. (2001) Notch1 regulates maturation of CD4+ and CD8+ thymocytes by modulating TCR signal strength. Immunity 14 253-64 PubMed GONUTS page
↑ Yoshikawa, SI et al. (2000) The ActR-I activin receptor protein is expressed in notochord, lens placode and pituitary primordium cells in the mouse embryo. Mech. Dev. 91 439-44 PubMed GONUTS page
↑ ^10.0 ^10.1 Ebner, R et al. (1993) Cloning of a type I TGF-beta receptor and its effect on TGF-beta binding to the type II receptor. Science 260 1344-8 PubMed GONUTS page
↑ ^11.0 ^11.1 ^11.2 Visser, JA et al. (2001) The serine/threonine transmembrane receptor ALK2 mediates Müllerian inhibiting substance signaling. Mol. Endocrinol. 15 936-45 PubMed GONUTS page
↑ ^12.0 ^12.1 Kaartinen, V et al. (2004) Cardiac outflow tract defects in mice lacking ALK2 in neural crest cells. Development 131 3481-90 PubMed GONUTS page
↑ ^13.0 ^13.1 ^13.2 ^13.3 Komatsu, Y et al. (2007) BMP type I receptor ALK2 is essential for proper patterning at late gastrulation during mouse embryogenesis. Dev. Dyn. 236 512-7 PubMed GONUTS page
↑ Gu, Z et al. (1999) The type I serine/threonine kinase receptor ActRIA (ALK2) is required for gastrulation of the mouse embryo. Development 126 2551-61 PubMed GONUTS page
↑ Kishigami, S et al. (2004) BMP signaling through ACVRI is required for left-right patterning in the early mouse embryo. Dev. Biol. 276 185-93 PubMed GONUTS page
↑ de Sousa Lopes, SM et al. (2004) BMP signaling mediated by ALK2 in the visceral endoderm is necessary for the generation of primordial germ cells in the mouse embryo. Genes Dev. 18 1838-49 PubMed GONUTS page
↑ Mishina, Y et al. (1999) Multiple roles for activin-like kinase-2 signaling during mouse embryogenesis. Dev. Biol. 213 314-26 PubMed GONUTS page
↑ Dudas, M et al. (2004) Craniofacial defects in mice lacking BMP type I receptor Alk2 in neural crest cells. Mech. Dev. 121 173-82 PubMed GONUTS page
↑ Dudas, M et al. (2004) Tgf-beta3-induced palatal fusion is mediated by Alk-5/Smad pathway. Dev. Biol. 266 96-108 PubMed GONUTS page

[PMID:16140292-1] 1.00 ^1.01 ^1.02 ^1.03 ^1.04 ^1.05 ^1.06 ^1.07 ^1.08 ^1.09 ^1.10 Wang, J et al. (2005) Atrioventricular cushion transformation is mediated by ALK2 in the developing mouse heart. Dev. Biol. 286 299-310 PubMed GONUTS page

[PMID:12151307-2] Rosendahl, A et al. (2002) Activation of bone morphogenetic protein/Smad signaling in bronchial epithelial cells during airway inflammation. Am. J. Respir. Cell Mol. Biol. 27 160-9 PubMed GONUTS page

[PMID:21873635-3] 3.00 ^3.01 ^3.02 ^3.03 ^3.04 ^3.05 ^3.06 ^3.07 ^3.08 ^3.09 ^3.10 ^3.11 ^3.12 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:17078885-4] 4.0 ^4.1 ^4.2 ^4.3 Wang, J et al. (2006) Defective ALK5 signaling in the neural crest leads to increased postmigratory neural crest cell apoptosis and severe outflow tract defects. BMC Dev. Biol. 6 51 PubMed GONUTS page

[PMID:12054694-5] 5.0 ^5.1 de Caestecker, MP et al. (2002) The novel type I serine-threonine kinase receptor Alk8 binds TGF-beta in the presence of TGF-betaRII. Biochem. Biophys. Res. Commun. 293 1556-65 PubMed GONUTS page

[PMID:7577669-6] Verschueren, K et al. (1995) Expression of type I and type IB receptors for activin in midgestation mouse embryos suggests distinct functions in organogenesis. Mech. Dev. 52 109-23 PubMed GONUTS page

[PMID:1646080-7] Mathews, LS & Vale, WW (1991) Expression cloning of an activin receptor, a predicted transmembrane serine kinase. Cell 65 973-82 PubMed GONUTS page

[PMID:11290335-8] Izon, DJ et al. (2001) Notch1 regulates maturation of CD4+ and CD8+ thymocytes by modulating TCR signal strength. Immunity 14 253-64 PubMed GONUTS page

[PMID:10704880-9] Yoshikawa, SI et al. (2000) The ActR-I activin receptor protein is expressed in notochord, lens placode and pituitary primordium cells in the mouse embryo. Mech. Dev. 91 439-44 PubMed GONUTS page

[PMID:8388127-10] 10.0 ^10.1 Ebner, R et al. (1993) Cloning of a type I TGF-beta receptor and its effect on TGF-beta binding to the type II receptor. Science 260 1344-8 PubMed GONUTS page

[PMID:11376112-11] 11.0 ^11.1 ^11.2 Visser, JA et al. (2001) The serine/threonine transmembrane receptor ALK2 mediates Müllerian inhibiting substance signaling. Mol. Endocrinol. 15 936-45 PubMed GONUTS page

[PMID:15226263-12] 12.0 ^12.1 Kaartinen, V et al. (2004) Cardiac outflow tract defects in mice lacking ALK2 in neural crest cells. Development 131 3481-90 PubMed GONUTS page

[PMID:17117439-13] 13.0 ^13.1 ^13.2 ^13.3 Komatsu, Y et al. (2007) BMP type I receptor ALK2 is essential for proper patterning at late gastrulation during mouse embryogenesis. Dev. Dyn. 236 512-7 PubMed GONUTS page

[PMID:10226013-14] Gu, Z et al. (1999) The type I serine/threonine kinase receptor ActRIA (ALK2) is required for gastrulation of the mouse embryo. Development 126 2551-61 PubMed GONUTS page

[PMID:15531373-15] Kishigami, S et al. (2004) BMP signaling through ACVRI is required for left-right patterning in the early mouse embryo. Dev. Biol. 276 185-93 PubMed GONUTS page

[PMID:15289457-16] Sousa Lopes, SM et al. (2004) BMP signaling mediated by ALK2 in the visceral endoderm is necessary for the generation of primordial germ cells in the mouse embryo. Genes Dev. 18 1838-49 PubMed GONUTS page

[PMID:10479450-17] Mishina, Y et al. (1999) Multiple roles for activin-like kinase-2 signaling during mouse embryogenesis. Dev. Biol. 213 314-26 PubMed GONUTS page

[PMID:15037318-18] Dudas, M et al. (2004) Craniofacial defects in mice lacking BMP type I receptor Alk2 in neural crest cells. Mech. Dev. 121 173-82 PubMed GONUTS page

[PMID:14729481-19] Dudas, M et al. (2004) Tgf-beta3-induced palatal fusion is mediated by Alk-5/Smad pathway. Dev. Biol. 266 96-108 PubMed GONUTS page

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MOUSE:ACVR1

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