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MGI:Zp3
Contents |
| Species (Taxon ID) | Mus musculus (house mouse) (taxon:10090) | |
| Gene Name(s) | Zp3 ( synonyms: Zp-3 ) | |
| Protein Name(s) | zona pellucida glycoprotein 3, | |
| External Links | ||
| MGI | MGI:99215 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0001809 |
positive regulation of type IV hypersensitivity |
MGI:MGI:4943411 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0001825 |
blastocyst formation |
MGI:MGI:4943828 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0002081 |
outer acrosomal membrane |
MGI:MGI:4942258 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0002455 |
humoral immune response mediated by circulating immunoglobulin |
MGI:MGI:4943828 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0002687 |
positive regulation of leukocyte migration |
MGI:MGI:4943379 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0002922 |
positive regulation of humoral immune response |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0004871 |
signal transducer activity |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0004871 |
signal transducer activity |
MGI:MGI:4942264 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0004871 |
signal transducer activity |
MGI:MGI:4943398 |
IMP: Inferred from Mutant Phenotype |
F |
From MGI |
|||
| GO:0004872 |
receptor activity |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0675 |
F |
From MGI |
||
| GO:0005384 |
manganese ion transmembrane transporter activity |
MGI:MGI:4942264 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0005515 |
protein binding |
MGI:MGI:1098917 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005515 |
protein binding |
MGI:MGI:2154647 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005515 |
protein binding |
MGI:MGI:4942258 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005515 |
protein binding |
MGI:MGI:68417 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005515 |
protein binding |
MGI:MGI:74309 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005576 |
extracellular region |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0964 |
C |
From MGI |
||
| GO:0005578 |
proteinaceous extracellular matrix |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0272 |
C |
From MGI |
||
| GO:0005615 |
extracellular space |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005622 |
intracellular |
MGI:MGI:2682187 |
IMP: Inferred from Mutant Phenotype |
C |
From MGI |
|||
| GO:0005622 |
intracellular |
MGI:MGI:3690518 |
IMP: Inferred from Mutant Phenotype |
C |
From MGI |
|||
| GO:0005622 |
intracellular |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005622 |
intracellular |
MGI:MGI:4943398 |
IMP: Inferred from Mutant Phenotype |
C |
From MGI |
|||
| GO:0005737 |
cytoplasm |
MGI:MGI:2181829 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005737 |
cytoplasm |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005771 |
multivesicular body |
MGI:MGI:3690518 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005783 |
endoplasmic reticulum |
MGI:MGI:2682187 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005783 |
endoplasmic reticulum |
MGI:MGI:3690518 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005794 |
Golgi apparatus |
MGI:MGI:2177349 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005794 |
Golgi apparatus |
MGI:MGI:2682187 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005886 |
plasma membrane |
MGI:MGI:2682187 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005886 |
plasma membrane |
MGI:MGI:4942258 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005886 |
plasma membrane |
MGI:MGI:4943662 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0006828 |
manganese ion transport |
MGI:MGI:4942264 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0006886 |
intracellular protein transport |
MGI:MGI:2682187 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0006886 |
intracellular protein transport |
MGI:MGI:3690518 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0007339 |
binding of sperm to zona pellucida |
MGI:MGI:1098917 |
IPI: Inferred from Physical Interaction |
P |
From MGI |
|||
| GO:0007339 |
binding of sperm to zona pellucida |
MGI:MGI:2154647 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0007339 |
binding of sperm to zona pellucida |
MGI:MGI:2181829 |
IGI: Inferred from Genetic Interaction |
P |
From MGI |
|||
| GO:0007339 |
binding of sperm to zona pellucida |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0007339 |
binding of sperm to zona pellucida |
MGI:MGI:4942258 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0010513 |
positive regulation of phosphatidylinositol biosynthetic process |
MGI:MGI:4943398 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0016020 |
membrane |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0472 |
C |
From MGI |
||
| GO:0016021 |
integral to membrane |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0812 |
C |
From MGI |
||
| GO:0030141 |
secretory granule |
MGI:MGI:2177349 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0031012 |
extracellular matrix |
MGI:MGI:2177349 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0031012 |
extracellular matrix |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0031012 |
extracellular matrix |
MGI:MGI:4943662 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0032190 |
acrosin binding |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0032234 |
regulation of calcium ion transport via store-operated calcium channel activity |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0032236 |
positive regulation of calcium ion transport via store-operated calcium channel activity |
MGI:MGI:4942264 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0032729 |
positive regulation of interferon-gamma production |
MGI:MGI:4943411 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0032753 |
positive regulation of interleukin-4 production |
MGI:MGI:4943411 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0035556 |
intracellular signal transduction |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0035556 |
intracellular signal transduction |
MGI:MGI:4942264 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0035803 |
egg coat formation |
MGI:MGI:2682187 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0035803 |
egg coat formation |
MGI:MGI:4943385 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0042102 |
positive regulation of T cell proliferation |
MGI:MGI:4943411 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0045860 |
positive regulation of protein kinase activity |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0045892 |
negative regulation of transcription, DNA-dependent |
MGI:MGI:4943379 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0045893 |
positive regulation of transcription, DNA-dependent |
MGI:MGI:4943379 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0048015 |
phosphatidylinositol-mediated signaling |
MGI:MGI:4943398 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0048471 |
perinuclear region of cytoplasm |
MGI:MGI:2682187 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0048599 |
oocyte development |
MGI:MGI:4943385 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0050729 |
positive regulation of inflammatory response |
MGI:MGI:4943379 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0051897 |
positive regulation of protein kinase B signaling cascade |
MGI:MGI:4943398 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0070528 |
protein kinase C signaling cascade |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0071421 |
manganese ion transmembrane transport |
MGI:MGI:4942264 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0090280 |
positive regulation of calcium ion import |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0090280 |
positive regulation of calcium ion import |
MGI:MGI:4942264 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:2000344 |
positive regulation of acrosome reaction |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:2000344 |
positive regulation of acrosome reaction |
MGI:MGI:4942264 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:2000360 |
negative regulation of binding of sperm to zona pellucida |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:2000368 |
positive regulation of acrosomal vesicle exocytosis |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:2000386 |
positive regulation of ovarian follicle development |
MGI:MGI:4943379 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:2000386 |
positive regulation of ovarian follicle development |
MGI:MGI:4943411 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:2000388 |
positive regulation of antral ovarian follicle growth |
MGI:MGI:4943385 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:2000388 |
positive regulation of antral ovarian follicle growth |
MGI:MGI:4943828 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
| ||
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 1.3 1.4 Clydesdale G et al. (2004) Contraception in mice immunized with recombinant zona pellucida subunit 3 proteins correlates with Th2 responses and the levels of interleukin 4 expressed by CD4+ cells. Reproduction 128: 737-45 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 Lloyd ML et al. (2010) Immunoglobulin to zona pellucida 3 mediates ovarian damage and infertility after contraceptive vaccination in mice. J Autoimmun 35: 77-85 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 3.3 Cohen N & Wassarman PM (2001) Association of egg zona pellucida glycoprotein mZP3 with sperm protein sp56 during fertilization in mice. Int J Dev Biol 45: 569-76 PubMed GONUTS page
- ↑ 4.0 4.1 4.2 4.3 4.4 O'Leary S et al. (2008) Immunization with recombinant murine cytomegalovirus expressing murine zona pellucida 3 causes permanent infertility in BALB/c mice due to follicle depletion and ovulation failure. Biol Reprod 79: 849-60 PubMed GONUTS page
- ↑ 5.0 5.1 5.2 5.3 5.4 5.5 5.6 5.7 O'Toole CM et al. (2000) Ca(2+) entry through store-operated channels in mouse sperm is initiated by egg ZP3 and drives the acrosome reaction. Mol Biol Cell 11: 1571-84 PubMed GONUTS page
- ↑ 6.0 6.1 6.2 6.3 6.4 Jungnickel MK et al. (2007) Phosphoinositide-dependent pathways in mouse sperm are regulated by egg ZP3 and drive the acrosome reaction. Dev Biol 304: 116-26 PubMed GONUTS page
- ↑ 7.0 7.1 Lu Q & Shur BD (1997) Sperm from beta 1,4-galactosyltransferase-null mice are refractory to ZP3-induced acrosome reactions and penetrate the zona pellucida poorly. Development 124: 4121-31 PubMed GONUTS page
- ↑ 8.0 8.1 Howes E et al. (2001) Interactions between mouse ZP2 glycoprotein and proacrosin; a mechanism for secondary binding of sperm to the zona pellucida during fertilization. J Cell Sci 114: 4127-36 PubMed GONUTS page
- ↑ Youakim A et al. (1994) Overexpressing sperm surface beta 1,4-galactosyltransferase in transgenic mice affects multiple aspects of sperm-egg interactions. J Cell Biol 126: 1573-83 PubMed GONUTS page
- ↑ Bookbinder LH et al. (1995) Tissue- and species-specific expression of sp56, a mouse sperm fertilization protein. Science 269: 86-9 PubMed GONUTS page
- ↑ 11.0 11.1 11.2 11.3 11.4 11.5 11.6 Zhao M et al. (2003) Mutation of a conserved hydrophobic patch prevents incorporation of ZP3 into the zona pellucida surrounding mouse eggs. Mol Cell Biol 23: 8982-91 PubMed GONUTS page
- ↑ 12.0 12.1 12.2 12.3 Hoodbhoy T et al. (2006) ZP2 and ZP3 traffic independently within oocytes prior to assembly into the extracellular zona pellucida. Mol Cell Biol 26: 7991-8 PubMed GONUTS page
- ↑ 13.0 13.1 Rankin TL et al. (1998) Human ZP3 restores fertility in Zp3 null mice without affecting order-specific sperm binding. Development 125: 2415-24 PubMed GONUTS page
- ↑ 14.0 14.1 14.2 El-Mestrah M et al. (2002) Subcellular distribution of ZP1, ZP2, and ZP3 glycoproteins during folliculogenesis and demonstration of their topographical disposition within the zona matrix of mouse ovarian oocytes. Biol Reprod 66: 866-76 PubMed GONUTS page
- ↑ 15.0 15.1 Monné M et al. (2008) Crystal structure of the ZP-N domain of ZP3 reveals the core fold of animal egg coats. Nature 456: 653-7 PubMed GONUTS page
- ↑ 16.0 16.1 16.2 Borillo J et al. (2008) Antibodies to two ZP3 B cell epitopes affect zona pellucida assembly. J Reprod Immunol 78: 149-57 PubMed GONUTS page
